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Application of philippine violet herb total phenol extract to treatment of hyperuricemia

A kind of technology of hyperuricemia and violetidine, applied in the field of natural medicine

Inactive Publication Date: 2011-10-12
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far there is no report that Viola ditin and its extracts have anti-hyperuricemia

Method used

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  • Application of philippine violet herb total phenol extract to treatment of hyperuricemia
  • Application of philippine violet herb total phenol extract to treatment of hyperuricemia
  • Application of philippine violet herb total phenol extract to treatment of hyperuricemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Violet Butterol Extract

[0017] Take 10kg of the whole herb of Viola chinensis, extract it twice with 95% ethanol which is 8 times the weight of the material, and heat reflux at 70°C for 2 hours each time. After the extract is concentrated, put it on a HPD300 macroporous resin column, first elute with 8 times the column volume of 25% ethanol to remove impurities, and then use 8 times the column volume of 40% ethanol to elute, collect the eluate, concentrate, and dry to obtain Zihuadi Total butyl phenol extract 235g. The total phenol content is 67.09%.

Embodiment 2

[0019] Acute Toxicity Test

[0020] After this test observes the total phenolic extract of Viola chinensis (made in Example 1, the same) after a single gavage of Kunming mice, due to the toxic reaction and death caused by absorption, the results show that Viola chinensis provided by the present invention After oral administration of 23.2g / kg of total phenolic extract, Kunming mice had no abnormality in their eating activities. Within 14 days after administration, the mice did not die. Therefore, the maximum administration dose of the total phenolic extract of Viola japonica to Kunming mice is >23.2g / kg.

[0021] 1 Test drug

[0022] The total phenolic extract of Viola fruticosa prepared in Example 1 of the present invention was divided into high, medium and low dose groups.

[0023] 2 Test animals

[0024] Kunming mice, half male and half male, weighing 18-22g.

[0025] 3 Test method

[0026] 20 Kunming mice were tested with the maximum concentration and maximum dose. Be...

Embodiment 3

[0032] Effects of the total phenolic extract of Viola japonica on gouty arthritis in rats induced by sodium urate crystals (MSU)

[0033] 1 Test drug

[0034] Total phenol extract of Viola chinensis, same as above; Esculin, purity>95%; Uric acid; Indomethacin.

[0035] 2 Test animals

[0036] SD rats, male, body weight 200g±20g.

[0037] 3 Test method

[0038] 56 male SD rats were randomly divided into 8 groups according to body weight after normal feeding for 1 week: (1) normal group, (2) model control group, (3) high-dose group of total phenolic viola: 1.42g / kg, (4) Medium-dose group of total phenol from viola: 0.71g / kg, (5) low-dose group of total phenol from viola: 0.36g / kg, (6) escin group: 142mg / kg, (7) Positive control group: indomethacin 10mg / kg. Gavage for 7 days. On the third day, the model was established before gavage. The rats in groups (2)-(8) were injected with 0.2 ml of sterile 2% MSU into the right ankle joint cavity, and the normal group was injected wi...

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Abstract

The invention relates to the field of natural medicaments, in particular to application of a philippine violet herb total phenol extract to treatment of hyperuricacidemia. Pharmacological tests prove that joint swelling of gouty arthritis of rats due to sodium urate crystals can be relieved obviously and the tread treatment of the rats can be improved by intragastric administration of the philippine violet herb total phenol extract. The philippine violet herb total phenol extract has the obvious inhibitory effect on hyperuricemia and urate nephropathy of mice due to a uricase inhibitor, adenine and ethambutol, but does not exert obvious influence on urinary volume, so the philippine violet herb total phenol extract has the effect of promoting the excretion of uric acid and has no effect of diuresis; and due to the single function of the philippine violet herb total phenol extract, doctors do not need to consider the influence of diuretic factors on patients during clinical application.

Description

technical field [0001] The invention relates to the field of natural medicines, in particular to the medical application of the total phenol extract of Viola japonica for treating hyperuricemia. Background technique [0002] Due to excessive uric acid and / or decreased excretion of uric acid due to purine metabolic disorders, when the blood uric acid concentration exceeds the upper limit of uric acid solubility, generally when the serum uric acid value is greater than 416 μmol / L (7 mg / dL), it is hyperuricemia. Needle-like or amorphous sodium urate crystals are prone to appear, which can deposit in any soft tissue (except the central nervous system), causing a series of lesions, mainly including acute and chronic gouty arthritis, tophi deposition, gouty nephropathy, uric acid Urinary stones, etc. Therefore, hyperuricemia is the main cause of gout (gout). [0003] The clinical treatment of hyperuricemia and gout is mainly to inhibit uric acid synthesis and increase uric acid ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/86A61P19/06A61P19/02A61P13/12A61P13/04
Inventor 秦民坚洪俊丽朱婕王强吴刚王琦秦晓颖
Owner CHINA PHARM UNIV
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