38 results about "Pain reduction" patented technology

Bone and joint surface reconstruction methods are disclosed for the therapeutic amelioration of joint defects caused by various conditions, injuries, and diseases to help eliminate or reduce pain and return the joint to its proper bio-mechanical function without the need to replace fully or partially the anatomical joint. The joint may specifically include mammalian joints such as the femorotibial joint, for example. The methods disclosed herein leverage the significant role the subchondral bone plays in the health status of the afflicted joint.

Methods and apparatus disclosed treat pain and mobility impairments by applying controlled subatmospheric pressure to skin over muscle tissue or joints during volitional muscle contractions against adaptive therapist resistance. Domes with basal openings sealing against skin perimeters, are evacuated to 13-90% of atmospheric pressure. Some embodiments have 3-10 second contraction intervals repeated at least three times per subatmospheric treatment cycle, before pressure is ramped to ambient pressure over at least 2 seconds. Results are improved range of motion, muscle strength, and pain reduction. Apparatus embodiments include vacuum manifolds, sensors for pressure and tissue distension, and optional integrated electrodes for performing TENS / STIM.

Bone and joint surface reconstruction methods are disclosed for the therapeutic amelioration of joint defects caused 2024 / 064830 by various conditions, injuries, and diseases to help eliminate or reduce pain and return the joint to its proper bio-mechanical function without the need to replace fully or partially the anatomical joint. The joint may specifically include mammalian joints such as the metatarsal phalangeal joint or other joint of the foot or ankle, for example. The methods disclosed herein leverage the significant role the subchondral bone plays in the health status of the afflicted joint.WO

This invention belongs to the field of biopharmaceuticals, specifically relating to an endoplasmic reticulum-targeting antioxidant nanozyme, its preparation method, and its applications. The novel antioxidant nanozyme (Arg-Mnzyme) provided by this invention can effectively inhibit NOX1 expression, eliminate the accumulation of reactive oxygen species, and inhibit NOX1 activation and oxidative stress after temporomandibular joint arthritis-related pain, thus alleviating pain hypersensitivity. Compared to natural enzymes, nanozymes have stronger modifiability; this invention will construct an endoplasmic reticulum-precise antioxidant nanozyme to achieve precise regulation of oxidative stress.

The utility model provides a portable external fixing device suitable for a hand fracture patient, and relates to the technical field of fracture rehabilitation. An arc-shaped groove is formed in the middle of the bearing block, and two through round holes are formed in the middle of the arc-shaped groove. The wrist of a patient can be fixed and limited through the limiting plate, four fingers can be fixed through the four finger grooves respectively, the thumb can be fixed and limited by the thumb groove and the thumb positioning plate, and therefore the fingers and the wrist can be fixed and limited respectively, the rehabilitation time of the wrist and the fingers is saved, the fracture end can be ensured not to move through wrist and finger fixing, and the rehabilitation effect is good. The device is simple in structure and convenient to use, bone healing is facilitated, movement of fracture parts can be reduced through good fixation, so that pain is relieved, and the problems that the wrist and the fingers of a patient are fractured and need to be fixed and limited respectively, otherwise, the wrist and the fingers are fixed together infirmly due to the too long distance, and the rehabilitation time of the wrist and the fingers is affected are solved.

A body and face oil composition is disclosed. The composition includes a sufficient amount of Dimethyl sulfoxide (DMSO), a sufficient amount of Cannabidiol (CBD), a sufficient amount of gold, a sufficient amount of one or more vitamins, and a sufficient amount of one or more minerals. The composition, when administered to a human at an effective dose, is beneficial for reducing pain, for regenerating nerves, skin, bone, and tissue, and for anti-aging.

The invention discloses a method for evaluating the analgesic effect of angelica sinensis stomachache dropping pills, belongs to the technical field of efficacy evaluation, and aims to solve the problem that no scientific method is provided for efficacy verification of dysmenorrhea traditional Chinese medicine preparations in the formula of angelica sinensis. The method comprises the steps of experimental mouse selection, acetic acid body twisting model test, hot plate pain model test and xylene inflammation model test. Selecting an experimental rat, and testing the primary dysmenorrhea model constructed by estradiol and oxytocin. The method comprises the following steps: constructing an analgesic effect evaluation model, and verifying analgesic and anti-inflammatory effects of angelica sinensis stomachache relieving; pharmacodynamic mechanism analysis is further carried out on the angelica sinensis stomachache dropping pill for simulating primary dysmenorrhea, it is revealed that the content of serum E2, IL-6, PROG, beta-EP and TNF-alpha of primary dysmenorrhea model rats treated by the angelica sinensis stomachache dropping pill has an adjusting effect, the effect of relieving dysmenorrhea can be achieved, the inflammation effect can be relieved by inhibiting NF-kappa B and MAPK channels, and the pain behavior can be relieved.

The invention discloses an application of a non-o gene in regulation and control of expression of Kcnq2. A chronic constriction injury rat model is combined with a multi-omics comprehensive analysis method, dynamic molecule and cell changes related to neuropathic pain are systematically analyzed, and it is found that overexpression of Non can recover expression of Kcnq2, pain sensitivity is relieved, and the neuropathic pain is relieved. The key effect of the Nono-Kcnq2 regulation axis in regulating neuronal excitability and neuropathic pain is emphasized, the application of the Nono-Kcnq2 regulation axis in preparing the medicine for treating the neuropathic pain is provided, and a new strategy is provided for studying treatment of the neuropathic pain.

This document presents a novel composition and method for treating osteoarthritis using a cannabinoid-based nanoplatform administered via intra-articular injection. The composition includes phytocannabinoids such as CBG and CBC, along with hyaluronic acid, type II collagen, and calcium gluconate, embedded within a nanoplatform designed to enhance bioavailability and ensure controlled release in the synovial space. Tailored for osteoarthritis patients, the treatment alleviates joint pain, stiffness, reduced mobility, inflammation, sensations of friction, muscle weakness, and joint deformity. Cannabinoids act through multiple mechanisms, including interaction with CB1 and CB2 receptors, cytokine modulation, inhibition of NF-κB, and activation of the TRPV1 receptor, providing a potent anti-inflammatory effect. The formulation aims to halt cartilage degeneration, reduce pain, and slow osteoarthritis progression. The production process uses nanoemulsification techniques to create particles smaller than 200 nm, with pre-sterilization through membrane filtration, ensuring both efficacy and safety.

This invention relates to the field of biomedical technology, providing a method for preparing a drug-eluting microsphere suspension, the drug-eluting microsphere suspension, and its applications. The method includes: S1. Removing the storage solution from the drug-eluting microspheres to obtain a microsphere precipitate; S2. Adding a chemotherapy drug solution to the microsphere precipitate to load the drug into the microspheres; S3. Mixing physiological saline and a non-ionic contrast agent at a volume ratio of 1.5:1 to prepare a dilution medium; S4. Adding the dilution medium prepared in step S3 to the microspheres after drug loading in step S2, so that the total suspension volume reaches a preset multiple of the microsphere precipitate volume, obtaining a microsphere suspension; S5. Shaking the microsphere suspension obtained in step S4 to mix thoroughly. This invention significantly reduces postoperative chemical stimulation pain by increasing the dilution factor of the drug-eluting microsphere suspension, while unexpectedly improving tumor response, achieving a synergistic effect of pain reduction and efficacy enhancement.

This present invention and its embodiments relates to methods for reducing pain during photodynamic therapy of actinic keratosis. The present invention also relates to methods of treating actinic keratosis with reduced pain during photodynamic therapy of actinic keratosis.

The present invention relates to new plasma or new platelet-rich plasma preparations, new cell dissociation methods, new cell associations or compositions, a method of preparation thereof, a use thereof, devices for the preparation thereof and preparations containing such a platelet-rich plasma preparation and cell associations or compositions. Specifically, the invention provides plasma or platelet-rich plasma alone or in cell composition preparations for use in tissue regeneration and bone regeneration and pain reduction.

Bone and joint surface reconstruction methods are disclosed for the therapeutic amelioration of joint defects caused by various conditions, injuries, and diseases to help eliminate or reduce pain and return the joint to its proper bio-mechanical function without the need to replace fully or partially the anatomical joint. The joint may specifically include mammalian joints such as the humeroradial joint or other joint of the elbow, wrist, or hand, for example. The methods disclosed herein leverage the significant role the subchondral bone plays in the health status of the afflicted joint.

The application provides an ultrasonic-assisted pain-reducing acupuncture micro-injection method and device, which comprises the following steps: S1, acquiring real-time ultrasonic images of an acupuncture part by using an ultrasonic imaging device to determine the position of a target acupoint and surrounding tissue structure information; S2, planning an injection path according to the acquired position of the target acupoint and surrounding tissue structure information, wherein the injection path avoids important blood vessels and nerves; and S3, slowly injecting an acupuncture needle into the skin along the planned injection path under the guidance of the ultrasonic images; the application acquires real-time ultrasonic images by using an ultrasonic imaging device, accurately determines the position of a target acupoint and surrounding tissue structure information, and plans an injection path that avoids important blood vessels and nerves, thereby greatly improving the injection accuracy; meanwhile, an ultrasonic-assisted pain-reducing module is started when the needle tip approaches the target acupoint, the ultrasonic vibration is used to reduce the pain of a patient, and the vibration amplitude and frequency are adjusted in real time according to the feedback of the patient, thereby realizing individualized pain reduction.

A lower adjusting air cushion is fixedly installed at the top of a base, positioning grooves are formed in the surface of the lower adjusting air cushion at equal intervals, a neck pillow roller is installed at the top of one end of the lower adjusting air cushion, and back pillow rollers are installed in the middle of the lower adjusting air cushion at equal intervals. According to the spine kyphosis rehabilitation pillow, the expansion degree of the lower adjusting air cushion can be conveniently adjusted, then the degree of a concave arc formed by the back pillow roller and the neck pillow roller is adjusted, the spine kyphosis rehabilitation pillow is matched with different degrees of spine kyphosis of a patient, personalized support is provided, pain is relieved, and the sleep quality is improved; meanwhile, the inflation volume and the thickness of the upper adjusting air cushion are adjusted, the distance between the neck pillow roller and the back pillow roller and the back of the patient is changed, support with appropriate hardness is provided for the patient during nursing, the comfort of the patient is improved, the control mode is accurate, and operation is easier.

This utility model belongs to the field of camel disease prevention and control testing technology, and particularly relates to a camel esophageal pharyngeal epithelial cell and mucus collection device. Addressing the problems of existing collection components being made of hard materials and having a fixed structure, making them unsuitable for the camel esophagus, prone to getting stuck, difficult to penetrate deeply, and easily causing mucosal abrasion and inflammation, thus affecting camel health, sample quality, and diagnosis, the following solution is proposed: a camel esophageal pharyngeal epithelial cell and mucus collection device, including a sampling sleeve with a sampling head at one end; the beneficial effects of this utility model are: the sampling sleeve uses a memory metal inner core to conform to the curvature of the esophagus; the outer protective sleeve and arc-shaped protective cover are made of medical-grade silicone to reduce friction and irritation; the arc-shaped protective cover sponge contains veterinary anesthetic for slow-release and pain reduction during insertion; the low-trauma rotating soft brush reduces mucosal damage; the sampling head soft brush and absorbent cotton simultaneously collect cells and mucus; the connecting rod structure allows the sampling head to rotate, improving the comprehensiveness of collection; and the sampling head is easy to disassemble and clean to prevent contamination.

A device for obtaining a blood sample, the device including a holder for receiving a sample source, the holder having an actuation portion and a port, a container engagement portion connected to the holder; and a pain reduction member provided on an inner surface of the holder.

The present invention is directed at a series of leg garments that provide support for reducing loads at the knee, hip, ankle, and spine, as well as options for leg shape contouring, muscle training, pain reduction, and injury treatment. The leg garments may comprise a base layer with reinforced portions disposed throughout. The leg garments may comprise adjustable support elements. The size, shape, position, quantity, and material composition of the reinforced portions and the adjustable support elements may be selected to achieve the desired tensive properties for the leg garment. Various tensioning mechanisms may be positioned at strategic areas to further control the leg garments' tensive properties, improving effectiveness and comfort. In some embodiments, cables may run through channels in the reinforced portions or support elements.

The invention relates to an aromatic ring compound, a preparation method thereof and application of the aromatic ring compound in medicine. Specifically, the invention relates to an aromatic ring compound shown in a general formula (I), a preparation method of the aromatic ring compound, a pharmaceutical composition containing the aromatic ring compound and application of the aromatic ring compound serving as a therapeutic agent, in particular to application of the aromatic ring compound serving as a Nav inhibitor and application of the aromatic ring compound to preparation of drugs for treating and / or relieving pain and pain-related diseases. Wherein each group in the general formula (I) is defined in the specification.

The present application relates to the field of medical devices, and discloses a medical device using microneedles as skin-breaking, stimulating and carrier functions, and a shock-absorbing and buffering technology for reducing the pain of patients during implementation. The present application uses a material with good elasticity and low elastic modulus as a shock-absorbing and buffering layer. The elastic material is adhered to the back of the microneedle. When the microneedle is pressurized, the mechanical transmission of the elastic material can buffer the pressure, so that the skin-breaking and stimulating functions are not reduced, and the drug carrying function is not affected. And / or, a flexible transition section is added between one end of the microneedle and the operating handle to achieve the purpose of shock absorption and pain reduction. The present application is not limited by the form of the microneedle device, and different elastic modulus shock-absorbing and buffering materials and / or flexible transition sections can be matched according to the use function of the microneedle product. During pressurization, the present application ensures the safety of the shock-absorbing and buffering layer material, the shock-absorbing and buffering layer and the microneedle layer have sufficient adhesive strength and do not fall off, and / or the addition of the flexible transition section does not affect the safety and flexibility of the original medical device, so as to achieve the purpose of reducing the pain of patients.

The invention relates to the technical field of traditional Chinese medicine plasters, in particular to a pain-relieving acupoint plaster and a preparation method thereof. The medicine component is prepared from the following raw materials: frankincense, myrrh, scorpion, centipede, corydalis tuber, clove, elecampane and cassia twig; according to the pain-relieving acupoint plaster disclosed by the invention, the traditional Chinese medicine components are scientifically screened and the ratio is optimized, and the components play specific functions in the pain-relieving process and form a synergistic effect. Boswellia carteri and myrrh are used as classic analgesic compatibility and have the effects of promoting blood circulation to remove blood stasis and promoting qi circulation to relieve pain, and effective components of frankincense and myrrh can permeate into local tissues to relieve qi and blood stasis of painful parts, so that pain is relieved from the source; the scorpio and the centipede have the effects of activating meridians to stop pain, and the active ingredients of the scorpio and the centipede can act on a pain sense conduction pathway to block the transmission of pain signals, so that the scorpio and the centipede have a remarkable inhibition effect on intractable pain.

The present disclosure relates a method of treating neuropathic pain in human patients comprising a treatment cycle comprising: - administering a compound according to formula (I), or an isomer thereof, or a tautomer thereof, or an isotope thereof, over a period T1; formula (I) having the structure of: formula (I); - discontinuing the administration of the compound according to formula (I) for a period T2 that immediately follows T1; - obtaining pain reduction over the total sum of the periods T1 and T2 of the treatment cycle. The present disclosure also relates a compound according to formula (I) for use in treatment of neuropathic pain. The present disclosure also relates use of a compound according to formula (I) for preparing a pharmaceutical composition for treating a human patient suffering from neuropathic pain.

The invention discloses medicinal liquor, and aims to solve the problem that the conventional medicine for traumatic injury is not suitable for pregnant women and people with allergic constitution. The traditional Chinese medicine is prepared from the following components in parts by weight: 8 to 15g of radix cynanchi paniculati, 8 to 15g of herba artemisiae anomalae, 5 to 10g of dragon's blood, 7 to 15g of radix zanthoxyli, 10 to 20g of cortex eucommiae, 10 to 20 of herba stasis stasis, 30 to 50g of herba paederiae, 6 to 10g of herba menthae, 8 to 15g of pararuellia delavayana, 3 to 10g of earthworm and 8 to 20g of viola japonica. The traditional Chinese medicinal materials adopted in the raw materials do not cause drug resistance to people, are convenient to decoct, do not have side effects and can effectively relieve pain.

The utility model belongs to the technical field of arch slippers, and particularly relates to a novel deodorant arch slipper which comprises a sole, the surface of the sole is fixedly connected with a slipper body, the surface of the sole is fixedly connected with a supporting pad, the supporting pad is of a hollow structure, and a cavity is formed in the sole and located on the lower side of the supporting pad. An adjusting assembly is arranged in the cavity, an elastic pad is fixedly connected to the position, located at the heel, of the surface of the sole, the space between the inner side of the elastic pad and the sole is an air collection cavity, and a heat dissipation and ventilation assembly is arranged on the surface of the sole. The adjusting assembly comprises a top plate which is movably connected to the surface of the shoe sole and located in the inner cavity of the supporting pad, and the top plate extends into the cavity. By adjusting the supporting height of a foot arch area, appropriate foot arch supporting can be provided for a high-foot-arch patient, sole pressure can be dispersed, and pain and discomfort can be relieved; the heat dissipation and ventilation assembly is used for increasing the gas flowability, the bacterium breeding of the feet can be reduced, and the antibacterial and deodorant purposes are achieved.

The present disclosure provides a method of reducing formation of one or more adhesions in a patient by administering a CRH1 receptor antagonist to the patient. Additional methods of administering a CRH1 receptor antagonist to patients are also provided, including methods of reducing gastrointestinal damage, reducing inflammation, and reducing pain.