41 results about "Iopromide" patented technology

The invention relates to a preparation method of a high-purity contrast medium raw material iopromide, wherein byproducts generated in the preparation process can be removed by introducing a compound shown in a formula (19): 5-methoxyl acetamido-2, 4, 6-triiodo isophthalic acid [(2, 3-diacetoxyl-N-methyl propyl)-(2, 3-diacetoxyl propyl)] diamide serving as an intermediate. The invention provides the preparation method of iopromide with high purity.

The invention discloses a novel synthesis method for iopromide. The novel synthesis method comprises the following steps of 1, enabling methoxyacetic acid to react with triphosgene to obtain a reaction product, and then, enabling the reaction production to be directly subjected to one-pot reaction with 5-amino-2, 4, 6-triiodo-isophthalicacyl chloride to prepare a compound 5-[(2-methoxyl) acetamido]-2, 4, 6-triiodo-isophthalicacyl chloride as shown in the formula (II); 2, condensing the compound as shown in the formula (II) and N-methyl-2, 3-dihydroxyl propylamine under the action of a solid catalyst ZrO2-Cr2O3 to obtain a compound 5-[(2-methoxyl) acetamido]-3-(2, 3-dihydroxyl-N-methylpropylaminoformoxyl)-2, 4, 6-triiodo-benzoyl chloride as shown in the formula (III); 3, condensing the compound as shown in the formula (III) and 2, 3-dihydroxylpropylamine under the action of a catalyst to prepare a compound iopromide as shown in the formula (I). The synthesis method for iopromide, disclosed by the invention, is few in byproduct, easy to control the product quality, high in product purity, cheap and easily-obtained in used reagent, few in step, simple in operation, relatively high in total yield and suitable for industrial production, and provides a novel approach for preparing iopromide.

The invention discloses a novel drug balloon, comprising a balloon body, the balloon body has a folded state and a filled state; in the filled state, the balloon body presents a concave structure, so that blood can flow through the concave structure Balloon body. The present invention also discloses a preparation method of the above-mentioned novel medicine balloon, which involves covering the medicine on the balloon body through iopromide by means of leaching and/or ultrasonic spraying. The concave structure of the novel drug balloon involved in the present invention ensures smooth blood flow, thereby prolonging the working time and making the treatment effect better.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of iopromide. The method comprises the steps that 5-amino-2,4,6-triiodo isophthalic acid is adopted as a raw material to obtain diester to react with methoxyacetyl chloride, and the product is subjected to an ester ammonolysis reaction with side-chain 3-amino propylene glycol and 3-methylamino propylene glycol respectively to obtain iopromide. The preparation method of the iopromide, a catalyst and a by-product methyl alcohol can be removed only through solvent crystallization, green production can be achieved, no industrial wastewater or waste gases or residues exist, and the preparation method is particularly suitable for preparing iopromide in industrial mass production.

The present invention relates to an X-ray contrast agent iopromide preparation method. According to the method, 3-methoxy acetyl-5-(2,3-dihydroxy-N-methyl-n-propyl-carbamoyl)-2,4,6-triiodobenzoic acid (4) is introduced as an intermediate, the used raw material is cheap and easy to obtain, the experiment operation is relatively simple, the reaction condition is mild, and the product purity is qualified.

The application of the invention relates to preparation methods of iopromide and an intermediate of the iopromide. The method specifically comprises the following steps: conducting a reduction reaction, an iodination reaction and an acylation reaction on a compound shown in the formula VI to prepare a compound shown in the formula III, and further preparing to obtain the iopromide. The method notonly avoids the generation of double acylation byproducts, but also effectively reduces the generation of byproducts in the preparation process, the intermediate is easy to separate and purify, and ahigh-purity product is obtained at a relatively high yield.

The present invention relates to a novel process for preparing iopromide which is used as a contrast agent for X-ray, wherein 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-diacetoxypropyl)amide chloride of formula (19) and 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid [(2,3-dihydroxy-N-methylpropyl)-(2,3-diacetoxypropyl)]diamide of formula (20) are introduced as intermediates, by which a bismer by-product generated during the preparation process can be removed even without an additional removal procedure and thus iopromide with high purity can be prepared in high yield.

The invention discloses an efficient contrast agent synthesizing method. The method includes the following steps of firstly, preparing an intermediate mixture of a compound shown in the formula (II) and a compound shown in the formula (I) and/or (III); secondly, conducting separating to obtain the compound shown in the formula (II) and the compound shown in the formula (I) and/or (III); thirdly, taking the compound shown in the formula (II) to prepare a contrast agent (iopromide); fourthly, taking the compound shown in the formula (III) to prepare a contrast agent (iobitridol), and/or taking the compound shown in the formula (I) to prepare a contrast agent (iohexol, ioversol, iopentol or iodixanol). In the method, the iodic contrast agent is prepared by synthesizing and separating intermediates in the formula (II) and the formula (I) and/or the formula (III) and using the intermediates as the raw materials, the problem that diacylation byproducts need to be removed in an existing method is effectively solved, all the intermediates are effectively used, efficiency is high, and the actual application prospects are good. The formulas (I), (II) and (III) can be seen in the description.

The present invention relates to a preparation method and intermediates of iopromide. The method specifically comprises: adopting a compound represented by a formula II as a starting raw material, and sequentially carrying out an acylation reaction, a lactonization reaction, a further acylation reaction, a reduction reaction, an iodination reaction, a re-acylation reaction and a final hydrolysis reaction to obtain the iopromide represented by a formula I, wherein a compound represented by a formula VII and a compound represented by a formula V are introduced as the intermediates so as to avoid the generation of the bismer by-product, the lactone ring is not easily subjected to ring opening removing during the iodination reaction process, and the introduced intermediates are easy to separate and purify, such that the high-purity iopromide can be prepared in the high-yield manner.

The invention relates to an iopromide decoloring and purifying process, mainly solving the technical problems of low yield, waste water environment pollution and the like and belonging to the technical field of chemical synthesis, separation and purification. The iopromide decoloring and purifying process is characterized by comprising the following steps of: weighing an iopromide crude product with the purity of 95%-98%, stirring to dissolve in deionized water until the concentration is 100-250 mg/ml, and filtering to remove impurities; then continuously flowing through a chromatographic column with macroporous polystyrene-divinylbenzene microsphere resin as a chromatographic packing at the flow velocity of 1-4 times of column volume per hour, wherein the ratio of the volume L of the macroporous polystyrene-divinylbenzene microsphere resin and the weight g of a sample is (1:10)-(1:80); eluting by using the deionized water as a mobile phase, collecting eluent with the purity of more than 99%, concentrating by using a nanofiltration membrane, and carrying out spray drying. According to the iopromide decoloring and purifying process, the chromatographic packing has the advantages of large adsorption quantity, good selectivity and the like; an iopromide product with the purity of 99% and the yield more than 90% can be obtained through one-time operation by eluting through the deionized water. The iopromide decoloring and purifying process disclosed by the invention has the advantages of simple process, high efficiency, easiness for industrialized production, less environmental pollution and the like.

A synthesis method of 3-methylamino-1,2-propanediol is disclosed in the invention, and it includes the following steps: (1) adding glycerin chlorohydrin, aqueous monomethylamine solution and an amination catalyst, namely NaOH solution and NaHCO₃, into a reactor, mixing the material sufficiently, and allowing amination reaction to proceed in two temperature stages; (2) removing monomethylamine and water from the amination solution after the amination reaction is completed, filtering out the solid resultant, and feeding the filtrate into a still; (3) distilling under reduced pressure to obtain 3-methylamino-1,2-propanediol, wherein the vacuum for distillation under reduced pressure is equal to or greater than 0.099 MPa and the temperature is 130-160° C. The product synthesized according to the invention, a liquid appearing colorless and transparent, has increased purity of over 99.5% (GC) and decreased impurities. Therefore, when this product is used for synthesis of iopromide as a hypo-osmolar nonionic contrast medium, it exactly meets the quality demand.

The present invention relates to a preparation method and intermediates of iopromide. The method specifically comprises: adopting a compound represented by a formula VIII as a starting raw material, and sequentially carrying out an acylation reaction, a further acylation reation, a bislactonization reaction, a reduction reaction, an iodination reaction, a re-acylation reaction and a final hydrolysis reaction to obtain the iopromide represented by a formula I, wherein a compound represented by a formula III and a compound represented by a formula V are introduced as the intermediates so as to avoid the generation of the bismer by-product, the bislactonization of the compound represented by the formula V is complete, the di-lactone ring is not easily subjected to ring opening removing during the iodination reaction process, and the introduced intermediates are easy to separate and purify, such that the high-purity iopromide can be prepared in the high-yield manner.

The invention discloses a method for establishing a rat contrast-induced nephropathy model. The method includes the following steps that 1, rats do not drink water within 24-55 hours; 2, iopromide isapplied to the rats who do not drink water within 24-55 hours to obtain the contrast-induced nephropathy model. After detecting renal damage markers such as serum creatinine after different water-forbidden time in the test, it comes to a conclusion through discussion that occurrence of CIN is promoted under suitable water-forbidden conditions, and there are no irreversible renal damage changes caused by water-forbidden operation factors. The operation steps in the modeling process are optimized, caudal vein furosemide injection operation is reduced, good vascular conditions are kept for injection of contrast agent, unnecessary intervention factors are reduced, the success rate of tail vein injection of the contrast agent and the success rate of model construction are increased, and the simplified and repeatable modeling process can be completed with fewer and effective steps.

The invention discloses a drying machine for iopromide processing, which comprises a vertical plate, the upper portion of the front end face of the vertical plate is rotatably connected with the front end face of a box body through a pin shaft, a transverse plate is arranged above the box body, a drying structure is arranged above the transverse plate, and the drying structure comprises a motor I, gears, a chain, a straight block, an annular plate, a belt, a bent plate, a sliding block I and a drying machine. According to the drying machine for the iopromide processing provided by the invention, through cooperation of a bottom plate, a straight plate, a transverse plate, a shell II, a first shell, the vertical plate, the box body and the drying structure, the motor I drives the gears on one side to rotate, the chain enables the two gears to rotate at the same time, then the chain rotates, the chain drives the belt to rotate, the belt drives the straight block to rotate, the straight block drives the annular plate to move left and right, the annular plate drives the sliding block I to move left and right, the sliding block I drives the drying machine to move left and right, then the drying machine moves left and right, the drying effect of iopromide is more uniform, and the drying effect is improved.

The invention discloses a positioning technique used under X ray. The positioning technique comprises the steps of S1, weighing a certain amount of iohexol and tromethamine, and grinding iohexol and tromethamine in a grinder into 200-500-mesh powder; S2, placing tromethamine in step 1 into a stirrer, then weighing a certain amount of hydrochloric acid, sodium calcium edentate and iopromide, placing hydrochloric acid, sodium calcium edentate and iopromide into the stirrer, adding a certain amount of methanol solution of 75-85% to the stirrer, starting the stirrer, maintaining temperature at 30-45 DEG C, and conducting stirring for 1-3 h; S3, placing iohexol powder in step 1 in the stirrer in step 2. The positioning technique is used for medical operation or examination and positioning, can well achieve recognition on skin, can achieve development during X-ray fluoroscopy and accurate positioning, and can not cause damage to human body.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of iopromide. The method comprises the following steps: (1) chloridizing 5-methylaminoisophthalic acid monomethyl ester as shown in a formula II and used as a raw material to obtain 3-amino-5-chloroformylbenzoate as shown in a formula III; (2) enabling reaction between the compoundas shown in the formula III and methoxyacetyl chloride to obtain 3-chloroformyl 5-[methoxyacetyl)amino)]-methyl benzoate as shown in a formula IV; (3) enabling reaction between the compound as shown in the formula IV and 3-aminopropanediol to obtain 3-[(2,3-dihydroxypropylaminoformyl)-5-[(methoxyacetyl)amino]-methyl benzoate as shown in a formula V; (4) enabling reaction between the compound as shown in the formula V and 3-methylamino propanediol to obtain N,N'-di(2,3-dihydroxyl)-5-[(methoxyacetyl)amino)]-N-methyl-1,3-phthalamide as shown in a formula VI; and (5) enabling reaction between thecompound as shown in the formula VI and NaICl2 to obtain the iopromide. The preparation method of the iopromide provided by the invention is low in production cost, high in reproducibility and high inyield.

The invention discloses a filter for iopromide processing. The filter comprises a support, wherein a box body is fixedly arranged on the inner wall of the support, a transverse plate is fixedly arranged on one side of the rear end of the support, a filtering structure is arranged above the transverse plate, the filtering structure comprises a first round plate, a round rod, a bent rod, a round block, a wide plate, a short rod, a first motor, a filter screen, a first sliding block and a first sliding rod, and the bottom of the first motor is fixedly connected with the top of the transverse plate. According to the filter for iopromide processing, through cooperation of a bottom plate, a square box, a support, the box body, a first shell, the transverse plate, a second shell and the filtering structure, the first motor drives the first round plate to rotate, the first round plate drives the round rod to rotate, the round rod drives the bent rod to rotate, the bent rod drives the round block to move leftwards, then the round rod drives the short rod to move rightwards, then the wide plate moves leftwards and rightwards, and the wide plate drives the filter screen to move left and right, so that a worker can conveniently move the filter screen left and right, the filtering rate of iopromide is increased, and the working efficiency is improved.

The invention discloses a condenser used for iopromide processing. The condenser used for iopromide processing comprises a base and supporting legs, wherein the supporting legs are welded to two ends of the base, a through hole is formed in a center of the base through machining, and a cooling device is installed above the base. According to the condenser used for iopromide processing, through mutual cooperation of a first shell, a box body, a liquid inlet pipe, a liquid outlet pipe, a condensation pipe and other structures, a stock solution which needs to be cooled can be injected into the box body through the liquid inlet pipe, then cooling liquid is injected into a cooling pipeline through external equipment, thus the stock solution in the box body is cooled, through mutual cooperation of a second shell, a rotating rod, fan blades, a first motor and other structures, the first motor can drive the rotating rod to rotate, and thus the rotating rod drives the fan blades to rotate, so that the box body is further cooled, and then the cooling efficiency is improved.