18 results about "Iopamidol" patented technology

The invention discloses a carbonate reservoir fracture permeability test method, and relates to the technical field of ore exploration, the test steps are as follows: S1, blending a tracer agent: preparing iohexol, iopamidol and barium sulfate suspension, and blending to obtain the tracer agent; s2, injecting the prepared tracer agent into the rock stratum, and waiting for diffusion of the tracer agent; s3, a CT scanning device is used for scanning the rock stratum, the flowing path of the tracer agent on the rock stratum is tracked, image data are collected and obtained, and the collected data image is preprocessed; and S4, constructing a three-dimensional model of the crack network by using a three-dimensional imaging technology, displaying a three-dimensional flow path of the tracer agent in the crack, analyzing the acquired CT image data, and measuring to obtain the concentration distribution of the tracer agent at different positions. By means of the tracer agent injection method, the rock stratum fracture permeability closer to the actual situation is obtained, and a more reliable basis is provided for development and evaluation of carbonate rock reservoirs.

The present invention relates to the field of organic chemistry, in particular to the synthesis of iodinated contrast agents. More specifically, the present invention relates to a sustainable process for the synthesis of iopamidol which allows for improved purity properties of the product and avoids the use of potentially dangerous reagents and solvents.

The invention provides a developing agent which is modified iopamidol, a clinically safe nonionic hydrophilic developing agent iopamidol is subjected to structural modification, a hydrophilic side chain and a connecting arm are introduced, and the iopamidol is introduced into a gelatin degradable microsphere matrix with good biocompatibility in a covalent bonding manner; the degradable non-ionic X-ray developing microsphere with good biocompatibility is formed. Developing microspheres prepared by adopting the developing agent provided by the invention not only keep excellent X-ray developing performance, solve the problems of aggregation tendency and biocompatibility of traditional developing microspheres and realize real-time visual monitoring of an embolism process, but also have degradability and good biological safety, and are not only suitable for permanent embolism treatment, but also suitable for treatment of embolism. The solid developing embolism agent can also be expanded to the fields of temporary embolism, tissue engineering and the like, and the solid developing embolism agent with precise developing and safe degradation performance is provided for minimally invasive interventional therapy of diseases such as tumor intervention and vascular malformation.

The utility model discloses a sample collection device based on iopamidol production, which belongs to the technical field of iopamidol processing, and comprises a box body and an iopamidol collection component arranged at the top of the box body, the collecting assembly comprises a bent sampling pipe inserted into one side of the top of the box body and a discharging pipe connected to the bottom of one end of the sampling pipe, the sampling pipe is provided with a control valve, a mounting plate is mounted at the top of the outer wall of one side of the box body, and a servo motor is mounted at the bottom of the mounting plate; the output end of the servo motor penetrates through the bottom of the mounting plate and is connected with a tray, a plurality of slots are annularly distributed and constructed in the top of the tray, sampling barrels corresponding to the discharge pipes are inserted into the inner sides of the slots, an inflator pump is mounted on the other side of the top of the box body, and an exhaust pipe is mounted at the end part of the output end of the inflator pump. The exhaust pipe penetrates through the top of the box body and extends to the inner side of the box body. The sample collection device based on iopamidol production is more convenient to operate during multiple times of sampling.

The invention relates to the technical field of iodinated organic matter deiodination, in particular to a deiodination method of an iodine-containing aqueous solution. According to the method, efficient deiodination of iodinated organic matters such as iopamidol and iodinated phenol in the iodine-containing aqueous solution is promoted through radiation illumination treatment of a 222nm ultraviolet lamp. In addition, it is found that by prolonging the illumination time, enhancing the illumination intensity or increasing the pH value of the buffer solution, the deiodination reaction is obviously promoted. The deiodination method provided by the invention is convenient to operate, does not need to add chemical reagents, is harmless to the health of a user, and is an economical, efficient and green deiodination method.

The present invention provides a method for preparing a compound of formula (II), wherein the method comprises: (i) reacting a compound of formula (I) with pyridine and 2-acetoxypropionyl chloride (APC) to obtain a compound of formula (II), wherein the compound of formula (I) has the following structure.

The utility model discloses a storage sealing structure for iopamidol production, which belongs to the technical field of storage and comprises a storage bottle, a bottle cap, a sealing cover and a sealing cover. The inner wall of the sealing cover is bonded with a sealing gasket which is made of a rubber material and is used for covering the bottle opening and carrying out sealed storage; a convex ring is integrally formed on the periphery of the bottle opening, the convex ring is rotationally connected with an inverted U-shaped assembly plate through a rotating shaft, and a threaded pipe is embedded in the top end of the assembly plate; the adjusting threaded rod is in threaded connection with the threaded pipe, the adjusting threaded rod is rotationally connected with a movable plate through a bearing, the periphery of the movable plate is sleeved with a hollow plate, the bottom end of the hollow plate is connected with an abutting plate used for abutting against and fixing the sealing cover, and a spring is connected between the abutting plate and the movable plate. According to the storage sealing structure for iopamidol production, not only can the stability be improved, but also the stability can be ensured.

The present invention relates to the field of organic chemistry, in particular to the synthesis of iodinated contrast agents. More in particular, the invention relates to a sustainable process for the synthesis of iopamidol which allows to improve the purity profile of the product and avoids the use of potentially hazardous reagents and solvents.

The invention relates to the technical field of pharmaceutical preparations, in particular to an iopamidol injection and a preparation method thereof. The iopamidol injection comprises iopamidol, glycine, sodium citrate, a pH regulator and water for injection, wherein the pH regulator enables the pH value of the injection to be 6.5-7.5. Compared with the prior art, the iopamidol injection disclosed by the invention is good in stability, can tolerate high-temperature sterilization, avoids the use of tromethamine and disodium calcium edetate, and is good in safety; compared with a reference preparation with the same specification, the iopamidol injection prepared by the invention has the advantages that the viscosity is reduced, and the compliance of clinical application is improved.

This application relates to the field of water treatment technology, specifically a method for the simultaneous degradation of iodine-based pollutants and adsorption removal of iodine products using ferric chloride and biochar-catalyzed PMS. The method includes the following steps: S1, adding iodine-based pollutants to water, replenishing water, and adjusting the pH to obtain a simulated polluted water sample; S2, under stirring conditions, adding biochar, ferric chloride solution, and PMS solution to the simulated polluted water sample obtained in step S1 to obtain a reaction solution, allowing the mixture to react, standing to precipitate, and collecting the supernatant. This method achieves a removal rate of over 96% for iopamidol, and the content of iodide ions and iodates in the polluted water sample is extremely low.

The invention relates to the technical field of embolism materials, in particular to a blood vessel embolism composition containing a biocompatible polymer and a preparation method of the blood vessel embolism composition, and the blood vessel embolism composition comprises the biocompatible polymer and a biocompatible iodine-containing developer; the biocompatible polymer is selected from a polylactic acid-glycolic acid copolymer (PLGA), polycaprolactone (PCL), a polyethylene glycol-polylactic acid copolymer (PEG-PLA) or poly trimethylene carbonate (PTMC); the biocompatible iodine-containing developing agent is selected from a triiodo phenoxyethyl acrylate-hydroxyethyl methylacrylate copolymer, iohexol, triiodo phenol, iopromide or iopamidol; a biocompatible iodine-containing developing agent is adopted, so that metal toxicity is avoided, the developing strength is high and uniform, and clinical precise positioning is met; the compatibility and the dispersity are good.

The present application relates to the technical field of embolic material, in particular to a vascular embolization composition containing a biocompatible polymer and a preparation method thereof, comprising a biocompatible polymer and a biocompatible iodine-containing contrast agent; the biocompatible polymer is selected from polylactic acid-glycolic acid copolymer PLGA, polycaprolactone PCL, polyethylene glycol-polylactic acid copolymer PEG-PLA or polytrimethylene carbonate PTMC; the biocompatible iodine-containing contrast agent is selected from triiodophenoxy ethyl acrylate-hydroxyethyl methacrylate copolymer, iohexol, triiodophenol, iopromide or iopamidol; the biocompatible iodine-containing contrast agent is used to avoid metal toxicity, has high and uniform development intensity, meets clinical precise positioning, and has good compatibility and dispersibility.

The invention discloses a preparation method of chlorodiiodo isophthalein acyl chloride and application of the chlorodiiodo isophthalein acyl chloride in preparation of an iopamidol impurity H. The method comprises the following steps: reacting diiodo-isophthalic acid with an acylating chlorination reagent to obtain diiodo-isophthalein acyl chloride, and then carrying out chlorination reaction on the diiodo-isophthalein acyl chloride and N-chlorosuccinimide (NCS) in an organic solvent to prepare a key intermediate chlorinated diiodo-isophthalein acyl chloride; further taking the intermediate as a raw material, acylating, and carrying out amidation and hydrolysis reaction with serinol to prepare the iopamidol impurity H. According to the method disclosed by the invention, through a strategy of firstly performing acylating chlorination and then performing chlorination, the defects of difficulty in direct chlorination reaction of diiodo isophthalic acid and poor regioselectivity of a conventional route are effectively overcome, and the method has the advantages of short synthesis route, high total yield, mild reaction conditions, simplicity and convenience in post-treatment and the like; the method is suitable for industrially preparing high-purity impurity reference substances.

The invention relates to the industrial preparation of non-ionic X-ray contrast agents. In particular, the present invention relates to a process for the synthesis of iopamidol using a continuous reactive extrusion process which enables efficient conversion of the relevant key intermediates, preferably in the absence of any solvent. The invention also relates to the preparation of radiographic X-ray contrast agents or key intermediates thereof by using reactive extrusion techniques.

The application discloses iodipam amorphous matter and a preparation method thereof, and the iodipam amorphous matter has an X-ray powder diffraction pattern and diffraction peaks as shown in Fig. 1. Crude iodipam of any crystal form is added into a first solvent, heated, refluxed and stirred until completely dissolved, refluxed, cooled and crystallized, and filtered to obtain wet iodipam. The wet iodipam is added into a second solvent, stirred until completely dissolved, and spray-dried at a certain temperature to obtain the iodipam amorphous matter. The amorphous crystal obtained through the production method has good stability, high application value, and the whole process is suitable for industrial and industrialized production.

The present invention relates to the field of organic chemistry, in particular to the synthesis of iodinated contrast agents: More in particular, the invention relates to a sustainable process for the synthesis of iopamidol which allows to improve the purity profile of the product and avoids the use of toxic reagents and solvents.

The present application relates to the technical field of pharmaceutical preparation, in particular to a iopamidol injection and a preparation method thereof.The iopamidol injection comprises iopamidol, glycine, sodium citrate, a pH regulator and water for injection, and the pH regulator makes the pH value of the injection be 6.5-7.5.Compared with the prior art, the iopamidol injection of the present application has good stability, can withstand high-temperature sterilization, and avoids the use of aminotriol and calcium disodium edetate, and has good safety; compared with the same specification reference preparation, the iopamidol injection prepared by the present application has reduced viscosity, and improves the compliance of clinical application.

The invention relates to a preparation method of iopamidol. Specifically, the invention provides a preparation method of iopamidol, and the method comprises the following steps: mixing a compound 2, a compound 3 and an organic solvent, carrying out amidation reaction, sequentially adding water and concentrated hydrochloric acid, carrying out stirring reaction, adding a sodium hydroxide aqueous solution, carrying out hydrolysis reaction, then adding dichloromethane for extraction, desalting a water phase through an electrodialysis method, and obtaining the iopamidol. And concentrating the desalted water phase under reduced pressure to obtain an oily substance, adding ethanol, heating and refluxing, cooling and crystallizing, filtering, and drying a filter cake under reduced pressure to obtain iopamidol. The iopamidol prepared by the method disclosed by the invention has excellent purity and yield, and the method disclosed by the invention is simple in process and operation and beneficial to industrial amplified production.