86 results about "Joint swelling" patented technology

The invention belongs to the technical field of biological medicines, and relates to a bionic integrated nano enzyme for effectively relieving gouty arthritis and inhibiting recurrence. The biomimetic integrated nano-enzyme is composed of a platinum nano-enzyme, hollow Prussian blue and a macrophage cell membrane. The bionic integrated nano enzyme can quickly and effectively relieve joint swelling caused by gouty arthritis and inhibit repeated recurrence of the gouty arthritis. The hollow Prussian blue loaded with the platinum nano-enzyme and a bionic preparation coated with a macrophage membrane are further prepared, the capabilities of catalyzing uric acid decomposition and removing active oxygen of the platinum nano-enzyme and the effects of targeting in vivo inflammation and rapidly relieving gout can be remarkably improved, and recurrence of the gout is inhibited. According to the invention, multi-strategy and multi-means treatment of gouty arthritis is facilitated, and the problems of rapid onset and easy recurrence of gouty arthritis are solved.

The invention belongs to the field of biological medicines, and particularly relates to application of loganic acid in preparation of a medicine for treating arthritis. Specifically, through experimental research of a collagen-induced arthritis mouse model, the loganin acid is found to be capable of remarkably relieving arthritis symptoms, relieving joint swelling, synovitis and cartilage injury in a dose-dependent manner, and reducing the levels of proinflammatory factors TNF-alpha and IL-6 in plasma. By further combining 16S rRNA sequencing analysis, the loganic acid can remarkably regulate the intestinal microbiota structure of arthritis mice, increase the abundance of Lactobacillus murinus in the intestinal tract and promote the generation of tryptophan metabolite indole-3-acetic acid, so that the effect of resisting rheumatoid arthritis is achieved through an intestinal flora dependent mechanism. Therefore, the invention provides a new application of loganin acid in preparation of a medicine for treating arthritis, and the compound has further research and application values as a potential small molecule medicine.

The invention discloses a preparation method and application of a medicinal and edible traditional Chinese medicine compound with an effect of treating uric acid diseases. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 to 25 parts of semen plantaginis, 15 to 25 parts of pawpaw, 5 to 15 parts of rhizoma smilacis glabrae, 5 to 15 parts of herba portulacae, 1 to 11 parts of radix glycyrrhizae preparata, 5 to 15 parts of folium mori, 5 to 15 parts of folium perillae, 1 to 11 parts of semen pruni, 5 to 15 parts of rhizoma polygonati, 1 to 11 parts of black dates and 1 to 9 parts of mulberries. The traditional Chinese medicine compound is composed of medicinal and edible raw materials, has stable efficacy of reducing uric acid and relieving uric acid liver and kidney injury, renal fibrosis and gouty arthritis, can relieve arthrocele caused by gout, reduces the level of joint inflammatory factors and the like, and takes effect quickly. The traditional Chinese medicine composition can be used for treating hyperuricemia, uric acid nephropathy, gouty arthritis and hyperuricemia accompanying symptoms.

The invention belongs to the technical field of medical equipment, and relates to an orthopedic emergency treatment splint fixing device, which comprises four arc-shaped splints, two clamping plates, four groups of clamping strips and two auxiliary plates, each first distance adjusting mechanism is used for adjusting the distance between the two connecting strips which are oppositely arranged so as to adapt to increase and decrease of swelling at different positions of the upper arm and the front arm; and the second distance adjusting mechanism is used for adjusting the distance between the two auxiliary discs so as to adapt to increase and decrease of elbow joint swelling. The distance between the two oppositely-arranged connecting strips can be adjusted respectively, the two oppositely-arranged clamping strips can adapt to increase and decrease of swelling of different positions of the upper arm and the forearm of a patient through rotating connection of the two adjacent connecting strips, meanwhile, the distance between the two auxiliary discs is adjusted, increase and decrease of elbow joint swelling are adapted, and the patient can feel more comfortable. Blood circulation disorder, fracture broken end displacement and the like of the affected limb caused by too tight or too loose clamping of the affected limb are avoided, and the pain of a patient is relieved.

The present invention relates to a Chinese medicine composition for preventing and / or treating refractory gout, wherein the Chinese medicine raw materials of the Chinese medicine composition are composed of the following ingredients: raw astragalus, leech, Poria, raw white atractylodes, chuanxiong, zedoaria, atractylodes, raw coix seeds, smilax, radix polygoni multiflori, white peony root, chuanxiong, and raw liquorice. The present invention also provides a preparation method of the Chinese medicine composition. The Chinese medicine composition of the present invention is used to prevent and / or treat (1) joint swelling and pain, (2) subcutaneous nodules or dark purple skin, (3) recurrent attacks, symptoms that do not heal over time, or at least one of the following three symptoms caused by refractory gout: (1) using a sufficient amount of conventional uric acid-lowering drugs alone or in combination for a sufficient course of treatment, the blood uric acid level is still ≥360 μmol / L; (2) receiving standardized treatment, gout still attacks ≥2 times / year; (3) the presence of multiple and (or) progressive tophi. The Chinese medicine composition of the present invention has significant therapeutic effect on preventing and / or treating refractory gout, has reasonable formula, safe and reliable therapeutic effect and small side effects.

The invention discloses a traditional Chinese medicine liniment for treating rheumatoid arthritis and a preparation process thereof, the traditional Chinese medicine liniment is composed of a wind-dispelling and pain-relieving liquid medicine and auxiliary materials, the wind-dispelling and pain-relieving liquid medicine contains eight traditional Chinese medicines of thorny elaeagnus root, erythrina bark, kadsura longepedunculata root, waxberry root, ardisia crenata, rose mallow root, glabrous sarcandra herb and wikstroemia canescens root, and is prepared by ultrasonic extraction; the auxiliary materials comprise polyvinyl alcohol, a chitosan-acetic acid solution, glycerol, azone, methylparaben, vanillyl butyl ether and ethanol. The liniment is short in film forming time and good in stability, has excellent transdermal absorption performance and antioxidant activity, can remarkably relieve joint swelling of RA model mice, improve the pain threshold value, improve joint pathological injuries, achieve local precise long-acting administration, reduce side effects of the whole body and improve patient compliance, is suitable for clinical treatment of RA, and has a wide application prospect. The problems that an existing rheumatoid arthritis treatment medicine is large in side effect, and a traditional Chinese medicine preparation is short in efficacy duration and inconvenient to use are solved.

The invention belongs to the field of biological medicine, and discloses a chicoric acid (CA)-loaded tetrahedral framework nucleic acid (tFNA) nano preparation for treating acute gouty arthritis. According to the preparation, tFNA formed by self-assembly is taken as a carrier, and a natural active ingredient CA is loaded to form a CA-tFNA compound. The compound overcomes the defects that CA is poor in water solubility and low in bioavailability, and existing drugs are weak in targeting and large in side effect. Through the targeted delivery and synergistic effect of tFNA, the preparation can be effectively enriched in inflammatory joints, significantly inhibit NF-kappa B signal pathways, and down-regulate the expression of key proinflammatory factors such as TNF-alpha and IL-1beta, so that joint swelling and synovial tissue damage are relieved, and repair is promoted. Experiments show that the traditional Chinese medicine composition is remarkable in curative effect and good in safety, and a novel efficient treatment strategy is provided for acute gouty arthritis.

The invention discloses external traditional Chinese medicine compound gel for treating joint swelling and pain and a preparation process thereof, and belongs to the field of traditional Chinese medicines. The invention discloses external traditional Chinese medicine compound gel for treating joint swelling and pain. The external traditional Chinese medicine compound gel is prepared from the following raw materials: 10-20 parts of radix aconiti preparata, 10-20 parts of radix aconiti kusnezoffii preparata, 10-20 parts of zaocys dhumnade, 10-20 parts of fructus mume and 20-40 parts of rhizoma corydalis. The five traditional Chinese medicines in the weight ratio are subjected to water extraction and prepared according to a gel dosage form to obtain the gel of the medicine, the gel is externally applied to an affected part, and the gel has the effects of treating rheumatoid arthritis, rheumatic arthritis, osteoarthritis and other arthritis with cold-dampness stasis collateral syndromes such as joint swelling and pain, unfavorable flexion and extension, intolerance of cold and cold limbs, dysfunction of activity and the like. The medicine has the curative effects of dispelling cold and dampness, clearing and activating the channels and collaterals and relieving swelling and pain, and is good in safety.

The present invention discloses the use of a benzenesulfonamide compound in the preparation of a medicament for preventing and / or treating osteoarthritis. This invention proposes for the first time the use of a benzenesulfonamide compound in a medicament for preventing and / or treating osteoarthritis. Experiments have shown that administration of a benzenesulfonamide compound can significantly improve joint swelling and wear in osteoarthritis mice; at the same time, the benzenesulfonamide compound can significantly reduce cartilage damage and inhibit the progression of joint fibrosis in osteoarthritis mice; in addition, the benzenesulfonamide compound significantly inhibits the expression of inflammation-related markers in the serum of osteoarthritis model mice. The above experiments demonstrate that benzenesulfonamide compounds can improve osteoarthritis and are of great significance for the future development of drugs and the prevention and treatment of such diseases.

The invention provides a traditional Chinese medicine preparation for dispelling wind and eliminating dampness and application, and relates to the technical field of traditional Chinese medicine pharmacy, the traditional Chinese medicine preparation is composed of honeysuckle stem, spatholobus stem, silkworm excrement, gentian, safflower, peach kernel, ash bark, arisaema cum bile, medicated leaven and honeycomb; the traditional Chinese medicine preparation can remarkably reduce the ankle joint swelling degree of an acute gouty arthritis model rat, reduce the expression level of inflammatory factors such as TNF-alpha, IL-1beta and IL-6 in serum and reduce the content of uric acid, creatinine and XOD in the serum, so that the effects of resisting inflammation, easing pain and reducing blood uric acid are achieved; clinical test results show that the traditional Chinese medicine preparation can relieve the pain degree of a patient, reduce the levels of inflammation-related factors TNF-alpha and IL-1beta in knee joint synovial fluid of the patient, reduce inflammation indexes WBC, ESR and CRP in serum, relieve the inflammatory reaction of the body of the patient, reduce the occurrence rate of adverse reactions, and improve the curative effect of the patient. A novel traditional Chinese medicine preparation with high safety and good curative effect is provided for treatment of acute gout.

The invention relates to the technical field of arthritis treatment jackets, in particular to a rheumatoid arthritis hand auxiliary treatment jacket which comprises a glove, the glove is divided into a palm face and a hand back face, a wrist is constructed on one side of the glove, and a pressure control piece is arranged on the glove; the pressure control part comprises a cavity constructed in the glove, the cavity divides the glove into an outer layer and an inner layer, the outer layer is made of a heat preservation material, and the inner layer is made of an elastic material; a water injection valve communicated with the cavity is arranged on the glove, and liquid is allowed to enter and exit from the cavity by opening and closing the water injection valve; the three pressure control modes of wrist air bag pressurization and hand movement dynamic pressurization are adjusted through the liquid medicine injection amount, a patient can autonomously select pressure gears according to the illness state and the scene, low-gear mild pressurization is conducted during daily office mild movement, slight aching pain is relieved, operation is not affected, middle-gear moderate pressurization is conducted when joint swelling pain is aggravated, and therefore the patient can feel more comfortable. During night rest, middle and low gears can be flexibly selected, and morning stiffness is relieved while constraint feeling is avoided.

The invention discloses an application of mPGES-2 as a target spot in developing, screening or preparing a medicine for preventing and / or treating osteoarthritis. The invention proposes that mPGES-2 is a drug target of osteoarthritis for the first time. Experiments show that mPGES-2 knockout can significantly relieve joint swelling, protect cartilage wear, improve bone metabolism abnormality and inhibit release of inflammatory factors; meanwhile, the mPGES-2 has a remarkable effect on improving osteoarthritis, can be used as a target spot for treating osteoarthritis, and is of great significance to development, prevention and treatment of drugs for the diseases in the future.

The application belongs to the technical field of natural medicinal chemistry, and relates to the use of a dibenzazepine compound in mistletoe in the preparation of a medicine for preventing or treating rheumatoid arthritis. In vitro experiments show that the use of the compound alone has different degrees of inhibitory effect on the proliferation of primary rat synovial fibroblasts, and the inhibitory effect is synergistically enhanced when the compound 2 is used in combination with mistletoe lectin. Animal experiments show that the use of the compound alone has different degrees of inhibitory effect on the joint swelling of a collagen-induced rat arthritis model, and the inhibitory effect of some dibenzazepine compounds is close to or better than that of a positive medicine, and the inhibitory effect of the compound 2 used in combination with mistletoe lectin on the joint swelling of the right hind foot of a rat is synergistically enhanced. In summary, the dibenzazepine compound in mistletoe has the potential to be developed into a medicine for treating rheumatoid arthritis, can provide more choices for clinical treatment, and has important social benefits and economic value.

The invention belongs to the technical field of biological medicines and microorganisms, and particularly relates to a parabacteroides couchneri MRD02 and application thereof, the parabacteroides couchneri is Parabacteroides couchneri MRD02, the preservation number is GDMCC No.64793, and the preservation unit is Guangdong Province Microbial Culture Collection Center. The invention further discloses a preparation method of the parabacteroides couchneri MRD02 and application of the parabacteroides couchneri MRD02. The Parabacteroides goldsteinii MRD02 disclosed by the invention can be used for remarkably inhibiting joint swelling and systemic inflammation of rheumatoid arthritis of mice, and the inhibiting effect of the Parabacteroides goldsteinii MRD02 is remarkably superior to that of other parabacteroides strains; meanwhile, due to the fact that the usage amount of the Parabacteroides goldsteinii MRD02 is small, gastrointestinal reactions of nausea, vomiting or diarrhea are not found in the Parabacteroides goldsteinii MRD02, and anaphylactic reactions are also not found in the Parabacteroides goldsteinii MRD02.

The invention belongs to the technical field of medicines. The invention relates to a plaster, in particular to a plaster containing anilinoprofen and a composition. The invention provides an externally applied medicine containing anilinoprofen or a composition containing anilinoprofen and iguratimod. Pharmacodynamic studies show that the aniline-ibuprofen single-prescription plaster can treat osteoarthritis (OA) and rheumatoid arthritis (RA), can effectively inhibit arthrocele and volume increase, remarkably reduces the level of proinflammatory factors, and improves the pathological score of joint tissue. After the anilinoprofen and the iguratimod are combined for use, the curative effect is further enhanced, multiple indexes are obviously superior to those of a single drug group, and an obvious synergistic interaction effect is shown. The iguratimod and anilinoprofen compound preparation disclosed by the invention is developed in an external form such as a gel plaster for the first time, an external compound system of anilinoprofen and iguratimod is innovatively constructed, a safe, effective and convenient novel local treatment choice is provided for OA / RA patients, especially people with oral taboo or needing long-term treatment, and the iguratimod and anilinoprofen compound preparation has good clinical transformation potential and application value.

The invention provides a targeted pathological B cell temperature-sensitive hydrogel bone repair material as well as a preparation method and application thereof, and belongs to the technical field of bone repair biomaterials.The targeted pathological B cell bone repair material HPCH / B3-Cu-Zn-MBGs temperature-sensitive hydrogel provided by the invention is prepared by mixing hydroxypropyl chitin HPCH and B3-Cu-Zn-MBGs, the mass ratio of the hydroxypropyl chitin HPCH to the B3-Cu-Zn-MBGs is (5: 1) to (1: 1); according to the HPCH / B3-Cu-Zn-MBGs provided by the invention, the joint swelling is remarkably improved through the comprehensive action of the HPCH / B3-Cu-Zn-MBGs, the arthritis index is reduced, and the clinical symptoms of RA (rheumatoid arthritis) are reduced.

A traditional Chinese medicine composition for treating joint swelling and pain and a preparation method thereof belong to the technical field of joint swelling and pain treatment, and the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials by weight: 15g of herba siegesbeckiae, 15g of climbing entada, 10g of berba aristolochiae mollissimae, 10g of spiderflower seed, 15g of dog tibia, 10g of cucumber seed, 10g of bamboo leaf, 15g of radix sophorae flavescentis, 15g of earthworm, 15g of turmeric, 6g of prepared nux vomica, 10g of sappan wood, 15g of menthol, 15g of garden balsam seed, 10g of dragon's blood and 10g of safflower. All the medicines are ground into powder, then a certain proportion of water is added, the mixture is blended into paste, and the traditional Chinese medicine external application plaster is prepared. All the components are combined to achieve the effects of dispelling wind and dampness, promoting blood circulation to remove blood stasis and activating meridians to stop pain.

The invention relates to the technical field of biological medicines, in particular to application of pellicine to preparation of a medicine for treating rheumatoid arthritis. The in-vivo echinaceine can interfere with the pathological process of rheumatoid arthritis in a multi-dimensional manner by inhibiting proliferation, migration and invasion of MH7A cells induced by TNF-alpha, promoting apoptosis of the MH7A cells and down-regulating protein expression of IL-6, MMP-3 and MMP-9. In vivo, the pellicine can relieve joint swelling, synovitis and cartilage injury of adjuvant arthritis rats by inhibiting protein expression of RF, IL-6, MMP-3 and MMP-9. The pellicine has the prospect of being developed into the medicine for treating rheumatoid arthritis.

The present invention discloses the combined use of scopolamine and hyoscyamine in the preparation of a drug for preventing or / and treating hyperuricemia. The combined use has an excellent synergistic effect, can significantly reduce the levels of serum uric acid, creatinine, and urea nitrogen, reduce the reabsorption of uric acid, creatinine, and urea nitrogen in urine by the kidney, and promote the excretion of the three, has significant anti-hyperuricemia activity, and has a protective effect on the kidney; it can also significantly reduce the generation of inflammatory factors, effectively improve the symptoms of joint swelling in gouty arthritis, and has clinical application value and development prospects.

The invention discloses an application of sanguisorba officinalis sapogenin in preparation of a medicine for treating gout. Compared with the prior art, it is found for the first time that sanguisorba sapogenin can treat gout, especially acute gouty arthritis. Animal research proves that the sanguisorba sapogenin can remarkably relieve joint swelling and tissue damage caused by acute gouty arthritis by inhibiting release of inflammatory factors such as IL-1beta and TNF-alpha. Meanwhile, the sanguisorba sapogenin can also remarkably reduce the level of serum uric acid, and also has a certain treatment effect on gout in a remission stage and a chronic stage. Therefore, the sanguisorba officinalis sapogenin can be used for treating gout and has the potential and prospect of being prepared into the anti-gout medicine.

The invention provides a traditional Chinese medicine composition with an anti-inflammatory effect and a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following functional components: oldenlandia diffusa, rhizoma smilacis glabrae, astragalus membranaceus, radix aconiti carmichaeli, sargentgloryvine stem, madder, centipede and liquorice. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 30-45 parts of oldenlandia diffusa, 30-45 parts of rhizoma smilacis glabrae, 30-45 parts of astragalus membranaceus, 10-15 parts of radix aconiti carmichaeli, 10-20 parts of sargentgloryvine stem, 10-15 parts of madder, 2-4 parts of centipede and 6-9 parts of liquorice through mixing and water extraction, and the components have a synergistic effect, so that the traditional Chinese medicine composition has the effects of detoxifying, expelling toxins and diminishing swelling, has a remarkable effect of treating rheumatoid arthritis and is free of toxic and side effects. The methotrexate pharmaceutical composition has the advantages that the methotrexate pharmaceutical composition has an obvious curative effect on treating joint swelling of a patient, especially has an obvious curative effect on improving joint swelling of a patient, can better reduce inflammation indexes ESR and CRP, has more advantages in long-term curative effects on improving joint pressing pain and joint swelling, and can effectively improve the drug effect of methotrexate and reduce toxic / side effects of methotrexate.

The application discloses application of a medicine composition in preparation of a medicine for treating rheumatoid arthritis (RA), and belongs to the field of RA treating medicines. The medicine composition is composed of swertiamarin (SW) and neochlorogenic acid (NCA) and is screened from two active ingredients in Danteng Yimu Decoction. With the help of animal model and cell model experiments, the action mechanism of the medicine composition in treating RA is explored, the related symptoms and indexes of collagen-induced arthritis (CIA) rats can be effectively improved, joint swelling can be relieved, arthritis inflammation index can be reduced, inflammatory factor release can be inhibited, joint bone quality can be protected, arthritis inflammation infiltration and cartilage destruction can be reduced, and the medicine safety is good. The composition can effectively inhibit the inflammatory factor release and migration ability of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). Animal experiments and cell experiments prove that the combination of neochlorogenic acid and swertiamarin (SW+NCA) can be effectively applied to clinical treatment of RA and has a wide application prospect.

The invention discloses a psychopath joint protection device, which relates to the technical field of joint protection, and comprises a protection clamping plate, the top end of the protection clamping plate is fixedly connected with a protection cover, the outer surface of the protection clamping plate is fixedly connected with a calandria seat, and one end, far away from the protection clamping plate, of the calandria seat is fixedly provided with a positioning ring. Comprising a supporting frame fixedly connected with the top face of a protective clamping plate, a micro motor is fixedly installed on the supporting frame, and the output end of the micro motor is fixedly connected with a rotating shaft fixedly connected with a main cam. The positioning protection mechanism is used for protecting the periphery of the joint of the patient while being matched with the massage mechanism to fix the positioning ring to the limb of the patient, the device can enable the multiple auxiliary push rods to repeatedly move up and down along the supporting frame, so that the multiple massage rings fluctuate in a ripple shape to lightly press and massage the periphery of the joint of the patient, muscle tension is relieved, and the patient can feel more comfortable. The traditional Chinese medicine composition can relieve joint burden, promote lymphatic circulation, help discharge inflammatory substances and relieve joint swelling and inflammation.

The application discloses application of myrtenal in preparation of a medicine for preventing and / or treating rheumatoid arthritis. The application verifies for the first time that myrtenal can block the RA inflammatory cascade from multiple aspects, and overcomes the limitation that single-target treatment is easy to produce drug resistance. Specifically, myrtenal can reduce the levels of inflammatory factors and metal proteins; inhibit the proliferation, migration and invasion of synovial fibroblasts SFs; inhibit the expression of glycolysis-related genes, reduce sugar metabolites; inhibit the synovial tissue hyperplasia, inflammatory cell infiltration, bone erosion and bone destruction of mice joints; promote the mental state of arthritis mice to be obviously improved, the food intake to be increased, the hair to be shiny, the joint swelling to be subsided, the bruise of the ankle joint to be subsided, the skin to be improved, and the activity to be sensitive. Therefore, the application proposes a new medical use of myrtenal in treating rheumatoid arthritis, and develops a brand-new therapeutic indication of myrtenal.

The present invention relates to a composition for strengthening joints and cartilage, comprising a fermented mushroom mycelium extract as an active ingredient. The composition for preventing or treating inflammatory osteoarticular diseases, comprising a fermented extract of Auricularia auricula mycelium and Sparassis crispa mycelium, as an active ingredient, according to the present invention, has an anti-inflammatory effect and the effect of reducing joint swelling, and thus can be effectively used as a composition for protecting and strengthening joints and cartilage.

The application discloses application of CPI2 protein in preparation of anti-gouty arthritis drugs and belongs to the technical field of biological medicine. The application discloses the application of the CPI2 protein in preparation of anti-gouty arthritis drugs, and the amino acid sequence of the CPI2 protein is shown as SEQ ID NO. 1. The CPI2 protein disclosed by the application can reduce joint swelling caused by sodium urate, reduce inflammatory cell infiltration, reduce the levels of proinflammatory cytokines IL-1beta, IL-6 and TNF-alpha, increase the level of anti-inflammatory cytokine IL-10, increase the activities of SOD and GSH-Px, and reduce the content of MDA, and can be prepared as a drug for preventing or treating gouty arthritis and has clinical application value.

The invention provides a nursing traditional Chinese medicine external preparation for relieving rheumatic arthralgia, and relates to the technical field of traditional Chinese medicines. On the basis of the theory of traditional Chinese medicine, a traditional Chinese medicine formula composed of pine nodular branch, ormosia henryi, shinyleaf pricklyash root, peach twig, lance asiabell root, arachnoid cyanotis root, dentiferous dendropanax root, rhizoma curculiginis, winter jasmine, wintergreen, folium cortex eucommiae, semen sesami nigrum, fructus viticis, semen allii tuberosi, rhizoma smilacis glabrae and herba menthae is prepared and used for externally treating rheumatoid arthritis in traditional Chinese medicine. The traditional Chinese medicine has the effects of promoting blood circulation to remove meridian obstruction, relieving swelling and pain, dispelling wind and eliminating dampness, tonifying liver and kidney, strengthening muscles and bones, clearing heat and promoting diuresis. The traditional Chinese medicine external preparation disclosed by the invention has excellent anti-inflammatory, detumescence and analgesic effects, has excellent performance in the aspects of improving clinical symptoms such as joint swelling, pain and pressing pain of a patient and improving sleep and joint functions, and takes effect quickly. The traditional Chinese medicine external preparation provides effective nursing means and measures for relieving or relieving rheumatic arthralgia.

An antibody, preferably a blocking antibody, and most preferably a monoclonal antibody (mAb), specific for human endothelial cell protein C receptor (EPCR) such as mAbs JRK 1494 or JRK 1535 is used to reduce or attenuate joint swelling, macrophage infiltration, iron deposition and / or blood vessel formation and to treat arthropathy in a hemophilic subject.

The invention provides a method for treating arthritis by using mesenchymal stem cells subjected to limited induction in vitro. Osteoarthritis is a common joint degenerative disease and is mainly characterized by cartilage injury and inflammatory response. The traditional treatment method is difficult to realize cartilage regeneration, but mesenchymal stem cells (MSC) show a prospect in joint repair due to multidirectional differentiation potential and immunomodulatory effect. According to the invention, bergenin (KGN) is utilized in vitro to induce MSC to differentiate into chondrocytes, so that the chondrogenic ability of the cells is enhanced. The inducible MSC is injected into a rat gonitis model, cartilage repair is remarkably promoted, and inflammation is reduced. Experimental results show that the method can effectively relieve arthrocele, improve the motion function and reduce the pain sensitivity. The invention not only improves the treatment effect of MSC, but also provides a safe and effective new approach for treating arthritis, and has important clinical application value.