Anticoagulant and metal-organic framework compound dual-modified in-vitro blood circulation pipeline coating and preparation method thereof

An organic framework and double modification technology, applied in the direction of anticoagulation treatment, coating, catheter, etc., can solve the problems of high risk of hypothrombocytemia, no consideration of antibacterial properties of materials, easy occurrence of thrombus, blood coagulation and other problems, and achieve improvement Blood compatibility and antibacterial performance, improvement of blood compatibility, effect of inhibiting bacterial adhesion

Inactive Publication Date: 2021-07-09
重庆天外天生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The current blood circulation tubes on the market have the following disadvantages: lack of anticoagulant coating, prone to side effects such as thrombus and blood coagulation; Anticoagulation is achieved through the mixing and extrusion of granular heparin, which will cause inactivation of heparin and lack of anticoagulant effect; some pipelines achieve anticoagulation through co-extrusion coating, involving a variety of organic solvents, which is not friendly to the environment , easy to produce toxic and side effects on the human body; coating at the same time leads to a thicker coating, which affects the thickness of the pipeline; the existing blood circulation pipeline usually does not consider the antibacterial properties of the material

Method used

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  • Anticoagulant and metal-organic framework compound dual-modified in-vitro blood circulation pipeline coating and preparation method thereof
  • Anticoagulant and metal-organic framework compound dual-modified in-vitro blood circulation pipeline coating and preparation method thereof
  • Anticoagulant and metal-organic framework compound dual-modified in-vitro blood circulation pipeline coating and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0044]Example 1. Preparation of MOF-Ag and Heparin Double Modified Extracorporeal Blood Circulation Tubing Coating

[0045] 1. Preparation of MOF-Ag and heparin double-modified coatings on the inner surface of extracorporeal blood circulation lines

[0046] Follow the steps below:

[0047] 1) The trimesic acid is prepared as a 0.05 g / ml solution of trimesic acid in absolute ethanol. Dissolve silver nitrate in ultrapure water to obtain a silver nitrate solution with a final concentration of 0.05 g / ml. Trimellitic acid solution and silver nitrate solution were mixed at a volume ratio of 3:1, and mechanically stirred for 8 hours. Then the obtained product was suction-filtered, and washed repeatedly with absolute ethanol and ultrapure water to obtain pure silver trimesic acid for use.

[0048] 2) Prepare Tris buffer solution (PH: 8.5) containing 2 mg / ml dopamine, and then dissolve silver trimesate in the dopamine solution to obtain solution 1 with a concentration of 0.5 mg / ml, ...

Embodiment 2

[0061] Example 2. Preparation of MOF-Cu and heparin double-modified extracorporeal blood circulation pipeline modification coating of the present invention

[0062] 1. Prepare MOF-Cu and heparin double modified coating of the present invention on the inner surface of the extracorporeal blood circulation pipeline

[0063] Follow the steps below:

[0064] 1) The trimesic acid is prepared as a 0.5 g / ml solution of trimesic acid in absolute ethanol. Copper nitrate was dissolved in ultrapure water to obtain a copper nitrate solution with a final concentration of 0.5 g / ml. Mix trimesic acid solution and copper nitrate solution at a volume ratio of 3:1, and stir mechanically for 16 hours. Then the obtained product was suction-filtered, and washed repeatedly with absolute ethanol and ultrapure water to obtain pure trimesic acid copper for future use.

[0065] 2) Prepare a Tris buffer solution (PH: 8.5) containing 2 mg / ml dopamine, and then dissolve copper trimesate in the dopamine ...

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Abstract

The invention discloses an anticoagulant and metal-organic framework compound dual-modified in-vitro blood circulation pipeline coating and a preparation method thereof. The anticoagulant of the coating is selected from heparin, hirudin, citric acid or argatroban, and the metal-organic framework compound in the coating is MOF-Ag or MOF-Cu; the coating is obtained by fixing the metal-organic framework compound on the inner wall of an in-vitro blood circulation pipeline through dopamine and then fixing the anticoagulant on a dopamine layer with the metal-organic framework compound in a chemical grafting mode. The coating is high in stability, can improve blood compatibility and has excellent anticoagulation and antibacterial effects; and the in-vitro blood circulation pipeline with the coating can be applied to conventional hemodialysis, blood adsorption and continuous blood purification treatment.

Description

technical field [0001] The invention relates to the technical field of blood purification, in particular to an extracorporeal blood circulation pipeline coating double-modified with an anticoagulant and a metal-organic framework compound and a preparation method thereof. Background technique [0002] Blood circulation pipelines are materials that are in contact with blood for a long time, and the anticoagulant performance of materials has always been a hot spot in the industry. When the blood comes into contact with the tubing, small molecules and plasma proteins in the plasma are first adsorbed on the surface of the tubing, leading to activation of thrombin and denaturation of fibrin, leading to platelet aggregation and thrombus formation. Therefore, for blood circulation lines, the anticoagulant performance of the tubing is very important. At present, the main clinical method to prevent blood coagulation is to inject heparin solution through a heparin tube to achieve the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L33/10A61L33/04A61L33/06A61L29/04A61L29/06A61L29/08A61L29/16C08G83/00
CPCA61L33/0029A61L33/04A61L33/08A61L33/12A61L29/06A61L29/041A61L29/085A61L29/16C08G83/008A61L2300/418A61L2300/232A61L2300/252A61L2300/21A61L2300/606C08L77/04C08L87/00
Inventor 高光勇谢银红秦继忠唐金龙
Owner 重庆天外天生物技术有限公司
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