1250 results about "Rheumatic Arthritis" patented technology

The invention discloses an externally-used plaster which is prepared from more than 80 kinds of Chinese medicinal materials including frankincense, myrrh, mercurous chloride, dragon's blood resin, camphor, boneol, orpiment, sulfur, gamboge, lead monoxide, native copper, white alum, colophony, dragon's blood resin, musk, orpiment, lead monoxide, alkanna tinctoria, colophony, buck grass, wasp's nest, camphor, mercurous chloride, wood louse, and can be used for treating rheumatic arthritis and proliferative arthritis.

The invention provides methods of inhibiting angiogenesis in an individual by administering a composition (such as protein containing composition) comprising colchicine or thiocolchicine dimer. The composition is in an amount that is effective in inhibiting angiogenesis but is in some embodiments insufficient to induce significant cytotoxicity in the individual. The methods described herein are useful for treating angiogenesis-associated diseases, such as age-related macular degeneration, diabetic retinopathy, rheumatic arthritis, psoriasis, and cancer.

A Chinese medicine in the form of plaster for treating rheumatic arthritis, cervical spondylopathy, lumbar intervertebral disk protrusion, lumbar hyperosteogeny, etc is prepared from the Chinese-medicinal materials. Its advantages are simple preparing process, high curative effect, and short course of treatment.

A Chinese medicine in the form of plaster for treating rheumatic arthritis, hyperosteogeny, cervical spondylopathy, lumbar intervertebral disk protrusion, and muscle and bone injury is prepared from 56 Chinese-medicinal materials including camphor, pinellia tuber, hot pepper, toad venom, etc. Its advantage is high curative effect.

The present invention relates to a Chinese medicine for effectively curing rheumatic arthritis, rheumatoid arthritis, arthralgia due to wind-cold-dampness, lumbago and numbness of the extremities, etc. Said Chinese medicine is made up by using 20 Chinese medicinal materials of pubscent angelica root, notopterygium root, raw aconite main tuber, raw wild aconite tuber, Chinese angelica root, salvia root and others through a certain preparation process.

The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human Rheumatoid Arthritis (RA). A variety of newly-identified markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with RA.

The invention discloses medicinal liquor for treating rheumatic arthritis and chronic infectious arthritis, which comprises the following raw materials in parts by weight: 33-38 parts of Chinese parsnip root, 8-13 parts of asarum, 28-33 parts of the root of bidentate achyranthes, 28-33 parts of ligusticum sinense oliver, 28-33 parts of notopterygium root, 28-33 parts of radix angelicae pubescentis, 23-28 parts of prepared monkshood, 28-33 parts of cassia twig, 28-33 parts of pawpaw, 28-33 parts of radix clematidis, 28-33 parts of cortex acanthopanacis, 28-33 parts of semen coicis, 28-33 parts of corydalis tuber, 28-33 parts of large-leaved gentian, 4-9 parts of long-noded pit viper, 28-33 parts of the root of fangji, 28-33 parts of rhizoma typhonii, 28-33 parts of ligusticum wallichii, 28-33 parts of zaocys dhumnade, and 7000-8000 parts of 50-60-degree white wine. The medicinal liquor disclosed by the invention has the advantages of being low in cost, high in curative rate and free from toxic and side effects; stimulation of the existing medicines on gastric mucosa is overcome; simultaneously, the medicinal liquor disclosed by the invention also has the functions of tonifying liver and kidney.

Disintegrin variants and pharmaceutical uses thereof are disclosed. The disintegrin variant includes an isolated polypeptide that has integrin αvβ3 receptor-antagonist activity and substantially reduced integrin αllbβ3 and/or α5β1 receptor-blocking activity as compared to a wild-type disintegrin. The variant is encoded by a modified disintegrin nucleotide sequence that encodes a modified amino acid sequence, resulting in a polypeptide having substantially reduced affinity to integrin αllbβ3 and/or α5β1 as compared to a wild-type disintegrin. The variant is useful for treatment and/or prevention of αvβ3 integrin-associated diseases in a mammal, which include osteoporosis, bone tumor or cancer growth, angiogenesis-related tumor growth and metastasis, tumor metastasis in bone, malignancy-induced hypercalcemia, angiogenesis-related eye diseases, Paget's disease, rheumatic arthritis, and osteoarthritis. The angiogenesis-related eye diseases include age-related macular degeneration, diabetic retinopathy, corneal neovascularizing diseases, ischaemia-induced neovascularizing retinopathy, high myopia, and retinopathy of prematurity.

An agent for inhibiting articular cartilage extracellular matrix degradation of the present invention, comprising a histone deacetylase-inhibiting compound as an active ingredient, is effective for the prevention and treatment of diseases and pathological conditions involving the degradation and degeneration of the articular cartilage extracellular matrix, in particular, arthrosteitis, rheumatic arthritis, osteoarthritis, and the like.

The invention develops a simplified method for the in-vitro isolation and expansion of umbilical mesenchymal stem cells (MSCs) and confirms that the MSCs obtained by the method have the effects of immunoregulation and inflammation inhibition in the treatment of rheumatoid arthritis.

The present invention discloses one kind of Chinese medicine composition and its preparation process. The Chinese medicine composition contains the effective components of atractylodes rhizome, coix seed, earthworm, tetramdra root, phellodendron bark and other seven kinds of Chinese medicinal materials. It may be prepared into granule, tablet, capsule or other common Chinese preparation form. It has the functions of dispelling wind, eliminating dampness, clearing away heat, relieving swelling, dredging meridian and relieving pain, and may be used in treating rheumatic arthritis, rheumatoid arthritis and gout.

The invention provides a flurbiprofen hydrogel plaster and a composition thereof. In the composition, the content of flurbiprofen is 0.1-3wt%, and a hydrogel substrate accounts for the rest. Based on the total weight of the hydrogel substrate, the hydrogel substrate comprises the following components: 0.1-40wt% of a hydrophilic base material, 0.01-2wt% of a crosslinking agent, 0.01-4wt% of a crosslinking regulator, 10-60wt% of a humectant, 0.05-45wt% of a penetration enhancer and 10-85wt% of a solvent. According to the flurbiprofen hydrogel plaster provided by the invention, a small number of medicines are used, and the permeability and stability are good; and the flurbiprofen hydrogel plaster can be applied to various arthralgia diseases such as rheumatic arthritis, gouty arthritis, ankylosing spondylitis, tenosynovitis, muscle pain and lumbago.

The invention discloses caper extract and a preparation method thereof. The method comprises the following steps: medicinal materials are crushed, decocted in water or subjected to heating reflux extraction by utilization of ethanol with different concentrations, and added with the ethanol for impurity precipitation after concentration of extract; supernatant or more than 80 percent ethanol extract is subjected to concentration at reduced pressure; extract 1 is obtained after recovery of the ethanol, dried and dissolved in water, subjected to deesterification by utilization of petroleum ether, and extracted by ethyl acetate; an extracted position and a water-soluble position of the ethyl acetate are subjected to vacuum concentration and drying respectively and prepared into extract 2 and extract 3 respectively; the extract 1 contains 30 compounds including 5 novel compounds such as caper alkali A, and so on; the extract 2 contains 18 compounds such as a para hydroxybenzoic acid, and so on ; and the extract 3 contains 18 compounds including 5 novel compounds such as the caper alkali A, and so on. As proved by pharmacodynamic experiments, the extract 1, the extract 2 and the extract 3 have analgesic and anti-inflammatory activity, and can be used for preparing medicines for treating rheumatic arthritis, rheumatoid inflammation or scapulohumeral periarthritis.

This invention discloses functional humanized antibody against CD20 molecules and its application. The functional humanized antibody specifies human CD20 molecules, and is composed of a light chain and a heavy chain, each of which comprises a constant region and a variable region. The constant region of the heavy chain is isotypic human IgG1 constant region, and that of the light chain is isotypic human kappa constant region. The variable region of the heavy chain is shown in SEQ ID No.2, and that of the light chain is shown in SEQ ID No.1. The functional humanized antibody has low immunogenicity. Experiments show that the functional humanized antibody has the same specificity and affinity as the original murine antibody. Drugs containing the functional humanized antibody and its derivatives can be used for treating cancers or immune system diseases with the high-expression of CD20, such as rheumatic arthritis and lupus erythematosus.

The invention relates to a traditional Chinese medicine for treating rheumatoid arthritis. The traditional Chinese medicine consists of the following raw material medicaments by weight: 9 to 20 grams of incised notopterygium rhizome, 6 to 12 grams of divaricate saposhnikovia root, 3 to 9 grams of prepared liquoric root, 9 to 20 grams of heracleum, 9 to 30 grams of Chinese taxillus twig, 6 to 18 grams of root of largeleaf gentian, 9 to 18 grams of Chinese angelica, 6 to 9 grams of cassia twig, 6 to 18 grams of achyranthes root, 6 to 15 grams of turmeric, 9 to 30 grams of mulberry twig and 9 to 18 grams of eucommia bark. The traditional Chinese medicine of the invention has simple and reasonable formula, wide medicinal herbs resource, low cost, remarkable curative effect and clinical application effective rate of 83.2 percent, does not have toxic or side effect, and is convenient to use.

Changes, increase or decrease, in the body fluid flow are passively detected by using a single pixel, non-linear blind de-mixing procedure, which can be extended to general biomedical measurement and diagnoses instruments. More specifically the single pixel, non-linear blind de-mixing procedure is applied on the hot spots of rheumatic arthritis or breast cancer detection problem using passive two-color infrared imaging as well as to passively detect blockages in the body fluid circulatory system that might be of importance for coronary artery bypass surgery, diabetes and deep vein thrombosis. Other applications of the mentioned algorithm include a pair of cameras for video, a pair of antennas for cell phones, and in situ data gathering or imaging using multiple mode fiberoptical sensing as well as selective amplification hearing aids through two-ear binaural processing for de-noise echo cancellation and signal classification.

The invention discloses an externally applied plaster prepared from pure traditional Chinese medicines and a preparation method thereof, and belongs to the technical field of pharmacy. The externally applied plaster is a pure traditional Chinese medicine combined formula consisting of decoction and boiling type crude materials and directly added fine materials, and comprises sesame oil, yellow lead, unprocessed common monkshood mother root, unprocessed kusnezoff monkshood root, ningpo yam rhizome, fortune drynaria rhizome, obscured homalomena rhizome, szechuan lovage rhizome, myrrh, native copper, frank incense, twotooth achyranthes root, Chinese angelica, incised notopterygium rhizome root, heracleum, turmeric, shortstalk monkshood root, himalayan teasel root, white mustard seed, wooly datchmanspipe herb, common clubmoss herb, nux vomica, safflower, eucommia bark, acanthopanax bark, musk, long-noded pit viper, centipede, scorpion and borneol serving as raw materials. The finished plaster is prepared by selecting materials, decocting, removing dregs of decoction, refining, adding the yellow lead, releasing fire-toxin and stretching. The prepared plaster is used for treating rheumatism, rheumatic arthritis, scapulohumeral periarthritis, swelling and pain of joints, bone spur, hyperosteogeny, femoral head necrosis and cervical spondylosis, has the effects of activating blood circulation to dissipate blood stasis, strengthening muscles and bones, and quickly diminishing swelling and relieving pain, along with local anesthesia, and has the advantages of short treatment period, definite curative effect, no side effect and the like.

A Chinese medicine in the form of powder for treating hyperosteogeny and rheumatic arthritis by both interior and exterior applications is prepared from 7 Chinese-medicinal materials including Chuan-xiong rhizome, acanthopanax bark, Chinese angelica root, safflower, etc through proportional mixing and pulverizing.

The invention relates to medicinal liquor for treating bone disease, which comprises the following substances by weight: 50 parts of Panax japonicum, 50 parts of tuber santsigu, 50 parts of ground beetle, 50 parts of safflower, 15 parts of Paris polyphylla, 15 parts of rhizoma drynariae, 18 parts of pseudo-ginseng, 30 parts of Sanguis Draconis, 50 parts of radix clematidis, 20 parts of myrrh, 50 parts of gardenia jasminoides, 12 parts of dried orange peel, 30 parts of cortex eucommiae, 30 parts of chaff flower root, 30 parts of pawpaw, 30 parts of buck grass, 30 parts of cassia twig, 50 partsof fiveleaf akebia, 24 parts of coralbean bark and 24 parts of common dodder. The present invention also relates to a method for preparing the medicinal liquor. The medicinal liquor provided by the invention can be used for treating rheumatic numbness of limbs, rheumatic arthritis, cervical spondylosis, periarthritis humeroscapularis, ischialgia caused by lumbar muscle strain, hyperosteogeny, hernia of intervertebral disc, spondylosis and ischemic necrosis of femoral head, traumatic injury, bone fracture, soft tissue contusion sequelae and the like.

The invention discloses 3-heterocycle schiff base-5-fluorine-indole-2-ketone compounds represented by a general formula (I), pharmaceutical salts thereof, or solvent compounds thereof. R1, R2, R3, R4 and R5 are respectively independent unsubstituted C1-4 alkyl, unsubstituted C1-3 alkoxy, halogen, sulfamic, nitro, or hydrogen; or R1, R2, R3, R4 and R5 are respectively independent C1-4 alkyl substituted by 1 to 3 substituents selected from halogen, nitro, C1-3 alkyl, or C1-2 alkoxy; or R1, R2, R3, R4 and R5 are respectively independent C1-3 alkoxy substituted by 1 to 3 substituents selected from halogen, nitro, C1-3 alkyl, or C1-2 alkoxy. The halogen is fluorine, chlorine or bromine. X is S or NH. The invention also discloses a preparation method of the compounds, and an application of the compounds. The compounds provided by the invention assist in regulating the conduction of tyrosine kinase signals, and in inhibiting cacoethic cellular proliferation and blood vessel growth. The compounds provided by the invention provide substantial curative effects against diseases such as tumors, diabetes mellitus, dermatitis, and rheumatic arthritis.

The invention relates to a medicament for treating arthralgia and myalgia. The medicament is prepare from the components in parts by weight as follows: 1000 parts of nux vomica, 100 parts of radix clematidis, 100 parts of caulis sinomenii, 100 parts of garden balsam stem, 100 parts of lycopodium clavatum, 100 parts of berba aristolochiae mollissimae, 100 parts of monkshood, 100 parts of radix aconiti agrestis, 100 parts of the root of red-rooted salvia, 100 parts of angelica sinensis, 100 parts of rheum officinale, 100 parts of dragon's blood, 100 parts of semen momordicae, 100 parts of eucommia ulmoides, 100 parts of cinnamon, 100 parts of radix angelicae pubescentis, 100 parts of notopterygium root, 100 parts of asarum, 100 parts of radix achyranthis bidentatae, 100 parts of homalomena occulta, 100 parts of anisetree bark, 100 parts of radices sileris, 100 parts of caper, 100 parts of monkshood, 100 parts of ligusticum wallichii, 100 parts of Chinese polyphaga, 100 parts of scorpio, 100 parts of centipede, 100 parts of frankincense, 100 parts of myrrh, 100 parts of leech, 60 parts of camphor, 60 parts of borneol, 20 parts of musk and 300 parts of zaocys dhumnade. The medicament provided by the invention can be used for treating cervical spondylosis, brain swelling cervical pain, scapulohumeral periarthritis, scapula back pain, pelvospondylitis, thoracic vertebra pain, elbow joint pain, pain in waist and lower extremities, lumbar disc herniation, cervical and lumbar spinal stenosis, osteoproliferation, ischiadic nerve pain, knee-joint dropsy, synovitis, knee pain and rheumatic arthritis.