10 results about "Anticoagulant Agent" patented technology

The utility model discloses a blood filtering treatment device, which relates to the technical field of filtering equipment and comprises a shell, and a liquid outlet notch communicated with an inner cavity of the shell is formed in the bottom wall of the shell; the filter cartridge is fixedly arranged in the cavity of the shell, and a plurality of filtrate ports are formed in the outer wall of the lower part of the filter cartridge in a penetrating manner; the hopper is arranged on the outer wall above the shell, and the lower end of the hopper is communicated with the inner wall of the filter drum. According to the blood filtering treatment device, blood and impurities are separated at a time, meanwhile, the shape of the impurities is not damaged, the product quality is not affected, blood clots coagulated in the blood can be reduced to be in a liquid state through equipment, the cost of an anticoagulant agent is saved from the source, the additional value of the product is greatly improved, and the production cost is reduced. According to the innovation of the equipment, the use area of a filtering workshop is greatly saved, the capital investment is reduced, and the equipment realizes breakthrough innovation in the blood filtering field, integrates independent crushing and independent filtering forms, and realizes the effect of integrating hair removal and pulping.

This invention relates to the field of biomedicine, specifically to the application of banana fruit extract in the preparation of anticoagulant or antithrombotic drugs. The banana fruit extract provided by this invention contains flavonoids, polyphenols, polysaccharides, hydroxyanthraquinones, triterpenoids, and other components. Flavonoids and polyphenols have been widely proven to have anti-inflammatory and antioxidant effects, which can synergistically enhance the anticoagulant effect. The high potassium content of banana fruit can indirectly improve vascular function by regulating sodium-potassium balance. The banana fruit extract provided by this invention can inhibit platelet production or promote platelet metabolism, prolong clotting time, and inhibit platelet aggregation. Its natural plant components interfere with platelet aggregation by inhibiting the production of thromboxane A2, achieving anticoagulant and antithrombotic effects. The mechanism of action of banana fruit extract differs from traditional anticoagulants such as heparin, reducing the risk of bleeding. Its natural component characteristics provide a direction for the development of novel plant-derived anticoagulant drugs.

A transdermal patch for delivering lidocaine for pain relief comprises a backing layer, an adhesive layer, and a composition containing lidocaine in an amount ranging from about 1% to about 10% by weight and heparin as a non-anticoagulant permeation enhancer in an amount ranging from about 1% to about 50% by weight. The heparin enhances permeation of lidocaine through the skin without exerting systemic anticoagulant effects by temporarily disrupting lipid bilayers in the stratum corneum to create microchannels for increased diffusion of lidocaine molecules. The patch provides effective relief for multiple pain types including neuropathic pain, inflammatory pain, ischemic pain, post-surgical pain, nociplastic pain, mechanical pain, and compressive pain. The transdermal patch is configured to provide sustained release of lidocaine for periods ranging from about 8 hours to about 24 hours, reducing pain by at least 50% with minimal systemic absorption.

Current approaches in small diameter vascular grafts for coronary artery bypass surgeries fail to address physiological variations along the graft that contribute to thrombus formation and ultimately graft failure. An interlayer drug delivery system can sustain delivery of heparin through the graft with a high degree of temporal and spatial control. A heparin-loaded gelatin methacrylate interlayer sits between a biohybrid composed of decellularized bovine pericardium and poly(propylene fumarate) and UV crosslinking is controlled via 3D printed shadow masks. The masks enable control of the resultant gelMA crosslinking and properties by modulating the incident light intensity on the graft. High doses of heparin have detrimental effects on endothelial cell function. When exposed to heparin in a slower, more sustained manner consistent with the masks, endothelial cells behave similarly to untreated cells. Slower release profiles cause significantly more release of tissue factor pathway inhibitor, an anticoagulant, than a faster release profile.

The application discloses a kind of automatic penetration sampling machines for nursing in nephrology department, and relates to the technical field of sampling device.It includes base, the upper surface of base is slidably connected with fixing frame, a plurality of groups of placing grooves are formed in the upper surface of fixing frame, and test tubes are arranged on the inner wall of placing groove, a plurality of groups of positioning cylinders are movably arranged on the upper surface of fixing frame, a transmission assembly for moving fixing frame is arranged in the base, a lifting assembly is arranged at the right position on the upper surface of base, and the lifting assembly includes motor.The application realizes automatic mixing operation of sample and anticoagulant in test tube by mixing assembly, without manual operation, which reduces the insufficient mixing of sample caused by insufficient number of test tube inversion or insufficient inversion angle to a certain extent, and the test tube generates synchronous rotation during inversion, which greatly increases the contact area of sample and anticoagulant, improves the mixing effect, and improves the accuracy of subsequent detection results to a certain extent.

This application discloses a microfluidic detection chip and detection device for simultaneous multiple detections. The detection device includes a microfluidic detection chip for simultaneous multiple detections. The microfluidic chip includes a substrate, on which are formed a sample inlet chamber, at least two independent quantitative regions, and at least two independent detection regions, with each quantitative region corresponding to a detection region. The inlet of each quantitative region is connected to the sample inlet chamber, and the outlet of each quantitative region is connected to the detection region. An anticoagulant is placed within each quantitative region, and the anticoagulant used in different quantitative regions is different. The microfluidic detection chip and detection device disclosed in this application solve the problem of low detection efficiency in existing microfluidic detection chips.

The present invention provides a method for using an anticoagulant reversal agent to prevent, treat or alleviate bleeding caused by anticoagulants. The anticoagulant reversal agent has a structure represented by formula I, can well inhibit bleeding complications caused by the anticoagulants, for example, can inhibit bleeding complications caused by the anticoagulants such as direct thrombin inhibitors and Xa factor inhibitors, and has the broad-spectrum and high-efficiency characteristics.

The application provides a high blood pressure blood sample protective agent, a vacuum blood collection tube for high blood pressure blood sample detection and application, and belongs to the technical field of medical devices. The high blood pressure blood sample protective agent is characterized in that raw materials of the high blood pressure blood sample protective agent include enalapril maleate, an anticoagulant and a complexing agent in terms of weight parts. The vacuum blood collection tube for high blood pressure blood sample detection has the high blood pressure blood sample protective agent. The application is to directly save blood by using the vacuum blood collection tube for high blood pressure blood sample detection. The vacuum blood collection tube for high blood pressure blood sample detection can reduce the cumbersome steps of reagent preparation and on-site reagent addition, thereby improving the detection efficiency and the accuracy of the detection result.

The invention belongs to the technical field of medical treatment, and discloses a method and a system for separating self red blood cells. Comprising the following steps: washing red blood cells with normal saline for three times, removing supernatant as much as possible under the condition of retaining an albuginea layer, retaining packed red blood cells, and uniformly mixing; adding at least two tubes of uniformly mixed packed red cells into the capillary tube by using a sample adding gun; sealing the bottom of the pipe with sealing mud; putting the capillary tube with the sealing mud at one end downwards into a blood collection tube without an anticoagulant, and tightening a blood collection tube cap; centrifuging for 5 minutes by using a blood sample centrifugal machine, wherein the centrifugal force setting condition is 2000g or 3500rpm; after centrifugation, the sample is carefully and vertically taken out from the blood collection tube without shaking; cutting off a capillary tube at one end without sealing mud, namely a proximal end, and transferring cells 5 mm away from the upper part of the capillary tube into a 12 * 75 mm test tube; after washing with normal saline, centrifuging, introducing the intercepted 5mm capillary tube and washing liquid into a waste liquid cylinder, and retaining the volume of red blood cells. According to the method, the operation cost and the equipment investment are effectively reduced by reducing the equipment requirement and shortening the centrifugal time.

The application discloses a self-derived protein anticoagulant coating and a preparation method and application thereof. The coating utilizes the oxidation of hydrogen peroxide generated by the reaction of an oxidizing agent or a reducing agent with oxygen in the air, is based on the endogenous active center (such as hematin) removal mechanism of self-extracted proteins (such as hemoglobin), induces the oxidative self-assembly of the proteins, and loads an anticoagulant in the assembly process to form a protein-anticoagulant composite nanofilm. The application utilizes the self-proteins to avoid the transmission risk of pathogens such as HIV, PERVs and prions from the source; the preparation method is simple and rapid, and the obtained coating has excellent adhesion stability, good biocompatibility and anti-biofouling capacity on the surface of various substrates. In-vitro and in-vivo experiments prove that the coating has superior anticoagulant performance, reduces the risk of bleeding and liver and kidney toxicity, and can be used for the surface modification of blood-contacting medical devices such as a heart stent, an artificial blood vessel, a central venous catheter and an extracorporeal oxygenator.