40 results about "Rheumatic Arthritis" patented technology

The invention provides a traditional Chinese medicine composition for treating rheumatic arthritis, a preparation and application, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following medicinal raw materials: 12-18 parts of sailong bone, 6-12 parts of radix aconiti lateralis preparata, 3-9 parts of radix aconiti preparata, 9-15 parts of cassia twig, 1-4 parts of asarum, 9-15 parts of radix clematidis, 20-40 parts of astragalus membranaceus, 3-9 parts of scorpio, 9-15 parts of earthworm, 9-15 parts of caulis sinomenii, 12-18 parts of bighead atractylodes rhizome, 12-18 parts of poria cocos, 9-15 parts of gentiana macrophylla, 12-18 parts of angelica sinensis, 20-40 parts of caulis spatholobi, 9-15 parts of rhizoma drynariae, 12-18 parts of radix paeoniae alba, 3-9 parts of honey-fried licorice root and 6-12 parts of rhizoma zingiberis. According to the traditional Chinese medicine composition for treating rheumatic arthritis, the medicine raw material composition of the traditional Chinese medicine composition for treating rheumatic arthritis is reasonably designed, four pathological links of cold, dampness, stasis and deficiency of rheumatic arthritis are covered through precise compatibility of monarch, minister, assistant and guide, and the traditional Chinese medicine composition has triple curative effects of anti-inflammatory analgesia, immunoregulation and bone protection.

The invention provides a preparation method and application of graphene pain-relieving health-care paste, and the method comprises the following steps: mixing carrageenan with water to obtain a carrageenan solution, and carrying out ionization degradation on the carrageenan solution to obtain a carrageenan oligosaccharide solution; the preparation method comprises the following steps: stirring graphene oxide and a carrageenan oligosaccharide solution, cleaning to obtain a mixed solution, adding sodium alginate into the mixed solution to prepare a gel precursor, and adding an anhydrous calcium chloride solution and effective components into the gel precursor to obtain the pain-relieving gel, and drying the gel to obtain the health-care paste. The health-care ointment has the effects of promoting blood circulation, activating collaterals and inhibiting inflammation, and is suitable for various chronic pains such as rheumatic arthritis and lumbar muscle degeneration and acute pains such as traumatic injury and muscle strain; the composition is also suitable for auxiliary relieving of postoperative pain, and has safety and long-term effect. Due to the thermal conductivity of the graphene oxide in the health-care cream, local skin blood circulation can be accelerated, the permeation efficiency of the herbal extract is improved, and the medicine effect of the effective components is improved.

According to the functional healthy plant blend oil and the application thereof disclosed by the invention, various edible oils are reasonably selected and matched, so that intake of different fatty acids can be met, the nutritional value is high, and the health-care effect of the functional healthy plant blend oil can be improved; the product has prevention and auxiliary improvement effects on part of diseases including high cholesterol, obesity, cancer, haemorrhoids, constipation, rheumatic arthritis and the like, for example, rich unsaturated fatty acid can achieve the effect of reducing cholesterol, and vitamin E contained in the product also has the effects of resisting oxidation and the like, so that damage of free radicals to cells can be reduced.

The application relates to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine containing Radix Sargentodoxae for treating rheumatic arthritis and a preparation method thereof. The traditional Chinese medicine contains the following components in parts of mass: 30-50 parts of Radix Sargentodoxae, 10-20 parts of Radix Cyathulae, 10-20 parts of Rhizoma Chuanxiong, 10-20 parts of Radix Paeoniae Alba, 5-10 parts of Fructus Lycii, and 5-10 parts of Radix Rehmanniae. The preparation method comprises the following steps: crushing the Radix Sargentodoxae, Radix Cyathulae, Rhizoma Chuanxiong, Radix Paeoniae Alba, Fructus Lycii and Radix Rehmanniae; extracting medicinal components of the above-mentioned medicinal materials; mixing the extract with phospholipids or polymers to form liposomes; the liposomes are pH-responsive nanoliposomes or temperature-responsive nanoliposomes; preparing the nanoliposomes through a film hydration method or a layer-by-layer self-assembly method; and obtaining the traditional Chinese medicine through filtration and drying. The pH-responsive and temperature-responsive nanoliposomes can precisely release the medicine to an inflammation area, ensure that the medicine is released only in a place where treatment is needed, and improve the treatment effect.

A preparation method of the wine comprises the following steps: 1) weighing the following raw materials in parts by weight: 18-22 parts of raw radix astragali, 13-17 parts of rhizoma drynariae, 13-17 parts of dog bone, 1-5 parts of semen strychni, 1 part of ginseng, 13-17 parts of herba epimedii, 13-17 parts of caulis spatholobi, 3-7 parts of gecko, 1 part of radix salviae miltiorrhizae, 3-7 parts of rhizoma corydalis, 1-5 parts of asarum heterotropoides, 1 part of gynostemma pentaphylla and 3-7 parts of chili; and 2) processing the raw materials into powder, placing the powder in a pottery clay jar, soaking the powder in 50-degree grain white spirit for more than half a year, performing high-temperature fermentation in summer, leaching the liquid medicine, and removing medicine residues to obtain the finished product of the fermented wine for rheumatic bone impediment. The traditional Chinese medicine has the advantages that the traditional Chinese medicine is reasonable in raw material design and convenient to prepare, has a good effect on treating various arthritis such as rheumatism, ankylosing spondylitis, rheumatic arthritis, lumbar disc herniation and hyperostosis, and has a very good popularization prospect and a very good medical economic value.

The invention relates to the technical field of medicine preparation, in particular to an exosome for preventing and / or treating rheumatic arthritis and a preparation method and application thereof. The exosome disclosed by the invention is prepared from the following components in parts by mass: 10-20 parts of onions, 20-30 parts of fresh ginger and 10-20 parts of fistular onion stalks. The exosome prepared from the components can reduce the inflammatory factor level in a mouse with rheumatoid arthritis, and does not affect the growth of the mouse. And after the exosome is prepared into a certain dosage form, the rheumatoid arthritis can be effectively treated. A basis is provided for the preparation of the plant exosome, and a basis is provided for the safe treatment of rheumatoid arthritis.

The invention provides a composition containing picocetinib hydrobromide and a preparation method thereof, the composition is a tablet, the active component picocetinib hydrobromide and a hydrophilic gel framework material (e.g., hydroxypropyl methylcellulose, polyoxyethylene resin or hydroxypropyl methyl cellulose acetate succinate) form a solid dispersion, and the solid dispersion is prepared into the composition containing the picocetinib hydrobromide and the hydrophilic gel framework material (e.g., hydroxypropyl methylcellulose, polyoxyethylene resin or hydroxypropyl methyl cellulose acetate succinate). The solubility of the medicine is improved, and stable release in vivo is realized; according to the present invention, with the addition of the pH value adjusting agent, the solubility of the picetinib hydrobromide can be maintained without limitation in the neutral pH region, the stability is good, and the stable release in the body is achieved so as to achieve the rheumatic arthritis treatment effect, improve the patient comfort and the treatment compliance, reduce the administration frequency and the medical cost, reduce the side effect, and provide the clinical application prospect. The whole preparation method is simple and suitable for industrial production.

The invention relates to a traditional Chinese medicine composition for treating rheumatic bone pain and application thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for treating rheumatic bone pain is prepared from the following raw materials: radix aconiti, radix aconiti agrestis, alpine yarrow herb, ardisia crenata, akebiaquinata, pawpaw, garden balsam stem, eucommia ulmoides, ligusticum chuanxiong hort, radix saposhnikoviae, radix stephaniae tetrandrae, caulis spatholobi, lycopodium clavatum, radix clematidis and radix bupleuri. The traditional Chinese medicine composition disclosed by the invention has the treatment effects of clearing and activating the channels and collaterals, dispelling wind and eliminating dampness, and warming channels and relieving pain, is mainly used for treating gout, waist and knee crymodynia, rheumatic arthritis, numbness of limbs and the like, and has relatively high effective rate.

The invention discloses a traditional Chinese medicine liniment for treating lumbocrural pain and hyperostosis and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine liniment is prepared from notopterygium root, radix angelicae pubescentis, angelica sinensis, fructus lycii, flos carthami, clove and radix saposhnikoviae according to a specific weight part ratio through soaking in wine and extracting, and auxiliary materials such as glycerol can also be added according to requirements. The traditional Chinese medicine composition is scientific in formula, integrates functions of promoting blood circulation to remove blood stasis, dispelling wind and eliminating dampness and tonifying liver and kidney, and is high in permeability, quick in effect, good in stability and small in side effect. The preparation method adopts a percolation method for extraction, so that effective components can be reserved to the greatest extent, and stable quality of liquid medicine is ensured. The traditional Chinese medicine can be used for effectively treating arthralgia such as lumbocrural pain, hyperostosis, lumbar disc herniation, rheumatic arthritis and the like, and has good clinical application value.

The invention relates to a preparation method of a traditional Chinese medicine transdermal patch for treating rheumatic arthritis, which can effectively solve the problems of long-acting effect, stability, good effect and medication for treating rheumatic arthritis in the preparation of a new traditional Chinese medicine transdermal patch, and is prepared from a traditional Chinese medicine compound, a matrix and a penetration enhancer, the traditional Chinese medicine compound and the matrix are prepared from radix angelicae pubescentis, radix saposhnikoviae, radix gentianae macrophyllae, ligusticum wallichii, angelica sinensis, garden balsam stem, radix paeoniae rubra, notopterygium root, hydrogel and glycerol; the penetration enhancer is composed of menthol, borneol, artificial musk and the balance of deionized water, the raw materials are extracted firstly, then nano particles are prepared, a first mixture is prepared, a second mixture is prepared, the pH value is adjusted, coating is conducted, and the traditional Chinese medicine transdermal patch for treating rheumatic arthritis is obtained. The patch is scientific and reasonable in components, convenient to paste, good in effect, capable of stably releasing effective components of the medicine for a long time, high in targeting property, capable of continuously relieving the symptoms of the rheumatic arthritis and ensuring the curative effect, is a great innovation in the aspect of medicines for treating the rheumatic arthritis, and is remarkable in economic and social benefits.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for promoting menstruation and removing stasis, an external preparation and application. The traditional Chinese medicine composition consists of teasel root, lycopodium clavatum, frankincense, myrrh, divaricate saposhnikovia root, pseudo-ginseng, turmeric, cinnamon, litsea cubeba, ligusticum wallichii, gardenia, mulberry twig, lotus leaf, rheum officinale, dragon's blood, salvia miltiorrhiza, safflower, folium artemisiae argyi and mint. The traditional Chinese medicine composition for promoting menstruation and removing stasis is reasonable in compatibility, has an excellent treatment effect on wind-cold-dampness arthralgia, and is suitable for patients with symptoms such as scapulohumeral periarthritis, cervical spondylosis, lumbocrural pain, muscle and joint pain, rheumatic arthritis, rheumatoid arthritis and gouty arthritis. A specific natural penetrant composition and a traditional Chinese medicine composition are selected to be prepared into an external dosage form, the medicine can be promoted to enter a target organ or tissue through a physiological barrier, the medicine can directly act on a focus, the effect is quick, the efficacy is lasting, the use is convenient, the patient compliance is good, no toxic or side effect exists, and a new choice of an external transdermal agent is provided for clinical treatment of chronic pain.

The invention provides a nursing traditional Chinese medicine external preparation for relieving rheumatic arthralgia, and relates to the technical field of traditional Chinese medicines. On the basis of the theory of traditional Chinese medicine, a traditional Chinese medicine formula composed of pine nodular branch, ormosia henryi, shinyleaf pricklyash root, peach twig, lance asiabell root, arachnoid cyanotis root, dentiferous dendropanax root, rhizoma curculiginis, winter jasmine, wintergreen, folium cortex eucommiae, semen sesami nigrum, fructus viticis, semen allii tuberosi, rhizoma smilacis glabrae and herba menthae is prepared and used for externally treating rheumatoid arthritis in traditional Chinese medicine. The traditional Chinese medicine has the effects of promoting blood circulation to remove meridian obstruction, relieving swelling and pain, dispelling wind and eliminating dampness, tonifying liver and kidney, strengthening muscles and bones, clearing heat and promoting diuresis. The traditional Chinese medicine external preparation disclosed by the invention has excellent anti-inflammatory, detumescence and analgesic effects, has excellent performance in the aspects of improving clinical symptoms such as joint swelling, pain and pressing pain of a patient and improving sleep and joint functions, and takes effect quickly. The traditional Chinese medicine external preparation provides effective nursing means and measures for relieving or relieving rheumatic arthralgia.

The invention discloses a finger function exercise device for scapulohumeral periarthritis and rheumatic arthritis, which is characterized in that a patient stretches fingers into fingerstalls and then controls a driving motor to work, and a rotating output shaft drives cam-shaped take-up reels to rotate, drives spaced take-up reels to synchronously take up or pay off and drives spaced fingertips; if the index finger and the ring finger or the middle finger and the little finger are synchronously driven to synchronously climb or descend, fingertips are assisted to climb a wall, blood circulation of the fingers is promoted, flexibility of finger joints is enhanced, and therefore pain is relieved, and the joint function is improved; in the exercising process, a toothed ring is driven to rotate by rotating a fluted disc, a cylinder is pushed to ascend and descend through a thread of the toothed ring, the distance between a first take-up reel and a second take-up reel is adjusted, the climbing distance between human bodies driven by the cam-shaped take-up reels is adjusted, and it is ensured that the device adapts to different patients and patients in different rehabilitation stages.

The invention relates to the technical field of body conditioning medicines, in particular to a medicine formula for conditioning a body movement system and a preparation process of the medicine formula. Comprising a main material and an auxiliary material, the main material is prepared by mixing the following raw materials by weight: 15-24 g of white peony root, 2-8 g of licorice, 4-12 g of achyranthes bidentata, 2-8 g of safflower, 5-15 g of dogwood, 5-12 g of prepared rehmannia root, 5-15 g of eucommia ulmoides, 2-10 g of fennel, 4-15 g of fructus aurantii and 15-25 g of folium artemisiae argyi; the auxiliary material is prepared by mixing the following raw materials by weight: 3-7 g of coix seed powder, 1-3 g of small red bean powder, 1-3 g of pea powder, 1-3 g of buckwheat powder, 1-3 g of Chinese yam powder, 1-3 g of soybean powder, 1-3 g of hyacinth bean powder, 8-12 g of Chinese wolfberry and 8-12 g of red dates. The formula has the beneficial effects that the formula is scientifically prepared, the nutrition is balanced, and diseases such as cervical spondylosis, chest, neck, waist and leg pains (chest, neck, waist and legs), protrusion of intervertebral disc, ankylosing spondylitis, arthritis, tennis elbow, rheumatic arthritis, femoral head necrosis, numbness of limbs, arthralgia, synovitis, knee effusion, meniscus injury, hyperostosis, sciatica and varicosity can be conditioned.

The invention discloses a traditional Chinese medicine composition for treating joint diseases and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 25 to 45 parts of radix angelicae pubescentis, 25 to 45 parts of cortex phellodendri, 20 to 40 parts of rhizoma smilacis glabrae, 20 to 40 parts of rhizoma dioscoreae septemlobae, 20 to 40 parts of rhizoma chuanxiong, 20 to 40 parts of semen coicis, 20 to 40 parts of radix cyathulae, 20 to 40 parts of herba artemisiae scopariae, 20 to 40 parts of herba lycopodii, 20 to 40 parts of rhizoma polygoni cuspidati, 20 to 40 parts of radix dipsaci, 20 to 40 parts of rhizoma atractylodis, 20 to 40 parts of semen plantaginis and 10 to 25 parts of liquorice root. The traditional Chinese medicine composition has a relatively good treatment effect on gout, rheumatic arthritis and rheumatoid arthritis, can treat both symptoms and root causes, and is relatively small in side effect and relatively small in harm to a human body.

The invention relates to a tendon-stretching pain-relieving plaster, which is prepared by soaking a plurality of Chinese herbal medicines such as Aristolochia delavayi, Chinese actinidia root, herba aristolochiae, kadsura pepper stem, pseudo-ginseng and yellow lead in clear sesame oil and decocting into the plaster for external use, and the tendon-stretching pain-relieving plaster is mainly prepared from traditional Chinese medicines, has the effects of clearing away heat and toxic materials, diminishing inflammation and relieving pain, is low in cost, has the effects of dredging tendons and activating blood, dispelling wind and eliminating dampness, and stretching tendons and relieving pain, and is suitable for rheumatoid arthritis. The traditional Chinese medicine composition is free of side effects and good in curing effect, and can be used for treating osteoarthropathy such as rheumatic arthritis, osteoproliferation and traumatic injury.

The invention discloses a medicinal moxa composition for preventing and treating bronchitis and rheumatic arthritis. The medicinal moxa composition comprises platycodon grandiflorum, ginseng, divaricate saposhnikovia root, schizonepeta and moxa. A plurality of volatile active ingredients of the medicinal moxa composition act on a plurality of key targets related to common diseases of bronchitis and rheumatic arthritis through external moxibustion. Composite volatile components released when a medicinal moxa stick prepared from the medicinal moxa composition burns can form a synergistic effect, the traditional Chinese medicine theory of treating an internal illness by external treatment is realized through a lung channel and meridian conduction mechanism, and a new thought and theoretical basis are provided for health care of bronchitis combined with rheumatic arthritis.

The invention relates to the technical field of Chinese patent medicine capsules, in particular to a Chinese patent medicine capsule for muscles and bones and a preparation method of the Chinese patent medicine capsule. The traditional Chinese medicine is characterized by being prepared from the following raw medicinal materials in parts by weight: 10 parts of honey-fried semen strychni, 12 parts of radix clematidis, 12 parts of fructus broussonetiae, 12 parts of eucommia ulmoides, 12 parts of radix achyranthis bidentatae, 12 parts of herba taxilli, 12 parts of scorpio, 10 parts of rhizoma atractylodis, 10 parts of frankincense, 10 parts of myrrh, 15 parts of black ants, 10 parts of radix gentianae macrophyllae and 6 parts of liquorice. On the basis of addition and reduction of a classic prescription, the compound loganin hard-energy-removing powder has the advantages that the effects of the medicinal materials are synergistic through scientific compatibility, the comprehensive treatment effects of activating meridians to stop pain, tonifying liver and kidney and promoting blood circulation to remove blood stasis are realized aiming at the etiology and pathogenesis of muscle and bone diseases, and the symptoms such as lumbar disc herniation, hyperostosis, apoplexy and rheumatic arthritis can be effectively relieved.

The invention provides a foot bath bag composition and a preparation method thereof, and relates to the field of traditional Chinese medicinal materials. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 to 40 parts of fructus forsythiae, 35 to 45 parts of folium artemisiae argyi, 5 to 15 parts of flos carthami, 15 to 25 parts of caulis spatholobi, 25 to 35 parts of ramulus mori, 15 to 25 parts of herba leonuri, 15 to 25 parts of radix clematidis, 5 to 15 parts of fructus chaenomelis, 15 to 25 parts of rhizoma corydalis, 5 to 15 parts of caulis sargentodoxae, 5 to 15 parts of herba lycopodii, 15 to 25 parts of rhizoma chuanxiong and 5 to 15 parts of liquorice root. According to the traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared by taking fructus forsythiae and folium artemisiae argyi as main components, extracting effective components through boiling, and absorbing the effective components in the composition through a foot bath mode, a sole Yongquan acupoint and skin, so that the traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, diminishing inflammation and relieving pain, can effectively relieve pain caused by gonitis, femoral head necrosis and rheumatic arthritis, and is good in treatment effect.

The invention relates to the field of medicines, and particularly discloses an anti-inflammatory and analgesic external emulsion as well as a preparation method and application thereof. The external emulsion is prepared from nine traditional Chinese medicines including radix clematidis, phryma leptostachya, radix angelicae pubescentis, scandent schefflera stem and leaf, corydalis tuber, ligusticum wallichii, angelica sinensis, pseudo-ginseng and borneol according to a specific ratio, volatile oil is extracted through steam distillation, then ethanol reflux extraction is combined, and finally an emulsifier and a wetting agent are added. The preparation method realizes full-effect utilization of volatile oil and water-soluble and alcohol-soluble components in the medicinal materials. The external emulsion has dual effects of rapid analgesia and long-acting anti-inflammation, and pharmacodynamic experiments show that the anti-inflammation and analgesia effects of the external emulsion are obviously superior to those of a same-prescription spray without volatile oil. Meanwhile, the medicament is good in stability, free of skin irritation and suitable for treating various pains and inflammations such as rheumatic arthritis, soft tissue contusion and cold-dampness dysmenorrhea.

Disclosed in the present invention are a polymorph of a benzo[c]chroman compound, a preparation method therefor and use thereof. The present invention particularly provides a polymorph of a compound represented by formula I, a preparation method therefor and use thereof. The compound represented by formula I is used as a cathepsin C inhibitor, and a crystalline form of the compound and a pharmaceutical composition comprising the crystalline form can be used for treating asthma, obstructive pulmonary diseases, bronchiectasis, ANCA-related vasculitis, psoriasis, α1-antitrypsin deficiency, lupus nephritis, diabetes, inflammatory bowel diseases, rheumatic arthritis, rhinosinusitis, hidradenitis suppurativa or cancers.

The invention discloses a traditional Chinese medicine composition for treating rheumatoid arthritis osteolysis and application thereof. The traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 6 to 12 parts of rhizoma curculiginis (roasted with wine), 9 to 15 parts of herba epimedii, 6 to 12 parts of radix clematidis, 10 to 15 parts of radix angelicae sinensis, 9 to 15 parts of radix achyranthis bidentatae, 6 to 15 parts of fructus lycii and 2 to 10 parts of liquorice root. The traditional Chinese medicine composition has the effects of synergistically warming and invigorating kidney yang and strengthening muscles and bones, can reduce expression of inflammatory factors TNF-alpha, IL-6 and IL-1beta in plasma of mice with collagen-induced arthritis (CIA), reduces inflammatory cell infiltration in synovial tissues, remarkably reduces the number of osteoclasts and erosion progress, and is good in safety.

The invention discloses a traditional Chinese medicine composition for treating arthralgia and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from peganum harmala, angelica sinensis, fructus lycii, liquorice, radix angelicae pubescentis, corydalis tuber and cornu cervi according to a specific weight part ratio, and is prepared into ointment through a specific extraction process. The traditional Chinese medicine composition follows the synergistic treatment principle of promoting blood circulation to remove blood stasis, dispelling wind, eliminating dampness and tonifying the liver and kidney, has a remarkable treatment effect on arthralgia such as lumbocrural pain, hyperostosis, lumbar disc herniation and rheumatic arthritis, and is small in skin irritation, low in allergy occurrence rate and free of toxic and side effects. The problems that an existing external plaster is single in curative effect, poor in durability, large in irritation and capable of treating the symptoms but not the root causes are solved, and wide clinical application prospects are achieved.

The present invention relates to a polypeptide AAMP and its application in analgesia and anti - inflammation. The amino acid sequence of the polypeptide AAMP is shown as SEQ ID NO.1. This polypeptide AAMP has good anti - inflammatory and analgesic activities; it can relieve the pain reaction caused by PNI and has good therapeutic effects on diseases such as fibromyalgia syndrome, rheumatoid arthritis, rheumatic arthritis, ankylosing spondylitis, and nerve injury.

The invention discloses a compound with BTK inhibitory activity and a preparation method and application thereof. The compound is shown as a formula I. The compound can effectively inhibit Bruton's tyrosine kinase, and can be applied to targeted drugs for treating diseases related to BTK signal channels, such as chronic lymphocytic leukemia, multiple myeloma, mantle cell lymphoma, systemic lupus erythematosus, rheumatic arthritis, chronic graft versus host disease and the like.

The invention relates to the technical field of medicines, and particularly discloses a non-steroidal anti-inflammatory drug choline salt and a preparation method and application thereof. The salt is formed by combining a non-steroidal anti-inflammatory drug and choline; the non-steroidal anti-inflammatory drug in the salt is a component A, a component B or a component C; the component A is S-flurbiprofen; the component B is naproxen; the component C is diclofenac; the molar ratio of S-flurbiprofen to choline is 1: 5-5: 1, the molar ratio of naproxen to choline is 1: 5-5: 1, and the molar ratio of diclofenac to choline is 1: 5-5: 1. According to the non-steroidal anti-inflammatory drug-choline salt successfully prepared by adopting a melting cooling method, the solubility of the non-steroidal anti-inflammatory drug in water is greatly improved, and the non-steroidal anti-inflammatory drug is stable in structure and is not decomposed at normal temperature. According to the medicine salt, the pharmacological activity of the non-steroidal anti-inflammatory medicine is kept, the analgesic activity is improved, and pains such as headache, limb pains, dysmenorrhea, rheumatic arthritis pains and osteoarthritis pains can be rapidly relieved.

The invention relates to a plant active ingredient for inhibiting synovial cell inflammatory response and a method for treating rheumatoid arthritis by using the plant active ingredient. The active ingredient is selected from one or more of kaempferide, quercetin, luteolin and alpinetin sesquiterpenoids, and is derived from medicinal plants such as alpinia pumila, glabrous sarcandra herb or herba epimedii and the like. The high-purity flavonoid monomer is obtained through a specific extraction process including ethanol reflux extraction, ethyl acetate extraction, macroporous resin enrichment and silica gel column chromatography separation. The composition can remarkably inhibit activation of NF-kappa B signal channels in synovial cells in vitro, reduce expression levels of inflammatory factors TNF-alpha, IL-1beta and IL-6 and reduce generation of reactive oxygen species (ROS) and nitric oxide (NO), and has a good anti-rheumatic arthritis effect. The active component can be prepared into various dosage forms such as capsules, granules, injections and the like, and is suitable for treatment or adjuvant treatment of rheumatic arthritis and related diseases thereof.

To provide a cyclic peptide that inhibits TNFR1 activity, and a pharmaceutical composition.SOLUTION: Provided is a compound of formula (I) or its pharmacologically acceptable salt, wherein (I) is capable of inhibiting TNFR1, and is useful as a therapeutic drug for IBD and rheumatic arthritis for example.SELECTED DRAWING: None

The invention provides traditional Chinese medicine bone liquid for inhibiting rheumatism and strengthening bones and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The invention provides traditional Chinese medicine bone liquid for inhibiting rheumatism and strengthening bones. The traditional Chinese medicine bone liquid is prepared from radix angelicae pubescentis, radix clematidis, eucommia ulmoides, rhizoma drynariae, cassia twigs, caulis spatholobi and liquorice. The traditional Chinese medicine bone liquid takes radix angelicae pubescentis and radix clematidis as monarch drugs and has the effects of dispelling wind, eliminating dampness and activating meridians to stop pain; ministerial drugs are eucommia ulmoides and rhizoma drynariae which can tonify liver and kidney and strengthen muscles and bones; cassia twig and suberect spatholobus stem are used as adjuvant drugs for warming meridians and dredging collaterals, and And the guide medicine is liquorice, harmonizes the medicines, and relieves spasm and pain. The traditional Chinese medicine bone liquid disclosed by the invention has both effects of expelling wind-damp and tonifying liver and kidney, not only can dispel wind-damp pathogenic qi, but also can strengthen muscles and bones, is suitable for diseases such as rheumatic arthritis and osteoporosis, and has relatively good comprehensive effects of resisting inflammation, easing pain and promoting bone repair. Different extraction methods are selected according to the characteristics of all the traditional Chinese medicine raw materials, and the effect of treating the rheumatism diseases is enhanced.

The invention relates to the technical field of biological medicines, and particularly discloses a wasp venom polypeptide extract as well as a preparation method and application thereof. The method comprises the following steps: by taking wasps as a raw material and an ethanol water solution as an extraction solvent, soaking the wasps for a preset time, centrifuging, taking supernate, filtering to remove impurities, and freeze-drying filtrate to obtain wasp venom crude extract powder; ultrasonically dissolving with water, and filtering with an organic filter membrane to obtain a sample solution of the vespid venom crude extract; and then carrying out separation and purification on a reverse chromatographic column with phenylsilane bonded silica gel as a filler, collecting an eluent, and carrying out freeze drying to obtain the wasp venom polypeptide extract. The wasp venom polypeptide extract provided by the invention can inhibit perception, transmission and amplification of pain signals by regulating and controlling various ion channels such as TRPV1, Nav1.8 and Cav2.2, can quickly relieve pain, and can be used for treating chronic pain such as sciatica, rheumatic arthritis, musculoskeletal pain, neuropathic pain and the like.