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Nano contrast agent and preparation method thereof

A nano-contrast agent and nano-particle technology, which is used in the preparation of X-ray contrast agents and inactive components of polymer compounds, can solve the problems of short circulation time, strong iodine allergy, and prohibition.

Inactive Publication Date: 2018-04-13
山西省肿瘤医院
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  • Abstract
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Problems solved by technology

[0004] In summary, the existing problems in the prior art are: early diagnosis of tumors is one of the important factors for the successful treatment of tumors. As a small organic iodine molecule, it has limitations such as short circulation time in the body, strong nephrotoxicity, and contraindication for those allergic to iodine.

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  • Nano contrast agent and preparation method thereof
  • Nano contrast agent and preparation method thereof

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Embodiment Construction

[0022] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0023] The application principle of the present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0024] Tungsten oxide nanoparticles (WO3-X) with a particle size (10-100nm) suitable for biological applications were prepared by a hydrothermal method. Transferrin (Tf) was selected as the targeting molecule and covalently modified onto tungsten oxide nanoparticles by polyethylene glycol (PEG). Using human normal liver cell line (L-02) and human liver cancer cell line (HepG2) with high expression of transferrin receptor as in vitro comparison models, the cell t...

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Abstract

The invention belongs to the technical field of imaging methods, and discloses a nano contrast agent and a preparation method thereof. The preparation method of the nano contrast agent comprises the following steps of synthesizing blue tungsten oxide nano particles with particle size of 60nm by using a hydrothermal method, and dispersing the nano particles in water uniformly, so as to synthesize suspension liquid; preparing a series of iodine and tungsten solutions of different concentrations by using iohexol and tungsten oxide nano particles, and detecting and imaging by using CT. The methoddiscloses the targetability of WO3-X at PEG-Tf, compares the difference of normal cells and cancer cells in endocytosis of targeted tungsten oxide nano particles and in vivo distribution of tumor-bearing rats and rats, gives an explanation that the WO3-X at PEG-Tf can be identified specifically and highly by cancer cells (the cancer cells have rich Tf receptors on the surface), argues the advantage of covalent modification of transferrin, and discloses SPECT / CT imaging and biocompatibility of the WO3-X at PEG-Tf.

Description

technical field [0001] The invention belongs to the technical field of imaging methods, and in particular relates to a nano-contrast agent and a preparation method thereof. Background technique [0002] Overcoming cancer is a major problem in the world. The successful treatment of cancer mainly faces four problems, namely late diagnosis, easy metastasis, severe multidrug resistance and easy recurrence. Early diagnosis of cancer is the key to successful treatment. Choosing the best and most sensitive diagnostic method can provide a strong basis for doctors to judge the disease. Currently commonly used diagnostic imaging techniques include: magnetic resonance imaging, fluorescence imaging, ultrasound imaging, and radionuclide imaging. According to the needs, different imaging technologies can be selected for on-site real-time detection of different parts of the living body, striving to achieve the clearest and most accurate images, and providing a reliable basis for pathologi...

Claims

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Application Information

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IPC IPC(8): A61K49/04A61K47/42
CPCA61K49/04A61K47/42
Inventor 郭晋纲张晓丽郭晋芸
Owner 山西省肿瘤医院
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