1166 results about "Contrast medium" patented technology

The invention is a delivery catheter, e.g., a guide catheter, having an imaging element in proximity to the distal end of the catheter. Catheters of the invention are able to placement of the catheter in proximity to an ostium, thereby increasing the efficiency of contrast delivery while reducing the risk of ischemia due to blocked blood supply. The invention additionally assists in maintaining catheter position during delivery of a fluid from the catheter, resulting in better performance with less fluid. For example, a catheter of the invention can be used to produce improved fluoroscopic images with less overall contrast. This improvement reduces the risk of an allergic reaction to the contrast while decreasing the length of time for a procedure, i.e., because of a need to re-contrast.

A method comprises receiving a user input to select a first point and a second point from a medical image, extracting a plurality of blood vessel regions from a plurality of frame images of the medical image, determining a plurality of first regions associated with the first point and a plurality of second regions associated with the second point, determining a first frame image and a second frame image with the contrast agent arriving at the first point and the second point, based on a change in pixel intensity for each of the plurality of first regions and the plurality of second regions, and computing the blood flow velocity from the first point to the second point based on a time interval between the first frame image and the second frame image and on a distance between the first point and the second point.

The present invention relates to ultrasound (US) mediated delivery of therapeutic agents, such as the delivery of a drug, gene, nanoparticle or radioisotope, using a bi-phasic microparticle system comprising gas microbubbles, emulsion microdroplets and clusters thereof. Thus, the present invention relates to a cluster composition and a pharmaceutical composition, and their use for delivery of therapeutic agents and as a contrast agent for ultrasound imaging. It further relates to methods for delivering such therapeutic agents and to the use of said compositions.

Methods and systems are provided for improving image quality without increasing dose of contrast agent. The method comprises: (a) receiving an input image comprising a pre-contrast image and a full-dose image, the pre-contrast image is a volumetric medical image of a subject acquired without administering contrast agent and the full-dose image is a volumetric image of the subject acquired with standard dose of contrast agent; (b) selecting a path from a plurality of paths to process the input image, the path comprises at least a first model trained to predict a contrast-enhanced image, and a second model trained to denoise an image and wherein the first model and the second model are arranged in a predetermined order to process the input image; generating a predicted image by processing the input image using the path selected in (b), the predicted image has an image quality improved over the input image.

For a biopsy guided by contrast-enhanced x-ray imaging, a breast imaging system may image a patient's breast subsequent to injection of contrast agent to locate a site for biopsy and / or position a biopsy device relative to the site. Once a tissue specimen is removed from the site for diagnostic evaluation, a confirmation that the specimen was removed from an intended area of interest for biopsy is performed using the systems and methods described herein. For example, the breast imaging system and / or a separate specimen imaging system may capture high and low energy images of the specimen, subtract the low energy image from the high energy image to generate a subtracted image of the specimen, and determine, based on the subtracted image, that the contrast agent is present within the specimen to confirm the site from which the specimen was removed is the intended site for biopsy.

The invention belongs to the technical field of medical image processing, and discloses a blood vessel segmentation reconstruction and bleeding analysis method and device. In the bleeding area detection model, detecting whether a bleeding area exists or not; and performing blood vessel segmentation and blood vessel three-dimensional reconstruction operation. According to the method, the time sequence image is adopted for comprehensive analysis, and the problems that blood vessel details are lost due to insufficient diffusion of a contrast agent and the image is blurred due to excessive diffusion are effectively solved. Based on an 8-neighborhood pixel tracking method, accurately identifying blood vessel cross points, and performing segmentation processing on the skeleton line by using the cross points. By constructing the topological structure of the blood vessel, the feature point matching efficiency is greatly improved, and the automatic three-dimensional reconstruction process is also realized. By introducing the architecture design of the hybrid convolutional neural network and the state space model, the local fine-grained feature extraction capability and the global long-range dependence modeling capability are effectively combined, so that the segmentation precision and robustness of the intracranial hemorrhage region are remarkably improved.

The invention relates to the technical field of ultrasound contrast, in particular to an ultrasound contrast T-tube sinus tract recognition method based on deep learning. The method comprises the following steps: firstly, collecting contrast agent parameters, ultrasonic equipment parameters and clinical information, adjusting a prediction model by utilizing the contrast agent parameters, and optimizing the contrast agent parameters in combination with the clinical information; and then, acquiring an ultrasonic contrast image of the T-tube sinus tract according to the updated contrast agent parameters and the ultrasonic equipment parameters. Thirdly, preprocessing the T-tube sinus tract ultrasonic contrast image, inputting the preprocessed T-tube sinus tract ultrasonic contrast image into the multi-task ultrasonic contrast image enhancement model, and performing image enhancement and adaptive adjustment in combination with ultrasonic equipment parameters; and finally, constructing an ultrasound contrast image multi-stage classification identification model, identifying the T-tube sinus tract ultrasound contrast enhanced image to obtain a T-tube sinus tract identification result, and combining clinical information to assist medical personnel in diagnosis. According to the invention, the T-tube sinus tract identification precision and accuracy can be improved.

The invention discloses a vascular access lesion recognition method and system based on target detection, and relates to the technical field of medical image processing, and the method comprises the steps: carrying out the cardiac cycle phase division according to an electrocardiogram signal, calculating a displacement vector field between adjacent frames of a blood vessel DSA image sequence, constructing a motion compensation model, and generating a stable DSA sequence; segmenting the stable DSA sequence into binary vascular mask images through a U-Net segmentation model, tracking motion displacement of contrast agent particles in continuous frames by using a particle image velocimetry algorithm, generating a blood flow velocity vector field, and calculating an eddy current intensity feature map; and carrying out channel cascading on the binarized blood vessel mask image and the vortex intensity feature map to generate a blood vessel feature tensor, and generating a lesion detection result by improving a YOLOv7 model. According to the method, the accuracy, robustness and clinical applicability of vascular disease recognition are improved, and a technical closed loop from multi-modal data processing to automatic diagnosis report generation is realized.

The application discloses a multi-marked endoscopic imaging lens for digestive tract, and belongs to the field of biomedical microscopic endoscopic imaging. The endoscopic imaging lens comprises a first lens, a second lens, a third lens, a fourth lens, a fifth lens, a sixth lens and a seventh lens; the first lens focuses laser; the second lens is matched with the first lens to limit a light beam in an effective light aperture of the lens; the third lens corrects chromatic aberration; the fourth lens and the fifth lens are combined to correct aberration; the sixth lens adopts an aspheric lens to correct spherical aberration caused in a collimating and focusing system; and the seventh lens is matched with the sixth lens to correct chromatic aberration. The working spectral range of the microscopic objective lens group is 488-860 nm, the effective light aperture is less than 1.8 mm, the mechanical outer diameter is not greater than 2.6 mm, the numerical aperture at the object side or the tissue is 0.55, the imaging field of view is 450 microns, the magnification is 2.14 times, and the working distance is 84 microns. The effect of matching excitation and fluorescence spectrum of a clinically available fluorescence contrast agent is realized.

The invention discloses an intracranial aneurysm rupture risk assessment method, device and equipment and a storage medium, and the method comprises the steps: firstly, generating a time sequence image containing flow field information based on the maximum density projection and center line extraction processing of a two-dimensional angiography image sequence in combination with contrast agent concentration change curve analysis; performing three-dimensional reconstruction, region-of-interest extraction and opening extension processing by using the three-dimensional image sequence to obtain detailed morphological parameters and a region-of-interest model after extension processing; secondly, displaying a time sequence image with flow field information and a region-of-interest model of which an opening is not prolonged in an overlapping manner, further optimizing setting of boundary conditions and performing hydrodynamic simulation by calculating a flow field vector in an observation ball and determining an actual blood flow direction, and calculating key hemodynamic parameters; and finally, in combination with the morphological parameters, the hemodynamic parameters and clinical information of the patient, obtaining an evaluation result of the aneurysm rupture risk.

The invention relates to the technical field of medical data processing, and discloses a non-invasive hemodynamic assessment system for coronary artery stenosis degree, comprising an image acquisition module used for acquiring a coronary artery computed tomography angiography image of a patient; the physiological signal acquisition module is used for synchronously acquiring physiological signals of a patient, and the physiological signals comprise electrocardiosignals and non-invasive arterial blood pressure signals; and the data processing module is used for preprocessing and segmenting the coronary artery computed tomography angiography image. Electrocardiogram and non-invasive arterial blood pressure signals are collected through the sensor, risks and complications caused by invasive examination of traditional coronary artery radiography are avoided, the problem that patients unsuitable for invasive examination such as contrast agent allergy and renal insufficiency are difficult to evaluate is solved, the pain of the patients is relieved, and the acceptability of the patients is improved.

The present invention relates to the nanoparticles (NP) of the invention, compositions thereof and their use as therapeutic agents, in particular in the field of oncology and / or as imaging agents. The NPs consist of first nanoparticles of at least one high-Z metal oxide material, to which smaller second nanoparticles are covalently bonded at the surface of the first nanoparticles. The second nanoparticles consist of a) at least one noble metal or at least one metal oxide, metal sulfide, metal selenide or metal sulfide / selenide as a Fenton or Fenton-like reaction catalyst. The NPs of the invention produce a surprising therapeutic effect when exposed to ionizing radiation such as X-rays, gamma-rays, protons, neutrons, radioisotopes and / or electron beams. Therefore, these NPs can be used as radiosensitizers in the field of oncology. These nanoparticles can also be used as contrast agents.

The invention is suitable for the technical field of ultrasonic imaging, and provides a three-dimensional ultrasonic imaging method and system, computer equipment and a computer program product, and the method comprises the steps: transmitting a multi-angle composite plane wave sequence to a target region through a one-dimensional ultrasonic array with the frequency gradual change characteristic in the elevation direction, and receiving a reflected echo signal sequence, generating a target gray-scale image sequence corresponding to the echo signal sequence, acquiring coordinates of each ultrasonic contrast agent microbubble in each frame of gray-scale image, generating a two-dimensional coordinate set, calculating the axial half-peak full width of a point spread function region of each ultrasonic contrast agent microbubble, and calculating the axial half-peak full width of the point spread function region of each ultrasonic contrast agent microbubble; determining the coordinate of each ultrasonic contrast agent microbubble in the elevation angle direction based on the axial half-peak full width, generating an elevation angle coordinate set, and generating a three-dimensional contrast image of the target area based on the two-dimensional coordinate set and the elevation angle coordinate set. According to the method provided by the invention, the problem that three-dimensional ultrasonic imaging is limited by the surface ultrasonic array can be solved, and low-cost, simple and efficient three-dimensional ultrasonic imaging based on the one-dimensional ultrasonic array is realized.

A solution for training a machine learning model (305) for use in medical imaging applications is presented. A corresponding method (400) includes providing (403-410) an incomplete sample set for each imaging process, each incomplete sample set including one (or more) sample target images and one (or more) sample baseline images for a sample target dose of contrast agent. One (411-445; 450-456) sample source images are simulated (411-445; 450-456) from each of the incomplete sample sets (or a portion thereof) to mimic contrast agent at a sample source dose that is lower than the sample target dose. One or more complete sample sets are generated (446; 457) for each imaging process by combining the incomplete sample sets with sample source images that have been simulated from other incomplete sample sets. The machine learning model (305) is then trained (458-473) using the complete set of samples. Further, a method of using a machine learning model in medical imaging applications is presented. A computer program (300) and a computer program product for implementing a method (400) are presented. Furthermore, a computing system (130) for executing the method (400) is presented. A corresponding medical method is also presented.

The invention belongs to the technical field of medical imaging, and discloses an angiography high-pressure injection system which comprises the following steps: acquiring physiological data information of a patient, and calculating an individualized contrast agent injection parameter coefficient based on the physiological data information; acquiring anatomical structure information of a blood vessel region of the target patient, and performing pressure evaluation based on hemodynamic characteristics to obtain blood vessel pressure bearing capacity and injection pressure regulation factors; performing physiological status assessment based on the physiological data information of the patient to obtain a physiological status influence factor and generate a risk marker value; performing multi-source data fusion according to the injection pressure regulation factor, the physiological status risk marker value and the historical radiography record, and constructing the radiography safety degree of the blood vessel sub-region; an optimal injection parameter path is obtained based on the radiography safety degree in combination with a deep reinforcement learning algorithm, and high-pressure injection equipment is controlled to execute injection operation; according to the invention, accurate and personalized control of contrast agent injection is realized, and the safety and imaging effect of contrast examination are remarkably improved.

The invention relates to the technical field of OCT imaging, and discloses an OCT automatic control system and method, and the system comprises a pushing and injecting device which is used for pushing and injecting a medium to be pushed and injected into a blood vessel through an injector connected with a catheter; the OCT pullback device is used for rotating the pullback catheter; and the OCT control module is connected with the injection device and the OCT pull-back device, is used for sending an injection instruction to the injection device and is also used for sending a pull-back instruction to the OCT pull-back device. The OCT control module is used for sending the control instruction, automatic synchronous work of the injection device and the OCT pull-back device can be achieved, injection of the contrast agent is accurately controlled, waste of the contrast agent and influence on life safety of a patient are avoided, meanwhile, OCT imaging quality can be effectively improved, and then the accuracy of subsequent diagnosis result judgment is improved.

The invention discloses a focused ultrasound transcranial nerve regulation and control platform and method based on photoacoustic imaging. The system comprises a synchronous pulse generator, a pulse ultrasound transmitting system, a photoacoustic signal collecting system and a fixing device. According to the method, the limitation of other imaging monitoring modes is overcome, monitoring is carried out by utilizing the characteristics of non-invasiveness, high resolution and high contrast of photoacoustic imaging, the TUS progress can be monitored for providing real-time dynamic imaging, and functional information can be provided; photoacoustic imaging is applied to focused ultrasound transcranial nerve regulation for the first time. And meanwhile, by utilizing high sound resolution and high optical contrast of photoacoustic imaging, the strongest photoacoustic signal can be provided in a near-infrared region for hemoglobin of a seat endogenous contrast agent, so that the PAT becomes an ideal imaging tool for detecting cerebral hemodynamics. In addition, key pathophysiological parameters are evaluated through functional imaging provided by the PAT, and the method can be used for evaluating brain changes in the low-intensity focused ultrasound stimulation process.

The invention provides a pulmonary artery embolism imaging method, and relates to the field of magnetic resonance imaging. According to the specific implementation scheme, an acquisition window is determined according to electrocardio data and diaphragm navigation data of an adaptive patient; according to the collection window, original frequency domain data are collected in a Cartesian filling mode; performing phase compensation on the original frequency domain data by utilizing pulmonary artery pulse vector field modeling and a dynamic compensation algorithm to obtain proportionality coefficient spatial data; and performing compressed sensing reconstruction on the proportionality coefficient spatial data to generate a three-dimensional pulmonary artery image. The scheme is used for detecting pulmonary artery embolism in the free breathing state, no contrast agent is needed, radiation is avoided, and the universality of applicable people and the inspection safety are improved. According to the technology, by reducing artifact interference and optimizing image quality and scanning efficiency, rapid and accurate diagnosis is achieved, the comfort level of a patient and clinical diagnosis efficiency are remarkably improved, and the technology has important application value and social benefits.

The embodiment of the invention discloses a long-range blood vessel imaging method and system.The method is applied to C-shaped arm imaging equipment, the C-shaped arm imaging equipment comprises a C-shaped arm, and a ray emitter and a ray detector are arranged at the two ends of the C-shaped arm respectively; the method comprises the following steps: injecting a contrast agent into a blood vessel of a target object; projection data are obtained in a spiral scanning mode through a ray emitter and a ray detector at the two ends of the C-shaped arm; and generating an angiography image based on the projection data.

The present application provides a method for preparing a liquid composition containing Compound I, which comprises a step of purifying a crude product containing Compound I by high performance liquid chromatography, and its use in myocardial perfusion PET imaging, wherein the mobile phase used in the purification step by high performance liquid chromatography contains ethanol and water. By optimizing the process parameters and process flow, it can be applied to large-scale batch activity production and meet the needs of automation. The resulting myocardial perfusion PET contrast agent has high radiochemical purity, high activity concentration, good product stability, and high and stable yield or output.

The invention discloses a contrast agent injection regulation and control device, and relates to the technical field of contrast agent injection.The contrast agent injection regulation and control device comprises an injection pipe, one end of the injection pipe is fixedly connected with a limiting plate, a piston is slidably installed in the injection pipe, a drawing rod is installed on one side of the piston, and one end of the drawing rod is fixedly connected with a pushing piece; a limiting ring is fixedly connected to the outer portion of the drawing rod, first limiting grooves are symmetrically formed in the outer portion of the injection pipe, and an adjusting mechanism is arranged on the outer portion of the injection pipe. The position of the positioning mechanism can be changed by moving the adjusting mechanism, the scale strip is arranged outside the injection tube, the adjusting mechanism can be conveniently moved to a proper position, and when a contrast agent is sucked, due to the cooperation of the positioning mechanism and the limiting ring, the drawing rod can only move to a designated position, so that the amount of the sucked contrast agent is guaranteed, and the contrast agent suction efficiency is improved. The situation that the subsequent radiography effect is affected after too much or too little inhalation is injected into the body of a patient is avoided, and adjustment can be conveniently conducted according to the condition of the patient.

The invention relates to the related technical field of medical instruments, in particular to a contrast injection device for enhancing nuclear magnetic resonance, which comprises a base, a mounting shell arranged at the upper part of the base, a first barrel arranged at the left upper part in the mounting shell, a second barrel arranged at the right upper part in the mounting shell, and a mixing barrel arranged in the middle of the upper part of the mounting shell, a first piston rod is arranged in the first barrel, a second piston rod is arranged in the second barrel, communicating pipes are respectively communicated between the first barrel and the mixing barrel and between the second barrel and the mixing barrel, a one-way water inlet pipe is arranged at the top of the barrel, and the one-way water inlet pipe is communicated with an external liquid storage tank. By rotating the adjusting screw rod, the adjusting screw rod drives the first wedge-shaped block to move to the position of the needed dosage, then the rodless air cylinder controls the extrusion plate to move upwards, and after the extrusion plate moves upwards and makes contact with the plate body, the piston rods move upwards to inject the contrast agent and normal saline of the corresponding dosage into the mixing barrel to be mixed.

The invention provides a novel macrocyclic compound, a gadolinium chelate thereof, a method for preparing the compound and application of the compound as a magnetic resonance contrast agent. The compound has pertinence on magnetic resonance detection of liver focal lesions and can be used for liver specific imaging.

The invention belongs to the technical field of near-infrared organic dye synthesis, and particularly discloses a cyanine dye with J aggregation characteristic, J aggregation nanoparticles, and preparation methods and applications of the cyanine dye and the J aggregation nanoparticles. The cyanine dye is 1-ethyl-2-(2-(2-(-3-(2-(1-ethyl-3, 3-dimethyl-1, 3-dihydro-2H-benzo [g] indole-2-subunit) ethylidene)-2-(2, 2, 2-trifluoro-N-(2-methylbenzyl) acetamide) cyclopent-1-ene-1-yl) vinyl)-3, 3-dimethyl-3H-benzo [g] indoleiodised salt, and the structural formula of the cyanine dye is shown in the description. The preparation method is simple, the J aggregation nanoparticles can be prepared by utilizing the unique property of J aggregation, the J aggregation nanoparticles have high light stability and have strong fluorescence emission in a near-infrared second region, and the material prepared by the invention can be used as a contrast agent and is applied to the field of near-infrared second region fluorescence imaging.

An information processing apparatus according to the present disclosure includes at least one processor, in which the processor is configured to: generate a difference image representing a difference between a low-energy image captured by irradiating a subject, in which a contrast agent is injected, with radiation having first energy and a high-energy image captured by irradiating the subject with radiation having second energy higher than the first energy; detect a lesion region including a lesion from each of the low-energy image and the difference image; perform a comparison determination of a position of the lesion region detected from the low-energy image and a position of the lesion region detected from the difference image; and output a comparison determination result.

An aqueous pharmaceutical composition including compound having the formula of tetragadolinium [4,10-bis(carboxylatomethyl)-7-{-3,6,12,15-tetraoxo-16-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]-9,9-bis({[({2-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propanoyl}amino)acetyl]amino}methyl)-4,7,11,14-tetraazaheptadecan-2-yl}-1,4,7,10-tetraazacyclododecan-1-yl]acetate wherein the stereochemistry at the chiral carbon of the four alanine substituents is selected from the group consisting of RRRR, SSSS, RSSS, RRSS, and RRRS stereoisomers, and racemic and diastereomeric mixtures of any thereof, or a tautomer, a hydrate, a solvate, or a salt thereof, or a mixture of same is described. The compounds may be used as an MRI contrast imaging agent.

The invention discloses a blood vessel inner diameter correction method and device based on an X-ray total attenuation conservation principle and a storage medium, and belongs to the technical field of medical image processing. The core of the method is to discover and utilize the total net attenuation of a blood vessel filled with a contrast agent in an actual motion state and the total net attenuation of the blood vessel in an ideal static state to be kept in conservation. The method comprises the steps that an angiography image is acquired, and a target area and an initial inner diameter measuring line are determined; calculating the gray scale decline amount and the maximum value of each pixel of the line; on the basis of the conservation principle, the inner diameter of the blood vessel in an ideal state is inversely calculated through the formula that the inner diameter is corrected to be equal to sigma [(delta Ii / delta Imax) * Li]. Furthermore, based on the same principle, the method can be expanded and applied to correction of the two-dimensional contour of the target blood vessel. According to the method, errors caused by motion artifacts and resolution limitation are fundamentally compensated through a volume measurement method based on integration and distribution, and the method is particularly suitable for accurate measurement of severe stenosis blood vessels.

A method for coronary road mapping may include receiving a current image associated with a medical scan, determining an image that matches the current image from a sequence of images for which respective blood vessel maps have been determined, and overlaying the current image with the blood vessel map associated with the matching image. The sequence of images may be captured when a contrast agent was present, and the matching image may be identified in response to determining that the physiological phase (e.g., cardiac cycle) and / or view depicted by the image match those depicted by the current image. Motion compensation may be performed as part of the blood vessel overlay, which may enable better visualization of blood vessels and medical device(s) (e.g., a catheter) placed in the blood vessels even when the contrast agent is worn out.

The invention relates to the technical field of blood vessel stenosis grading, in particular to a blood vessel stenosis degree grading system based on coronary angiography images. The method comprises the following steps: dividing a vascular skeleton line of an angiography image into vascular segments based on a bifurcation point, and determining a stenosis point on the vascular segment according to the blood flow velocity difference of the vascular segment at the front edge position of a contrast agent in each frame of angiography image and a neighborhood angiography image; according to the blood vessel diameter difference between each bifurcation point and the other bifurcation points and the distance between the other bifurcation points and the main blood vessel section, a reference adaptation degree is obtained, a reference point of each bifurcation point is selected, and according to the blood flow speed difference between each bifurcation point and the branch blood vessel section of the reference point and the reference adaptation degree, narrow points in the bifurcation points are screened; and grading the blood vessel stenosis degree based on the blood vessel diameter of the stenosis point. The blood vessel skeleton line is divided into two conditions of the blood vessel segment and the bifurcation point to analyze the blood vessel physiological stenosis position, and the accuracy of positioning the pathological stenosis position in the coronary artery is improved.

The invention relates to a cryoablation system, a cryoablation catheter and a control method of the cryoablation catheter. The cryoablation catheter comprises a slender body, an expandable assembly and a temperature measuring assembly, the expandable assembly is arranged at the far end of the slender body, and the expandable assembly can block a vein mouth when in an expanded structure; the slender body comprises an outer tube and a main body tube, the outer tube and the main body tube define an airflow channel, the main body tube is provided with a first conveying channel, the airflow channel is communicated with the expandable assembly, and the first conveying channel penetrates through the main body tube and is used for conveying mild liquid to veins; the temperature measuring assembly is arranged on the expandable assembly and can detect the temperature of the vein mouth so as to judge the effectiveness of plugging of the expandable assembly. Thus, the temperature measuring assembly on the expandable assembly is used for measuring temperature changes to judge the blocking state, the usage amount of contrast agents and X-rays can be reduced, the specific leakage position can be judged, ablation treatment can be conveniently carried out in the later period, and the treatment effect is guaranteed.