The invention discloses a solid phase method for synchronizing Argatroban, including the following steps: (1) (2R, 4R)-N-Fmoc-4-methyl-2-nipecotic acid, macromolecule resin, protective amino acid, coupling reagent and organic base are used as starting raw materials to form (2R, 4R)-N-Fmoc-4-methyl-2-nipecotic acid-resin; (2) Fmoc protection is removed, and a solid phase method is adopted to couple Fmoc-Arg(X)-OH so as to obtain Fmoc-Arg(X)-(2R, 4R)-4-methyl-2-nipecotic acid-resin; (3) the Fmoc protection is removed, and after 3-methyl-1,2,3 4-tetrahydroquinoline-sulfonic acid chloride is coupled, complete full protection Argatroban-resin is obtained; (4) complete peptide protection Argatroban-resin is reacted with a side chain separated blocking group so as to gain the crude product of the Argatroban; and (5) after the operation of recrystallization is carried out, the Argatroban with high purity is obtained. The technical process of the invention has the advantages of simple reaction operation, easy post treatment, less raw material, low cost, more than 80 percent of total yield, considerable economic and practical value as well as broad application prospect in the field of designing and synchronizing polypeptide drugs.