34results about How to "Increase the push rate" patented technology

The invention discloses lactobacillus paracasei CCFM1069 and an application thereof. The lactobacillus paracasei CCFM1069 can bear stomach intestine environment of human bodies, notably increase watercontent of excrement and urine, increase the propelling rate of small intestines, shorten the time of discharging a first granule of black stool, reduce the content of peptide YY in serum, raise thelevel of 5-hydroxytryptamine in colon tissue, raise the level of nerve nutrition factors 3 in the colon tissue, reduce Aqp4 genetic transcription level in the colon tissue, increase the number of Cajal interstitial cells in the colon tissue, and increase the content of short chain fatty acids in intestinal tracts; and the lactobacillus paracasei CCFM1069 has high adsorption capacity on pentadecafluorooctanoic acid, has the capacity of relieving PFOA toxicity and has quite good application prospects.

The invention discloses Lactobacillus fermentum zhao capable of regulating intestinal movement and preventing constipation and application thereof, wherein the preservation number of the Lactobacillus fermentum zhao is CCTCCM2013513. The strain has higher acid resistance, has a survival rate reaching 85.12% plus/minus 5.18% after staying in pH3.0 artificial gastric juice for 3 h, can grow slowly in cholate with the concentration of 1.0% and has a growth efficiency reaching 18.33% plus/minus 0.52% of that of cholate-free culture. The hydrophobicity of Lactobacillus fermentum zhao cells is up to 70.80% plus/minus 0.61%. The Lactobacillus fermentum zhao can grow normally in human intestinal tracts. In-vivo tests using mice show that the Lactobacillus fermentum zhao can reduce the weight reduction tendency of the mice, shorten the time of defecation of dark stool, improve the peristalsis of small intestines, increase MTL, Gas, ET, AchE, SP and VIP factors to different extents, reduce SS factors, increase food consumption and water consumption, reduce the tendency that stool amount, stool pieces and stool water content decline, play an effect similar to that of a constipation medicine and show a certain constipation prevention effect.

The invention discloses a lactobacillus fermentum Lee working leavening agent product and constipation-prevention and health application thereof. The preservation number of lactobacillus fermentum Lee in China Center for Type Culture Collection is CCTCCM 2013512. The lactobacillus fermentum Lee can normally grow in intestinal tracts of human bodies. A mouse in vivo test further shows that the lactobacillus fermentum Lee can be used for retarding a mouse weight-reducing tendency caused by constipation; melena defecation time is accelerated and the small intestine propelling rate is improved; levels of MTL, Gas, ET, AchE, SP and VIP factors of blood serum can be increased to different extents, and SS factors are reduced; the food intake and the water drinking amount are increased; the tendency that defecation amount, the defecation grain quantity, and the moisture content of excrement decline are reduced; and the effect similar with constipation drugs is realized and a certain constipation-prevention effect is represented. The optimal use dosage is 1.0*10<9>CFU per kilogram of weight.

The invention discloses lactobacillus rhamnosus CCFM1068 and application thereof.Thelactobacillus rhamnosus CCFM1068 can rapidly colonize in an intestinal tract, the water content of feces issignificantly increased, the intestinal propulsive rate is increased, defecation time of a first black stool is shortened, the content of peptide YYin serum is down-regulated, the level of5-hydroxytryptamine in colon tissuesis up-regulated, the level of neurotrophin-3 in thecolon tissues is up-regulated, the level of brain-derived neurotrophic factorsin thecolon tissues is up-regulated, and the level of Aqp4 gene transcriptionin thecolon tissues is up-regulated. In addition, the lactobacillus rhamnosus CCFM1068has a strong adsorption capacity for perfluorooctanoic acid and the ability to alleviate thetoxicity of PFOA. The lactobacillus rhamnosus CCFM1068 can well tolerate simulated gastrointestinal fluid, be used for preparing pharmaceutical compositions and fermented foods for relieving constipation and PFOA toxicity, and has a very broad application prospect.

The invention discloses use of one or more cannabinoid compounds or medicinal salts thereof to preparation of a pharmaceutical composition for treating irritable bowel syndrome. The invention furtherprovides a composition for treating irritable bowel syndrome. The composition comprises: 1) one or more cannabinoid compounds or medicinal salts thereof, and 2) one or more pharmaceutically acceptablecarriers or excipients.

The invention discloses a lactobacillus casei strain Qian (CCTCC No. M2013514) working leavening agent product and an intestinal tract regulating health use thereof. The lactobacillus casei strain Qian working leavening agent product and a downstream product thereof are relatively strong in acid resistance, are 62.51+/-7.35% in survival rate after being treated for 3 hours in artificial gastric juice with pH of 3.0, and are capable of slowly growing in 1.0% cholate, wherein the growth efficiency is 7.86+/-0.45% that in non-cholate cultivation; the hydrophobic property of lactobacillus casei strain Qian cells is up to 51.30+/-4.28%, and the lactobacillus casei strain Qian working leavening agent product normally grows in human intestinal tract. The lactobacillus casei strain Qian working leavening agent product can be used for slowing down mouse weight reducing trend caused by constipation, shortening dark stool defecating time, increasing a small intestine advance rate, reducing the gene expression level of mouse TRPV1. NOS, reducing the defecation quantity, and reducing defecation granule number and excrement moisture content reducing trend, achieves similar effects of constipation drugs and shows a certain constipation prevention effect.

The present invention discloses a pure Chinese medicine preparation for curing gastrointestinal type summer-heat and dampness common cold and its preparation method. Said invention adopts molecular distillation and supercritical CO2 fluid extraction equipment to extract the effective active substances of agastache/patchouli, magnolia bark, atractylodes root and dried ginger, after the agastache/patchouli extract, magnolia bark extract, atractylodes root extract and dried ginger extract are mixed according to a certain ratio, the medicinal vegetable oil auxiliary material is added, then they are made into the soft capsule by means of drum granule-pressing machine.

The invention discloses a lactobacillus casei strain Qian working stock culture product and an intestinal tract regulation dietary therapy funtion thereof. The lactobacillus casei strain Qian working stock culture product and downstream products thereof are stronger in acid-resistance, after being processed in artificial gastric juice of PH 3.0 for 3 hours, the survival rate of the products reaches 62.51+/-7.35%, can grow slowly in 1.0% cholate with the production efficiency being 7.86+/-0.45% of no cholate culture, hydrophobicity of lactobacillus casei strain Qian cells reaches 51.30+/-4.28%, and the lactobacillus casei strain Qian cells can grow normally in the intestinal tract of human beings; the weight losing tendency of mice caused by constipation can be alleviated, the dark stool defecating time is shortened, the small intestine advance rate is improved, the TRRV1,NOS gene expression level of mice is lowered, and the tendency that defecating amount, the defecating particles and faeces water content are decreased is lowered, so that the lactobacillus casei strain Qian working stock culture product has the function similar to that of constipation medicine, and shows certain constipation prevention effect.

The invention belongs to the field of medicine, and relates to medical application of a composition. In order to solve the problem of constipation caused by taking an analgesic by a cancer patient, the invention provides the application of the composition in preparation of medicines for preventing and treating constipation. Mouse small intestine propulsion test results of pharmacodynamic embodiments show that the composition provided by the invention can significantly improve the small intestine carbon juice propulsion rate of mice; and mouse defecation test results show that the composition provided by the invention can significantly shorten the first defecation time of mice and increase the defecation times. Clinical results show that the effective components in the composition can playa significant synergistic effect, can significantly reduce the recurrence rate, and has important significance in solving the constipation problem of cancer patients.

The invention discloses a traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux. The traditional Chinese medicine compound composition is prepared from the following components in parts by weight: 10-20 parts of inula flower, 10-20 parts of processed rhizoma pinelliae, 10-20 parts of processed rhizoma cyperi, 4-14 parts of caulis perllae, 10-20 parts of raw folium eriobotryae, 10-20 parts of pericarpium citri reticulatae, 10-20 parts of poria cocos, 20-40 parts of cuttlebone and 20-40 parts of fried semen raphani. The traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux provided by the invention has an anti-inflammatory effect, can improve the gastric emptying rate of rabbits, improve the small intestine peristalsis of the rabbits and improve the small intestine propulsion rate, can reduce the expression of inflammatory factors in gastric tissues, has no adverse reaction and no obvious toxic or side effect, and is safe and effective.

The invention discloses monascus bean dreg vinegar and a preparation method thereof, and belongs to the technical field of vinegar brewing. Bean dregs and monascus vinegar are combined for the first time, namely the bean dregs serving as raw materials are used for preparing distiller's yeasts and vinegar fermented grains; meanwhile the monascus bean dreg vinegar is prepared by taking the bean dregs as the main raw materials through the processes of cooking and liquefying, performing alcoholic fermentation, performing acetic acid fermentation, ageing, blending and the like. Cellulose and sugarin the bean dregs are subjected to microbial fermentation, particularly under the action of monascus, aspergillus niger, acetic acid bacteria and lactic acid bacteria, the flavor, the color and the nutritional value of the monascus bean dreg vinegar are increased; meanwhile the effects of promoting gastrointestinal motility as well as invigorating stomach and promoting digestion are achieved; in addition, an important function of promoting effective utilization of bean dreg resources is achieved.

Chronic constipation is a common disease of the digestive system, and the prevalence rate of chronic constipation around the world is 0.7 to 79%. The invention discloses a pharmaceutical composition for treating chronic constipation. The pharmaceutical composition comprises 4-12 mg of an active medicinal ingredient and other pharmaceutically acceptable carriers, diluents and excipients. The pharmaceutical composition of the invention can increase the number of ILL, repair the function of ILL and achieve the purposes of restoring colonic functions, improving the propulsion rate of small intestine and alleviating the symptoms of constipation.