23 results about "Functional constipation" patented technology

The invention discloses a lactobacillus helveticus metaplasm complex and application thereof in constipation treatment, and relates to the technical field of constipation treatment, a specific lactobacillus helveticus KLDS 1.1 1105 strain is adopted, and metaplasm is prepared through fermentation and spray drying. The invention further provides a three-layer embedded compound structure. The outer layer is composed of pitaya powder and prune powder and is used for rapidly relaxing the bowels; the middle layer contains a pomegranate peel extract and is used for regulating flora; the core is colon-targeted lactobacillus helveticus metagen and inulin and is used for long-acting regulation. According to the compound, through the multi-target synergistic effect, gastrointestinal hormone is regulated, related signal channels are activated, the function of intestinal pace-making cells is promoted, and generation of short-chain fatty acid is increased, so that the constipation symptom is rapidly relieved, meanwhile, the intestinal function is fundamentally repaired, and the intestinal microecology is improved. The product disclosed by the invention is good in stability, high in safety and suitable for preparing medicines or functional foods for treating functional constipation.

This invention provides a traditional Chinese medicine preparation for treating or relieving functional constipation in children, belonging to the field of traditional Chinese medicine technology. The preparation is made from raw Atractylodes macrocephala, banana root, Citrus reticulata, mulberry, Lophatherum gracile, Hovenia dulcis leaf, Ziziphus jujuba leaf, Pogostemon cablin, Citrus reticulata peel, Torreya grandis seed, and licorice. This traditional Chinese medicine preparation significantly increases the number of fecal particles in constipation model rats over 24 hours, increases fecal water content, and improves intestinal propulsion rate, thus improving intestinal peristalsis. In clinical observation, this traditional Chinese medicine preparation effectively relieves the core symptoms of children, shortens the interval between defecation, softens stool, and alleviates straining during defecation. It also improves accompanying symptoms such as abdominal distension and halitosis. After the course of treatment, bowel regularity returns, and there is no significant recurrence during follow-up, providing a new option for the clinical treatment of functional constipation in children.

The invention provides a traditional Chinese medicine composition for treating senile chronic functional constipation, which is prepared by extracting the following traditional Chinese medicines in parts by weight: 4-8 parts of prepared rhubarb, 8-12 parts of angelica sinensis, 10-20 parts of astragalus membranaceus, 8-12 parts of codonopsis pilosula, 6-12 parts of immature bitter orange, 4-8 parts of cimicifugae foetidae, 8-12 parts of radix rehmanniae recen, 4-8 parts of rhizoma anemarrhenae, 4-8 parts of platycodon grandiflorum, 6-12 parts of aster, 4-8 parts of fructus cannabis and 4-8 parts of almond. The traditional Chinese medicine composition is mainly used for dispersing blood stasis and promoting blood circulation, and is also used for tonifying qi, promoting blood circulation and nourishing blood, so that qi and blood in intestinal tracts are smooth, the functions of nourishing and conduction are self-recovered, and constipation is relieved. The invention also discloses a preparation method and application of the traditional Chinese medicine composition.

The present application discloses a composition, oral tablets and their preparation method and application, and belongs to the field of food and drug technology. The composition includes sodium sulfate, magnesium sulfate and potassium chloride, and the weight ratio of the sodium sulfate, magnesium sulfate and potassium chloride is (5-10): (1-2): (0.5-1.5); the particle size of the sodium sulfate is less than 700 μm, the purity is not less than 98%, and the moisture content is less than 0.5%; the particle size of the magnesium sulfate is less than 700 μm, the purity is not less than 98.5%, and the moisture content is less than 5.0%; the particle size of the potassium chloride is less than 700 μm, the purity is not less than 98.5%, and the moisture content is less than 1.0%. Each component function is fully exerted, improves the intestinal environment, restores intestinal health, and alleviates functional constipation.

The present application provides a kind of nutrition composition which is helpful to lubricate intestine and defecate, which is composed of natto, red rice, taurine, vitamin B1, vitamin B2 and acceptable adjuvant in specific content ratio.The present application has the advantages that: the composition has synergistic effect, can lubricate intestine and defecate, is used for preventing or assisting treatment of functional constipation, and has small side effect and does not produce dependency.In addition, the compound form of the product can significantly improve the compliance of the user population and save the overall use cost.

The invention discloses an abdomen massage device for relieving functional constipation, relates to the technical field of massage tools, and aims to solve the problems that traditional abdomen massage tools are single in function, most of the traditional abdomen massage tools can only realize simple pressing or kneading, diversified massage techniques of professional massagers are difficult to simulate, and ideal treatment effects cannot be achieved. The invention provides an abdominal massage device for relieving functional constipation, which comprises a containing shell, a driving component, a massage component and a massage component, the massage assembly is arranged on the chassis, and the driving assembly can drive the massage assembly to press, rotationally push and knead the abdomen of the patient. The abdominal acupoints and muscles can be stimulated more accurately and comprehensively, intestinal tract movement is promoted, the functional constipation symptom is effectively relieved, and a non-invasive treatment choice without side effects is provided for patients.

The application belongs to the technical field of traditional Chinese medicine polysaccharide development, and particularly relates to an active polysaccharide CWP-3 extracted from medicinal materials of Coptis deltoidea or residues after extraction of volatile oil, and a preparation method and application thereof. The homogeneous polysaccharide CWP-3 obtained by the application is a heteropolysaccharide, monosaccharide composition includes rhamnose (Rha), galacturonic acid (GalA), galactose (Gal) and arabinose (Ara), the molecular weight is 400-1000 kDa, the types and connection modes of sugar residues are determined by using HPLC, FTIR, GC-MS and NMR and other analysis technologies, and the atomic force microscope (AFM) analysis shows that the CWP-3 has a clear three-strand helical structure. In addition, the pharmacological experiments show that the CWP or CWP-3 has good antioxidant and treatment effects on blood stasis syndrome, cardiovascular diseases, dysmenorrhea and functional constipation.

The invention relates to the field of traditional Chinese medicine, and particularly discloses a spleen-tonifying intestine-moistening traditional Chinese medicine composition and an application method thereof in functional constipation. The spleen-tonifying intestine-moistening traditional Chinese medicine composition comprises the following components in parts by weight: roasted rhizoma atractylodis macrocephalae, codonopsis pilosula, poria cocos, pericarpium citri reticulatae, fructus cannabis and bunge cherry seeds; the formula is accurately matched with the core pathogenesis of spleen dysfunction in transportation and intestine dysfunction in moistening, the roasted rhizoma atractylodis macrocephalae, the codonopsis pilosula and the like are used for invigorating the spleen and replenishing qi to consolidate the root, the fructus cannabis and the bunge cherry seeds are used for relaxing bowel to treat the symptoms, the defect of emphasizing a single effect is avoided, and the formula is suitable for multi-subtype constipation, and has the advantages of no toxic or side effect, no toxic or side effect, no toxic or side effect, no toxic or side effect, no toxic or side effect, no toxic or side effect, no toxic or side effect, no toxic or side effect, no toxic or side effect, no toxic or side effect and the like. The traditional Chinese medicine is especially suitable for patients with spleen-stomach deficiency with intestinal dryness type functional constipation.

The invention discloses an abdominal massage device for relieving functional constipation, relates to the technical field of abdominal massage, and provides the following scheme that the abdominal massage device comprises a massage device shell, a through hole is formed in the center of the top of the massage device shell, a fixed shell is fixedly installed in the through hole, and a lifting plate is slidably connected to the interior of the fixed shell. A first rotating ring and a second rotating ring are arranged at the bottom of the lifting plate and connected with massage balls through connecting columns, a servo motor drives a gear, the two rotating rings rotate through an inner gear ring and an outer gear ring, the massage balls rotate in multiple directions, the abdomen is massaged in multiple directions, intestinal tract movement is promoted, constipation is relieved, the height of the lifting plate can be adjusted through a servo electric cylinder, and the massage effect is good. Massaging strength requirements of different patients are met, the height of the moxibustion box placed in the shell is adjustable, different requirements are met, smoke acts on the abdomen for adjuvant therapy through the smoke outlet through hole of the box cover, fixing and adjusting are convenient through a tightening belt and an adjusting buckle at the bottom of the shell, and the use experience is improved.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and promoting qi circulation to relieve constipation and application thereof.The traditional Chinese medicine composition comprises 14 basic active components including, by weight, 30-60 g of radix rehmanniae recen, 10 g of flos carthami, 20-30 g of radix angelicae sinensis, 10 g of radix achyranthis bidentatae and the like, and is suitable for qi stagnation and blood stasis type functional constipation with the disease course larger than or equal to 6 months and defecation smaller than or equal to 2 times per week; corresponding components are added when symptoms of heavy dampness, blood deficiency and the like are accompanied; when the composition is applied, the composition is taken according to echelon, 20-30 days are taken as a course of treatment, the composition is stopped after six courses of treatment for 1 month, defecation is monitored, and the composition is satisfied if the Bristol score is greater than or equal to 4. The traditional Chinese medicine composition can improve the qi-stagnation and blood stasis type functional constipation symptom, reduces relapse through echelon taking, is scientific in component compatibility, suitable for various syndromes, safe in medication, free of obvious side effects and stable in curative effect, widens the application range, and overcomes the defects of a traditional scheme.

The invention relates to the technical field of medicines, and discloses application of a pugionium cornutum extract in improvement of functional constipation. Animal experiments prove that the pugionium cornutum extract can shorten gastrointestinal passage time, increase the number, weight and water content of excrement, improve the intestinal propulsion rate, regulate the content of gastrointestinal regulation transmitters in serum and colon tissue, repair pathological damage of colon tissue, lower expression of aquaporin 3 in colon tissue, and improve the intestinal development rate of the pugionium cornutum extract. The functional constipation symptom is remarkably improved through multiple ways of improving the intestinal flora structure and the like, no damage is caused to main organs of animals, and the safety is high. The invention provides a new natural product source for improving the functional constipation, and can be used for preparing the medicine for improving the functional constipation.

The invention discloses a plant lactobacillus LP-Z6 for improving functional constipation of infants and an application thereof, and relates to the technical field of biological medicines. The invention provides a lactobacillus plantarum LP-Z6 strain, wherein the preservation number of the lactobacillus plantarum LP-Z6 strain is CGMCC (China General Microbiological Culture Collection Center) No. 34294, and the preservation number of the lactobacillus plantarum LP-Z6 strain is CGMCC No. 34294. The plant lactobacillus LP-Z6 has the effects of preventing and treating constipation, increasing defecation times, improving intestinal peristalsis, promoting intestinal moisture secretion, softening excrement, improving symptoms of defecation pain and defecation strenuous, and remarkably increasing the clinical constipation cure rate; the diversity of intestinal microorganisms is obviously increased; the intestinal flora structure is changed, the abundance of beneficial bacteria is increased, and harmful bacteria are inhibited; the serum 5-HT level is obviously increased. The clinical application safety of the plant lactobacillus LP-Z6 meets the requirements.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine compound sustained-release patch for treating senile constipation and application thereof.The patch is prepared from 10 parts of fructus evodiae, 10 parts of fresh ginger, 15 parts of codonopsis pilosula, 10 parts of water chestnuts, 10 parts of white pepper, 8 parts of clove, 15 parts of folium artemisiae argyi, 10 parts of dried ginger and 2 parts of borneol. According to the traditional Chinese medicine compound sustained-release patch for treating the senile constipation and the application of the traditional Chinese medicine compound sustained-release patch, targeted absorption of the medicine is enhanced by utilizing the characteristics of the Shenque acupoint, the medicine is continuously released within 12-24 hours, the clinical total effective rate is 95.0% and is obviously higher than 78.9% of a lactulose control group, and the traditional Chinese medicine compound sustained-release patch has the advantages that the traditional Chinese medicine compound sustained-release patch is suitable for being used for treating the senile constipation and the application of the traditional Chinese medicine compound sustained-release patch. The traditional Chinese medicine composition is free of systemic adverse reaction, only has 3.3% of transient skin erythema, can improve defecation frequency, consumed time and excrement characters, regulate intestinal flora and fill the medicine blank of over 80-year-old super-elderly patients, and is suitable for old patients with deficiency-cold type functional constipation.

The invention relates to the field of pharmaceutical compositions, in particular to application of akebia saponin D or salt thereof in preparation of a pharmaceutical composition for preventing and treating constipation. The pharmaceutical composition containing the akebiaquinata saponin D or the salt of the akebiaquinata saponin D contains the akebiaquinata saponin D or the salt of the akebiaquinata saponin D and pharmaceutic adjuvants. The akebia saponin D can be used for treating functional constipation by increasing the water content of excrement and the number of excrement grains, shortening the defecation time, improving the intestinal propulsion rate and increasing the number of goblet cells.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine compound preparation for treating functional constipation and a preparation method thereof. The traditional Chinese medicine compound preparation for treating functional constipation comprises the following components in parts by mass: 8-12 parts of betel nuts, 8-12 parts of lindera aggregata, 18-22 parts of immature bitter oranges, 25-35 parts of raw atractylodes macrocephala, 18-22 parts of semen raphani, 13-17 parts of trichosanthes kirilowii maxim and 18-22 parts of cistanche deserticola. According to the preparation, through the synergistic effect of multiple traditional Chinese medicines, overall regulation of liver-spleen disharmony type constipation is achieved, main symptoms such as defecation difficulty, abdominal distension and belching are relieved, and the multiple effects of tonifying the spleen, regulating qi, moistening the intestines, tonifying the kidney and the like are also achieved. The traditional Chinese medicine composition is scientific and reasonable in preparation process, effective components are fully extracted, the dosage form is suitable for modern clinical application, the traditional Chinese medicine composition has good safety and tolerance, and an effective and high-compliance traditional Chinese medicine treatment scheme is provided for patients with functional constipation.

The application discloses a traditional Chinese medicine composition for treating functional constipation of children, which is prepared from the following raw medicine materials in parts by weight: 10-30 parts of Rubus parvifolius L, 10-30 parts of Paederus fuscipes Motschulsky, 10-30 parts of Atractylodes macrocephala Koidz, 5-20 parts of Rehmannia glutinosa Libosch, 5-20 parts of Citrus reticulata Blanco, 5-20 parts of Magnolia officinalis Rehd et Wils, 5-20 parts of Pogostemonis Herba, and 5-20 parts of Nelumbinis Folium. The medicine composition can fundamentally improve the intestinal function of children with functional constipation, and can avoid drug dependence and side effects caused by long-term use of western medicine purgative, effectively treat functional constipation, and prevent children from suffering from fecal impaction. The clinical application proves that the application can effectively treat functional constipation of children, keep the children's stool unobstructed, has no side effects, has good long-term curative effect, and effectively prevents children from suffering from fecal impaction.

The present application provides a kind of composition, by specific content proportion of probiotics, traditional Chinese medicine extract and acceptable adjuvant composition is formed.Therein, probiotics includes lactobacillus, lactobacterium, bifidobacterium;Traditional Chinese medicine extract includes astragalus extract, radix codonopsis extract.The advantages of the present application are: the composition has synergistic effect, can moisten intestines, defecate, for preventing or auxiliary treatment functional constipation, especially suitable for senile qi deficiency type constipation, and side effect is small, does not produce dependence.In addition, the compound form of the product can significantly improve the compliance of the user population, and save the overall use cost.

The invention discloses an application of fucoidin in preparation of a medicine for treating functional constipation. The effect of the fucoidin or the fucoidin composition on treating functional constipation is investigated by measuring the influence of the fucoidin or the fucoidin composition on defecation parameters and various biochemical indexes of mice with functional constipation. Test results prove that the fucoidin or the fucoidin composition has a remarkable curative effect on functional constipation and has no toxic or side effect.

The invention discloses bifidobacterium longum, a bacterial agent and a preparation method and application of the bacterial agent. The bifidobacterium longum disclosed by the invention is bifidobacterium longum OH317 of which the preservation number is GDMCC (China General Microbiological Culture Collection Center) No.66537. The bifidobacterium longum newly researched and developed in the invention has good gastrointestinal environment resistance and intestinal adhesion colonization characteristics, can effectively improve functional constipation symptoms and regulate intestinal flora balance, has specific drug resistance characteristics, and meets clinical drug combination requirements when constipation is combined with intestinal infection; the microbial inoculum prepared from the strain comprises powder and enteric capsules, and is high in viable bacteria retention rate and good in stability. The invention provides a new scheme and way for prevention and treatment of functional constipation and balance adjustment of intestinal microecology.

The present invention relates to the fields of microbiology and food biotechnology, and provides a composition of Lactobacillus paracasei and tagatose for synergistically treating functional constipation. The active ingredients of the composition are Lactobacillus paracasei ZYhyy-004 and tagatose. The Lactobacillus paracasei is named ZYhyy-004, and this strain is deposited in the China General Microbiological Culture Collection Center, and the taxonomic name is Lacticaseibacillus paracasei , and the deposit number is CGMCC No. 31554, and the deposit date is August 5, 2024. Experiments have confirmed that in the composition of Lactobacillus paracasei and tagatose described in the present application, Lactobacillus paracasei ZYhyy-004 and tagatose have a synergistic effect in treating and / or improving the functional constipation of animals, and can be used to improve or treat functional constipation.

The invention relates to the technical field of biological medicine, in particular to a traditional Chinese medicine composition for treating senile functional constipation, which comprises radix rehmanniae recen, radix ophiopogonis, radix scrophulariae, fructus cannabis, semen pruni, semen boitae, peach kernel, angelica sinensis, poria cocos, raw rhizoma atractylodis macrocephalae, fried endothelium corneum gigeriae galli, fried rice sprout, fried malt, fried fructus aurantii, rhizoma sparganii and curcuma zedoary. The traditional Chinese medicine composition can achieve the technical effects of treating senile functional constipation, improving intestinal functions and promoting natural defecation, has no side effect, and solves the problems that in the prior art, senile constipation treatment mainly depends on laxative, intestinal motility promoting drugs and the like, and the treatment effect is poor. The side effects of intestinal dysfunction, electrolyte imbalance and the like can be caused by long-term use of the medicines.

The invention belongs to the field of food, and relates to application of breast milk oligosaccharide to improvement of intestinal flora environment under the condition of constipation, in particular to application of 2 '-fucosyllactose to preparation of food which is taken by a constipation body and contributes to regulation of intestinal flora and intestinal environment. The food provided by the invention can effectively improve functional constipation, and the improvement of functional constipation comprises the following steps: adjusting the abundance of beneficial bacteria and harmful bacteria in intestinal tracts, improving the diversity of intestinal flora, especially adjusting the abundance of some bacteria related to maintaining flora balance and promoting short-chain fatty acid production in the intestinal tracts, and improving the functional constipation. The content of short-chain fatty acid is increased.