1250 results about "Rheumatic Arthritis" patented technology

The invention discloses an externally-used plaster which is prepared from more than 80 kinds of Chinese medicinal materials including frankincense, myrrh, mercurous chloride, dragon's blood resin, camphor, boneol, orpiment, sulfur, gamboge, lead monoxide, native copper, white alum, colophony, dragon's blood resin, musk, orpiment, lead monoxide, alkanna tinctoria, colophony, buck grass, wasp's nest, camphor, mercurous chloride, wood louse, and can be used for treating rheumatic arthritis and proliferative arthritis.

The invention provides methods of inhibiting angiogenesis in an individual by administering a composition (such as protein containing composition) comprising colchicine or thiocolchicine dimer. The composition is in an amount that is effective in inhibiting angiogenesis but is in some embodiments insufficient to induce significant cytotoxicity in the individual. The methods described herein are useful for treating angiogenesis-associated diseases, such as age-related macular degeneration, diabetic retinopathy, rheumatic arthritis, psoriasis, and cancer.

The longevity medicated wine and its manufacture method, which uses 60 - 65 Deg. C pure valley white liquor, adding furl seal's kidney, deer's muscle, the winter Chinese caterpillar fungus, the melinda officinalis, Beiqi, Tianma, the seahorse, the gecko and so on 75 kinds of Chinese native medicines raw material for soaking, latter adds the white sugar and the tap water configuration. This invention medicated wine enhances men's and women's sexual dive energy, strengthens the human body vigor for mainly, makes up cloudyly and fortifies female, the synthesis recuperates the human body vital organs of the human body, expels sickness and builds up strength, thus achieves the benefit goal which prolongs the life. Its manufacture method is simple, the medicated wine soaking output contains Chinese native medicine ingredient content which obtains is high, the medicated wine palatableness is good, the feeling in the mouth is pure, preserves long. Long-time drinking can nourish the human body in vital organs, as well balances human body distributed masculine and feminine elements, and promotes metabolism, makes up the vitality, the strong physique, which prevents disease and expels sickness, the effect of prolonging the life. Regarding the hypertension, sleepless, the sexual impotence, the kidney empty lumbago, the prostate gland disease, the rheumatic arthritis, the asthma, the woman post-natal is weak, irregular menses and so on sickness also has the effect of better treatment. Stopping from pain also is its advantage.

A Chinese medicine in the form of plaster for treating rheumatic arthritis, cervical spondylopathy, lumbar intervertebral disk protrusion, lumbar hyperosteogeny, etc is prepared from the Chinese-medicinal materials. Its advantages are simple preparing process, high curative effect, and short course of treatment.

A Chinese medicine in the form of plaster for treating rheumatic arthritis, hyperosteogeny, cervical spondylopathy, lumbar intervertebral disk protrusion, and muscle and bone injury is prepared from 56 Chinese-medicinal materials including camphor, pinellia tuber, hot pepper, toad venom, etc. Its advantage is high curative effect.

The present invention relates to a Chinese medicine for effectively curing rheumatic arthritis, rheumatoid arthritis, arthralgia due to wind-cold-dampness, lumbago and numbness of the extremities, etc. Said Chinese medicine is made up by using 20 Chinese medicinal materials of pubscent angelica root, notopterygium root, raw aconite main tuber, raw wild aconite tuber, Chinese angelica root, salvia root and others through a certain preparation process.

The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human Rheumatoid Arthritis (RA). A variety of newly-identified markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with RA.

The invention discloses medicinal liquor for treating rheumatic arthritis and chronic infectious arthritis, which comprises the following raw materials in parts by weight: 33-38 parts of Chinese parsnip root, 8-13 parts of asarum, 28-33 parts of the root of bidentate achyranthes, 28-33 parts of ligusticum sinense oliver, 28-33 parts of notopterygium root, 28-33 parts of radix angelicae pubescentis, 23-28 parts of prepared monkshood, 28-33 parts of cassia twig, 28-33 parts of pawpaw, 28-33 parts of radix clematidis, 28-33 parts of cortex acanthopanacis, 28-33 parts of semen coicis, 28-33 parts of corydalis tuber, 28-33 parts of large-leaved gentian, 4-9 parts of long-noded pit viper, 28-33 parts of the root of fangji, 28-33 parts of rhizoma typhonii, 28-33 parts of ligusticum wallichii, 28-33 parts of zaocys dhumnade, and 7000-8000 parts of 50-60-degree white wine. The medicinal liquor disclosed by the invention has the advantages of being low in cost, high in curative rate and free from toxic and side effects; stimulation of the existing medicines on gastric mucosa is overcome; simultaneously, the medicinal liquor disclosed by the invention also has the functions of tonifying liver and kidney.

Disintegrin variants and pharmaceutical uses thereof are disclosed. The disintegrin variant includes an isolated polypeptide that has integrin αvβ3 receptor-antagonist activity and substantially reduced integrin αllbβ3 and / or α5β1 receptor-blocking activity as compared to a wild-type disintegrin. The variant is encoded by a modified disintegrin nucleotide sequence that encodes a modified amino acid sequence, resulting in a polypeptide having substantially reduced affinity to integrin αllbβ3 and / or α5β1 as compared to a wild-type disintegrin. The variant is useful for treatment and / or prevention of αvβ3 integrin-associated diseases in a mammal, which include osteoporosis, bone tumor or cancer growth, angiogenesis-related tumor growth and metastasis, tumor metastasis in bone, malignancy-induced hypercalcemia, angiogenesis-related eye diseases, Paget's disease, rheumatic arthritis, and osteoarthritis. The angiogenesis-related eye diseases include age-related macular degeneration, diabetic retinopathy, corneal neovascularizing diseases, ischaemia-induced neovascularizing retinopathy, high myopia, and retinopathy of prematurity.

An agent for inhibiting articular cartilage extracellular matrix degradation of the present invention, comprising a histone deacetylase-inhibiting compound as an active ingredient, is effective for the prevention and treatment of diseases and pathological conditions involving the degradation and degeneration of the articular cartilage extracellular matrix, in particular, arthrosteitis, rheumatic arthritis, osteoarthritis, and the like.

The invention develops a simplified method for the in-vitro isolation and expansion of umbilical mesenchymal stem cells (MSCs) and confirms that the MSCs obtained by the method have the effects of immunoregulation and inflammation inhibition in the treatment of rheumatoid arthritis.

The present invention discloses one kind of Chinese medicine composition and its preparation process. The Chinese medicine composition contains the effective components of atractylodes rhizome, coix seed, earthworm, tetramdra root, phellodendron bark and other seven kinds of Chinese medicinal materials. It may be prepared into granule, tablet, capsule or other common Chinese preparation form. It has the functions of dispelling wind, eliminating dampness, clearing away heat, relieving swelling, dredging meridian and relieving pain, and may be used in treating rheumatic arthritis, rheumatoid arthritis and gout.

The invention provides a flurbiprofen hydrogel plaster and a composition thereof. In the composition, the content of flurbiprofen is 0.1-3wt%, and a hydrogel substrate accounts for the rest. Based on the total weight of the hydrogel substrate, the hydrogel substrate comprises the following components: 0.1-40wt% of a hydrophilic base material, 0.01-2wt% of a crosslinking agent, 0.01-4wt% of a crosslinking regulator, 10-60wt% of a humectant, 0.05-45wt% of a penetration enhancer and 10-85wt% of a solvent. According to the flurbiprofen hydrogel plaster provided by the invention, a small number of medicines are used, and the permeability and stability are good; and the flurbiprofen hydrogel plaster can be applied to various arthralgia diseases such as rheumatic arthritis, gouty arthritis, ankylosing spondylitis, tenosynovitis, muscle pain and lumbago.

The invention discloses caper extract and a preparation method thereof. The method comprises the following steps: medicinal materials are crushed, decocted in water or subjected to heating reflux extraction by utilization of ethanol with different concentrations, and added with the ethanol for impurity precipitation after concentration of extract; supernatant or more than 80 percent ethanol extract is subjected to concentration at reduced pressure; extract 1 is obtained after recovery of the ethanol, dried and dissolved in water, subjected to deesterification by utilization of petroleum ether, and extracted by ethyl acetate; an extracted position and a water-soluble position of the ethyl acetate are subjected to vacuum concentration and drying respectively and prepared into extract 2 and extract 3 respectively; the extract 1 contains 30 compounds including 5 novel compounds such as caper alkali A, and so on; the extract 2 contains 18 compounds such as a para hydroxybenzoic acid, and so on ; and the extract 3 contains 18 compounds including 5 novel compounds such as the caper alkali A, and so on. As proved by pharmacodynamic experiments, the extract 1, the extract 2 and the extract 3 have analgesic and anti-inflammatory activity, and can be used for preparing medicines for treating rheumatic arthritis, rheumatoid inflammation or scapulohumeral periarthritis.

This invention discloses functional humanized antibody against CD20 molecules and its application. The functional humanized antibody specifies human CD20 molecules, and is composed of a light chain and a heavy chain, each of which comprises a constant region and a variable region. The constant region of the heavy chain is isotypic human IgG1 constant region, and that of the light chain is isotypic human kappa constant region. The variable region of the heavy chain is shown in SEQ ID No.2, and that of the light chain is shown in SEQ ID No.1. The functional humanized antibody has low immunogenicity. Experiments show that the functional humanized antibody has the same specificity and affinity as the original murine antibody. Drugs containing the functional humanized antibody and its derivatives can be used for treating cancers or immune system diseases with the high-expression of CD20, such as rheumatic arthritis and lupus erythematosus.

The invention relates to an externally-applied traditional Chinese medicine for treating arthritis, which comprises the following components in part by weight: 1 to 3 parts of common monkshood mother root, 1 to 3 parts of kusnezoff monkshood root, 4 to 8 parts of angelica dahurica, 4 to 6 parts of incised notopterygium rhizome, 3 to 7 parts of pubescent angelica root, 1 to 3 parts of manchurian wildginger, 2 to 4 parts of szechuan lovage rhizome, 2 to 4 parts of cassia twig, 0.5 to 0.9 part of clematis root, 0.4 to 0.8 part of common clubmoss herb and 0.3 to 0.7 part of garden balsam stem. A preparation method comprises the following steps of: mixing the components according to the ratio, decocting in water, filtering dregs of decoction and extracting solution for three times, and mixing the obtained liquid medicine for three times uniformly for later use. Before each time of use, the externally-applied traditional Chinese medicine is heated, and after being fumed by the heated externally-applied traditional Chinese medicine, painful joints are immersed and washed for at least twice in a day. The externally-applied traditional Chinese medicine has wide raw material sources and scientific and reasonable formula, can act on a lesion site directly, can be widely used for treating rheumatic arthritis, osteoarthritis and rheumatoid arthritis, and has the characteristics of simple using method, no toxic or side effect and obvious effect.

The invention relates to a traditional Chinese medicine for treating rheumatoid arthritis. The traditional Chinese medicine consists of the following raw material medicaments by weight: 9 to 20 grams of incised notopterygium rhizome, 6 to 12 grams of divaricate saposhnikovia root, 3 to 9 grams of prepared liquoric root, 9 to 20 grams of heracleum, 9 to 30 grams of Chinese taxillus twig, 6 to 18 grams of root of largeleaf gentian, 9 to 18 grams of Chinese angelica, 6 to 9 grams of cassia twig, 6 to 18 grams of achyranthes root, 6 to 15 grams of turmeric, 9 to 30 grams of mulberry twig and 9 to 18 grams of eucommia bark. The traditional Chinese medicine of the invention has simple and reasonable formula, wide medicinal herbs resource, low cost, remarkable curative effect and clinical application effective rate of 83.2 percent, does not have toxic or side effect, and is convenient to use.

A medical wine for treating rheumatic arthritis and osteoarthritis is prepared from 28 Chinese-medicinal materials including safflower, scorpion, tangerine peel, Chuan-xiong rhizome, etc through proportional mixing, crushing, immersing in liquor and filtering.

Changes, increase or decrease, in the body fluid flow are passively detected by using a single pixel, non-linear blind de-mixing procedure, which can be extended to general biomedical measurement and diagnoses instruments. More specifically the single pixel, non-linear blind de-mixing procedure is applied on the hot spots of rheumatic arthritis or breast cancer detection problem using passive two-color infrared imaging as well as to passively detect blockages in the body fluid circulatory system that might be of importance for coronary artery bypass surgery, diabetes and deep vein thrombosis. Other applications of the mentioned algorithm include a pair of cameras for video, a pair of antennas for cell phones, and in situ data gathering or imaging using multiple mode fiberoptical sensing as well as selective amplification hearing aids through two-ear binaural processing for de-noise echo cancellation and signal classification.

The invention discloses an externally applied plaster prepared from pure traditional Chinese medicines and a preparation method thereof, and belongs to the technical field of pharmacy. The externally applied plaster is a pure traditional Chinese medicine combined formula consisting of decoction and boiling type crude materials and directly added fine materials, and comprises sesame oil, yellow lead, unprocessed common monkshood mother root, unprocessed kusnezoff monkshood root, ningpo yam rhizome, fortune drynaria rhizome, obscured homalomena rhizome, szechuan lovage rhizome, myrrh, native copper, frank incense, twotooth achyranthes root, Chinese angelica, incised notopterygium rhizome root, heracleum, turmeric, shortstalk monkshood root, himalayan teasel root, white mustard seed, wooly datchmanspipe herb, common clubmoss herb, nux vomica, safflower, eucommia bark, acanthopanax bark, musk, long-noded pit viper, centipede, scorpion and borneol serving as raw materials. The finished plaster is prepared by selecting materials, decocting, removing dregs of decoction, refining, adding the yellow lead, releasing fire-toxin and stretching. The prepared plaster is used for treating rheumatism, rheumatic arthritis, scapulohumeral periarthritis, swelling and pain of joints, bone spur, hyperosteogeny, femoral head necrosis and cervical spondylosis, has the effects of activating blood circulation to dissipate blood stasis, strengthening muscles and bones, and quickly diminishing swelling and relieving pain, along with local anesthesia, and has the advantages of short treatment period, definite curative effect, no side effect and the like.

The invention relates to a Chinese medicine composite used for treating rheumatoid arthritis which belongs to the field of external applying and infusing Chinese medicine products. The technical proposal is that the composite comprises the materials according to the parts by weight as follows: 15 to 18 parts of Angelica sinensis, 15 to 18 parts of safflower, 15 to 18 parts of garden balsam stem, 15 to 18 parts of medical cyathula root, 15 to 18 parts of szechuan aconite, 15 to 18 parts of wild aconite, 10 to 18 parts of asarum, 10 to 15 parts of frankincense, 10 to 15 parts of myrrh, 15 to 20 parts of nidus vespae, 10 to 15 parts of mulberry twig, 5 to 8 parts of borneol, 10 to 15 parts of clematis root, 15 to 20 parts of pepper stem, 15 to 20 parts of astragalus root, 10 to 15 parts of rhizoma cibotii, 10 to 15 parts of heracleum hemsleyanum michaux, 10 to 15 parts of cassia twig, 10 to 15 parts of lycopodium calvatum, 10 to 15 parts of artemisia leaf, 10 to 15 parts of rhizoma ligustici wallichii and 8 to 10 parts of whole worm. The composite which is compatible with various materials has the efficacies of stimulating circulation to end stasis, relieving rigidity of muscles and activating collaterals, easing joint movement, dispersing cold and relieving pain, etc.

The invention provides a medicament for treating rheumatism and gout, belongs to a prescribed traditional Chinese medicament, and particularly relates to a traditional Chinese medicament for treating rheumatism and gout. The medicament comprises the following raw medicinal materials: astragalus membranaceus, ligusticum wallichii, cassia twig, liquorice, codonopsis pilosula nnannf, Chinese angelica, eucommia ulmoides, bottlebrush orchid, roasted rhizoma atractylodis macrocephalae, prepared rehmannia root, achyranthes root, poria, mistletoe, radix paeoniae rubra, salvia miltiorrhiza, cortex phellodendri, radix angelicae pubescentis, large-leaved gentian, suberect spatholobus stem, radix clematidis, divaricate saposhnikovia root, asarum and ephedra. The medicament starting from the mechanisms of tonifying qi-blood, nourishing liver and kidney, strengthening tendon and bone and dredging channels in traditional Chinese medicine is reasonable in administration compatibility, and can be used for treating rheumatic arthritis and gout diseases caused by multiple reasons with low relapse rate.

A Chinese medicine in the form of powder for treating hyperosteogeny and rheumatic arthritis by both interior and exterior applications is prepared from 7 Chinese-medicinal materials including Chuan-xiong rhizome, acanthopanax bark, Chinese angelica root, safflower, etc through proportional mixing and pulverizing.

The invention discloses nano-silver anionic far-infrared element fabric underwear for preventing and treating rheumatic arthritis, and belongs to the technical field of the production of health element fiber fabric underwear. The content of zinc in human bones is 50 percent of the total amount of the zinc in a human body, and intractable arthritis is caused by the deficiency of zinc, selenium, strontium, calcium and the like in human bodies and the unbalance of elements in the human bodies. In the invention, anionic tourmaline nano-powder can be automatically generated by using medical stone nano-powder which is rich in trace elements; the anionic tourmaline nano-powder, selenium and germanium elements which are rare on the earth and are deficient in the human bodies and Chinese medicines are nano-crushed and then are specially treated by a high-tech process to ensure that each kind of trace element has a positive charge center effect; then the elements are refined into the manufacturing process of a fiber fabric so as to obtain a durable functional element fiber fabric; and the elements are permeated into the human bodies through skin pores and sweat pores by closely contacting the skin so as to balance the elements in the human bodies, strengthen organism immunity and improve disease resistance; therefore, the element fabric underwear for preventing and treating rheumatic arthritis fulfills the aim of better curing the disease.

The invention relates to medicinal liquor for treating bone disease, which comprises the following substances by weight: 50 parts of Panax japonicum, 50 parts of tuber santsigu, 50 parts of ground beetle, 50 parts of safflower, 15 parts of Paris polyphylla, 15 parts of rhizoma drynariae, 18 parts of pseudo-ginseng, 30 parts of Sanguis Draconis, 50 parts of radix clematidis, 20 parts of myrrh, 50 parts of gardenia jasminoides, 12 parts of dried orange peel, 30 parts of cortex eucommiae, 30 parts of chaff flower root, 30 parts of pawpaw, 30 parts of buck grass, 30 parts of cassia twig, 50 partsof fiveleaf akebia, 24 parts of coralbean bark and 24 parts of common dodder. The present invention also relates to a method for preparing the medicinal liquor. The medicinal liquor provided by the invention can be used for treating rheumatic numbness of limbs, rheumatic arthritis, cervical spondylosis, periarthritis humeroscapularis, ischialgia caused by lumbar muscle strain, hyperosteogeny, hernia of intervertebral disc, spondylosis and ischemic necrosis of femoral head, traumatic injury, bone fracture, soft tissue contusion sequelae and the like.

A Chinese patent medicine for treating rheumatoid arthritis, relieving inflammation and relaxing pain is prepared from oriental bittersweet stem through extracting and separating.

This invention discloses functional humanized antibody against CD20 molecules and its application. The functional humanized antibody specifies human CD20 molecules, and is composed of a light chain and a heavy chain, each of which comprises a constant region and a variable region. The constant region of the heavy chain is isotypic human IgG1 constant region, and that of the light chain is isotypic human kappa constant region. The variable region of the heavy chain is shown in SEQ ID No.2, and that of the light chain is shown in SEQ ID No.1. The functional humanized antibody has low immunogenicity. Experiments show that the functional humanized antibody has the same specificity and affinity as the original murine antibody. Drugs containing the functional humanized antibody and its derivatives can be used for treating cancers or immune system diseases with the high-expression of CD20, such as rheumatic arthritis and lupus erythematosus.

The invention discloses a traditional Chinese medicine composition for treating rheumatic arthritis and a preparation method thereof and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine is prepared from the following raw materials: ampelopsis heterophylla, honeysuckle stem, ramulus mori, garden balsam stem, semen coicis, radix angelicae, notopterygium root, radix angelicae pubescentis, rhizoma smilacis glabrae, divaricate saposhnikovia root, Radix Stephaniae Tetrandrae, radix clematidis, grapevine root, cassia twig, loofah sponge, frankincense, herba epimedii, eucommia ulmoides, herba cistanche, angelica sinensis, the root of bidentate achyranthes, ligusticum wallichii, cortex acanthopanacis, caulis spatholobi, white paeony root, astragalus, honeysuckle stem and liquorice. The traditional Chinese medicine composition disclosed by the invention starts from etiology and pathology of rheumatic arthritis, medicinal materials with the effects of nourishing liver and kidney, replenishing qi and blood, enhancing the immunity of the body and clearing away heat and toxic materials are matched with general medicinal materials with the effects of expelling wind-damp and activating meridians to stop pain, the synergistic effect of the drug effects is greatly enhanced, the treatment effect of the rheumatic arthritis is obviously improved, and an ideal treatment effect is achieved. Moreover, according to the clinical test, complications, dental ulcer and other symptoms caused by low immunity of the body can be effectively improved.

The invention discloses 3-heterocycle schiff base-5-fluorine-indole-2-ketone compounds represented by a general formula (I), pharmaceutical salts thereof, or solvent compounds thereof. R1, R2, R3, R4 and R5 are respectively independent unsubstituted C1-4 alkyl, unsubstituted C1-3 alkoxy, halogen, sulfamic, nitro, or hydrogen; or R1, R2, R3, R4 and R5 are respectively independent C1-4 alkyl substituted by 1 to 3 substituents selected from halogen, nitro, C1-3 alkyl, or C1-2 alkoxy; or R1, R2, R3, R4 and R5 are respectively independent C1-3 alkoxy substituted by 1 to 3 substituents selected from halogen, nitro, C1-3 alkyl, or C1-2 alkoxy. The halogen is fluorine, chlorine or bromine. X is S or NH. The invention also discloses a preparation method of the compounds, and an application of the compounds. The compounds provided by the invention assist in regulating the conduction of tyrosine kinase signals, and in inhibiting cacoethic cellular proliferation and blood vessel growth. The compounds provided by the invention provide substantial curative effects against diseases such as tumors, diabetes mellitus, dermatitis, and rheumatic arthritis.

The invention relates to a medicament for treating arthralgia and myalgia. The medicament is prepare from the components in parts by weight as follows: 1000 parts of nux vomica, 100 parts of radix clematidis, 100 parts of caulis sinomenii, 100 parts of garden balsam stem, 100 parts of lycopodium clavatum, 100 parts of berba aristolochiae mollissimae, 100 parts of monkshood, 100 parts of radix aconiti agrestis, 100 parts of the root of red-rooted salvia, 100 parts of angelica sinensis, 100 parts of rheum officinale, 100 parts of dragon's blood, 100 parts of semen momordicae, 100 parts of eucommia ulmoides, 100 parts of cinnamon, 100 parts of radix angelicae pubescentis, 100 parts of notopterygium root, 100 parts of asarum, 100 parts of radix achyranthis bidentatae, 100 parts of homalomena occulta, 100 parts of anisetree bark, 100 parts of radices sileris, 100 parts of caper, 100 parts of monkshood, 100 parts of ligusticum wallichii, 100 parts of Chinese polyphaga, 100 parts of scorpio, 100 parts of centipede, 100 parts of frankincense, 100 parts of myrrh, 100 parts of leech, 60 parts of camphor, 60 parts of borneol, 20 parts of musk and 300 parts of zaocys dhumnade. The medicament provided by the invention can be used for treating cervical spondylosis, brain swelling cervical pain, scapulohumeral periarthritis, scapula back pain, pelvospondylitis, thoracic vertebra pain, elbow joint pain, pain in waist and lower extremities, lumbar disc herniation, cervical and lumbar spinal stenosis, osteoproliferation, ischiadic nerve pain, knee-joint dropsy, synovitis, knee pain and rheumatic arthritis.