577results about How to "Prevent coagulation" patented technology

A device for treating blood by extracorporeal circulation comprising a filter having a first chamber and a second chamber separated by a semi-permeable membrane. The device has an arterial line connected to the first chamber of the filter, a venous line issuing from the first chamber of the filter, a channel used for pre-infusion of a substance for regional anticoagulation and linked to the arterial line, a purge channel issuing from the second chamber of the filter, and an air separator on the venous line. The device also includes a line for post-infusion of a solution at least partially re-establishing the ionic equilibrium of the blood downstream of the air separator, the post-infusion line being configured immediately upstream of an air detector.

A microwave applicator for insertion into living body tissue for use in microwave coagulation and ablation treatments includes a microwave transmission line extending between an attachment end of the applicator and an antenna toward an insertion end of the applicator with an outer conductive sleeve forming an enclosed cooling fluid space around the transmission line. Circulation of cooling fluid is guided in the cooling fluid space by a guide sleeve. A fluid circulation system provides a plurality of fluid supply connectors and fluid return connectors which can be connected and used with any number of applicators between one and the number of the fluid supply connectors provided by the system. A portion of the applicator inserted into the tissue can stick to the tissue to stabilize the applicator during treatment. A warning marking on the applicator can be used during track ablation to prevent ablation of the patient skin tissue.

A method and apparatus to endovascularly treat blood vessels using a light beam that causes minimal collateral damage to surrounding tissue is described. The technique can improve the appearance of a blood vessel and/or reduce its size, as well as relieve other medical symptoms. The wavelength of the light beam can be selected so as to heat one or more chromophores either inside the blood vessel or within the blood vessel wall itself. Access to the vein lumen of the targeted blood vessel can be obtained via an optical fiber inserted into the blood vessel through a catheter.

A biodegradable antithrombotic conjugate having heparin and other anti-thrombotic moieties are introduced as side chains to the polymer backbone modified by click chemistry. Various bioabsorbable monomers and dimers such as valerolactone may be used in the monomer derivation, homo- and co-polymerization, and the conjugation with a biologically active molecule by click chemistry. A coating comprising a biocompatible and bioabsorbable polymer anti-thrombotic conjugate is applied to at least a portion of an implantable device to prevent or reduce the formation of thrombosis on the surface of the implantable device. A first or sub-layer of the coating is prepared by mixing a polymeric material and a biologically active agent with a solvent, thereby forming a homogeneous solution. A second or outer layer comprising the present anti-thrombotic conjugate may be applied over the inner drug-containing layers using, for example, a dip coating or spray coating process.

Disclosed is a stent assembly for expanding in vivo vessels, the assembly comprising first and second radially expandable mesh stents, wherein the first stent is separated by a predetermined distance from the second stent and a stent jacket spans the predetermined distance such that a first end of the jacket is operatively associated with the first stent and a second end of the jacket is operatively associated with the second stent.

Various embodiments include a method of producing chemically pure and stably dispersed metal and metal-alloy nanoparticle colloids with ultrafast pulsed laser ablation. A method comprises irradiating a metal or metal alloy target submerged in a liquid with ultrashort laser pulses at a high repetition rate, cooling a portion of the liquid that includes an irradiated region, and collecting nanoparticles produced with the laser irradiation and liquid cooling. The method may be implemented with a high repetition rate ultrafast pulsed laser source, an optical system for focusing and moving the pulsed laser beams, a metal or metal alloy target submerged in a liquid, and a liquid circulating system to cool the laser focal volume and collect the nanoparticle products. By controlling various laser parameters, and with optional liquid flow movement, the method provides stable colloids of dispersed metal and metal-alloy nanoparticles. In various embodiments additional stabilizing chemical agents are not required.

Catheter systems and methods are disclosed. An exemplary catheter includes an outer tubing housing and an inner fluid delivery tubing, the inner fluid delivery tubing having at least one fluid delivery port. The catheter also includes a deployment member movable axially within the inner fluid delivery tubing. A plurality of splines are each connected at a proximal end to the outer tubing and at a distal end to deployment member. A seal is provided between the outer tubing and the inner fluid delivery tubing. A gasket is provided between the deployment member and the inner fluid delivery tubing. Both the seal and the gasket are configured to prevent blood or other fluid from ingressing into the outer tubing.

A plastic container for liquid medicine, which, concerning the effective components of liquid medicine, is capable of prevention of deterioration in quality due to mixing of oxygen and water vapor, prevention of variation in concentration due to water volatilization and moisture absorption, etc. A plastic container for liquid medicine, which is a plastic container internally coated with DLC (diamond-like carbon) film wherein water vapor permeability is 0-0.006 g/container/day and oxygen permeability is 0-0.011 ml/container/day, such properties being obtained by optimizing the three conditions, composition, density and film thickness of the DLC film.

The present invention relates to compounds to inhibit blood coagulation, and more particularly to novel diketopiperazine derivatives, pharmaceutically acceptable salts and compositions thereof, to specifically inhibit thrombin. The compound has the following general structure

wherein R¹, R² and R⁴ consist of a hydrogen, alkyl or aryl moiety, R³ consist of an alkyl or aryl moiety, wherein R⁵ consists of a hydrogen, alkyl, aryl, hydroaryl, heteroaryl, hydroheteroaryl, sulfonylalkyl, sulfonylaryl, sulfonylhydroaryl, sulfonylheteroaryl or sulfonylhydroheteroaryl moiety, and wherein R⁶ consists of a hydrogen, alkyl, aryl, hydroaryl, heteroaryl or hydroheteroaryl moiety. Also disclosed are methods of using the compound for treating coagulation disorders such as thrombosis and heparin associated thrombocytopenia.

The Chinese medicine oral preparation with the functions of warming channels, expelling pathogenic cold, removing dampness, promoting blood circulation, removing stasis, replenishing qi, nourishing blood, relieving rigidity of muscles and joints and stopping pain for curing acute and chronic osteoarthropathy and rheumatoid arthritis is made of 33 Chinese medicinal amterials of notopterygium root,pubescenjt angelica root, turmeria, Chinese angelica root, red peony root, astragalus root and others through the processes of proportioning, mixing and pulvering, rate.

A lubricant composition is disclosed that comprises: (a) a lubricant and (b) at least one molybdenum-containing compound in the form of surface-capped nanosized particles of the general formula: (Z)_n(X—R)_m wherein Z is an inorganic moiety comprising molybdenum and sulfur in the form of particles having dimensions in the range of from about 1 to about 100 nm; (X—R) is a surface-capping reagent wherein R is a C₄ to C₂₀ straight or branched-chain alkyl or alkylated cycloalkyl radical or radicals and X is a functional group capable of specific sorption and/or chemical interaction with molybdenum/sulfur moiety; n is the number of molecules of Z in the particles; m is an integer representing the amount of surface-capping reagents relative to a single particle; and the ratio of m to n is in the range of from about 1:1 to about 10:1.

The present invention provides a hot melt conductor paste composition that includes conductive particles and glass particles dispersed in a thermoplastic polymer system. The hot melt conductor paste composition according to the invention is a solid at room temperature, but melts at a temperature of from about 35° C. to about 90° C. to form a flowable liquid that can be applied to a silicon substrate by screen printing. The hot melt conductor paste composition is particularly suitable for use in the fabrication of photovoltaic cells.

A device for separating plasma from whole blood is provided having an evacuated primary collection chamber capable of fluid communication through a porous filter to an evacuated secondary collection chamber. An agglutinating agent is provided within the primary collection chamber so as to aggregate blood cells within a whole blood sample. The porous filter has a pore size which is small enough to capture the aggregated blood cells therein, yet large enough to permit plasma to transfer therethrough under pressures associated with conventional evacuated blood collection tubes. The primary and secondary collection chambers may be provided in separate containers or tubes, with transfer occurring therebetween through a transfer device including the porous filter therein.

A single-use system for separating blood and producing platelet concentrates includes an elongated container for receiving blood from a patient. The container has a movable plunger mounted within the blood container for expressing blood fractions separated during centrifugation of the container through a first port mounted at one end of said container, a second port mounted on the plunger, and a third port mounted on a plunger rod attached to the plunger.

The invention belongs to the technical field of functional polymer materials, and in particular relates to a super-hydrophobic/super-oleophylic polyurethane oil-absorption sponge and a preparation method thereof. According to the technical scheme, the super-hydrophobic/super-oleophylic polyurethane oil-absorption sponge is prepared from the following components in parts by weight: 10-50 parts of polyisocyanates, 20-60 parts of a chain extender, 0.05-1.5 parts of a catalyst, 1-4 parts of a chemical foaming agent, 1.0-8.0 parts of a physical foaming agent, 0.5-3 parts of a cross-linking agent and 2-20 parts of other additives. The invention further provides the preparation method of the super-hydrophobic/super-oleophylic polyurethane oil-absorption sponge. The oil-absorption sponge provided by the invention has the advantages of super-hydrophobicity, super-oleophylicity, large specific surface area, porous polymolecular layers, capillary agglutination super oil-absorption property, environment inertia and the like, and is a high-efficiency rapid separation material which can be applied to emergency treatment on ocean oil overflowing pollution accidents.

A composition and method for formulating and delivering an adjuvanted immunological active agent, especially a vaccine, wherein adjuvant coagulation and concomitant loss of vaccine efficacy enhancement is mitigated or avoided. The adjuvanted, immunologically-active agent can be subjected to freezing, drying, freeze-drying, or lyophilization, and when reconstituted, retains a high level of potency. The present invention further provides for a composition and method for formulating and delivering a stable, adjuvanted, immunologically-active agent capable of being deposited on a transdermal delivery device or microprojection or array thereof.

The invention discloses a preparation method of high-quality and large-scale novel two-dimensional material, namely, single-crystal less-layer antimonene. The liquid phase ultrasonic stripping technology is adopted, and a fifth main-group antimony nano-sheet is stripped through ultrasonic assisting of antimony powder, ethanol and surfactant. Firstly, the antimony powder and ethanol are mixed at room temperature; secondly, a proper amount of surfactant is added, the mixture is ultrasonically treated for a period of time under certain power, and then antimonene is massively prepared. Preparation process parameters are adjusted, and the size of antimonene can be adjusted. Reaction conditions are mild, the preparation process is simple, and the preparation method can be used for large-scale preparation. The less-layer antimonene prepared through the method is uniform in thickness and size, adjustable in size, high in purity and good in degree of crystallinity.

The present invention relates to a device for treating the eye, including a body portion configured to be positioned adjacent the exterior surface of the cornea and a heating means for heating the body portion to a predetermined temperature to affect at least one of the following: facilitation of the escape of aqueous humor from the eye and substantially preventing coagulation of the corneal tissue, while substantially destroying tumor cells.