2results about How to "Reduce thrombosis" patented technology

The application discloses an implant device interface system capable of realizing rapid cell adhesion and controllable release, a method and application, and relates to the technical field of biomedical materials and tissue engineering. The interface system comprises a first reaction group fixed on the surface of an implant device and a second reaction group inserted into the membrane of target cells through a membrane anchoring molecule; the membrane anchoring molecule comprises a cleavable linker; the first and second reaction groups constitute a complementary system such as click chemistry or biological orthogonality. The system realizes rapid adhesion within 0.5-6 hours, the cell migration rate increases after 6 hours of triggering, and a monolayer is formed within 12-48 hours, the cell tight junction is enhanced, and the blood compatibility is good (hemolysis rate < 5%). The system is applicable to different materials and cell types, and is suitable for surface cell construction and biological integration improvement of small-diameter artificial blood vessels, vascular stents, catheters, valves and other devices.

This specification provides a structure for in vitro blood perfusion that can effectively remove reactive oxygen species (ROS) that cause inflammation in the blood, an in vitro blood perfusion tube including the structure and an in vitro blood purification device, a method for preparing the structure, and an in vitro blood purification method using the in vitro blood purification device, wherein the structure for in vitro blood perfusion includes cerium dioxide nanoparticles and a carrier loaded with cerium dioxide nanoparticles.