2043 results about "Aching pain" patented technology

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

The invention relates to the technical field of pain assessment, in particular to a paediatric pain assessment system which comprises a muscle group rhythm recognition module, a behavior linkage screening module, a periodic fluctuation extraction module, a behavior physiological difference module and a pain grading judgment module. According to the method, a linkage offset identification path is constructed through an angle relation between facial muscle groups and a starting time sequence, multi-muscle cooperative imbalance performance is identified, a region-level dynamic behavior judgment basis is formed, and a behavior cooperative judgment mechanism is established by utilizing response overlapping conditions of multiple behavior characteristics in the same time period; path signals which do not form effective cooperation are eliminated, the effectiveness of behavior characteristics is enhanced, a continuous trend structure of peak time in rhythm change is introduced, a periodic response sudden change monitoring channel is constructed, the recognition sensitivity of a short-time fluctuation concentration section is improved, and a response mismatch section is extracted based on a trigger time dislocation state between behavior and physiological response, so that the recognition sensitivity of the short-time fluctuation concentration section is improved. And a pain judgment key point is positioned in the time sequence overlapping region.

The invention discloses a whole-process patient self-control analgesia management platform and method based on artificial intelligence, and relates to the related field of analgesia management, and the platform comprises a multi-source data interaction module which is used for building a time sequence standard data set; the information configuration module is used for starting the self-control analgesia pump; the AI pain evaluation module is used for generating a pain scoring result; and the identification early warning module is used for generating graded early warning. The technical problems of insufficient safety and unstable effect in the analgesia management process due to dependence on a fixed dose threshold and lagged artificial pain assessment in traditional patient self-control analgesia management are solved, the whole-process pain management platform based on artificial intelligence is constructed, multi-source data can be analyzed in real time, and the pain management efficiency is improved. And the pain state of the patient is dynamically evaluated, and the parameters of the analgesia pump are automatically adjusted, so that the technical effects of personalized analgesia management and safety and effectiveness in the analgesia process are realized.

An angled intraosseous access system includes a guide assembly including a guide block and a guide plate. The system can include a driver and a needle assembly rotatably coupled thereto. The guide assembly is configured to align the needle at a predetermined angle relative to the medullary cavity. Advantageously, the angled needle of the intraosseous access system can mitigate pain during infusion and mitigate backwalling.

The invention relates to the field of medical instruments, and discloses an anesthesia injury monitoring evaluation and management system for pain monitoring and rehabilitation acceleration. Comprising a sensor module configured to collect acupuncture point skin temperature data in a percutaneous acupuncture point electrical stimulation process, current parameter data output by an electrical stimulation device and skin impedance change data in real time; the control module is used for inputting the temperature data, the current parameter data and the skin impedance data which are acquired in real time into a multi-parameter risk assessment model, calculating a real-time risk value and generating a parameter change curve containing a time sequence; when the real-time risk value exceeds a preset safety threshold value, or any single parameter in the parameter change curve reaches a temperature change rate threshold value, an accumulated electrical stimulation energy threshold value or a skin impedance abnormal fluctuation threshold value, triggering a multi-stage early warning signal; according to the early warning level of the early warning module, the output power, the pulse frequency or the action time of the electrical stimulation device is automatically adjusted, or electrical stimulation is forcibly terminated when early warning is performed at the highest level.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

The invention provides a pain assessment system and method based on multi-modal physiological signals. The system comprises a multi-modal signal acquisition module, a signal preprocessing module, a multi-modal feature extraction module, a deep fusion analysis module, an individualized calibration module and a result output and early warning module. By synchronously collecting and analyzing multi-dimensional data such as facial expressions, sound features, physiological signs and behavior responses and combining deep learning and multi-modal information fusion technologies, objective quantitative evaluation and real-time monitoring of the pain degree are achieved, and accurate decision support is provided for clinical pain management.

The invention discloses a pain management method based on bioelectrical impedance data and a machine learning algorithm, and relates to the technical field of medical health, and the method comprises the steps: carrying out the phase delay analysis of an impedance phase spectrum matrix, calculating the change rate of a phase angle of each frequency point along with time, and obtaining the maximum phase lag time; according to the temperature field sequence and the maximum phase lag time, time-space registration is carried out through a multi-modal data fusion method and impedance modulus changes of the corresponding areas, and a pain biomarker feature library is generated; through a bidirectional LSTM and a cross attention fusion method, time sequence modeling and cross-modal correlation analysis are carried out on bioelectricity signal characteristics extracted by a sliding window and historical pain data, a dynamic evolution rule of pain development is captured, a pain management triple containing pain intensity, intervention response and prognosis evaluation is generated, and a pain management result is obtained. And a quantitative basis is provided for personalized treatment.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

The invention relates to a pain assessment method and system based on a visual large language model. The method comprises the following steps: S100, synchronously collecting video data of the face and limbs of a target object; s200, performing space-time sampling processing on the video data to obtain image data; s300, generating a multi-step guide instruction sequence based on a preset pain assessment dimension; s400, inputting the image data and the instruction sequence into a visual big language model, and gradually reasoning the visual big language model according to a preset pain assessment dimension; and S500, the visual big language model sequentially generates a scoring basis, a scoring result and a comprehensive pain grade of each dimension according to the reasoning result of each dimension. Through the arrangement, the technical problem of objective assessment of the pain degree in the medical operation process is solved.

An interactive pain management system is provided comprising a laser treatment device and an application executing on the device that receives entry of identification information for a first patient and receives entry of a body region to receive treatment. The system also receives entry of a present pain level experienced in the body region, accesses stored information describing previously reported conditions of the first patient and based on the received entries and the accessed store information, determines a treatment regimen for the first patient. The laser treatment device executes the treatment regimen by manual administration by the first patient or a qualified technician. The system requests entry of the first patient's present condition, the condition comprising one of feeling worse, feeling better, and experiencing no change since an immediately previous treatment. Changes in the condition of the first patient are incorporated into the determination of the treatment regimen.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

An apparatus includes a pair of engaging members to engage a first and second portion of a body toward an upper and lower portion of a neck, and a plurality of assemblies connecting the first engaging member and the second engaging member to maintain a distance between bones of a body portion comprising an area of the neck, wherein the body portion resides between the first and second portions, and wherein each assembly comprises a plurality of rods coupling the first engaging member and the second engaging member, and a coupling tube with a first rod of the plurality of rods secured to a proximal end and a second rod of the plurality of rods secured to a distal end, wherein rotation of the coupling tube adjusts a gap between the first and second rods in the coupling tube to control the distance between the bones of the body portion.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

The invention relates to the field of medical data analysis, in particular to an interventional therapy patient perioperative period pain data analysis method and system. An interventional therapy patient perioperative period pain data analysis system comprises a data acquisition module, a weight acquisition module, a pain prediction module and a pain monitoring module. According to the method, a standardized multi-source data coding system is established, pre-operative static characteristics and intra-operative dynamic time sequence signals are subjected to nonlinear weight calculation based on mutual information coefficients, complex threshold correlation and interaction effects among parameters are captured, and then a parallel architecture of an LSTM network and a static weighting layer is adopted; deep correlation information of a time sequence dependence mode generated by intraoperative operation and basic background parameters is extracted, the recognition ability of the model for high-risk patients is improved, and high-precision prediction of the pain intensity and type in the perioperative period is achieved.

Systems, devices, and methods for neurostimulation using a combination of implantable and external devices to treat pain are disclosed.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

The invention relates to the technical field of medical monitoring, and particularly discloses a pain degree assessment method and system based on multi-modal sensing and wearable equipment. The method comprises the following steps: acquiring physiological signals and limb movement data of a patient to form a multi-dimensional pain feature vector; a dynamic weight distribution algorithm is adopted, and physiological and limb action modal weight coefficients are adjusted in real time based on each modal data prediction confidence coefficient; a multi-modal classifier is utilized, features are fused through a cross-modal attention mechanism, and 0-10 levels of pain quantized values are output; and intelligent regulation and control of analgesia parameters are realized. The system comprises a multi-modal sensing module, a feature extraction module, a dynamic weight distribution module, a multi-modal classification module and an analgesia equipment control module. The wearable device integrates a sensor and a processing unit to realize data acquisition and analysis. According to the invention, the dynamic, precise and intelligent pain assessment is realized, the technical problems of strong subjectivity and poor real-time performance of the traditional assessment method are solved, and reliable technical support is provided for clinical analgesia management.

The invention belongs to the field of massage control, and relates to a hand massager which comprises a base, an upper cover and a cavity arranged between the base and the upper cover, the cavity is defined by a first lining piece and a second lining piece and is provided with a plurality of air bags used for different areas of a hand, and the air bags comprise a finger air bag, a hand back air bag, an upper wrist air bag, a lower wrist air bag and a palm air bag; the cavity extends to the middle section of the arm of a user, and two or more EMS electrotherapy sheets are arranged in the cavity and connected to the control panel; a dip angle alpha is arranged at the bottom of the cavity, so that the palm and the wrist of a user are kept in a natural fit posture, the dip angle structure is fixed or suspended, and an elastic element is arranged below the suspended dip angle structure; and a lithium battery is also arranged in the hand massager. The problems that a traditional massager only limits physical pressing, is insufficient in coverage area and poor in comfort are solved, the massage depth and the treatment effect are remarkably improved, and the massager is suitable for relieving hand fatigue and neuropathic pain and assisting in rehabilitation treatment.

Disclosed herein are compositions comprising an NSAID such as meloxicam and / or rizatriptan in combination with a cyclodextrin and / or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.

Systems and techniques are disclosed to adjust programming of an implantable electrical neurostimulation device for treating chronic pain of a human subject, through the use of a dynamic model adapted to identify pain treatment parameters for a human patient and determine a best device operational program to implement the pain treatment parameters to address the chronic pain condition. In an example, the system to adjust programming of the neurostimulation device performs operations that: obtain data related to a state of pain of the human subject; identify pain treatment parameters using a dynamic model adapted to evaluate the pain treatment parameters in the human subject over a time period, based on the data related to the state of pain; and select a neurostimulation program for the neurostimulation device, corresponding to at least a portion of the identified pain treatment parameters.

The invention discloses a multi-mode postoperative child pain identification method. The method aims at improving the accuracy of child postoperative pain recognition by fusing ECG (electrocardiogram), SPO2 (blood oxygen) and EEG (electroencephalogram) multi-mode data. The method comprises the following steps of: firstly, respectively acquiring and preprocessing each modal data, and converting EEG (electroencephalogram) into two types of two-dimensional frames; then, feature extraction is automatically conducted on the data of all the modes through specific neural networks including the frequency domain flow neural network, the time domain flow neural network, the oxyhemoglobin saturation CNN-GRU neural network and the electrocardio CNN-GRU neural network; and finally, inputting the extracted features into an MLP feature fusion layer to carry out pain identification. Compared with a traditional single-mode identification method, the postoperative child pain related characteristics can be more comprehensively captured, the pain identification accuracy is effectively improved, and powerful support is provided for medical staff to accurately evaluate the postoperative child pain degree in time.

The present invention provides a cold and hot compress integrated care device for orthopedic pain patients. 【Solution means】 Belonging to the technical field of medical devices, it comprises an upper clamp plate 1 and a lower clamp plate 2 connected by a twist spring, and both have an arc portion along the curvature of the limbs. The through groove 3 is provided on the upper clamp plate 1 and extends to the lower clamp plate 2 side and reaches both ends of the upper clamp plate 1. The slide grooves are symmetrically provided on the upper clamp plate 1 in the through groove 3 and extend in an arc shape. The slide block is slidably connected in the slide groove. By the cooperation of the provided heat conduction plate and the movable parts, the spring plate gradually covers the human body, and at the same time, the movable parts receive downward pressure, thereby causing the U-shaped plate 6 to act to form a space for preventing pressure load on the human body surface, realizing the protection of the patient and the pain prevention effect.

The invention discloses an AI-based personalized pain management system and method, and the system comprises a multi-dimensional data collection module which is used for collecting multi-dimensional monitoring data including user physiological state data, motion data and location information data, and bio-electricity signal sensing data in real time; the pain type identification module is used for performing feature extraction on the physiological state data and the bio-electricity signal sensing data and identifying the pain type and the pain level of the user in combination with basic information of the user; the pain trend prediction module is used for performing time sequence analysis based on the pain type, the pain level and the multi-dimensional monitoring data, and predicting the pain trend of the user in a future preset time period; and the feedback evaluation module is used for outputting a pain management evaluation report of the user according to the pain type, the pain level and the pain trend. According to the invention, accurate monitoring, assessment and intervention of pain can be realized, so that pain management is more intelligent and personalized, and help is provided for improving the life quality of a user.