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Anticoagulation PVDF flat separation film and making method thereof

A technology of PVDF-ARG and separation membrane, which is applied in the field of anticoagulant PVDF flat separation membrane and its preparation, can solve problems such as blood coagulation, achieve the effects of reduced hemolysis rate, prolonged recalcification time, and easy industrial implementation

Inactive Publication Date: 2016-02-10
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem of blood coagulation occurring in the contact between the existing PVDF membrane and blood, the technical problem to be solved by the present invention is to provide a PVDF flat separation membrane with good anticoagulant performance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Alkali treatment of PVDF powder: Prepare 2.5mol / L potassium hydroxide solution, pour 400ml of the prepared potassium hydroxide solution into the flask, place the flask in a constant temperature water bath at 60°C, and after half an hour, put it in the flask again Add 60g of PVDF powder to the reaction system, add 12ml of absolute ethanol to the reaction system to fully disperse the PVDF in the system, stir and react for 15min, filter the obtained product with suction, and wash it with distilled water for several times, and finally put the washed powdery solid product into Dry in an oven at 60°C until use.

[0029] (2) Preparation of PVDF-g-PAA copolymer: Weigh 10g of alkali-treated PVDF powder into a 250ml three-neck flask, then add 120ml of DMF solvent, heat and stir in a water bath at 65°C to dissolve completely. Blow nitrogen, weigh 10g AA, add 0.2g initiator AIBN into the reaction system, stir and react for 12h in nitrogen environment to obtain PVDF-g-PAA copoly...

Embodiment 2

[0034] (1) Alkali treatment of PVDF powder: with embodiment 1.

[0035](2) Preparation of PVDF-g-PAA copolymer: Weigh 10 g of alkali-treated PVDF powder into a three-necked flask, then add 120 ml of DMF solvent, heat and stir in a constant temperature water bath at 70°C to dissolve. Nitrogen was blown, 5gAA was weighed, 0.2g initiator AIBN was added into the reaction system, and the reaction was stirred and reacted for 12h in a nitrogen environment to obtain a PVDF-g-PAA copolymer. After the reaction is over, use about 250ml of methanol to precipitate the reaction liquid, filter it with suction, and wash it repeatedly with distilled water to remove unreacted monomers, initiators, and homopolymers, and finally drain it, and put the copolymerized product in an oven at 60°C to dry .

[0036] (3) Preparation of PVDF-g-PAA flat film: Same as Example 1.

[0037] (4) Preparation of PVDF-ARG film: Same as Example 1.

Embodiment 3

[0039] (1) Alkali treatment of PVDF powder: with embodiment 1.

[0040] (2) Preparation of PVDF-g-PAA copolymer: same as Example 1.

[0041] (3) Preparation of PVDF-g-PAA flat film: Same as Example 1.

[0042] (4) Preparation of PVDF-ARG membrane: Cut the PVDF-g-PAA flat separation membrane into a 3×3cm2 membrane, soak it in 10ml ethanol, then add 200mgDTMMM to the ethanol to activate the carboxyl groups on the membrane surface, Half an hour later, add 200 mg of argatroban powder, react at room temperature for 24 hours, take out the membrane and rinse it with a large amount of distilled water to obtain a PVDF-ARG flat separation membrane.

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Abstract

The invention discloses an anticoagulation PVDF flat separation film, also discloses a making method of the anticoagulation PVDF flat separation film, and belongs to the technical field of films. The making method of the anticoagulation PVDF flat separation film comprises the following steps: 1, preparing a polyacrylic acid grafted polyvinylidene fluoride copolymer PVDF-g-PAA; 2, making a PVDF-g-PAA flat separation film; and 3, making an argatroban grafted and modified PVDF-ARG film. A PVDF film is modified by micro-molecular argatroban with a high efficiency anticoagulation effect with acrylic acid as a medium in order to obtain a PVDF separation film material with a good anticoagulation effect. The anticoagulation PVDF flat separation film can obviously prolong the recalcification time of the film, substantially reduces adhesion of platelet erythrocytes on the surface of the film, reduces the hemolysis rate, improves the anticoagulation performance and greatly improves the blood compatibility. The method has the characteristics of simple process and easy industrialization enforcement.

Description

technical field [0001] The invention belongs to the technical field of membranes, in particular to a modified PVDF flat separation membrane with good anticoagulant performance. Background technique [0002] Cardiovascular disease is one of the common diseases that seriously threaten human life and health. Blood purification is an important means to treat this disease. The commonly used equipment is blood purifier. The hemodialysis membrane is the core component of the purification filter. At present, the common hemodialysis membranes include polyethersulfone, cellulose, and polyacrylonitrile. Polyvinylidene fluoride (PVDF) is a polymer material with excellent performance. Its outstanding chemical stability, radiation resistance, pollution resistance and heat resistance make it widely used in the field of membrane separation and is expected to become a potential blood Dialysis membrane material. However, the performance of PVDF itself determines that its blood compatibility...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/06B01D71/78B01D67/00B01D69/02
Inventor 陈莉姜智旭杨宁申向赵义平冯霞
Owner TIANJIN POLYTECHNIC UNIV
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