Modified polycarbonate with high anticoagulant activity

A polycarbonate, blood-based technology, applied in the field of polycarbonate modification, can solve the problems of inability to provide reaction sites, low PC grafting rate, unsatisfactory, etc., to achieve improved anticoagulant ability, wide derivatization performance, Research Potential for High Effects

Pending Publication Date: 2019-06-21
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But obviously, for this polymer, there are at most two phosphorylcholine groups on one polymer chain, such a low PC grafting rate does not meet its clinical use as a biomedical ma

Method used

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  • Modified polycarbonate with high anticoagulant activity
  • Modified polycarbonate with high anticoagulant activity
  • Modified polycarbonate with high anticoagulant activity

Examples

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Example Embodiment

[0015] Example 1

[0016] a. Synthesis of 5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one (MAC)

[0017] Using 2,2-(bis-hydroxymethyl)propionic acid (bis-HPA) as raw material, 5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one (MAC) was synthesized. This monomer provides a functionalized double bond for the side chain of the polycarbonate.

[0018] b. Preparation of TMC and MAC random copolymer

[0019] Weigh a certain amount of TMC and MAC monomers (molar ratio of 3:1) and a clean and dry magnetic stirrer into a special dry single-necked flask sealed with a rubber stopper, and pump the reaction device with an oil pump for half an hour After vacuuming, the catalyst and initiator were dissolved in dry n-hexane to dilute, and stannous octoate (4×10 - 4 mol catalyst), n-octanol (2×10 -5 After the mol initiator is injected into the reaction device, pull out the syringe and seal it with vacuum ester. After continuing to evacuate for one hour, stop evacuation and seal. Then, the reaction device wa...

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Abstract

The invention discloses modified polycarbonate with high anticoagulant activity. Modified polycarbonate is a linear macromolecular polymer, wherein a side chain of the polymer contains functionalizeddouble bonds and hydrophilic phosphorylcholine groups. Modified polycarbonate comprises copolymers A, B and C. The preparation process of modified polycarbonate comprises the following steps: copolymerizing TMC (trimethylene carbonate) and a trimethylene derivative firstly, and then grafting the side chain of the copolymer with MPC (2-methacryloyloxyethyl phosphorylcholine) through a chick reaction of dithiol and the double bonds to obtain the target product modified polycarbonate with high anticoagulant activity. According to modified polycarbonate with high anticoagulant activity, performance of polycarbonate can be changed by adjusting monomer types and proportion and quantity of the phosphorylcholine groups on the side chain, and the anticoagulant capability of polycarbonate as a biodegradable medical polymer material can be improved; reaction sites can be provided by the double bonds on the side chain for follow-up grafting with biomacromolecules or other functional molecules, theresearch potential is high, and the derivative performance is wide.

Description

technical field [0001] The invention relates to the technical field of modification of biomedical engineering functional materials, in particular to the modification of polycarbonate. Background technique [0002] Biodegradable aliphatic polycarbonate has good biodegradability, excellent biocompatibility and physical and mechanical properties. It is an important class of biodegradable medical polymer materials. It has been used in subcutaneous contraceptive implants and three-dimensional tissue engineering scaffolds , nerve repair and drug controlled release and other fields have shown great application and potential. The most common and widely studied biodegradable aliphatic polycarbonate is polytrimethylene carbonate (PTMC), an amorphous or slightly crystalline polycarbonate with a glass transition temperature of approximately -17 °C, good elasticity at room temperature and in vivo conditions. At the same time, the degradation of PTMC in the body will not release acid su...

Claims

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Application Information

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IPC IPC(8): C08G64/42C08G64/30
Inventor 赵元聪吕杜娟李培闯赵昌波王锐王进陈航黄楠
Owner SOUTHWEST JIAOTONG UNIV
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