608 results about "Contrast medium" patented technology

The invention relates to the technical field of medical data processing, and discloses a non-invasive hemodynamic assessment system for coronary artery stenosis degree, comprising an image acquisition module used for acquiring a coronary artery computed tomography angiography image of a patient; the physiological signal acquisition module is used for synchronously acquiring physiological signals of a patient, and the physiological signals comprise electrocardiosignals and non-invasive arterial blood pressure signals; and the data processing module is used for preprocessing and segmenting the coronary artery computed tomography angiography image. Electrocardiogram and non-invasive arterial blood pressure signals are collected through the sensor, risks and complications caused by invasive examination of traditional coronary artery radiography are avoided, the problem that patients unsuitable for invasive examination such as contrast agent allergy and renal insufficiency are difficult to evaluate is solved, the pain of the patients is relieved, and the acceptability of the patients is improved.

The invention is suitable for the technical field of ultrasonic imaging, and provides a three-dimensional ultrasonic imaging method and system, computer equipment and a computer program product, and the method comprises the steps: transmitting a multi-angle composite plane wave sequence to a target region through a one-dimensional ultrasonic array with the frequency gradual change characteristic in the elevation direction, and receiving a reflected echo signal sequence, generating a target gray-scale image sequence corresponding to the echo signal sequence, acquiring coordinates of each ultrasonic contrast agent microbubble in each frame of gray-scale image, generating a two-dimensional coordinate set, calculating the axial half-peak full width of a point spread function region of each ultrasonic contrast agent microbubble, and calculating the axial half-peak full width of the point spread function region of each ultrasonic contrast agent microbubble; determining the coordinate of each ultrasonic contrast agent microbubble in the elevation angle direction based on the axial half-peak full width, generating an elevation angle coordinate set, and generating a three-dimensional contrast image of the target area based on the two-dimensional coordinate set and the elevation angle coordinate set. According to the method provided by the invention, the problem that three-dimensional ultrasonic imaging is limited by the surface ultrasonic array can be solved, and low-cost, simple and efficient three-dimensional ultrasonic imaging based on the one-dimensional ultrasonic array is realized.

The invention discloses a blood vessel inner diameter correction method and device based on an X-ray total attenuation conservation principle and a storage medium, and belongs to the technical field of medical image processing. The core of the method is to discover and utilize the total net attenuation of a blood vessel filled with a contrast agent in an actual motion state and the total net attenuation of the blood vessel in an ideal static state to be kept in conservation. The method comprises the steps that an angiography image is acquired, and a target area and an initial inner diameter measuring line are determined; calculating the gray scale decline amount and the maximum value of each pixel of the line; on the basis of the conservation principle, the inner diameter of the blood vessel in an ideal state is inversely calculated through the formula that the inner diameter is corrected to be equal to sigma [(delta Ii / delta Imax) * Li]. Furthermore, based on the same principle, the method can be expanded and applied to correction of the two-dimensional contour of the target blood vessel. According to the method, errors caused by motion artifacts and resolution limitation are fundamentally compensated through a volume measurement method based on integration and distribution, and the method is particularly suitable for accurate measurement of severe stenosis blood vessels.

An ultrasound diagnosis apparatus includes: a transmission and reception circuitry configured to perform, via an ultrasound probe, a first ultrasound scan on a first region in a subject who has a contrast agent injected and a second ultrasound scan on at least a part of a second region in the subject overlapping with the first region, the second ultrasound scan including transmitting and receiving two types of ultrasound waves of which one or both of amplitude levels and phases are different from each other; and processing circuitry configured to generate a blood flow image corresponding to one frame by implementing a Doppler method on the basis of a data sequence including reception data obtained from the first ultrasound scan performed multiple times in mutually the same position within the first region to have the second ultrasound scan performed in-between and to generate a contrast-enhanced image based on a result of the second ultrasound scan performed at least one time.

An ultrasound transducer ultrasonically processes a target volume by emitting a sequence of acoustic pulses to the target volume to alter tissue properties while at least one acoustic detector detects an ultrasound reflected signal from the target volume after each acoustic pulse, and a controller (i) estimates an activity of the contrast agent at the target volume based on a comparison between values of signal parameters in the reflected signal following successive acoustic pulses, and (ii) controls the ultrasound transducer to alter the tissue property based on the estimated activity.

The invention discloses a human brain specific fluid flow direction identification method comprising the following steps: S1, multi-input network model construction: using a decoder to segment a task, and introducing a boundary detection task; high-density lesions and surrounding edema in the medical image are accurately segmented according to the Vi < T > and an attention mechanism; s2, fluid mechanics model construction and parameter setting, focus classification and risk quantification: optimizing time windows of two times of CT scanning; constructing a three-dimensional geometric model of high-density lesions, peripheral edema and normal brain tissue RO I; constructing initial physical field distribution; setting boundary conditions corresponding to a vascular rupture source and a focus drainage area; and dynamically adjusting the time step length based on the flow velocity and the diffusion coefficient. The invention provides a human brain specific fluid flow direction identification method, which combines image high-dimensional features with a multi-physics field coupling model, and reveals the heterogeneity of human brain specific fluid-blood conversion and contrast agent leakage in absorption and peripheral edema expansion modes.

The application discloses an ultrasonic-temperature double-triggered double-liquid gas phase change contrast agent and a preparation method thereof. The preparation steps comprise the following steps: adding an isotonic buffer solution into a prepared composite phospholipid film, oscillating after ultrasonic dispersion, obtaining a targeted phospholipid vesicle dispersion; then high-pressure double-liquid co-loading is carried out, and the phase change temperature and the ultrasonic response are calibrated; filtering through a filter membrane, collecting the precipitate after centrifugation, adding a protective solution after washing with a PBS buffer solution, and sealing and storing to obtain the double-liquid gas phase change contrast agent. After the contrast agent enters the body, under the ultrasonic double triggering of the physiological temperature and an ultrasonic imaging instrument, the double-liquid gas synchronously phase changes into a gaseous state, drives the contrast agent to rapidly expand from a nano-sized particle into a micron-sized microbubble, realizes ultrasonic enhanced imaging, and has a significant clinical application value.

The invention provides an esophageal stenosis dilatation balloon which comprises a dilatation tube mechanism, and a guide-in assembly and a suction tube are arranged in the dilatation tube mechanism; the balloon main body is arranged on the outer surface wall of the expansion tube mechanism, the balloon main body is communicated with the guide-in assembly, a contrast agent can be injected through the injection device to expand the balloon main body, the expansion diameter is matched with the injection pressure, repeated suction can be carried out to gradually expand the balloon main body to a target diameter, and marking lines visible under X rays are arranged at the two ends of the balloon main body. The invention relates to the technical field of medical instruments, in particular to a balloon which is convenient for real-time observation of dilatation during operation and capable of accurately controlling the dilatation diameter of a balloon main body by injecting a contrast agent and utilizing the matching relation between the contrast agent and pressure, avoiding blind operation and improving safety. Suction and injection can be repeatedly carried out, and progressive and controllable expansion is achieved.

The invention belongs to the technical field of medical instruments. In order to solve the problem that an existing device is tedious in operation, the multifunctional automatic injection system is designed and comprises an injector, an automatic injection device and an auxiliary Y valve, and the auxiliary Y valve is connected with a catheter, a guide wire and the automatic injection device. Therefore, the automatic injection device can inject the contrast agent, the medicine or the embolic agent in the injector, the contrast or treatment efficiency is improved, meanwhile, the guide wire can be rapidly fixed, the guide wire does not need to be completely withdrawn out of the catheter, the surgical operation difficulty is reduced, and the surgical time is shortened.

The present application relates to an aneurysm treatment device for implanting into an aneurysm, comprising: a balloon including a hollow balloon body, the balloon body being inflatable or contractible, the balloon body having an opening, the balloon body being capable of entering into the aneurysm, the balloon body being capable of allowing filling or discharging of contrast agent; and an inflation assembly arranged in the balloon body, the inflation assembly being used for supporting the balloon body and opening or closing the opening, the inflation assembly being capable of sealing the balloon body when the inflation assembly closes the opening; when the balloon body is filled with the contrast agent, the balloon body is inflated and an outer wall thereof is capable of abutting against at least part of an inner wall of the aneurysm; when the balloon body discharges the contrast agent, the balloon body is contracted and a negative pressure effect is capable of reducing the aneurysm. Thus, the size of the aneurysm can be reduced after the operation, and the aneurysm space occupation can be avoided.

The invention relates to a three-dimensional image construction method and device based on perfusion scanning, computer equipment and a computer readable storage medium. The method comprises the following steps: acquiring scanning data after a scanning object is subjected to multi-circle scanning in a contrast agent perfusion process; according to the scanning data after the multi-circle scanning, obtaining reconstruction data of a plurality of target moments through interpolation operation and reconstruction processing; according to the reconstruction data of the multiple target moments and the mask data of the scanning object, perfusion peak data of the scanning object is obtained; and constructing a three-dimensional image of the scanned object according to the perfusion peak data. By adopting the method, the image quality of the three-dimensional image can be improved.

The invention relates to the technical field of radiotherapy auxiliary instruments, in particular to an injectable calcium sodium alginate hydrogel spacer for radiotherapy and a preparation method of the injectable calcium sodium alginate hydrogel spacer. Nano calcium carbonate is used as an adjusting switch, an adjustable mechanical and degradation performance foundation of the hydrogel is laid, and the material is endowed with unique bifunctional characteristics through the synergistic effect of the nano calcium carbonate, a contrast agent iodized oil and a degradation liquid diethylenetriamine pentaacetic acid. The hydrogel can quickly form gel after being injected, keeps long-term structural stability and clear CT imaging capability in vivo, and can monitor the position and form of the hydrogel in a lossless manner; and when the radiotherapy period is finished, the on-demand and rapid degradation of the hydrogel can be realized only by injecting the diethylenetriamine pentaacetic acid, so that the risk of long-term retention is avoided. In-vitro and in-vivo experiments prove that the material has good biocompatibility, can significantly reduce the radiation dose of normal tissues such as rectum and the like, realizes the technical span from invisibility and difficult degradation to visibility and degradability, and has great clinical transformation value.

Disclosed are methods for quantification of a perivascular space in a subject's central nervous system. The methods include administering contrast agent into cerebrospinal fluid of the subject; performing quantitative ultra-short time-to-echo contrast-enhanced magnetic resonance imaging (QUTE-CE MRI) on a region of interest of the subject's brain; and determining presence of the contrast agent in the perivascular space within the region of interest.

The invention relates to the technical field of image enhancement, in particular to an angiocardiography high-precision angiography enhancement method and system. The method comprises the steps that an ECG curve of electrocardiosignals before and after contrast agent injection of a patient and a blood vessel image are obtained; determining the compressible degree of each wave band according to the change of different wave bands and the change of the heart rate in the QT interval before and after the contrast agent is injected; determining the increment duration of each wave band in combination with the standard duration, the actual duration and the compressible degree; performing standardized adjustment on the ECG time phase of each frame of blood vessel image in combination with the increment time length and the actual time length of each wave band to obtain a standard time phase; determining a mask matched with each negative film according to the standard time phases of the negative films and the masks; and carrying out image subtraction on each negative film and the matched mask, and carrying out angiography enhancement processing. The blood vessel imaging precision after digital subtraction can be improved, the blood vessel artifact phenomenon is reduced, and the blood vessel imaging precision and reliability are enhanced.

An electrical connection material having a contrast agent infused within, and related systems and methods of detection thereof, are disclosed herein. Computer electronics such as printed circuit boards have electronic components attached to a substrate by an electrical connection material. The electrical connection material has at least one component infused with a contrast agent. The contrast agent is of a concentration to provide a visual distinction or highlight when imaged by an inspection system, such as an x-ray system of computed tomography (CT) scanning system. The presence of the contrast agent demonstrates that not all of residual electrical connection material has been cleaned away from the printed circuit board after manufacture.

The invention discloses a contrast agent filtering device for coronary surgery and a using method thereof, the device is integrally in a plastic bag shape and comprises a filtering bag body, the bottom of the filtering bag body is provided with a transfusion connector and a blood transfusion connector which are provided with sealing covers, and an inner opening is sleeved with a filter screen support with a filter screen; the filter bag body is divided into a filter area and an adsorption particle storage area through a middle seal, a flushing connector and a hanging hole are arranged at the top, and the filter bag body can be matched with a vibration disc for use. The use method comprises the steps that blood containing a contrast agent is extracted and input into the filtering area, the middle seal is opened through pressing, the blood makes full contact with the adsorption particles through vibration or manual extrusion so as to adsorb the contrast agent, then the filtered blood is infused back, and residual plasma can be infused back after being diluted with normal saline. The device is simple in structure, low in cost and easy and convenient to operate, the filtering effect is improved by 30% compared with the prior art, the adsorption rate reaches 75%-85%, contrast agents in blood can be effectively removed, damage to the kidney of a patient is reduced, and the device is particularly suitable for blood treatment of the patient after coronary angiography.

The invention relates to the technical field of medical image analysis, in particular to a dynamic DR digestive tract radiography automatic tracking and focus marking system which comprises a dynamic DR imaging module, an image real-time processing module, a contrast agent motion tracking module and a focus intelligent marking module. A deep learning algorithm is utilized to segment a contrast agent flowing area in real time and construct a dynamic three-dimensional model of a digestive tract, a contrast agent movement track is analyzed and tracked in combination with time-space domain features, and meanwhile, based on morphological anomaly detection and comparison with a focus feature library, focus positions such as stenosis, ulcers and space-occupying lesions are automatically marked; the problems of image blurring and tracking offset caused by alimentary canal peristalsis are solved by adopting a self-adaptive registration optimization algorithm of dynamic DR images and motion characteristics of alimentary canal contrast agents; by means of the method, the problems that traditional digestive tract radiography depends on manual interpretation of dynamic DR images, the focus tracking efficiency is low, and marking is prone to omission are solved.

A system for controllably inducing tissue death in an anatomical region inside a target. The system includes an ultrasound transducer for ultrasonically treating a target region in the presence of a contrast agent in the target region to cause sufficient damage to a blood vessel to kill or alter the function of tissue supplied by the damaged blood vessel; an acoustic detection system, the acoustic detection system comprising at least one detector for detecting an ultrasonic reflected signal from the target region after each acoustic pulse; and a controller configured to: (i) control the ultrasound transducer to deliver a series of acoustic pulses to the target region; (ii) receiving data characterizing the detected reflected signal from the acoustic detection system; and (iii) determining a degree of damage to vascular tissue within the target region based at least in part on the received data from the sound detection system.

The invention relates to the field of medicine. In particular, the present invention relates to a protein-based biosensor comprising a substrate binding protein that binds to an MRI contrast agent by a chelating agent. More specifically, the present invention relates to a glutamic acid biosensor comprising a glutamic acid binding protein bound to an MRI contrast agent, characterized in that the glutamic acid binding protein comprises SEQ ID NO: 10, preferably SEQ ID NO: 5, and a sequence encoding a fluorescent protein.

The invention relates to a computer-implemented method for providing a result data set, the method comprises: a) acquiring an image dataset of the examination object, the image dataset mapping a flow of contrast agent in a branched hollow organ of the examination object in a spatially and temporally resolved manner, b) identifying a section of the hollow organ in the image dataset on the basis of the mapped flow of contrast agent, c) classifying sub-sections of the identified sections as single-fed and multi-fed sub-sections on the basis of the flow direction of the mapped contrast agent flow and the identification of the confluence of the identified sections of the hollow organ mapped in the image data set, the sub-sections of the hollow organ arranged downstream of the confluence being classified as multi-fed sub-sections, and the sub-sections of the hollow organ arranged downstream of the confluence being classified as single-fed and multi-fed sub-sections. D) providing a result dataset on the basis of the image dataset and the classified sub-segments of the hollow organ, the result dataset having a sub-dataset for each classified sub-segment of the hollow organ, the sub-dataset having a dedicated representation of the contrast agent flow in each classified sub-segment of the hollow organ. Furthermore, the invention relates to a provision unit, a medical imaging device and a computer program product.

This invention relates to the field of clinical contrast-enhanced injection technology, and more particularly to a clinical contrast-enhanced injection device for cardiovascular medicine. The device includes a housing, a reservoir mounted on the top of the housing, a dispensing tube connected to the upper end of the reservoir, a heating tube installed inside the reservoir, a pressure plate installed inside the heating tube, a fixing column fixedly connected to the center of the reservoir, a transport tube connected to the bottom of the fixing column, a connector connected to the bottom of the transport tube, a pipe groove inside the housing, a sealing door installed at the groove opening, a receiving groove inside the pipe groove, a receiving mechanism installed inside the receiving groove, and a transport mechanism installed inside the housing. This invention allows for free control of the injection tube's length, and the heated injection tube is more adaptable to deformation, maintaining a small temperature difference with the contrast agent in the reservoir when extended for use, thus maintaining the stability of the contrast agent during use.

The invention belongs to the technical field of medical ultrasonic diagnosis auxiliary equipment, and discloses an electric right heart acoustic radiography foaming device which comprises a device body, the device body comprises a base, a mounting plate is fixedly arranged on the rear side of the base, a driving assembly is arranged on the front side of the mounting plate, and the driving assembly comprises fixing frames fixed to the upper side and the right side of the mounting plate; a stepping motor is fixedly arranged at the top of the fixing frame, a ball screw is fixedly arranged at the tail end of a main shaft of the stepping motor, a sliding block is spirally arranged on the outer side of the ball screw in a sleeving mode, and a connecting rod is fixedly arranged at the bottom of the sliding block, so that accurate controllability of power transmission and visual adjustment of parameters in the contrast agent injection process are achieved; specifically, key parameters such as injection speed and dosage can be accurately set through the operation panel, a traditional manual injection mode is replaced, and the stability of the foaming effect of the contrast agent is guaranteed.

An ultrasound imaging disclosure according to an embodiment of the present disclosure relates to an ultrasound imaging apparatus configured to irradiate ultrasonic waves to an object to which an ultrasonic contrast agent is administered, receive an echo signal reflected from the object, and analyze a contrast enhanced ultrasound image for the object, the ultrasound imaging apparatus including an image processor configured to set a region of interest in the ultrasound image, and generate a time intensity curve representing brightness of each frame of the ultrasound image within the set region of interest and a curve fitting model representing a tendency of the time intensity curve according to a predetermined mathematical model.

An application for the EGT-AuNPs in preparing contrast agents and / or antioxidants is provided, where the EGT-AuNPs include gold nanoparticles (AuNPs), the AuNPs are connected to L-ergothioneine (EGT) by gold-sulfur bonds, and the antioxidants include medicines for preventing and / or treating acute kidney injury (AKI). EGT-AuNPs with antioxidant activity are designed and synthesized through the combination of the higher imaging contrast of gold and the antioxidant natural product EGT, and they are ultra-small AuNPs, which achieve the combination of CT imaging and antioxidant effects, and are suitable for renal imaging, particularly for the early diagnosis and treatment of AKI, realizing the integration of diagnosis and treatment, circumventing the toxicity of contrast agents present in the conventional nanomaterials, lowering the serum creatinine and urea nitrogen levels, and reducing the degree of renal tubular damage.

The application discloses an anti-seepage and anti-explosion automatic control pressure high-pressure injector device and belongs to the field of image contrast diagnosis and treatment equipment. The device comprises a driving pushing unit and an injection cylinder. A hose is connected to the discharge end of the injection cylinder through a joint. A first pressure sensor, a second pressure sensor and a buffer are sequentially installed on the hose. The first pressure sensor is close to the discharge end of the injection cylinder. The buffer is arranged downstream of the second pressure sensor. A movable block in the buffer can divide a liquid channel of the connected hose and a volume-adjustable exchange chamber. The driving pushing unit is transmissionally connected to an injection plug in the injection cylinder and is electrically connected to a control box receiving signals of the two sensors. The application can compare and distinguish two types of faults, i.e. blockage and overload in the cylinder and blockage of the distal pipeline, by means of the double sensors, so that the control system can be stopped in advance for protection, the defects of lagging and poor fault tolerance of single pressure detection and identification can be made up, medical risks such as extravasation of contrast medium, pipeline burst and blood vessel injury can be reduced, the injection pressure is stable and controllable, and medical staff need not to be on duty for a long time.

The application discloses an old person free breathing coronary artery scanning image lesion analysis system and relates to the technical field of scanning image lesion analysis. In order to solve the problem that the accurate condition of a patient cannot be obtained according to a scanning image. The application adopts a diameter method, an area method and a contrast agent filling condition to judge the stenosis degree and the hemodynamic change, analyzes the lesion from the morphological and functional double angles, provides comprehensive information for clinical decision-making, identifies the R wave peak value and divides the cardiac phase, matches the respiratory signal and the projection data in time, can accurately capture the characteristics of the heart in different motion states and the respiratory stage, effectively avoids the interference of the artifacts caused by the heart beat and the respiratory motion, makes the reconstructed image clearer and more accurate, sets the CT and the injector parameters in sequence from the scanning type confirmation, each link is closely related and the target is clear, improves the work efficiency, and is convenient for quality control and process management.

Disclosed herein are sonographic devices and methods of making and delivering a visualizable contrast medium composition, and methods for visualizing, diagnosing and treating structures in a subject.

To provide a chemical injection device for setting an injection protocol capable of emphasizing different kinds of blood vessels at the same timing while giving a contrast difference in a region of interest.SOLUTION: The control unit of the chemical liquid injector includes a process of acquiring information on a required amount of iodine associated with a physical feature of a subject, a process of acquiring information on a body weight of the subject, a process of calculating a contrast agent amount to be injected based on component information of the contrast agent and the information on the required amount of iodine and the body weight, and a process of setting an injection protocol capable of simultaneously enhancing arteries and veins. And processing for receiving input of information on d3: injection time of the second contrast medium phase, receiving input of information on d4: duration of the interval phase, and setting an injection protocol on the basis of the information.SELECTED DRAWING: Figure 5

The application provides a kind of basic phosphatase induced T1 and T2 signal switching response type magnetic resonance imaging contrast agent and its preparation method and application, the response type magnetic resonance imaging contrast agent includes superparamagnetic nanoparticle, and polyethylene glycol phosphoric acid monoester modified to the surface of superparamagnetic nanoparticle;The superparamagnetic nanoparticle includes ferroferric oxide nanoparticle.The contrast agent of the application can realize T1 and T2 signal switching, is used for stem cell osteogenic differentiation monitoring, not only improves the detection sensitivity of magnetic resonance imaging to microstructure and function, also provides new tools and methods for stem cell treatment in biomedical research and clinical practice.

The application provides a liver hydatid disease screening method and system based on plain CT and deep learning, belongs to the technical field of intelligent medical treatment, and realizes liver hydatid disease identification based on plain CT by combining a liver segmentation model, a liver hydatid lesion identification model and a liver hydatid screening model, reduces the risk of patients of intake of more radiation due to enhanced CT, reduces the risk of patients of allergy due to injection of contrast agent, and has strong clinical applicability; can realize patient-level diagnosis on the basis of slice-level identification, classification and segmentation, and has interpretability; in combination with the real situation of hydatid disease in clinical diagnosis and treatment and the clinical characteristics of hydatid disease, the identification accuracy is greatly improved, and in addition, the population including healthy people can be identified and screened, and the use range is wide.