The invention relates to a hafnium-base mixed metal material and an iodination preparation method thereof, and belongs to the field of synthesis and preparation of mixed metal materials. The hafnium-base mixed metal material is composed of a matrix metal hafnium and other metal compositions, and the other metal compositions comprise one or two or more of Zr, Ti, Al, B, Ba, Be, Ca, Ce, Co, Cs, Dy, Er, Fe, Gd, Ho, La, Mg, Mn, Mo, Nb, Ni, Pr, Sc, Sm, Sr, Ta, V, W, Y and Yb. The hafnium-base mixed metal material with the purity up to 99.95 wt% can be prepared through an iodination reaction, and continuous batch production can be realized, and the advantages of uniform product compositions, high production efficiency, relatively low production cost and the like are provided.