174 results about "Optical contrast" patented technology

A method for detecting and localizing a target tissue within the body in the presence of ambient light in which an optical contrast agent is administered and allowed to become functionally localized within a contrast-labeled target tissue to be diagnosed. A light source is optically coupled to a tissue region potentially containing the contrast-labeled target tissue. A gated light detector is optically coupled to the tissue region and arranged to detect light substantially enriched in target signal as compared to ambient light, where the target signal is light that has passed into the contrast-labeled tissue region and been modified by the contrast agent. A computer receives signals from the detector, and passes these signals to memory for accumulation and storage, and to then to image processing engine for determination of the localization and distribution of the contrast agent. The computer also provides an output signal based upon the localization and distribution of the contrast agent, allowing trace amounts of the target tissue to be detected, located, or imaged. A system for carrying out the method is also described.

A method for detecting and localizing a target tissue within the body in the presence of ambient light in which an optical contrast agent is administered and allowed to become functionally localized within a contrast-labeled target tissue to be diagnosed. A light source is optically coupled to a tissue region potentially containing the contrast-labeled target tissue. A gated light detector is optically coupled to the tissue region and arranged to detect light substantially enriched in target signal as compared to ambient light, where the target signal is light that has passed into the contrast-labeled tissue region and been modified by the contrast agent. A computer receives signals from the detector, and passes these signals to memory for accumulation and storage, and to then to image processing engine for determination of the localization and distribution of the contrast agent. The computer also provides an output signal based upon the localization and distribution of the contrast agent, allowing trace amounts of the target tissue to be detected, located, or imaged. A system for carrying out the method is also described.

A calibration device which has at least two targets. Each target has at least one surface exhibiting areas of optical contrast, and each surface has a general plane of orientation. The targets are oriented such that a general plane of orientation of one target is inclined at an angle relative to the general plane of orientation of a surface of the second target which has areas of optical contrast.

An apparatus for determining the refraction of a patient's eye includes a wavefront measurement device that determines aberrations in a return beam from the patient's eye viewing a target through a corrective test lens in the apparatus. The wavefront measurement device preferably outputs an display representative of the quality of vision afforded the patient through the test lens. The display may be, e.g., a representation of a Snellen chart convolved with the optical characteristics of the patient's vision, an overall quality of vision scale, or the optical contrast function, all of which are based on the wavefront measurements of the patient's eye. The examiner may use the display information to conduct a refraction examination or other vision tests without the subjective response from the patient.

An opaque article having a surface and substantially asymmetric striae extending along the surface. A portion of the striae reside in a first area and have an orientation. Another portion of the striae reside in a second area and have an orientation substantially opposite the striae in the first area. The first area striae and the second area striae create an optical contrast therebetween at a wide range of viewing angles and illumination angles. The opaque article can be a tire. The striae can reside at numerous locations on the tire, including, for example, the sidewall, tread ribs or blocks, and stone ejectors.

Many medical procedures, such as needle-sticking, could benefit from an assistive device that improves the optical contrast of externally targeted features and lumens of interest residing in and underneath the skin and / or exposed organ tissues. The inventive inexpensive device and method are useable on such externally targeted features and lumens while also protecting the practitioner and freeing up both of his / her hands, if necessary, to thereby eliminate practitioner self-sticking problems. The present device provides good optical contrast and also provides splash-protection against HIV, hepatitis and other blood-borne diseases. The inventive device method and apparatus may also include vibratory subcutaneous electrical nerve stimulation (TENS), drug-based or heating treatment capabilities for reducing pain, both perceived and real pain, associated with a device guided procedure. Finally, the pain reduction mechanisms have also been found useful for lumen dilation.

A method and an illumination device is provided for optical contrast enhancement of an object through a spatially and / or temporally modulated illumination of the object by way of at least one light projection unit, wherein the spatial and / or temporal modulation of the illumination of the object is determined using a set of image data associated with the object.

The present invention relates to near-field scanning optical microscopy (NSOM) and near-field / far-field scanning microscopy methods, systems and devices that permit the imaging of biological samples, including biological samples or structures that are smaller than the wavelength of light. In one embodiment, the present invention permits the production of multi-spectral, polarimetric, near-field microscopy systems that can achieve a spatial resolution of less than 100 nanometers. In another embodiment, the present invention permits the production of a multifunctional, multi-spectral, polarimetric, near-field / far-field microscopy that can achieve enhanced sub-surface and in-depth imaging of biological samples. In still another embodiment, the present invention relates to the use of polar molecules as new optical contrast agents for imaging applications (e.g., cancer detection).

In-vivo optical molecular imaging methods for producing an image of an animal are described. A time series of image data sets of an optical contrast substance in the animal is acquired using an optical detector Each image data set is obtained at a selected time and has the same plurality of pixels, with each pixel having an associated value. The image data sets are analyzed to identify a plurality of distinctive time courses, and respective pixel sets are determined from the plurality of pixels which correspond to each of the time courses. In one embodiment, each pixel set is associated with an identified anatomical or other structure, and an anatomical image map of the animal can be generated which includes one or more of the anatomical structures.

A patterned-media magnetic recording disk drive uses an optical system for clocking the write data and a patterned-media disk that has discrete magnetizable data islands with nonmagnetic spaces between the islands, wherein the nonmagnetic spaces contain optical contrast material. The optical contrast material may be optically absorptive material, fluorescent material, or a metal layer that generates surface plasmons when excited by radiation of a specific wavelength. Radiation from a primary radiation source is directed to a near-field transducer maintained near the disk surface and a radiation detector detects radiation reflected back from the transducer. If the disk has fluorescent material or a metal layer in the nonmagnetic spaces, then a secondary radiation source irradiates the fluorescent material or metal layer with radiation of a specific wavelength to cause the fluorescent material to emit radiation or the metal layer to generate surface plasmons. As the disk rotates, reflected optical power from the transducer varies depending on whether an island or space is under the transducer. The output signal from the radiation detector output controls the write clock.

An apparatus for determining the objective refraction of a patient's eye includes a transparent window and a wavefront measurement device that determines aberrations in a return beam from the patient's eye after the beam passes through a corrective test lens in the apparatus. The wavefront measurement device outputs an instant display representative of the quality of vision afforded the patient through the test lens. The display can be a representation of a Snellen chart, convoluted with the optical characteristics of the patient's vision, an overall quality of vision scale or the optical contrast function, all based on the wavefront measurements of the patient's eye. The examiner may use the display information to conduct a refraction examination and other vision tests without the subjective response from the patient.

The present invention is an imaging system for detecting concealed objects on an individual. The imaging system includes an imaging zone that is illuminated with millimeter wave energy. A plurality of millimeter wave cameras are focused to fully surround the imaging zone and have the ability to detect millimeter wave frequencies reflected from the imaging zone. As an individual passes through the imaging zone the plurality of millimeter wave cameras detect concealed objects by identifying differences in the millimeter wave energy reflected by the individual's body and a concealed object. A composite image is generated by a central processing unit and displayed on a monitor showing the concealed object on the individual through optical contrast.

Cyanine and Indocyanine dye compounds and bioconjugates are disclosed. The present invention includes several cyanine and indocyanine dyes, including bioconjugates of the same, with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds of the invention may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of compounds of the invention allows favorable delivery to tumor cells as compared to larger molecular weight imaging agents. Further, use of a biocompatible organic solvent such as dimethylsulfoxide may be said to assist in maintaining the fluorescence of compounds of the invention. The compounds and bioconjugates herein disclosed are useful in a variety of medical applications including, but not limited to, diagnostic imaging and therapy, endoscopic applications for the detection of tumors and other abnormalities, localized therapy, photoacoustic tumor imaging, detection and therapy, and sonofluorescence tumor imaging, detection and therapy.

Provided is a multifunctional particle comprising: (a) an inner metallic core, (b) a biocompatible shell comprising an optical contrast agent embedded therein, and (c) a targeting biomolecule conjugated to the biocompatible shell through a multidentate ligand, wherein the multidentate ligand is chelated to an imaging agent. Also provided are compositions comprising the multifunctional particle and methods of using the multifunctional particle, including a method of diagnostic imaging and a method of treatment.

For labeling a component provided with a metallic cover layer, it is proposed that at least one additional contrast layer is arranged over the cover layer. The contrast layer produces an optical contrast with the metallic cover layer and is capable of being eroded by a laser for producing a label.

A structural improvement to a touch panel is provided. comprising a substrate, and a first induction layer and a second induction layer are disposed on different surfaces of the substrate. said induction layers have a plurality of induction lines respectively. Each of the induction lines have a plurality of first induction blocks and second induction blocks having a same area respectively. said induction blocks are connected by first connection sections and second connection sections respectively. The first induction lines and the second induction lines are arranged alternately. said connection sections have a same area, and are in an overlapped area. Thereby, a blank area of the induction layers are reduced, and an induction area inside the touch panel is increased, so as to lower an optical contrast. Moreover, the connection sections have a capacity effect generating a same capacitance value, which prevents error determination or inaccuracy in touch control.

A binocular display deals with an optical contrast imbalance problem between display screens manifest over a range of interpupillary distances by orienting contrast asymmetries between the display screens in opposite directions.

Embodiments of the invention pertain to methods for imaging a light absorption coefficient distribution. Embodiments of the subject method can be implemented without knowing the strength of incident light in advance and without requiring careful calibrations in the non-scattering medium. Embodiments of the method can combine conventional photoacoustic tomography (PAT) with diffusing light measurements coupled with an optimization procedure based on the photon diffusion equation. Images of absorbing targets as small as 0.5 mm in diameter embedded in a 50 mm diameter background medium can be quantitatively recovered. Small targets with various optical contrast levels relative to the background can be detected well. Embodiments of the subject reconstruction method can include first obtaining the map of absorbed optical energy density. Embodiments can obtain the map of absorbed optical energy density through a model-based reconstruction algorithm that is based on a finite element solution to the photoacoustic wave equation in frequency domain subject to the radiation or absorbing boundary conditions (BCs). The distribution of optical fluence can then be obtained. Embodiments can obtain the distribution of optical fluence using the photon diffusion equation based optimization procedure. The distribution of optical absorption coefficient can then be recovered from the distribution of optical fluence and the absorbed energy density.

A method of enhancing the contrast of an image of a sample, comprises forming an image of a mixture, by exposing the mixture to electromagnetic radiation. The mixture comprises the sample and microparticles. The enhancement is particularly suitable for optical coherence tomography.

An imaging method for microcalcification displays microcalcification distribution by acquiring and overlapping a photoacoustic image of microcalcification and an ultrasonic image of tissue. The image acquired by the present invention, in comparison to images acquired by ultrasonic and X-ray mammography, has advantages in no speckle noises, higher optical contrast, higher ultrasonic resolution, and so on. The present invention also has advantage in safety by adopting a light source having no ionizing radiation. An imaging method for diagnosing breast cancer is also herein disclosed.

The invention discloses a reversibly piezochromic security element for the forgery-protection of value documents, the security element being characterized in that it comprises a collection of optically contrasting pigment particles in a film or a coating layer of an elastic polymer. In a particular embodiment, the particles are optically variable pigment flakes, oriented in a position which is substantially different from an alignment in the plane of the film or coating layer.

The present invention relates to near-field scanning optical microscopy (NSOM) and near-field / far-field scanning microscopy methods, systems and devices that permit the imaging of biological samples, including biological samples or structures that are smaller than the wavelength of light. In one embodiment, the present invention permits the production of multi-spectral, polarimetric, near-field microscopy systems that can achieve a spatial resolution of less than 100 nanometers. In another embodiment, the present invention permits the production of a multifunctional, multi-spectral, polarimetric, near-field / far-field microscopy that can achieve enhanced sub-surface and in-depth imaging of biological samples. In still another embodiment, the present invention relates to the use of polar molecules as new optical contrast agents for imaging applications (e.g., cancer detection).

A patterned-media magnetic recording disk drive uses an optical system for clocking the write data and a patterned-media disk that has discrete magnetizable data islands with nonmagnetic spaces between the islands, wherein the nonmagnetic spaces contain optical contrast material. The optical contrast material may be optically absorptive material, fluorescent material, or a metal layer that generates surface plasmons when excited by radiation of a specific wavelength. Radiation from a primary radiation source is directed to a near-field transducer maintained near the disk surface and a radiation detector detects radiation reflected back from the transducer. If the disk has fluorescent material or a metal layer in the nonmagnetic spaces, then a secondary radiation source irradiates the fluorescent material or metal layer with radiation of a specific wavelength to cause the fluorescent material to emit radiation or the metal layer to generate surface plasmons. As the disk rotates, reflected optical power from the transducer varies depending on whether an island or space is under the transducer. The output signal from the radiation detector output controls the write clock.

A method of performing a three-dimensional (3D) scan of an object includes applying an optical contrast powder to the object and illuminating the object with light. First and second two-dimensional (2D) color image data corresponding to the object is generated. First and second 2D monochrome image data corresponding to the object is generated using the first and second 2D color image data. 3D data corresponding to the object is generated using the first and second monochrome 2D image data. Color 3D image data corresponding to the object is generated by adding color information to the 3D data. The color 3D image data is displayed.

Techniques for automatically adjusting and / or optimizing the color and / or intensity of the illuminating light used in a vision system is presented. The intensity of each of a plurality of illuminating light colors is allowed to be independently adjusted to adapt the illumination light based on the color of a part feature against the part feature background of a part being viewed by the vision system to produce high contrast between the part feature and background. Automated contrast optimization may be achieved by stepping through all available color combinations and evaluating the contrast between the part feature and background to select a color combination having a “best” or acceptable contrast level. Alternatively, contrast optimization may be achieved by performing a “smart” search in which a high contrast coarse illumination light is first selected, and then all available color combinations within range of the selected coarse illumination color are stepped through to select a fine illumination color resulting in optimal contrast.

The invention provides a solid electrolyte electrochromism flexible device preparation based on conductive polymer. The preparation method comprises steps of preparation of solid electrolyte, preparation of positive electrode material, preparation of negative electrode material and assembling of single-layered solid device. The solid electrolyte is self-designed by a laboratory, prepared in a simple way and has great environmental stability; the conductive polymer electrochromism material is advantaged by various structural types, wide color-changing ranges, high optical contrast ratio, great processing performance and fast response speed compared with inorganic and organic small molecules; the conductive polymer-based solid device thin film has electrochromic performance, thereby having wide application prospect in fields of displays, intelligent windows and electronic paper; the electrochromism material is advantaged by low driving voltage and color memory effect; and obvious electricity-saving effect can be achieved and passive luminescence is great for human eye protection.

Cyanine and indocyanine dye compounds and bioconjugates are disclosed. The present invention includes several cyanine and indocyanine dyes, including bioconjugates of the same, with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds of the invention may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of compounds of the invention allows favorable delivery to tumor cells as compared to larger molecular weight imaging agents. Further, use of a biocompatible organic solvent such as dimethylsulfoxide may be said to assist in maintaining the fluorescence of compounds of the invention. The compounds and bioconjugates herein disclosed are useful in a variety of medical applications including, but not limited to, diagnostic imaging and therapy, endoscopic applications for the detection of tumors and other abnormalities, localized therapy, photoacoustic tumor imaging, detection and therapy, and sonofluorescence tumor imaging, detection and therapy.