21 results about "Iohexol" patented technology

The invention discloses an online optical clear solution for three-dimensional structure imaging of a large-volume biological sample, which is characterized in that the solution comprises iohexol, urea, 1, 2-propylene glycol, dimethyl sulfoxide, 3-[3-(cholamidopropyl) dimethylamino] propanesulfonic acid inner salt and water. The invention further discloses a three-dimensional imaging method for the large-volume biological sample. The method comprises the following steps: carrying out transparentizing treatment on the biological sample by using the online optical transparentizing solution, and carrying out three-dimensional imaging on the transparentized biological sample by using a fluorescence microscope. The fluorescence microscope comprises a confocal microscope and / or a light sheet microscope. When the online optical transparent solution is used for imaging, the transparent depth of a surface sample is large, the single imaging depth can be increased, and the cutting thickness can be improved, so that the cutting frequency is reduced, and finally the data acquisition efficiency of a large-volume sample is improved.

The invention discloses a carbonate reservoir fracture permeability test method, and relates to the technical field of ore exploration, the test steps are as follows: S1, blending a tracer agent: preparing iohexol, iopamidol and barium sulfate suspension, and blending to obtain the tracer agent; s2, injecting the prepared tracer agent into the rock stratum, and waiting for diffusion of the tracer agent; s3, a CT scanning device is used for scanning the rock stratum, the flowing path of the tracer agent on the rock stratum is tracked, image data are collected and obtained, and the collected data image is preprocessed; and S4, constructing a three-dimensional model of the crack network by using a three-dimensional imaging technology, displaying a three-dimensional flow path of the tracer agent in the crack, analyzing the acquired CT image data, and measuring to obtain the concentration distribution of the tracer agent at different positions. By means of the tracer agent injection method, the rock stratum fracture permeability closer to the actual situation is obtained, and a more reliable basis is provided for development and evaluation of carbonate rock reservoirs.

The invention discloses a preparation method of an intestinal canal filling temperature-sensitive gel injection for gastrointestinal anastomosis guided by an ultrasonic endoscope, and belongs to the technical field of regenerative medicine. According to the specific method, poloxamer, chitosan, polycarbophil, polyvinylpyrrolidone, iohexol and methylene blue are utilized to construct the novel intestinal canal filling temperature-sensitive gel injection. The injection can be injected into the anastomotic intestinal segment of the small intestine by using a conventional nasobiliary drainage tube which is clinically used at present, and the injection becomes viscous immediately under the action of the pH value of the small intestine after injection, so that the injection is inhibited from spreading all around. Meanwhile, the injection is quickly converted into high-strength hydrogel under the action of body temperature, and the hydrogel is adhered to small intestine mucosa to inhibit gel sliding. Therefore, the injection can form a section of gel on a target small intestine section, local immobilization filling and supporting of the target small intestine section are achieved, development can be achieved, the operation difficulty of intestinal tube puncture and stent placement in gastrointestinal anastomosis guided by an ultrasonic endoscope can be greatly reduced, the operation efficiency and the success rate are improved, and the operation cost is reduced. The dosage is less than that of normal saline which is conventionally used clinically, and the effect is better. Moreover, the gel temperature can be reduced by injecting low-temperature normal saline after the operation, so that the gel is thoroughly dissolved into a solution and discharged out of the body, and the phenomenon that the gel remains in the intestinal canal after the operation to cause obstruction is avoided. Therefore, the novel intestinal canal filling temperature-sensitive gel injection has very important clinical practical application value for gastrointestinal anastomosis guided by an ultrasonic endoscope.

The utility model discloses a filling mechanism for iohexol injection production, which belongs to the technical field of injection filling and comprises a filling cylinder for containing iohexol injection, a platform plate is arranged below the filling cylinder, bottle limiting portions for placing bottle bodies are arranged on two sides of the top of the platform plate, and the filling cylinder is provided with a plurality of filling holes. A plurality of quantitative covers are installed at the bottom of the inner circumference of the filling barrel, a plurality of liquid inlet notches are formed in the peripheries of the quantitative covers, filling openings are formed in the positions, located in the centers of the quantitative covers, of the bottom of the filling barrel, sealing heads are arranged on the inner circumferences of the filling openings in a sealing mode, and side pressing blocking pieces are arranged on the side walls of the inner circumferences of the quantitative covers in a matched mode; the lower half portion of the side pressing blocking piece penetrates through the filling cylinder, and an abutting piece is arranged on the upper half portion of the inner circumference of the side pressing blocking piece. According to the filling mechanism for iohexol injection production, the filling amount can be accurately controlled, the stability of the filling amount is guaranteed, the overall design is simple, and the manufacturing cost is low.

This invention, applicable to the field of medical contrast agents, provides a method for preparing and applying ultrasmall nano-high-entropy alloys for high-energy computed tomography (CT) imaging. Using a low-temperature oil-phase strategy, the method successfully synthesizes uniformly sized, approximately 5 nm, ultrasmall nano-high-entropy alloys (HEAs) from a mixture of cetyltrimethylammonium chloride and oleylamine, with the addition of a metal source and molybdenum hexacarbonyl, at ambient pressure and temperatures not exceeding 250°C. These ultrasmall nano-HEAs can be used in high-energy CT imaging, exhibiting excellent contrast-enhanced imaging capabilities and maintaining strong X-ray attenuation across a wide range of photon energies, particularly at high photon energies. Not only does their attenuation strength surpass that of the commercial contrast agent iohexol, but they also offer a wider energy range of application, making them valuable for the noninvasive and precise detection and diagnosis of lesions.

The utility model discloses a filtering device for an iohexol intermediate, which belongs to the technical field of iohexol processing and comprises a tank body and a filtering component which is mounted on the inner side of the tank body and is used for the iohexol intermediate, the filter assembly comprises a partition plate transversely and fixedly inserted into the inner side of the tank body and a second filter cylinder mounted at the bottom of the tank body, a waterproof motor is mounted in the center of the bottom of the partition plate, the output end of the waterproof motor penetrates through the bottom of the partition plate and is connected with a connecting disc, and a first filter cylinder is supported at the top of the connecting disc; four inserting rods are welded to the top of the connecting disc in a rectangular distribution mode, inserting grooves for containing the inserting rods are formed in the bottom of the first filter cylinder, a plurality of leaking holes are evenly formed in the side wall of the first filter cylinder, two lifting handles are symmetrically welded to the outer wall of the first filter cylinder, and two electric heating plates are symmetrically installed on the upper portion of the inner wall of the tank body in a nested mode. According to the filtering device for the iohexol intermediate, filtered impurities can be conveniently taken out.

The invention relates to the technical field of small-molecule contrast agents, in particular to a small-molecule contrast agent and a preparation method thereof. According to the micromolecule contrast agent provided by the invention, a divalent glycosyl group is introduced into a binary triiodo-benzene ring structure, so that each molecule contains six iodine atoms (the theoretical iodine content reaches 48.7 wt%), the molecular weight is controlled to be 2000Da or below, the water solubility is remarkably improved, the viscosity is reduced, and the performance is superior to that of a traditional contrast agent. Preliminary CT imaging experiments show that under the same molar concentration, the average CT value generated by the contrast agent YJY-86-2 is obviously higher than that generated by iohexol, and the contrast agent shows stronger imaging contrast ability. The characteristic is expected to realize better image quality while reducing the dosage of administration and reducing the risk of iodine exposure, and provides a powerful candidate material for realizing high-sensitivity detection of early tumors.

The invention is suitable for the technical field of medical contrast agents, and provides a preparation method and application of an energy CT imaging ultra-small nano high-entropy alloy. According to the method, a low-temperature oil phase strategy is adopted, a mixed system of hexadecyl trimethyl ammonium chloride and oleylamine is taken as a basis, a metal source and molybdenum hexacarbonyl are added, and the ultra-small nano high-entropy alloy (HEAs) which is uniform in size and about 5nm is successfully synthesized under the conditions of normal pressure and no more than 250 DEG C. The ultra-small nano HEAs can be applied to energy CT (computed tomography) imaging, has excellent contrast-enhanced imaging capability, still keeps high X-ray attenuation in a large photon energy range, especially under high photon energy, has the attenuation intensity superior to that of a commercial contrast agent iohexol, has a wider energy application range, and can be applied to the field of X-ray imaging. The method has an important value for non-invasive accurate detection and diagnosis of the focus.

The invention discloses a metal coordination iohexol nano particle as well as a preparation method and application thereof. The metal coordination iohexol nanoparticles are prepared by reacting metal salt with iohexol in an organic medium; the particle size range of the metal coordination iohexol nano particles is 50 to 100 nm. The metal iohexol nanoparticles are synthesized through a one-pot method, the preparation method is simple, and multi-step reaction is not needed. The prepared metal iohexol nanoparticles are mainly accumulated in the liver, only a small amount of metal iohexol nanoparticles are accumulated in the kidney, the toxicity of a chronic renal failure model mouse to the kidney after CT imaging can be greatly reduced, and the metal iohexol nanoparticles have good biocompatibility in vitro and almost have no cytotoxicity.

The invention discloses a tumor cell-derived drug-loaded vesicle and temperature-sensitive nanogel composition and a preparation method and application thereof, and belongs to the technical field of tumor treatment, and the composition comprises a poly-N-isopropylacrylamide-butyl methacrylate nanogel, iohexol and a drug-loaded vesicle. According to the tumor cell-derived drug-loaded vesicle and temperature-sensitive nanogel composition as well as the preparation method and the application thereof, the bioavailability of Dug (at) MPs is improved, the bioavailability of non-target visceral organs is reduced, the intra-tumor penetration distance of the drug is increased, precise cooperation of chemotherapy and interventional embolism treatment is realized, and the curative effect of the drug is improved. The medicine is far better than interventional embolism therapy or conventional interventional embolism chemotherapy, and recurrence and metastasis of tumors are effectively inhibited.

The invention relates to the technical field of small-molecule contrast agents, in particular to a small-molecule contrast agent and a preparation method thereof. The structure is shown in the specification. According to the micromolecular contrast agent provided by the invention, based on a symmetric skeleton coupled by iohexol dimer and glycosyl, the imaging performance and the stability of the micromolecular contrast agent are superior to those of a traditional micromolecular contrast agent. Compared with clinical classical iohexol, the molecule integrates two iohexol monomers and a glycosyl targeting group, the number of iodine atoms in each molecule is increased to six, and the high iodine content is directly converted into high inherent contrast brightness.

This invention belongs to the field of biomedical materials technology, and discloses a one-step chitosan-grafted iohexol self-illuminating microsphere, its preparation method, and its applications. The microsphere uses chitosan, a natural biocompatible material, as the carrier framework, iohexol as the self-illuminating functional component, and genipin, a natural extract, as the cross-linking agent. A one-step grafting and cross-linking curing process is used to form self-illuminating microspheres with uniform particle size and stable structure. These microspheres exhibit clear imaging under X-rays and also possess good biocompatibility, biodegradability, and sustained-release properties, making them widely applicable in medical fields such as tumor embolization therapy and tissue engineering tracing, achieving integrated diagnosis and treatment. The preparation process of this invention is simplified, requiring no multi-step reactions, with mild control conditions, and is easy for industrial production, solving the problems of complex preparation, poor biocompatibility, and imbalance between imaging and biological properties in traditional self-illuminating materials.

The present invention belongs to the field of water treatment technology and relates to a method for the far-ultraviolet photodegradation of iohexol and acetochlor. The method comprises the following steps: S1, adjusting the pH of a treated aqueous solution containing target pollutants to 4-10; S2, conducting the reaction at an ultraviolet wavelength of 200-230 nm. Compared with existing technologies, the present invention not only efficiently degrades iohexol and acetochlor, but also can treat other new pollutants with different structures in surface water. It has multiple advantages, including no secondary pollution, low cost, simple process, and no risk of mercury leakage, ensuring safe and stable use.

The present invention belongs to the technical field of ultrasonic imaging agents, and specifically relates to a microcapsule ultrasonic contrast agent and a preparation method thereof. The method comprises dissolving artemisinin in an organic solvent, dispersing iohexol in the organic solvent, adding bovine serum albumin to obtain an organic solution of iohexol as an oil phase; dissolving λ-carrageenan in hot water as an aqueous phase, mixing and ultrasonicating to obtain a primary oil-in-water emulsion; passing through a membrane, centrifuging, washing with water, and freeze-drying to obtain an ultrasound contrast agent. After accelerated testing, it was verified that the content of related substances of the active ingredient in the contrast agent was significantly reduced, the storage stability was significantly improved, and it was used in clinical practice, meeting higher standards of quality control requirements.

The invention relates to the technical field of embolism materials, in particular to a blood vessel embolism composition containing a biocompatible polymer and a preparation method of the blood vessel embolism composition, and the blood vessel embolism composition comprises the biocompatible polymer and a biocompatible iodine-containing developer; the biocompatible polymer is selected from a polylactic acid-glycolic acid copolymer (PLGA), polycaprolactone (PCL), a polyethylene glycol-polylactic acid copolymer (PEG-PLA) or poly trimethylene carbonate (PTMC); the biocompatible iodine-containing developing agent is selected from a triiodo phenoxyethyl acrylate-hydroxyethyl methylacrylate copolymer, iohexol, triiodo phenol, iopromide or iopamidol; a biocompatible iodine-containing developing agent is adopted, so that metal toxicity is avoided, the developing strength is high and uniform, and clinical precise positioning is met; the compatibility and the dispersity are good.

The present application relates to the technical field of embolic material, in particular to a vascular embolization composition containing a biocompatible polymer and a preparation method thereof, comprising a biocompatible polymer and a biocompatible iodine-containing contrast agent; the biocompatible polymer is selected from polylactic acid-glycolic acid copolymer PLGA, polycaprolactone PCL, polyethylene glycol-polylactic acid copolymer PEG-PLA or polytrimethylene carbonate PTMC; the biocompatible iodine-containing contrast agent is selected from triiodophenoxy ethyl acrylate-hydroxyethyl methacrylate copolymer, iohexol, triiodophenol, iopromide or iopamidol; the biocompatible iodine-containing contrast agent is used to avoid metal toxicity, has high and uniform development intensity, meets clinical precise positioning, and has good compatibility and dispersibility.

The invention discloses a method for detecting glycidol in iohexol, and relates to the technical field of pharmaceutical analysis. According to the method, the content of glycidol in iohexol is detected by adopting a GC-MS method, and trace residual glycidol in iohexol can be accurately determined by optimizing gas chromatography conditions and mass spectrometry conditions. The detection method provided by the invention has the advantages of high sensitivity, good repeatability and accurate result.

The invention relates to the technical field of coal mine underground dustproof materials, in particular to a coal mine underground dust suppression material as well as a preparation method and a dustproof method thereof. According to the dust suppression material, iohexol, citraconic acid and arabinogalactan serve as main raw materials, the adding proportion of all the raw materials is adjusted in a targeted mode, covalent bond connecting molecules are constructed through step-by-step esterification reaction, the water content of the obtained material can reach 6% in the high-temperature environment of 40 DEG C for 16 h, the hardness of a curing layer reaches 81.82 HA, the dust suppression efficiency at the wind speed of 15 m / s reaches up to 89.25%, and the dust suppression effect is good. The remarkable effect of lasting dust suppression under the high-temperature severe condition is achieved, and the key problems that a high-temperature underground dust suppressant is short in service life and prone to failure are solved.

The invention relates to a preparation method of an iohexol intermediate. Specifically, the invention provides a preparation method of a compound 2, which comprises the following steps: mixing a compound 1, acetic anhydride and a catalyst, carrying out acetylation reaction, carrying out reduced pressure distillation on the acetic anhydride until no liquid is distilled off, adding methanol, heating and refluxing, rectifying to remove methyl acetate, adding alkali liquor to adjust the pH value to 7-11, continuing heating and refluxing, cooling, filtering, and drying a filter cake to obtain the compound 2. A compound 2 is obtained. The compound 2 prepared by the method disclosed by the invention has excellent purity and yield, and the method disclosed by the invention is simple in process and operation and beneficial to industrial amplified production.

This invention discloses a metal-coordinated iohexol nanoparticle, its preparation method, and its applications. The metal-coordinated iohexol nanoparticles of this invention are prepared by reacting a metal salt with iohexol in an organic medium; the particle size range of the metal-coordinated iohexol nanoparticles is 50-100 nm. This invention synthesizes metal-coordinated iohexol nanoparticles via a one-pot method, which is simple and does not require multiple reaction steps. The metal-coordinated iohexol nanoparticles prepared by this invention mainly accumulate in the liver, with only a small amount accumulating in the kidneys. They can significantly reduce the nephrotoxicity of chronic renal failure model mice after CT imaging, and exhibit good biocompatibility and almost no cytotoxicity in vitro.

Investigations of fine tissue structures, such as those in non-neural, non-bony tissues or organs, are best carried out in intact tissues. Compositions and methods for rendering tissues transparent for subsequent three-dimensional analysis are described herein. The inventive compositions as tissue clearing compositions consist of four core components: (1) homogenizing agents such as N-methylglucamine, urea, thiourea, guanidine, guanidine chloride, lithium perchlorate, ethylenediamine and its derivatives; (2) water-soluble regulators such as iohexol, sodium thiosulfate, polyethylene glycol and its derivatives; (3) lipid-soluble regulators such as 2,2'-thiodiethanol, propylene glycol and its derivatives; and (4) borate compounds such as boric acid, tetraboric acid, disodium tetraborate and its derivatives. The disclosed tissue clearing compositions are particularly suitable for non-neural, non-bony tissues or organs. These tissues or organs can be fresh, archived or recovered from paraffin-embedded tissues.