61 results about "Pain reduction" patented technology

The present invention relates to a drug injection multi-needle of which the surface to come into contact with the skin provides either a cooling or warming sensation so that pain can be reduced and, simultaneously, a hemostatic effect can be increased and, specifically, comprises: an injection part to which a drug syringe for storing a drug is coupled and into which the drug is injected by means of pressure; a needle coupling part which is coupled to the front surface of the injection part and to which a plurality of needles to penetrate the skin are coupled; a suction part into which the needle coupling part is inserted and which suctions air at a position coming into contact with the skin; and a temperature-regulating part which is formed on the front surface of the suction part and which regulates the temperature.

Bone and joint surface reconstruction methods are disclosed for the therapeutic amelioration of joint defects caused by various conditions, injuries, and diseases to help eliminate or reduce pain and return the joint to its proper bio-mechanical function without the need to replace fully or partially the anatomical joint. The joint may specifically include mammalian joints such as the femorotibial joint, for example. The methods disclosed herein leverage the significant role the subchondral bone plays in the health status of the afflicted joint.

A device that decompresses the lower spine while the wearer is seated or standing. The device includes two belt-shaped straps. The first strap circles the upper torso just below the breast line. The second strap circles the waist at or slightly above the normal belt line riding on the hip. In the present invention, the lower strap can be a normal belt. The straps can be equipped with pockets that are aligned along the upper edge of the upper strap and the lower edge of the lower strap designed to receive and hold flat splints. Typically, two rigid flat splints extend vertically between the straps centered laterally on the left and right sides of the torso. When the device is worn, it decompresses the lower spine when the person stands or sits. In the new embodiments the flat splints are adjustable length and the pockets are horizontally moveable along the lower and upper straps and the “U”shaped end that attaches to the wearers belt is optional.

The present invention relates to a handpiece for injecting a drug, which can reduce pain and improve hemostatic effect while cooling or heating the surface of the skin by passing cold air and hot air through the inside of a compound needle that is in contact with the skin, and specifically, comprises: a compound needle that is coupled to a drug syringe that stores a drug and that is inserted into the skin, medicine is permeated for operation; the body is used for fixing the compound needle and the medicine injector and adjusting the injection amount of the medicine and the temperature of the compound needle; the medicine injection device is formed in the body, and the injection amount of medicine is adjusted by adjusting the pressure of a medicine injector; and the temperature adjusting device is formed at the lower part of the medicine injection device, is connected with the compound needle and is used for adjusting the temperature.

The application discloses a chronic ulcer wound repairing gel and a preparation method and application thereof, and belongs to the technical field of medical materials. Since bacterial cellulose has the advantages of good biocompatibility, high water retention and moisturizing capacity, strong mechanical property, good air permeability, low toxicity and the like, the bacterial cellulose is used to prepare the bacterial cellulose-based chronic ulcer wound repairing gel capable of promoting chronic wound healing by compounding functional components. The gel can bidirectionally regulate the wet balance of a wound surface; contains a large amount of hydroxyl groups, can highly retain water, has an ice-cool feeling, effectively relieves pain, simultaneously reduces irritation to a wound and a mucous membrane, reduces the sensitivity of exposed nerves, and reduces pain; the photosensitizer in the gel can inhibit bacterial infection by irradiation of near-infrared laser; active components can inhibit inflammatory diffusion, promote collagen deposition and angiogenesis, and the like, so as to promote the healing of a chronic ulcer wound surface.

The utility model belongs to nursing paste technical field, and disclose a kind of local cold compress and hemostasis integration nursing paste after inoculation, including backing layer, the lower surface of backing layer is equipped with cold compress layer, and the lower surface of cold compress layer is equipped with hemostasis layer, the lower surface of backing layer is fixedly equipped with the fit circle, the outer surface of cold compress layer and hemostasis layer is all with fit circle movable fit, the lower surface of fit circle is connected with isolation layer with adhesion, the upper surface of cold compress layer is fixedly equipped with positioning column symmetrically, the upper surface of backing layer is equipped with column groove symmetrically, the upper end of positioning column is penetrated through corresponding column groove and is fixedly connected with limit ball. Through the above scheme, cold compress and hemostasis function are integrated in nursing paste, simplify inoculation nursing process, save time manpower, reduce pain swelling, accelerate wound healing, reduce infection risk;Meanwhile, through positioning column, limit ball and fit circle design, guarantee cold compress layer stability, improve nursing paste fit degree and use experience.

Methods and apparatus disclosed treat pain and mobility impairments by applying controlled subatmospheric pressure to skin over muscle tissue or joints during volitional muscle contractions against adaptive therapist resistance. Domes with basal openings sealing against skin perimeters, are evacuated to 13-90% of atmospheric pressure. Some embodiments have 3-10 second contraction intervals repeated at least three times per subatmospheric treatment cycle, before pressure is ramped to ambient pressure over at least 2 seconds. Results are improved range of motion, muscle strength, and pain reduction. Apparatus embodiments include vacuum manifolds, sensors for pressure and tissue distension, and optional integrated electrodes for performing TENS / STIM.

The present disclosure relates to an aromatic ring compound, a preparation method therefor, and a use thereof in medicine. Specifically, the present disclosure relates to an aromatic ring compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and a use thereof as a therapeutic agent, particularly a use as a Nav inhibitor, and a use thereof in the preparation of a medicament for treating and / or alleviating pain and pain-related disorders. The groups in general formula (I) are as defined in the description.

Bone and joint surface reconstruction methods are disclosed for the therapeutic amelioration of joint defects caused 2024 / 064830 by various conditions, injuries, and diseases to help eliminate or reduce pain and return the joint to its proper bio-mechanical function without the need to replace fully or partially the anatomical joint. The joint may specifically include mammalian joints such as the metatarsal phalangeal joint or other joint of the foot or ankle, for example. The methods disclosed herein leverage the significant role the subchondral bone plays in the health status of the afflicted joint.WO

This invention belongs to the field of biopharmaceuticals, specifically relating to an endoplasmic reticulum-targeting antioxidant nanozyme, its preparation method, and its applications. The novel antioxidant nanozyme (Arg-Mnzyme) provided by this invention can effectively inhibit NOX1 expression, eliminate the accumulation of reactive oxygen species, and inhibit NOX1 activation and oxidative stress after temporomandibular joint arthritis-related pain, thus alleviating pain hypersensitivity. Compared to natural enzymes, nanozymes have stronger modifiability; this invention will construct an endoplasmic reticulum-precise antioxidant nanozyme to achieve precise regulation of oxidative stress.

Cannabinoids are a promising and potent class of agents in the management of pain, and preclinical studies in rodent models suggest that cannabinoids may be particularly potent in relieving neuropathic pain. Despite the potential benefits and value of cannabinoids, clinical acceptance has been limited due to CNS side effects at systemic analgesic doses and the fear of misuse potential. What is needed are novel cannabinoid-acting compositions and methods for treating pain. The present disclosure relates to compositions targeting cannabinoid receptors and uses thereof for treating, preventing, and / or mitigating pain.

The utility model provides a portable external fixing device suitable for a hand fracture patient, and relates to the technical field of fracture rehabilitation. An arc-shaped groove is formed in the middle of the bearing block, and two through round holes are formed in the middle of the arc-shaped groove. The wrist of a patient can be fixed and limited through the limiting plate, four fingers can be fixed through the four finger grooves respectively, the thumb can be fixed and limited by the thumb groove and the thumb positioning plate, and therefore the fingers and the wrist can be fixed and limited respectively, the rehabilitation time of the wrist and the fingers is saved, the fracture end can be ensured not to move through wrist and finger fixing, and the rehabilitation effect is good. The device is simple in structure and convenient to use, bone healing is facilitated, movement of fracture parts can be reduced through good fixation, so that pain is relieved, and the problems that the wrist and the fingers of a patient are fractured and need to be fixed and limited respectively, otherwise, the wrist and the fingers are fixed together infirmly due to the too long distance, and the rehabilitation time of the wrist and the fingers is affected are solved.

Apparatus and associated methods relate to a thermal compressive surgical treatment mask. In an illustrative example, a multi-layered mask assembly is configured to simultaneously apply heat or cold and graduated compression to a predetermined medical target area (e.g., skull cap, face, ears, jaw, chin, or neck). The multi-layered mask assembly includes a multi-layered mask including a silicone-based gel layer and an aperture configured to fit the eyes and nose. A detachable neck strap is operably coupled to the multi-layered mask to extend therapeutic coverage along the cervical region. The multi-layered mask assembly is configured to provide effective thermal therapy and compressive therapy to reduce pain and swelling and enhance lymphatic and venous drainage for a patient post-surgery. Various embodiments may advantageously conform to different anatomical regions, accommodate diverse surgical procedures, and improve patient comfort and recovery by integrating both thermal and compressive functionalities in a single wearable system.

A body and face oil composition is disclosed. The composition includes a sufficient amount of Dimethyl sulfoxide (DMSO), a sufficient amount of Cannabidiol (CBD), a sufficient amount of gold, a sufficient amount of one or more vitamins, and a sufficient amount of one or more minerals. The composition, when administered to a human at an effective dose, is beneficial for reducing pain, for regenerating nerves, skin, bone, and tissue, and for anti-aging.

The invention discloses a method for evaluating the analgesic effect of angelica sinensis stomachache dropping pills, belongs to the technical field of efficacy evaluation, and aims to solve the problem that no scientific method is provided for efficacy verification of dysmenorrhea traditional Chinese medicine preparations in the formula of angelica sinensis. The method comprises the steps of experimental mouse selection, acetic acid body twisting model test, hot plate pain model test and xylene inflammation model test. Selecting an experimental rat, and testing the primary dysmenorrhea model constructed by estradiol and oxytocin. The method comprises the following steps: constructing an analgesic effect evaluation model, and verifying analgesic and anti-inflammatory effects of angelica sinensis stomachache relieving; pharmacodynamic mechanism analysis is further carried out on the angelica sinensis stomachache dropping pill for simulating primary dysmenorrhea, it is revealed that the content of serum E2, IL-6, PROG, beta-EP and TNF-alpha of primary dysmenorrhea model rats treated by the angelica sinensis stomachache dropping pill has an adjusting effect, the effect of relieving dysmenorrhea can be achieved, the inflammation effect can be relieved by inhibiting NF-kappa B and MAPK channels, and the pain behavior can be relieved.

The invention discloses an application of a non-o gene in regulation and control of expression of Kcnq2. A chronic constriction injury rat model is combined with a multi-omics comprehensive analysis method, dynamic molecule and cell changes related to neuropathic pain are systematically analyzed, and it is found that overexpression of Non can recover expression of Kcnq2, pain sensitivity is relieved, and the neuropathic pain is relieved. The key effect of the Nono-Kcnq2 regulation axis in regulating neuronal excitability and neuropathic pain is emphasized, the application of the Nono-Kcnq2 regulation axis in preparing the medicine for treating the neuropathic pain is provided, and a new strategy is provided for studying treatment of the neuropathic pain.

Wearable equipment and a wire system for relieving pain are provided. The utility model discloses a wearable device for relieving pain. The wearable device has been designed and configured to provide low-level random pattern electrical stimulation to the skin to mask associated pain. The device is intended to provide a better normal state with less pain. The wearable device may be an oversleeve having a plurality of electrodes with a conductive medium that may provide random stimulation to the skin. The wearable device may include a wearable fabric lined with a conductive medium, a power medium (e.g., a battery pack), a processor for processing input / output (I / O) from / to a mobile application or controller, a transmitter, a receiver, and a motion sensor. With a wearable device disclosed herein, it is targeted to act on a number of parts (from limbs to torso) of a user's body. The simplicity of the embodiment hardly brings inconvenience or cost to users.

This document presents a novel composition and method for treating osteoarthritis using a cannabinoid-based nanoplatform administered via intra-articular injection. The composition includes phytocannabinoids such as CBG and CBC, along with hyaluronic acid, type II collagen, and calcium gluconate, embedded within a nanoplatform designed to enhance bioavailability and ensure controlled release in the synovial space. Tailored for osteoarthritis patients, the treatment alleviates joint pain, stiffness, reduced mobility, inflammation, sensations of friction, muscle weakness, and joint deformity. Cannabinoids act through multiple mechanisms, including interaction with CB1 and CB2 receptors, cytokine modulation, inhibition of NF-κB, and activation of the TRPV1 receptor, providing a potent anti-inflammatory effect. The formulation aims to halt cartilage degeneration, reduce pain, and slow osteoarthritis progression. The production process uses nanoemulsification techniques to create particles smaller than 200 nm, with pre-sterilization through membrane filtration, ensuring both efficacy and safety.

This invention relates to the field of biomedical technology, providing a method for preparing a drug-eluting microsphere suspension, the drug-eluting microsphere suspension, and its applications. The method includes: S1. Removing the storage solution from the drug-eluting microspheres to obtain a microsphere precipitate; S2. Adding a chemotherapy drug solution to the microsphere precipitate to load the drug into the microspheres; S3. Mixing physiological saline and a non-ionic contrast agent at a volume ratio of 1.5:1 to prepare a dilution medium; S4. Adding the dilution medium prepared in step S3 to the microspheres after drug loading in step S2, so that the total suspension volume reaches a preset multiple of the microsphere precipitate volume, obtaining a microsphere suspension; S5. Shaking the microsphere suspension obtained in step S4 to mix thoroughly. This invention significantly reduces postoperative chemical stimulation pain by increasing the dilution factor of the drug-eluting microsphere suspension, while unexpectedly improving tumor response, achieving a synergistic effect of pain reduction and efficacy enhancement.

The present invention relates to a handpiece for injecting a drug capable of reducing pain and enhancing a hemostatic effect by allowing cold and heat to penetrate the inside of a multi-needle that comes into contact with the skin, thereby cooling or warming the skin surface. Specifically, the handpiece for drug injection comprises: a multi-needle, coupled to a drug syringe containing a drug, which delivers the drug as the needles are inserted into the skin; a main body that fixes the multi-needle and the drug syringe and regulates both the injection amount of the drug and the temperature of the multi-needle; a drug injection device formed inside the main body for adjusting the injection amount of the drug by controlling the pressure of the drug syringe; and a temperature control device formed at a lower portion of the drug injection device and connected to the multi-needle for controlling the temperature.

This present invention and its embodiments relates to methods for reducing pain during photodynamic therapy of actinic keratosis. The present invention also relates to methods of treating actinic keratosis with reduced pain during photodynamic therapy of actinic keratosis.

The present application relates to the technical field of knee joint rehabilitation equipment, and is a rehabilitation treatment device for knee joint osteoarthritis, comprising a treatment bed, two foot fixing assemblies and two first driving assemblies. The top surface of the first end of the treatment bed is provided with a backrest, and the top surface of the second end of the treatment bed is provided with two guide grooves, and the two foot fixing assemblies are arranged in the two guide grooves respectively. The inside of the treatment bed is provided with an assembly cavity, and the two first driving assemblies are arranged in the assembly cavity, and the output ends of the two first driving assemblies are connected with the two foot fixing assemblies respectively. When the present application is used, not only the posture of the patient can be standardized, but also uniform and appropriate force joint traction can be implemented, safe joint surface separation and effective treatment can be realized, and the rehabilitation speed of the knee joint of the patient can be accelerated. The present application aims to help patients with knee osteoarthritis to increase the range of motion of the knee joint, release the joint negative pressure, relieve pain and improve the quality of life.

The present invention relates to new plasma or new platelet-rich plasma preparations, new cell dissociation methods, new cell associations or compositions, a method of preparation thereof, a use thereof, devices for the preparation thereof and preparations containing such a platelet-rich plasma preparation and cell associations or compositions. Specifically, the invention provides plasma or platelet-rich plasma alone or in cell composition preparations for use in tissue regeneration and bone regeneration and pain reduction.

Bone and joint surface reconstruction methods are disclosed for the therapeutic amelioration of joint defects caused by various conditions, injuries, and diseases to help eliminate or reduce pain and return the joint to its proper bio-mechanical function without the need to replace fully or partially the anatomical joint. The joint may specifically include mammalian joints such as the humeroradial joint or other joint of the elbow, wrist, or hand, for example. The methods disclosed herein leverage the significant role the subchondral bone plays in the health status of the afflicted joint.

The invention provides a dysmenorrhea relieving device which comprises a flat attaching pad internally provided with a heating wire and a channel for containing the heating wire. The first connecting waistband and the second connecting waistband are connected to the two ends of the attaching pad respectively; the massage assembly is installed on the side, close to the lower abdomen, of the attaching pad, the servo motor is installed in the shell, an output shaft of the servo motor is connected with the supporting rod, the first massage roller and the second massage roller are installed at the two ends of the supporting rod respectively, the shell is wrapped with the protective soft pad, and the servo motor drives the supporting rod to deflect so as to drive the first massage roller and the second massage roller to move. Relates to the technical field of medical instruments, in particular to a hot compress massage device, hot compress and massage functions are deeply combined to play a synergistic role, and uniformly distributed heating wires realize comprehensive and uniform hot compress, so that abdominal blood circulation can be effectively promoted, uterine smooth muscles are relieved, and pain is relieved.

The present disclosure relates to aromatic ring compounds, a preparation method therefor, and pharmaceutical use thereof. Specifically, the present disclosure relates to an aromatic ring compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and use thereof as a therapeutic agent, especially use thereof as a Nav inhibitor and use thereof in the preparation of a drug for treating and / or alleviating pain and pain-related diseases. Each group in general formula (I) is as defined in the specification.