10 results about "Polytrimethylene carbonate" patented technology

The invention provides an absorbable tissue bonding patch and a preparation method thereof. The absorbable tissue bonding patch comprises a supporting layer and a bonding agent layer which are in contact with each other; wherein the supporting layer comprises interwoven fibers with the diameter of 10 nm to 100 microns, and the supporting layer is of a porous structure; and the support layer is derived from a film-forming composition, the film-forming composition comprising a polyester compound, the polyester compound comprising poly (trimethylene carbonate). The absorbable tissue bonding patch is simple in structure, through combination of the supporting layer and the adhesive layer, on the premise of excellent bonding force, the absorbable tissue bonding patch further has good elasticity and high rupture strength, can better conform to tissue movement under the pressure condition, keeps tight and lasting adhesion on the tissue surface, and has the advantages that the absorbable tissue bonding patch can be used for absorbing tissues, and the absorbable tissue bonding patch has a good application prospect. And wound tearing caused by tensile deformation of tissues near the wound is effectively inhibited, and clinical use is convenient and the effect is good.

The invention relates to the technical field of embolism materials, in particular to a blood vessel embolism composition containing a biocompatible polymer and a preparation method of the blood vessel embolism composition, and the blood vessel embolism composition comprises the biocompatible polymer and a biocompatible iodine-containing developer; the biocompatible polymer is selected from a polylactic acid-glycolic acid copolymer (PLGA), polycaprolactone (PCL), a polyethylene glycol-polylactic acid copolymer (PEG-PLA) or poly trimethylene carbonate (PTMC); the biocompatible iodine-containing developing agent is selected from a triiodo phenoxyethyl acrylate-hydroxyethyl methylacrylate copolymer, iohexol, triiodo phenol, iopromide or iopamidol; a biocompatible iodine-containing developing agent is adopted, so that metal toxicity is avoided, the developing strength is high and uniform, and clinical precise positioning is met; the compatibility and the dispersity are good.

The present invention relates to an electrospun multilayer tube or wrap for the protection or bridging of damaged nerves, comprising an electrospun isolating outer layer and at least one electrospun inner layer, the electrospun isolating outer layer comprising at least one polymer selected from the group consisting of polycaprolactone, polylactide, polyglycolide, polytrimethylene carbonate, polydioxanone, polyethylene glycol, polyurethane, copolymers thereof or mixtures thereof, the at least one electrospun inner layer comprising an agent capable of forming a covalent bond with proteins and peptides, the agent comprising at least one group selected from the group consisting of N-hydroxysuccinimide, maleimide, thio-NHS, biotin-NHS, carboxylic acid or aldehyde. Furthermore, the present invention relates to a method of manufacturing such a tube or wrap and to their use for the protection or bridging of nerves or for stimulating nerve growth and cell proliferation.

The present application relates to the technical field of embolic material, in particular to a vascular embolization composition containing a biocompatible polymer and a preparation method thereof, comprising a biocompatible polymer and a biocompatible iodine-containing contrast agent; the biocompatible polymer is selected from polylactic acid-glycolic acid copolymer PLGA, polycaprolactone PCL, polyethylene glycol-polylactic acid copolymer PEG-PLA or polytrimethylene carbonate PTMC; the biocompatible iodine-containing contrast agent is selected from triiodophenoxy ethyl acrylate-hydroxyethyl methacrylate copolymer, iohexol, triiodophenol, iopromide or iopamidol; the biocompatible iodine-containing contrast agent is used to avoid metal toxicity, has high and uniform development intensity, meets clinical precise positioning, and has good compatibility and dispersibility.

To provide a material for embolic arterial intervention (embolotherapy or arterial embolotherapy) and a method for preparing the material.SOLUTION: Radiopaque, bioresorbable spherical microparticles for embolization or vascular occlusion therapy are provided which comprise a copolymer of an iodo-containing, halogenated phenyl-containing unit, such as an iodinated desaminotyrosine derivative, and a rubbery component such as polyethylene glycol (PEG), polycaprolactone (PCL), polytetramethylene oxide (PTMO) or polytrimethylene carbonate (PTMC). The provided microbeads can further contain or be coated with a therapeutic agent, such as paclitaxel, for targeted delivery of the therapeutic agent.SELECTED DRAWING: Figure 3

The invention relates to the technical field of macromolecular flame-retardant materials, and particularly discloses a bio-based flame-retardant antibacterial macromolecular material and a preparation method thereof. The bio-based flame-retardant antibacterial high polymer material is prepared from the following components in parts by mass: 100 parts of polylactic acid, 5-15 parts of an antibacterial compound, 8-20 parts of a flame-retardant compound, 2-5 parts of a montmorillonite-loaded magnesium-phosphorus compound, 1-3 parts of a compatilizer, 0.5-2 parts of a hydrolysis inhibitor and 6-8 parts of poly (trimethylene carbonate), the antibacterial compound comprises hydroxypropyl distarch phosphate, quaternary ammonium salt and guanidine salt. The flame-retardant compound comprises hydrophobic modified microcrystalline cellulose, phytic acid or ammonium phytate and melamine cyanurate. The bio-based flame-retardant antibacterial high polymer material prepared by the invention has excellent flame retardant property, good mechanical property and relatively high antibacterial rate.

The invention relates to a fibrous membrane, a tubular tissue repair product and a preparation method thereof. The fiber membrane comprises a first electrospinning layer and a second electrospinning layer, the second electrospinning layer is made of poly trimethylene carbonate, and the fiber membrane is prepared through the steps that the first electrospinning layer is formed through spinning, and then the second electrospinning layer is formed on the first electrospinning layer through spinning. The tubular tissue repair product is of a tubular structure formed by fiber membranes and comprises at least one composite fiber layer formed by the fiber membranes, the composite fiber layer comprises a first electrospinning layer and a second electrospinning layer, and the tubular tissue repair product is obtained by preparing the fiber membranes, then winding the fiber membranes by at least one circle and fixing the fiber membranes in a self-bonding mode. The fiber membrane can be self-adhered and fixed to form a tubular tissue repair product after being curled, adhesion can be realized without additionally introducing an adhesive, the forming process is simple and easy to operate, and the production efficiency is high.

The present invention relates to electrospun multilayer tubes or wraps for the protection or bridging of damaged nerves, said tubes or wraps comprising an electrospun isolating outer layer and an active inner layer, said electrospun isolating outer layer comprising at least one polymer selected from the group consisting of polycaprolactone, polylactide, polyglycolide, polytrimethylene carbonate, polydioxanone, polyethylene glycol, polyurethane, copolymers or mixtures thereof, said active inner layer comprising at least one electrically conductive compound and / or at least one ionically conductive compound and / or at least one peptide or protein to stimulate nerve growth. Furthermore, the present invention relates to a method for the manufacture of such tubes or wraps and their use for the protection or bridging of nerves or for the stimulation of nerve growth and cell proliferation.

The application discloses a yin-yang structure wound dressing, which comprises two layers, wherein the upper layer is a dense hydrophobic layer, which is a polytrimethylene carbonate fiber membrane and simulates an epidermis structure; and the lower layer is a hydrophilic layer, which is a natural high molecular fiber hydrogel membrane and simulates a dermis structure. Meanwhile, the application also discloses a preparation method of the yin-yang structure wound dressing. The multifunctional wound dressing with the yin-yang membrane structure is prepared by firstly adopting electrospinning technology to prepare a natural high molecular fiber hydrogel membrane and a polytrimethylene carbonate fiber membrane with two different properties, and then bonding the two membranes with different properties together by a photo-crosslinking method to construct a multi-level wound repair dressing with a stable structure and simulating skin, so that the nanofiber structure of human skin is restored to the maximum extent, and the purpose of promoting the growth of granulation tissue at a wound and the recovery of structures such as hair follicles, blood vessels and nerves is achieved from the structure of the skin itself.

Methods, copolymer materials and devices are provided for embolic arterial interventions (embolization therapy or embolotherapy). More particularly, radiopaque, bioresorbable spherical microparticles for embolization or vascular occlusion therapies, comprising copolymers of iodine-containing, halogenated phenyl-containing units, such as iodinated desaminotyrosine derivatives, and rubbery components, such as polyethylene glycol (PEG), polycaprolactone (PCL), polytetramethylene oxide (PTMO) or polytrimethylene carbonate (PTMC), are provided. The provided microbeads may further contain, or be coated with, therapeutic agents such as paclitaxel, for targeted delivery of the therapeutics.