222results about "Filtering accessories" patented technology

A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is in a range from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is in a range from about 0.1:100 to 100:0.1 to produce a third filtrate.

A method may comprise (a) inserting an insulin delivery device subcutaneously into a body of a subject, which comprises an amperometric glucose sensor comprising an electrode layer comprising an indicating electrode and underlying a redox-catalytic layer comprising a redox mediator; (b) using said insulin delivery device to deliver an insulin formulation (e.g., comprising a phenol or cresol excipient) subcutaneously to said subject; and (c) using said amperometric glucose sensor to measure a subcutaneous glucose concentration, which comprises using said redox-catalytic layer to allow electron transfer from subcutaneous glucose to said indicating electrode sufficient to cause a response of said amperometric glucose sensor at an applied bias potential of no more than +250 millivolts, wherein (b) and (c) are performed at the same time for at least one hour, while maintaining a sensor sensitivity of at least 50% of an initial sensor sensitivity for up to one hour.

[Problem] The purpose of the present invention is to provide a portable anticancer agent container for preventing exposure and infection to the human body caused by chemical solution leakage that arises during a removal operation of a coupling connector at the time of system cleaning using a cleaning solution. [Solution] Provided is a pressurization-type drug injector having a drug exposure preventive function and having a system cleaning function, the pressurization-type drug injector comprising: a reservoir that has a chemical solution filling opening and a chemical solution discharging opening; a pressurization deformation means that undergoes pressurization and deformation by the injection of a chemical solution and that pushes out the chemical solution by a force caused by restoration of the pressurization and deformation; a flow rate control means that adjusts the flow rate of the chemical solution by resistance; a system cleaning port that includes a cleaning solution injection opening, a chemical solution filling opening, and a liquid discharging opening; and a case that contains therein said reservoir, said pressurization deformation means, and said system cleaning port. The case has openings respectively in the vicinity of the chemical solution filling opening, the system cleaning injection opening, and the chemical solution discharging opening. The chemical solution being filled is filled into the pressurization deformation means from the chemical solution filling opening of the reservoir, and moves from the chemical solution discharging opening of the reservoir to the exterior of the container via the flow rate control means. A cleaning solution is injected from the injection opening of the cleaning port arranged downstream from the flow rate control means, and moves to the exterior of the container. The pressurization-type drug injector having a drug exposure preventive function is characterized in that the periphery of the cleaning port is completely covered by a sterile seal, and thus, the cleaning port injection opening is kept clean until use.

A disposable fluid transfer and mixing device is disclosed and includes an injector support surface for receiving an injection device thereon. A lyophilized drug vial, a diluent vial and a syringe are also attached to the device. The device features fluid passageways and a manual valve that may be manipulated so that the syringe may be used to transfer diluent from the diluent vial to the lyophilized drug vial, for reconstitution of the drug. The valve may also be configured so that the reconstituted drug is transferred from the lyophilized drug vial to the injection device. An automated transfer and mixing device receives an injection device, a lyophilized drug vial and a diluent vial and transfers diluent from the diluent vial to the lyophilized drug vial and shakes or vibrates the lyophilized drug vial to reconstitute the drug. The device then transfers the reconstituted drug from the lyophilized drug vial to the injection device.

A method of preparing a giving set for administration of intravenous therapy to a patient, in a pharmacy. The method comprising steps of providing a filled IV bag (10) with an outlet port (12), connecting an IV line (20) to the outlet port, and connecting a gas trap device (30) to a distal end of the IV line. The trap device has a chamber (31) and a priming port (34) which is open. The method further includes squeezing the bag to force gas from the bag and through the line and out of the trap device. When liquid reaches the trap device (30) and substantially fills the chamber, the priming port is closed, thereby providing a pre-primed giving set comprising the bag, the line and the trap device filled with liquid. The actuator may have a roller which is forced in a direction towards the outlet port while the bag is constrained in a housing (51).

A system for managing air bubbles in fluid lines includes a pump, valves, a bubble chamber, sensors, and a controller unit. The pump pulls fluid from a reservoir, valves create a dual pressure network, and the bubble chamber captures air bubbles. Sensors measure physical properties and the controller unit receives input from these sensors to control system components.

A gas trap device (100) has a chamber (102), an inlet port (103) to the chamber, an outlet conduit (110) from within the chamber to the outlet port. The chamber has a venting outlet (111), and a stopcock valve (101) is arranged to control opening and closing of the venting outlet and the outlet conduit. The stopcock valve has a barrel (150) and a handle (151), valving being controlled by rotation of the handle. The valve is at a 90° angle to an axial flow direction of the outlet port when the venting port is open. For venting the barrel is in registry with both a dedicated venting outlet (111) and the outlet conduit (110, 126) for comprehensive venting through two paths.

A device for delivering insulin or insulin analog formulations and measuring subcutaneous glucose concentrations may include a hollow tube and a current-type glucose sensor located proximal to the distal end of the hollow tube. The current-type glucose sensor may include a redox mediator and an enzyme comprising glucose oxidase or glucose dehydrogenase. Applying a bias potential allows the electrode layer of the current-type glucose sensor to remain substantially free from electropolymerization of the excipients of the insulin or insulin analog formulation during continuous operation of the current-type glucose sensor. The sensitivity of the current-type glucose sensor to subcutaneous glucose concentrations can be maintained in the presence of insulin or insulin analog formulations.

The micropore precision filter structurally comprises a lower cover, a liquid outlet pipe, a protruding block, an air outlet hole, an upper cover and a liquid inlet pipe, the liquid outlet pipe and the lower cover are of an integrated structure, the air outlet hole penetrates through the top of the protruding block, the liquid inlet pipe is communicated with the protruding block, and the protruding block and the upper cover are of an integrated structure; the lower cover comprises a communicating hole, a filter membrane supporting block and a partition plate, the communicating hole penetrates through the partition plate to be communicated with the liquid outlet pipe, the filter membrane supporting block is fixed to the outer surface of the partition plate and used for supporting a filter membrane, gas existing in the upper cover is exhausted through the gas outlet hole, and in the liquid conveying process, the inclination angle of the interior of the downward flowing channel and the inclination angle of the communicating hole are different. The liquid can be assisted in guiding and flowing in the specified direction by the aid of the through holes, the partition plates shield the space between the containing grids and the liquid outlet, a large amount of liquid is collected in the containing grids, and the liquid can only be uniformly and orderly conveyed through the through holes.

A method may comprise (a) inserting an insulin delivery device subcutaneously into a body of a subject, which comprises an amperometric glucose sensor comprising an electrode layer comprising an indicating electrode and underlying a redox-catalytic layer comprising a redox mediator; (b) using said insulin delivery device to deliver an insulin formulation (e.g., comprising a phenol or cresol excipient) subcutaneously to said subject; and (c) using said amperometric glucose sensor to measure a subcutaneous glucose concentration, which comprises using said redox-catalytic layer to allow electron transfer from subcutaneous glucose to said indicating electrode sufficient to cause a response of said amperometric glucose sensor at an applied bias potential of no more than +250 millivolts, wherein (b) and (c) are performed at the same time for at least one hour, while maintaining a sensor sensitivity of at least 50% of an initial sensor sensitivity for up to one hour.

The invention belongs to the technical field of medical instruments, and particularly relates to an infusion air supply device. The invention aims to provide an infusion air supply device which is composed of a compressed air storage tank, a soft air bag, a filter membrane, a puncture needle, a protective sleeve, a pipeline and a clamp, compressed sterile clean air is stored in the compressed air storage tank, and an air inlet device and a separated air inlet device on a disposable infusion apparatus (air inlet gravity infusion type) can be replaced. When the infusion air supply device is used, the easily-folded thin tube with the closed end, inserted into the soft air bag, on the compressed air storage tank is broken firstly, compressed sterile clean air is input into the soft air bag, an air inlet device on the disposable infusion apparatus (air inlet gravity infusion type) is closed by medical staff before infusion, then a puncture needle on the infusion air supply device is inserted into an infusion bottle, and then the infusion air supply device is closed. During infusion, a clip on a pipeline of the infusion air supply device is opened, and when the pressure of air in an infusion bottle is lower than the atmospheric pressure, sterile clean air in the soft air bag automatically enters an infusion system to be supplemented, so that closed normal gravity infusion is realized in the whole process, and adverse events of infusion can be reduced.

The utility model discloses a filtering three-way structure of an infusion apparatus. A three-way main body comprises a straight pipe section and a side pipe section which are communicated with each other; a communication port communicated with the bypass pipe section is formed in the straight pipe section; the filtering assembly comprises a filtering main body, a first filtering sheet and a second filtering sheet; the filtering main body is provided with a main flow channel and a branch flow channel which extends from the outer wall and is communicated with the main flow channel; a first slot for cutting off the main flow channel and a second slot for cutting off the branch flow channel are formed in the filtering main body; the first filter sheet is in insertion fit with the first slot; the second filter sheet is matched with the second slot in an inserting manner; the filter main body is provided with an assembly position which is inserted into the first end of the straight pipe section along the axial direction; and at the assembly position, the outer wall of the filter main body is in sealing fit with the inner wall of the straight pipe section, and the branch flow channels are communicated with the communication ports. According to the tee joint, the filter pieces in the two channels of the tee joint body can be disassembled, assembled and replaced at the same time, disassembly and assembly of the filter pieces are convenient, time and labor are saved, actual application requirements are effectively met, and practicability is high.

The invention relates to the technical field of medical instruments, in particular to a medical medicine quantitative infusion device which comprises an intravenous needle, a Luer taper liquid medicine filter, a bottle stopper puncture outfit, a Murphy type drip chamber, an infusion hose and a flow rate adjusting mechanism. An automatic liquid stopping mechanism is arranged in the Murphy type drip chamber and comprises a cylindrical shell fixedly connected to the inner bottom wall of the Murphy type drip chamber. By arranging the flow speed adjusting mechanism, the abutting arc block can be driven to stably move along the guide rod by rotating a flow speed adjusting knob, an infusion hose is accurately extruded to change the diameter of a pipeline, fine adjustment of the infusion flow speed of liquid medicine is achieved, and compared with a traditional speed regulator, the self-locking characteristic is better; the problem that the infusion speed is too high or too low due to poor stability of a speed regulator is effectively solved, the infusion speed can be flexibly set according to the medicine type, the illness state of a patient and the tolerance degree, the accuracy of the medicine infusion dosage and speed is guaranteed, and the medicine treatment effect is improved.

Filter for medical infusion lines comprising a box-like body (1) having an inlet connector (6) and inside which there is arranged a plate-like element (8) on whose one or both opposite faces there are formed respective channels (9) placed in communication with an outlet connector (7). Filtering hydrophilic membranes (10) separate the channels (9) from at least one interspace (12) placed in communication with the inlet connector (6). With the outlet connector (7) there is operatively associated an overpressure valve (14) incorporated in the box-like body (1) of the filter.

Provided is a novel hemostasis valve-equipped indwelling needle that is capable of discharging air in an internal flow path. A hemostasis valve-equipped indwelling needle 10 including a cannula 12 to be inserted percutaneously into a blood vessel on a distal end side thereof, a link connector 14 on a proximal end side thereof, an internal flow path 18 extending from the cannula 12 to the link connector 14, and a hemostatic valve 16 disposed inside the link connector 14. An air vent passage 118 that allows the internal flow path 18 to communicate with an external space is formed in the link connector 14 further on the cannula 12 side than the hemostatic valve 16, and a filter 120 that allows gas to pass through but does not allow liquid to pass through is mounted in a compressed state on the air vent passage 118.

An extracorporeal blood filtering machine can include a blood circuit, an effluent circuit, and a source fluid circuit and can be controlled by a controller. The extracorporeal blood filtering machine can also include access ports for connecting the source fluid circuit to the blood circuit, as well as blood sensors to detect possible issues with the extracorporeal blood filtering machine. The extracorporeal blood filtering machine can include density sensors and flow sensors that enable it to be more accurate and to operate while being transported. The extracorporeal blood filtering machine can further include a user interface and can display fluid inflow / outflow information. A medical fluid container can automatically empty after being filled. An apparatus for supporting a medical fluid container can include a hanger and an attachment member with the apparatus able to adjust to ensure the medical fluid container remains properly oriented directly under a medical fluid container scale.

The invention provides a dual-purpose infusion apparatus capable of being connected with an indwelling needle, and relates to the technical field of medical instruments. The infusion tube is provided with a drip cup and a flow regulator, and the tail end of the infusion tube is fixedly communicated with a dual-purpose connector; the dual-purpose connector is provided with a remaining needle connecting end and a conventional infusion end, the outer portion of the conventional infusion end is connected with an infusion needle head through a connecting pipe, switching sealing assemblies are arranged inside the remaining needle connecting end and the conventional infusion end respectively, and warning rings are arranged outside the remaining needle connecting end and the conventional infusion end respectively. By arranging the dual-purpose connector and the switching sealing assembly, two modes of connection with a conventional infusion device or connection with an indwelling needle can be flexibly switched, additional matching with an adapter connector or a special infusion device is not needed, clinical diversified infusion requirements are met, meanwhile, stable connection of the connecting position can be guaranteed, falling off or connector pollution can be avoided, and the infusion device is convenient to use. The problem that an existing infusion apparatus is not suitable for being connected with an indwelling needle is solved.

The utility model relates to the technical field of infusion apparatuses, in particular to an infusion apparatus with a filtering and dosing structure, which comprises an upper infusion tube, a filter cartridge, a lower infusion tube, a coarse filter layer, a fine filter layer, an ultrafiltration layer and a flushing component, the filter cartridge is connected with the upper infusion tube, the lower infusion tube is connected with the filter cartridge, the coarse filter layer is connected with the filter cartridge, the fine filter layer is connected with the coarse filter layer, and the ultrafiltration layer is connected with the flushing component. The ultra-filtration layer is connected with the fine filtration layer, the flushing component is arranged on the filter cartridge, the coarse filtration layer is used for intercepting large-particle impurities, the fine filtration layer is used for further filtering small particles, and finally, the ultra-filtration layer is made of a nano-scale filtration material, so that the purity of a liquid medicine solution is ensured; the filtered liquid medicine is input into a human body through the lower infusion tube and the connecting needle head, so that the influence of impurities in the liquid medicine on the human body is avoided.

The invention discloses an infusion port which is characterized by comprising an injection seat shell (1), a channel (2) is arranged at the upper end of the injection seat shell (1), a guide pipe (3) is arranged at the lower end of the injection seat shell (1), and the infusion port is characterized in that a first cavity (4), a filter plate (6) and a second cavity (5) are arranged in the injection seat shell (1); an anti-backflow box (13) is fixedly arranged in the lower end of the injection seat shell (1), a discharge port (14) is formed in the upper portion of the anti-backflow box (13), a discharge channel (18) is formed in the anti-backflow box (13) and communicated with a guide pipe (3) of the discharge port (14), and an elastic piece (19) is fixedly arranged on the inner wall of the lower end of the discharge channel (18); and the inner wall of the upper end of the discharge channel (18) is fixedly provided with a stop block (20) which is inclined by more than 90 degrees towards the direction close to the discharge port (14). The catheter can be used for preventing smooth circulation of liquid from being hindered when the catheter is bent or pressed externally and preventing blood from flowing backwards when infusion is stopped.

This invention describes agents, methods, compositions, kits and uses of medicaments for inhibiting or suppressing expression of TGF-β2 for treating or ameliorating the symptoms of a CNS disease in a human subject or animal, including diffuse midline glioma (DMG) and K27M GBM. The agents may be used in combination with cancer drugs. These purposes can be achieved with formulations of agents for inhibiting or suppressing expression of TGF-β2. More particularly, this invention discloses compositions, methods and uses for antisense oligonucleotides against TGF-β2, in a regimen for CNS disease. This invention further describes novel devices and methods for delivering a pharmaceutical composition by intracranial infusion.

The utility model provides an infusion apparatus with a rolling structure, which comprises a tube body and the rolling mechanism, an elastic belt is arranged on the annular side surface of a circular shaft, outer rings of two ball bearings are respectively and fixedly sleeved with circular rings, magnetic blocks are respectively arranged in the left end and the right end of the circular shaft, and magnetic rings are respectively arranged in inner rings of the two ball bearings. The middle of the rear side of the square plate is in threaded connection with a lead screw, the front end of the lead screw is fixedly connected with a square block, a roller bearing is embedded in the rear side of the square block, and the front ends of the two square columns are each provided with an arc-shaped magnetic plate. The rolling device for the infusion apparatus has the advantages that the structure is reasonable, the practicability is good, the rotation effect of the bearing is utilized, the infusion apparatus can be conveniently rolled and taken down, the simplicity and convenience are improved, the centralized treatment is orderly, and the space is saved.

The invention relates to the technical field of stem cell introduction, and discloses a stem cell introduction device which comprises a conduction mechanism, a guide sliding butt joint mechanism is arranged at the top end of the conduction mechanism, a detachable driving mechanism is arranged at the bottom end of the guide sliding butt joint mechanism, and an expansion type turbulent flow mechanism is arranged at the top end of the guide sliding butt joint mechanism. The surface of the guiding and sliding butt joint mechanism is provided with a fixed anti-falling mechanism, the conveying and guiding mechanism comprises an infusion tube, the guiding and sliding butt joint mechanism comprises an installation head and a lower connection threaded ring, and the installation head is fixedly installed at the top end of the infusion tube. According to the stem cell leading-in device, through the arrangement of the conveying and guiding mechanism, the guiding and sliding butt joint mechanism, the detachable driving mechanism, the expansion type turbulent flow mechanism and the fixed anti-falling mechanism, the detachable driving mechanism can be used for driving the expansion type turbulent flow mechanism to perform periodic slow expansion and contraction at a certain frequency during use, so that turbulent flow of liquid medicine is realized; therefore, the mesenchymal stem cells are kept in a suspension state in the intravenous infusion process.

The utility model relates to an infusion device, in particular to a liquid storage infusion device which comprises a protective bottle and a bottle cap with a capsule core, the protective bottle is connected with the bottle cap with the capsule core in a sealed mode, a liquid storage capsule is arranged on the capsule core in the protective bottle, a three-way connector is arranged on the capsule core on the bottle cap, a pressure gauge is connected to the three-way connector, and the pressure gauge is connected with a pressure sensor. A three-way dosing valve is arranged on the three-way connector, a medicine outlet pipeline is arranged on the three-way dosing valve, a flow stopping clamp is arranged on the medicine outlet pipeline, an inflation tube is connected to the protection bottle, an inflation bag is arranged at the end of the inflation tube, an inflation switch is arranged on the inflation tube, and an air inlet valve is arranged on the inflation bag. According to the liquid storage infusion device, when the deformation of the liquid storage bag caused by the fact that the liquid storage bag conveys liquid medicine outwards is small, the protection bottle can be inflated through the inflation bag so as to increase the pressure in the protection bottle, and therefore it is guaranteed that the pressure of the liquid storage bag on the internal liquid medicine is basically kept unchanged, and the output pressure of the liquid medicine is stable; and the accuracy of the infusion amount of liquid medicine can be ensured.