7results about How to "Reduce thrombosis" patented technology

The invention relates to the technical field of medical instruments, in particular to an intravascular stent. According to the specific technical scheme, the intravascular stent comprises a stent skeleton, after the stent skeleton is subjected to surface treatment, at least one layer of film covering section is arranged outside the stent skeleton, and medicine release sections are arranged at the two ends of the stent skeleton. The problems that in the drug release process of an existing stent, the drug release rate is uneven, biocompatibility is poor, and thrombus and restenosis are caused by a metal stent are solved.

The invention relates to an acellular matrix material with biological functional activity and a preparation method thereof. The preparation method comprises the following steps: 1) providing an acellular matrix material subjected to crosslinking treatment; 2) reacting the crosslinked acellular matrix material with a biocompatible polymer, wherein the biocompatible polymer has a reactive group and a first subject and / or guest molecule; the reactive group is covalently bonded to a functional group on the acellular matrix material; and 3) reacting the acellular matrix material obtained in the step 2) with a second subject and / or guest molecule modified by a biological functional active substance through subject-guest interaction. Through the mode, the anti-calcification performance and the biological activity of the acellular matrix material can be improved at the same time, and the acellular matrix material is flexibly endowed with various biological function activities.

The invention discloses an active substance for strengthening cardiovascular functions of dogs and cats and a preparation method and application of soft capsules, and relates to the technical field of animal health care products. The composition comprises components such as kelp powder extract, coix seed extract, Omega-3 fatty acid, coenzyme Q10, L-carnitine, vitamin B6, vitamin E and the like, and the components jointly act on proliferation, metabolism and transcription processes of vascular endothelial cells of dogs and cats. Through in-vitro metabonomics and transcriptomics analysis, the composition has the effects of promoting proliferation of vascular endothelial cells of dogs and cats, increasing cell elasticity, reducing the risk of thrombus and sclerosis and the like. In addition, the invention also provides application of the composition in preparation of food for strengthening cardiovascular functions of dogs and cats. Compared with the prior art, the composition provided by the invention can provide an effective health-care strategy and can remarkably promote cardiovascular functions of dogs and cats.

The application discloses an implant device interface system capable of realizing rapid cell adhesion and controllable release, a method and application, and relates to the technical field of biomedical materials and tissue engineering. The interface system comprises a first reaction group fixed on the surface of an implant device and a second reaction group inserted into the membrane of target cells through a membrane anchoring molecule; the membrane anchoring molecule comprises a cleavable linker; the first and second reaction groups constitute a complementary system such as click chemistry or biological orthogonality. The system realizes rapid adhesion within 0.5-6 hours, the cell migration rate increases after 6 hours of triggering, and a monolayer is formed within 12-48 hours, the cell tight junction is enhanced, and the blood compatibility is good (hemolysis rate < 5%). The system is applicable to different materials and cell types, and is suitable for surface cell construction and biological integration improvement of small-diameter artificial blood vessels, vascular stents, catheters, valves and other devices.

This specification provides a structure for in vitro blood perfusion that can effectively remove reactive oxygen species (ROS) that cause inflammation in the blood, an in vitro blood perfusion tube including the structure and an in vitro blood purification device, a method for preparing the structure, and an in vitro blood purification method using the in vitro blood purification device, wherein the structure for in vitro blood perfusion includes cerium dioxide nanoparticles and a carrier loaded with cerium dioxide nanoparticles.

The invention relates to the technical field of nutritious food, in particular to a composition for treating and preventing cardiovascular and cerebrovascular balancing enzyme and a preparation method, and the composition comprises the following raw materials by weight percentage: streptokinase, catalase, lipase, soybean protease, red yeast rice, flavonoids, anthocyanin, short-chain fatty acid and green tea polyphenol. The specific composition comprises the following raw materials: 10-15 parts of streptokinase, 8-12 parts of catalase, 12-15 parts of lipase, 9-12 parts of soybean protease, 6-10 parts of red yeast rice, 7-10 parts of flavonoids, 2-8 parts of anthocyanin, 4-7 parts of short-chain fatty acid and 11-14 parts of green tea polyphenol. Clinical tests and animal experiments prove that the cardiovascular and cerebrovascular balancing enzyme composition can remarkably improve key physiological indexes of blood fat, blood sugar and blood pressure and reduce cardiovascular and cerebrovascular risk factors such as arteriosclerosis and thrombosis, and meanwhile, patients who use the cardiovascular and cerebrovascular balancing enzyme composition for a long time have no toxic or side effects. The indexes such as arteriosclerosis index and blood fat are obviously improved, and the occurrence risk of cardiovascular and cerebrovascular diseases is greatly reduced.

The invention discloses a coronary rapamycin targeted elution stent which is thin in wall, small in occupied space, good in blood vessel trafficability, small in interference on blood flow, beneficial to maintaining normal blood flow, high in supporting force and pushing force, more flexible in the conveying process and capable of passing through tortuous and narrow coronary artery diseased regions more easily. The stent body can be well attached to the blood vessel wall, the gap between the stent body and the blood vessel wall is reduced, growth and covering of vascular endothelial cells are facilitated, and the risk of thrombosis and restenosis is reduced; the connecting piece is omega-shaped, so that the bracket main body can form enough radial strength; the polymer coating coated on the surface of the stent main body not only can finish precise sustained release of a drug, but also can realize complete degradation, and the polymer coating can promote growth and repair of vascular endothelial cells, accelerate the vascular endothelialization process, and is beneficial to recovery of normal physiological functions of blood vessels, so that the stent has a good application prospect. And the risk of thrombosis and restenosis is reduced.