5 results about "Anticoagulant Agent" patented technology

This invention relates to the field of biomedicine, specifically to the application of banana fruit extract in the preparation of anticoagulant or antithrombotic drugs. The banana fruit extract provided by this invention contains flavonoids, polyphenols, polysaccharides, hydroxyanthraquinones, triterpenoids, and other components. Flavonoids and polyphenols have been widely proven to have anti-inflammatory and antioxidant effects, which can synergistically enhance the anticoagulant effect. The high potassium content of banana fruit can indirectly improve vascular function by regulating sodium-potassium balance. The banana fruit extract provided by this invention can inhibit platelet production or promote platelet metabolism, prolong clotting time, and inhibit platelet aggregation. Its natural plant components interfere with platelet aggregation by inhibiting the production of thromboxane A2, achieving anticoagulant and antithrombotic effects. The mechanism of action of banana fruit extract differs from traditional anticoagulants such as heparin, reducing the risk of bleeding. Its natural component characteristics provide a direction for the development of novel plant-derived anticoagulant drugs.

Current approaches in small diameter vascular grafts for coronary artery bypass surgeries fail to address physiological variations along the graft that contribute to thrombus formation and ultimately graft failure. An interlayer drug delivery system can sustain delivery of heparin through the graft with a high degree of temporal and spatial control. A heparin-loaded gelatin methacrylate interlayer sits between a biohybrid composed of decellularized bovine pericardium and poly(propylene fumarate) and UV crosslinking is controlled via 3D printed shadow masks. The masks enable control of the resultant gelMA crosslinking and properties by modulating the incident light intensity on the graft. High doses of heparin have detrimental effects on endothelial cell function. When exposed to heparin in a slower, more sustained manner consistent with the masks, endothelial cells behave similarly to untreated cells. Slower release profiles cause significantly more release of tissue factor pathway inhibitor, an anticoagulant, than a faster release profile.

The application discloses a kind of automatic penetration sampling machines for nursing in nephrology department, and relates to the technical field of sampling device.It includes base, the upper surface of base is slidably connected with fixing frame, a plurality of groups of placing grooves are formed in the upper surface of fixing frame, and test tubes are arranged on the inner wall of placing groove, a plurality of groups of positioning cylinders are movably arranged on the upper surface of fixing frame, a transmission assembly for moving fixing frame is arranged in the base, a lifting assembly is arranged at the right position on the upper surface of base, and the lifting assembly includes motor.The application realizes automatic mixing operation of sample and anticoagulant in test tube by mixing assembly, without manual operation, which reduces the insufficient mixing of sample caused by insufficient number of test tube inversion or insufficient inversion angle to a certain extent, and the test tube generates synchronous rotation during inversion, which greatly increases the contact area of sample and anticoagulant, improves the mixing effect, and improves the accuracy of subsequent detection results to a certain extent.

This application discloses a microfluidic detection chip and detection device for simultaneous multiple detections. The detection device includes a microfluidic detection chip for simultaneous multiple detections. The microfluidic chip includes a substrate, on which are formed a sample inlet chamber, at least two independent quantitative regions, and at least two independent detection regions, with each quantitative region corresponding to a detection region. The inlet of each quantitative region is connected to the sample inlet chamber, and the outlet of each quantitative region is connected to the detection region. An anticoagulant is placed within each quantitative region, and the anticoagulant used in different quantitative regions is different. The microfluidic detection chip and detection device disclosed in this application solve the problem of low detection efficiency in existing microfluidic detection chips.

The application discloses a self-derived protein anticoagulant coating and a preparation method and application thereof. The coating utilizes the oxidation of hydrogen peroxide generated by the reaction of an oxidizing agent or a reducing agent with oxygen in the air, is based on the endogenous active center (such as hematin) removal mechanism of self-extracted proteins (such as hemoglobin), induces the oxidative self-assembly of the proteins, and loads an anticoagulant in the assembly process to form a protein-anticoagulant composite nanofilm. The application utilizes the self-proteins to avoid the transmission risk of pathogens such as HIV, PERVs and prions from the source; the preparation method is simple and rapid, and the obtained coating has excellent adhesion stability, good biocompatibility and anti-biofouling capacity on the surface of various substrates. In-vitro and in-vivo experiments prove that the coating has superior anticoagulant performance, reduces the risk of bleeding and liver and kidney toxicity, and can be used for the surface modification of blood-contacting medical devices such as a heart stent, an artificial blood vessel, a central venous catheter and an extracorporeal oxygenator.