24 results about "Rheumatic Arthritis" patented technology

The invention provides a traditional Chinese medicine composition for treating rheumatic arthritis, a preparation and application, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following medicinal raw materials: 12-18 parts of sailong bone, 6-12 parts of radix aconiti lateralis preparata, 3-9 parts of radix aconiti preparata, 9-15 parts of cassia twig, 1-4 parts of asarum, 9-15 parts of radix clematidis, 20-40 parts of astragalus membranaceus, 3-9 parts of scorpio, 9-15 parts of earthworm, 9-15 parts of caulis sinomenii, 12-18 parts of bighead atractylodes rhizome, 12-18 parts of poria cocos, 9-15 parts of gentiana macrophylla, 12-18 parts of angelica sinensis, 20-40 parts of caulis spatholobi, 9-15 parts of rhizoma drynariae, 12-18 parts of radix paeoniae alba, 3-9 parts of honey-fried licorice root and 6-12 parts of rhizoma zingiberis. According to the traditional Chinese medicine composition for treating rheumatic arthritis, the medicine raw material composition of the traditional Chinese medicine composition for treating rheumatic arthritis is reasonably designed, four pathological links of cold, dampness, stasis and deficiency of rheumatic arthritis are covered through precise compatibility of monarch, minister, assistant and guide, and the traditional Chinese medicine composition has triple curative effects of anti-inflammatory analgesia, immunoregulation and bone protection.

The invention provides a preparation method and application of graphene pain-relieving health-care paste, and the method comprises the following steps: mixing carrageenan with water to obtain a carrageenan solution, and carrying out ionization degradation on the carrageenan solution to obtain a carrageenan oligosaccharide solution; the preparation method comprises the following steps: stirring graphene oxide and a carrageenan oligosaccharide solution, cleaning to obtain a mixed solution, adding sodium alginate into the mixed solution to prepare a gel precursor, and adding an anhydrous calcium chloride solution and effective components into the gel precursor to obtain the pain-relieving gel, and drying the gel to obtain the health-care paste. The health-care ointment has the effects of promoting blood circulation, activating collaterals and inhibiting inflammation, and is suitable for various chronic pains such as rheumatic arthritis and lumbar muscle degeneration and acute pains such as traumatic injury and muscle strain; the composition is also suitable for auxiliary relieving of postoperative pain, and has safety and long-term effect. Due to the thermal conductivity of the graphene oxide in the health-care cream, local skin blood circulation can be accelerated, the permeation efficiency of the herbal extract is improved, and the medicine effect of the effective components is improved.

The invention relates to the technical field of medicine preparation, in particular to an exosome for preventing and / or treating rheumatic arthritis and a preparation method and application thereof. The exosome disclosed by the invention is prepared from the following components in parts by mass: 10-20 parts of onions, 20-30 parts of fresh ginger and 10-20 parts of fistular onion stalks. The exosome prepared from the components can reduce the inflammatory factor level in a mouse with rheumatoid arthritis, and does not affect the growth of the mouse. And after the exosome is prepared into a certain dosage form, the rheumatoid arthritis can be effectively treated. A basis is provided for the preparation of the plant exosome, and a basis is provided for the safe treatment of rheumatoid arthritis.

The invention provides a composition containing picocetinib hydrobromide and a preparation method thereof, the composition is a tablet, the active component picocetinib hydrobromide and a hydrophilic gel framework material (e.g., hydroxypropyl methylcellulose, polyoxyethylene resin or hydroxypropyl methyl cellulose acetate succinate) form a solid dispersion, and the solid dispersion is prepared into the composition containing the picocetinib hydrobromide and the hydrophilic gel framework material (e.g., hydroxypropyl methylcellulose, polyoxyethylene resin or hydroxypropyl methyl cellulose acetate succinate). The solubility of the medicine is improved, and stable release in vivo is realized; according to the present invention, with the addition of the pH value adjusting agent, the solubility of the picetinib hydrobromide can be maintained without limitation in the neutral pH region, the stability is good, and the stable release in the body is achieved so as to achieve the rheumatic arthritis treatment effect, improve the patient comfort and the treatment compliance, reduce the administration frequency and the medical cost, reduce the side effect, and provide the clinical application prospect. The whole preparation method is simple and suitable for industrial production.

The invention discloses a traditional Chinese medicine liniment for treating lumbocrural pain and hyperostosis and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine liniment is prepared from notopterygium root, radix angelicae pubescentis, angelica sinensis, fructus lycii, flos carthami, clove and radix saposhnikoviae according to a specific weight part ratio through soaking in wine and extracting, and auxiliary materials such as glycerol can also be added according to requirements. The traditional Chinese medicine composition is scientific in formula, integrates functions of promoting blood circulation to remove blood stasis, dispelling wind and eliminating dampness and tonifying liver and kidney, and is high in permeability, quick in effect, good in stability and small in side effect. The preparation method adopts a percolation method for extraction, so that effective components can be reserved to the greatest extent, and stable quality of liquid medicine is ensured. The traditional Chinese medicine can be used for effectively treating arthralgia such as lumbocrural pain, hyperostosis, lumbar disc herniation, rheumatic arthritis and the like, and has good clinical application value.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for promoting menstruation and removing stasis, an external preparation and application. The traditional Chinese medicine composition consists of teasel root, lycopodium clavatum, frankincense, myrrh, divaricate saposhnikovia root, pseudo-ginseng, turmeric, cinnamon, litsea cubeba, ligusticum wallichii, gardenia, mulberry twig, lotus leaf, rheum officinale, dragon's blood, salvia miltiorrhiza, safflower, folium artemisiae argyi and mint. The traditional Chinese medicine composition for promoting menstruation and removing stasis is reasonable in compatibility, has an excellent treatment effect on wind-cold-dampness arthralgia, and is suitable for patients with symptoms such as scapulohumeral periarthritis, cervical spondylosis, lumbocrural pain, muscle and joint pain, rheumatic arthritis, rheumatoid arthritis and gouty arthritis. A specific natural penetrant composition and a traditional Chinese medicine composition are selected to be prepared into an external dosage form, the medicine can be promoted to enter a target organ or tissue through a physiological barrier, the medicine can directly act on a focus, the effect is quick, the efficacy is lasting, the use is convenient, the patient compliance is good, no toxic or side effect exists, and a new choice of an external transdermal agent is provided for clinical treatment of chronic pain.

The invention provides a nursing traditional Chinese medicine external preparation for relieving rheumatic arthralgia, and relates to the technical field of traditional Chinese medicines. On the basis of the theory of traditional Chinese medicine, a traditional Chinese medicine formula composed of pine nodular branch, ormosia henryi, shinyleaf pricklyash root, peach twig, lance asiabell root, arachnoid cyanotis root, dentiferous dendropanax root, rhizoma curculiginis, winter jasmine, wintergreen, folium cortex eucommiae, semen sesami nigrum, fructus viticis, semen allii tuberosi, rhizoma smilacis glabrae and herba menthae is prepared and used for externally treating rheumatoid arthritis in traditional Chinese medicine. The traditional Chinese medicine has the effects of promoting blood circulation to remove meridian obstruction, relieving swelling and pain, dispelling wind and eliminating dampness, tonifying liver and kidney, strengthening muscles and bones, clearing heat and promoting diuresis. The traditional Chinese medicine external preparation disclosed by the invention has excellent anti-inflammatory, detumescence and analgesic effects, has excellent performance in the aspects of improving clinical symptoms such as joint swelling, pain and pressing pain of a patient and improving sleep and joint functions, and takes effect quickly. The traditional Chinese medicine external preparation provides effective nursing means and measures for relieving or relieving rheumatic arthralgia.

The invention discloses a traditional Chinese medicine composition for treating joint diseases and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 25 to 45 parts of radix angelicae pubescentis, 25 to 45 parts of cortex phellodendri, 20 to 40 parts of rhizoma smilacis glabrae, 20 to 40 parts of rhizoma dioscoreae septemlobae, 20 to 40 parts of rhizoma chuanxiong, 20 to 40 parts of semen coicis, 20 to 40 parts of radix cyathulae, 20 to 40 parts of herba artemisiae scopariae, 20 to 40 parts of herba lycopodii, 20 to 40 parts of rhizoma polygoni cuspidati, 20 to 40 parts of radix dipsaci, 20 to 40 parts of rhizoma atractylodis, 20 to 40 parts of semen plantaginis and 10 to 25 parts of liquorice root. The traditional Chinese medicine composition has a relatively good treatment effect on gout, rheumatic arthritis and rheumatoid arthritis, can treat both symptoms and root causes, and is relatively small in side effect and relatively small in harm to a human body.

The invention relates to a tendon-stretching pain-relieving plaster, which is prepared by soaking a plurality of Chinese herbal medicines such as Aristolochia delavayi, Chinese actinidia root, herba aristolochiae, kadsura pepper stem, pseudo-ginseng and yellow lead in clear sesame oil and decocting into the plaster for external use, and the tendon-stretching pain-relieving plaster is mainly prepared from traditional Chinese medicines, has the effects of clearing away heat and toxic materials, diminishing inflammation and relieving pain, is low in cost, has the effects of dredging tendons and activating blood, dispelling wind and eliminating dampness, and stretching tendons and relieving pain, and is suitable for rheumatoid arthritis. The traditional Chinese medicine composition is free of side effects and good in curing effect, and can be used for treating osteoarthropathy such as rheumatic arthritis, osteoproliferation and traumatic injury.

The invention discloses a medicinal moxa composition for preventing and treating bronchitis and rheumatic arthritis. The medicinal moxa composition comprises platycodon grandiflorum, ginseng, divaricate saposhnikovia root, schizonepeta and moxa. A plurality of volatile active ingredients of the medicinal moxa composition act on a plurality of key targets related to common diseases of bronchitis and rheumatic arthritis through external moxibustion. Composite volatile components released when a medicinal moxa stick prepared from the medicinal moxa composition burns can form a synergistic effect, the traditional Chinese medicine theory of treating an internal illness by external treatment is realized through a lung channel and meridian conduction mechanism, and a new thought and theoretical basis are provided for health care of bronchitis combined with rheumatic arthritis.

The invention relates to the technical field of Chinese patent medicine capsules, in particular to a Chinese patent medicine capsule for muscles and bones and a preparation method of the Chinese patent medicine capsule. The traditional Chinese medicine is characterized by being prepared from the following raw medicinal materials in parts by weight: 10 parts of honey-fried semen strychni, 12 parts of radix clematidis, 12 parts of fructus broussonetiae, 12 parts of eucommia ulmoides, 12 parts of radix achyranthis bidentatae, 12 parts of herba taxilli, 12 parts of scorpio, 10 parts of rhizoma atractylodis, 10 parts of frankincense, 10 parts of myrrh, 15 parts of black ants, 10 parts of radix gentianae macrophyllae and 6 parts of liquorice. On the basis of addition and reduction of a classic prescription, the compound loganin hard-energy-removing powder has the advantages that the effects of the medicinal materials are synergistic through scientific compatibility, the comprehensive treatment effects of activating meridians to stop pain, tonifying liver and kidney and promoting blood circulation to remove blood stasis are realized aiming at the etiology and pathogenesis of muscle and bone diseases, and the symptoms such as lumbar disc herniation, hyperostosis, apoplexy and rheumatic arthritis can be effectively relieved.

The invention provides a foot bath bag composition and a preparation method thereof, and relates to the field of traditional Chinese medicinal materials. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 to 40 parts of fructus forsythiae, 35 to 45 parts of folium artemisiae argyi, 5 to 15 parts of flos carthami, 15 to 25 parts of caulis spatholobi, 25 to 35 parts of ramulus mori, 15 to 25 parts of herba leonuri, 15 to 25 parts of radix clematidis, 5 to 15 parts of fructus chaenomelis, 15 to 25 parts of rhizoma corydalis, 5 to 15 parts of caulis sargentodoxae, 5 to 15 parts of herba lycopodii, 15 to 25 parts of rhizoma chuanxiong and 5 to 15 parts of liquorice root. According to the traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared by taking fructus forsythiae and folium artemisiae argyi as main components, extracting effective components through boiling, and absorbing the effective components in the composition through a foot bath mode, a sole Yongquan acupoint and skin, so that the traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, diminishing inflammation and relieving pain, can effectively relieve pain caused by gonitis, femoral head necrosis and rheumatic arthritis, and is good in treatment effect.

The invention relates to the field of medicines, and particularly discloses an anti-inflammatory and analgesic external emulsion as well as a preparation method and application thereof. The external emulsion is prepared from nine traditional Chinese medicines including radix clematidis, phryma leptostachya, radix angelicae pubescentis, scandent schefflera stem and leaf, corydalis tuber, ligusticum wallichii, angelica sinensis, pseudo-ginseng and borneol according to a specific ratio, volatile oil is extracted through steam distillation, then ethanol reflux extraction is combined, and finally an emulsifier and a wetting agent are added. The preparation method realizes full-effect utilization of volatile oil and water-soluble and alcohol-soluble components in the medicinal materials. The external emulsion has dual effects of rapid analgesia and long-acting anti-inflammation, and pharmacodynamic experiments show that the anti-inflammation and analgesia effects of the external emulsion are obviously superior to those of a same-prescription spray without volatile oil. Meanwhile, the medicament is good in stability, free of skin irritation and suitable for treating various pains and inflammations such as rheumatic arthritis, soft tissue contusion and cold-dampness dysmenorrhea.

Disclosed in the present invention are a polymorph of a benzo[c]chroman compound, a preparation method therefor and use thereof. The present invention particularly provides a polymorph of a compound represented by formula I, a preparation method therefor and use thereof. The compound represented by formula I is used as a cathepsin C inhibitor, and a crystalline form of the compound and a pharmaceutical composition comprising the crystalline form can be used for treating asthma, obstructive pulmonary diseases, bronchiectasis, ANCA-related vasculitis, psoriasis, α1-antitrypsin deficiency, lupus nephritis, diabetes, inflammatory bowel diseases, rheumatic arthritis, rhinosinusitis, hidradenitis suppurativa or cancers.

The invention discloses a traditional Chinese medicine composition for treating arthralgia and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from peganum harmala, angelica sinensis, fructus lycii, liquorice, radix angelicae pubescentis, corydalis tuber and cornu cervi according to a specific weight part ratio, and is prepared into ointment through a specific extraction process. The traditional Chinese medicine composition follows the synergistic treatment principle of promoting blood circulation to remove blood stasis, dispelling wind, eliminating dampness and tonifying the liver and kidney, has a remarkable treatment effect on arthralgia such as lumbocrural pain, hyperostosis, lumbar disc herniation and rheumatic arthritis, and is small in skin irritation, low in allergy occurrence rate and free of toxic and side effects. The problems that an existing external plaster is single in curative effect, poor in durability, large in irritation and capable of treating the symptoms but not the root causes are solved, and wide clinical application prospects are achieved.

The invention discloses a compound with BTK inhibitory activity and a preparation method and application thereof. The compound is shown as a formula I. The compound can effectively inhibit Bruton's tyrosine kinase, and can be applied to targeted drugs for treating diseases related to BTK signal channels, such as chronic lymphocytic leukemia, multiple myeloma, mantle cell lymphoma, systemic lupus erythematosus, rheumatic arthritis, chronic graft versus host disease and the like.

The invention relates to the technical field of medicines, and particularly discloses a non-steroidal anti-inflammatory drug choline salt and a preparation method and application thereof. The salt is formed by combining a non-steroidal anti-inflammatory drug and choline; the non-steroidal anti-inflammatory drug in the salt is a component A, a component B or a component C; the component A is S-flurbiprofen; the component B is naproxen; the component C is diclofenac; the molar ratio of S-flurbiprofen to choline is 1: 5-5: 1, the molar ratio of naproxen to choline is 1: 5-5: 1, and the molar ratio of diclofenac to choline is 1: 5-5: 1. According to the non-steroidal anti-inflammatory drug-choline salt successfully prepared by adopting a melting cooling method, the solubility of the non-steroidal anti-inflammatory drug in water is greatly improved, and the non-steroidal anti-inflammatory drug is stable in structure and is not decomposed at normal temperature. According to the medicine salt, the pharmacological activity of the non-steroidal anti-inflammatory medicine is kept, the analgesic activity is improved, and pains such as headache, limb pains, dysmenorrhea, rheumatic arthritis pains and osteoarthritis pains can be rapidly relieved.

The invention relates to a plant active ingredient for inhibiting synovial cell inflammatory response and a method for treating rheumatoid arthritis by using the plant active ingredient. The active ingredient is selected from one or more of kaempferide, quercetin, luteolin and alpinetin sesquiterpenoids, and is derived from medicinal plants such as alpinia pumila, glabrous sarcandra herb or herba epimedii and the like. The high-purity flavonoid monomer is obtained through a specific extraction process including ethanol reflux extraction, ethyl acetate extraction, macroporous resin enrichment and silica gel column chromatography separation. The composition can remarkably inhibit activation of NF-kappa B signal channels in synovial cells in vitro, reduce expression levels of inflammatory factors TNF-alpha, IL-1beta and IL-6 and reduce generation of reactive oxygen species (ROS) and nitric oxide (NO), and has a good anti-rheumatic arthritis effect. The active component can be prepared into various dosage forms such as capsules, granules, injections and the like, and is suitable for treatment or adjuvant treatment of rheumatic arthritis and related diseases thereof.

This invention belongs to the field of traditional Chinese medicine. It relates to a Tonglaga-5 poultice, its preparation process, and its application in treating rheumatoid arthritis. Tonglaga-5 powder is extracted with ethanol to prepare a concentrated Tonglaga-5 solution. The concentrated solution is then freeze-dried to obtain a lyophilized Tonglaga-5 powder, which is further used to prepare a Tonglaga-5 gel ointment and a Tonglaga-5 poultice. Specifically, the optimal extraction process for the Tonglaga-5 concentrate is 77% ethanol (volume fraction), a material-to-liquid ratio of 1:20, and an extraction time of 1 hour. The optimal formulation for the Tonglaga-5 gel is a ratio of carbomer-941: Tonglaga-5 lyophilized powder: sodium polyacrylate: glycerin: aluminum hydroxyl group of 1:2:4:20:5. Pharmacological experiments show that the prepared Tonglaga-5 gel ointment has a uniform and fine appearance, and the Tonglaga-5 poultice prepared using this as a matrix can effectively inhibit the inflammatory response in CIA rats and delay the progression of bone damage.

The invention relates to a double-cavity rheumatoid arthritis hydrops puncture needle and an application method. The double-cavity rheumatoid arthritis hydrops puncture needle comprises a needle head and a socket, the socket comprises a large sleeve and a small sleeve which are sleeved in a sliding manner, the large sleeve is matched with the outer diameter of the injector, and one end, far away from the large sleeve, of the small sleeve is connected with the needle through a hose; a spacer is arranged in the middle of the interior of the large sleeve, a spacer cap is formed on the spacer, and an extrusion needle is arranged on the spacer cap in a penetrating manner; a rubber plug is arranged in the small sleeve, a through hole is formed in the rubber plug, one end of the through hole is hermetically communicated with the hose, and the other end is matched with the extrusion needle; an overflow groove is formed in the surface of the side, facing the small sleeve, of the partition piece, a protruding strip corresponding to the overflow groove is arranged on the rubber plug, and an overflow hole corresponding to the overflow groove is formed in the large sleeve. In conclusion, the invention provides a safe, efficient, convenient and economical joint cavity effusion puncture injection solution, and the medical experience and the medical safety of the patient are improved to the maximum extent while the treatment effect is guaranteed.

The application belongs to the field of medicine, and discloses a compound, rhusenol, a preparation method and a pharmaceutical composition of the compound, and an application of the compound in analgesia and anti-inflammation. The rhusenol is shown as formula (I), has analgesic and anti-inflammatory effects, prolongs the reaction time of a mouse in pain caused by light heat induction, and improves the effect of tinea urticae oil-induced mouse ear swelling. The rhusenol can relieve and / or treat diseases related to analgesic and anti-inflammatory effects, such as rheumatoid arthritis, osteoarthritis, rheumatic arthritis, gouty arthritis, and lupus erythematosus syndrome.

The invention discloses an oral and fumigated traditional Chinese medicine composition for treating gynecological diseases and application thereof, and relates to the technical field of traditional Chinese medicines, the weight ranges of the raw materials of the two compositions are both 0.1-100g, and the dosage is flexible and adjustable. The oral composition consists of 31 traditional Chinese medicines such as Chinese angelica and fried red peony root, is decocted into 200ml / bag of decoction, is orally taken after a meal, and is suitable for various gynecological diseases such as hypomenorrhea, polycystic ovarian syndrome, premature ovarian failure, uterus cold infertility and the like; the fumigation composition is composed of 29 traditional Chinese medicines such as radix aconiti preparata and pepper, 30-70 g of the traditional Chinese medicines are smashed, boiled and fumigated for 30 min, feet can be soaked or affected parts can be washed, one treatment course lasts for 10-15 days, the fumigation composition is continuously used for 3 treatment courses, and the fumigation composition is suitable for gynecological diseases and rheumatic bone diseases such as rheumatic arthritis and lumbar disc herniation. The traditional Chinese medicine composition realizes simultaneous internal and external treatment, is scientific in compatibility, high in pertinence, stable in curative effect and high in safety, solves the problems of large side effect, single dosage form and insufficient curative effect of an existing treatment scheme, and has outstanding clinical practical value.

The invention provides a wasp polypeptide with an analgesic effect and application thereof, and belongs to the technical field of polypeptide medicines. The wasp polypeptide with the analgesic effect, provided by the invention, is specifically as follows A1) or A2): A1) an amino acid sequence is shown as any one of SEQ ID NO.1-SEQ ID NO.6; experiments prove that the wasp polypeptide can inhibit the sensing, transmission and amplification of pain signals and quickly relieve pain by regulating and controlling multiple ion channels of Nav1.8 and Cav2.2, has a remarkable effect and can be used for treating chronic pain such as sciatica, rheumatic arthritis, musculoskeletal pain and neuropathic pain.

The utility model relates to a rheumatic arthritis physiotherapy device which comprises a base and a liftable chair seat arranged at the rear end of the top of the base, a physiotherapy plate is hinged to the front end of a chair plate of the chair seat, and the front end of the physiotherapy plate is arranged on the base through wheels; a foot placing mechanism and a transverse moving mechanism for driving the foot placing mechanism to move in the front-back direction of the physical therapy plate are arranged above the physical therapy plate; the front end of the physiotherapy plate is hinged with a sealing shell with a lower opening; two via holes are formed in the bottom of the rear end of the sealing shell; physical therapy equipment is arranged between the physical therapy plate and the sealing shell. According to the rheumatic arthritis physical therapy device, the angle of the physical therapy plate can be adjusted through the lifting seat, the patient can find the most comfortable physical therapy posture by adjusting the inclination angle of the physical therapy plate, the experience feeling is better when knees bend and unbend, and posture adjustment is flexible and convenient. The knee bending angle of the patient can be accurately controlled through the transverse moving mechanism, and the joints can be subjected to physical therapy in various modes through the fumigator and the physical therapy lamp at the same time.