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94 results about "Functional constipation" patented technology

Functional constipation, known as chronic idiopathic constipation (CIC), is constipation that does not have a physical (anatomical) or physiological (hormonal or other body chemistry) cause. It may have a neurological, psychological or psychosomatic cause. A person with functional constipation may be healthy, yet has difficulty defecating.

Therapy for enteric infections

ActiveUS8772242B2Antibacterial agentsBiocideNervous systemDiverticulitis
There is disclosed herein a composition for treating gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhea, chronic idiopathic nausea, IBD-associated constipation and diarrhea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinsons disease, MS, Alzheimers Disease, Motor Neurone Disease or autism, the composition comprising: (i) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (ii) at least one anti-clostridial agent selected from the above combined with an opioid blocking agent. There is also disclosed herein a method of treating various gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhea, chronic idiopathic nausea, IBD-associated constipation and diarrhea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinsons disease, MS, Alzheimers Disease, Motor Neurone Disease or autism, the method comprising administering orally, via enema or by suppository: (i) a composition of the invention; (ii) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (iii) at least one anti-clostridial agent selected from the above and an opioid blocking agent to a patient in need of such treatment.
Owner:BORODY THOMAS JULIUS

Pyridine derivatives as rearranged during transfection (RET) kinase inhibitors

This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and / or secretion and / or abdominal disorders or diseases and / or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity.
Owner:GLAXOSMITHKLINE INTPROP DEV LTD

Traditional Chinese medicine composition for treating constipation and preparation method and clinical preparation thereof

The invention belongs to the field of traditional Chinese medicines and discloses a traditional Chinese medicine composition for treating constipation and a preparation method and a clinical preparation thereof. The traditional Chinese medicine composition is prepared by prepared rhubarb, linum, white paeony root, fructus aurantii, mangnolia officinalis, costusroot, semen cassiae, unprepared fleece-flower root and licorice roots northwest origin, and the traditional Chinese medicine composition has effects of clearing heat, lubricating intestines, regulating vital energy and clearing hollow viscera. According to modern pharmacology study and clinical tests, the traditional Chinese medicine composition has the advantages that the function of relaxing bowels is effectively achieved, the usage is convenient, the curative effect is remarkable, the traditional Chinese medicine composition is comfortable and safe and free of toxic and side effects, besides, the traditional Chinese medicine composition serving as a good remedy for treating the constipation can be widely applied to clinical treatment for constipation patients with functional constipation and senile constipation and other constipation patients which are required to take cathartics for ages, and particularly applicable to treatment for dryness-heat and body fluid deficiency type constipation and excessive heat and vital energy stagnation type constipation. Simultaneously, medicinal materials of the traditional Chinese medicine composition has the advantages of being free of toxics, small in medicine dependence by long-term usage, low in price, applicable to short-term and long-term usage, and having a broad market prospect.
Owner:THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV

Flammulina velutipes polysaccharide, extraction method of flammulina velutipes polysaccharide and application of flammulina velutipes polysaccharide to preparation of medicine for treating functional constipation

The invention discloses an extraction method of flammulina velutipes polysaccharide. The method is concretely characterized in that crushed needle mushroom entities are sequentially subjected to room temperature digestion by petroleum ether and 75+/-10 percent ethanol; the obtained residue is subjected to hot decoration and boiling by water at 90+/-5 DEG C; filtering is performed; filtering liquid is subjected to alcohol deposition; precipitates are taken and are sequentially washed by absolute ethyl alcohol, acetone and petroleum ether; then, freeze drying is performed; the flammulina velutipes polysaccharide is obtained. The invention also discloses application of the flammulina velutipes polysaccharide to an aspect of the preparation of medicine for treating functional constipation. Through experiments, the effects that the flammulina velutipes polysaccharide can obviously raise the contents of MTL (motillin), GAS (gastrin) and P substances in blood serum, and can reduce the content of SS (somatostatin), so that the functional constipation can be effectively relieved are discovered. The result shows that the flammulina velutipes polysaccharide belongs to ideal medicine for treating the functional constipation.
Owner:HENAN UNIVERSITY

Traditional Chinese medicine composition for treating functional constipation and application thereof

The invention relates to a traditional Chinese medicine composition for treating functional constipation and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials of radix paeoniae alba, bighead atractylodes rhizome, radix rehmanniae recen, bran-fried immaturus aurantii, ginger-fried magnolia officinalis and hemp kernel. The invention also provides the application of the traditional Chinese medicine in preparation of medicines for treating the functional constipation. The traditional Chinese medicine composition has the advantages that 1, the selected raw materials have moderate cold and warm properties, and wetness and dryness properties, the dredging function is integrated into the tonifying function, and the effects of invigorating the spleen and clearing heat, nourishing Yin and wetting dryness, and activating Qi circulation and activating bowels are realized; 2, the compounding meets the principle of 'monarch, ministerial, conductant and envoy', the number of medicine types is fewer, the treatment effect is high, any toxic or side effect is avoided, the cost is low, and the like; 3, the selected crude drugs and the proportional ratio are screened by test, so that the effect is obvious; 4, the symptom of functional constipation (intestine excess-heat syndrome), traditional Chinese medicine and life quality can be effectively improved, the application is safe in short term, and the adverse reaction is low.
Owner:SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M

Chinese patent medicine for promoting gastrointestinal motility and its preparation method

The invention discloses a Chinese patent medicine for promoting gastrointestinal motility. The Chinese patent medicine is made from the following raw materials by weight: 9-18 parts of purslane, 15-28 parts of ovateleaf knotweed rhizome, 12-22 parts of radix aucklandiae, 8-17 parts of Mangnolia officinalis, 12-18 parts of aconite, 9-20 parts of perilla powder, 10-25 parts of securinega suffruticosa, 8-15 parts of Pericarpium Arecae, 2-4 parts of fritillary flowers, 8-14 parts of Evodia lepta, and 6-14 parts of herba belladonnae. The components of the Chinese patent medicine provided in the invention come from common traditional Chinese medicines, and are mostly edible medicinal products. With the characteristics of cheap raw materials, simple preparation and convenient use, the Chinese patent medicine is proved to have significant efficacy on irritable bowel syndrome, functional dyspepsia, functional abdominal bloating, functional constipation and other gastrointestinal functional lesions after many years of clinical application and pharmacological study. The raw material drugs together play a role in helping digestion and harmonizing stomach, descending the adverse-rising qi and arresting vomiting, promoting the circulation of qi and removing stagnation, soothing liver and descending qi, and can reach a good curative effect on gastroenteritis caused by various causes.
Owner:朱晓岩

Chinese herbal medicine brewing tea for treating old people constipation and preparation method thereof

The invention relates to a Chinese herbal medicine brewing tea for treating old people constipation, and a preparation method thereof, belonging to the technical field of sanitary and medical services. For the purposes of simplicity, convenience and cheapness and good effect, on the basis of ancient formula, the basic prescription comprising semen cassia, herba cistanche, radix astragali, honey and the like is selected through optimization. Supplementary are added along with symptoms on the basis of the basic formula, wherein angelica sinensis and red dates are supplemented for treating deficient constipation; radix codonopsis and cynomorium songaricum are supplemented for treating qi constipation; radix scutellariae and dried radix rehmanniae are supplemented for treating heat constipation; and longan pulp and radix rehmanniae preparata are supplemented for treating cold constipation. The preparation method comprises the steps of weighing according to the proportion of active ingredients supplemented along with the symptoms in the components in the basic formula except for honey, crushing the accurately weighed semen cassia, herba cistanche and radix astragali, then filtering with a 100-mesh sieve; and then evenly mixing the sieved mixture with the honey to prepare the brewing tea for treating old people constipation, and drying and packaging to obtain the finished product brewing tea for treating constipation. The Chinese herbal medicine brewing tea has the characteristics of being small in medicine administration amount, low in price, good in effect, accurate in curative effect, abundant in medicine source, simple to prepare, short in curative period, low in cost, and safe and reliable.
Owner:邳州亚联环保科技有限公司

Edible and medicinal traditional Chinese medicine composition for improving functional constipation and preparation method thereof

The invention discloses an edible and medicinal traditional Chinese medicine composition for improving functional constipation. The composition is prepared from the following raw materials in parts by weight: 10-20 parts of fructus cannabis, 25-35 parts of radix paeoniae alba, 6-12 parts of fructus aurantii immaturus, 6-12 parts of flos magnolisa officinalis, 6-12 parts of apricot kernels, 15-25 parts of angelica sinensis, 15-25 parts of black sesame, 10-20 parts of Chinese wolfberry fruits, 10-20 parts of radix cyathulae and 3-9 parts of licorice roots. In the edible and medicinal traditional Chinese medicine composition, the raw materials are edible and medicinal traditional Chinese medicinal raw materials, have small toxic and side effects, are safe to use, are reasonably combined and scientific in compatibility and are combined to achieve the effects of smoothing intestine, relieving constipation, nourishing yin, moistening dryness, nourishing liver and kidneys, and have a remarkable synergistic effect, so that mutual promotion and mutual enhancement relationship can be sufficiently achieved. The traditional Chinese medicine composition can be used for effectively improving the symptom of constipation, is safe, and does not have toxic or side effect.
Owner:王季馨

Chinese patent medicine for treating chronic gastric disease of spleen deficiency and preparation method of Chinese patent medicine

The invention discloses a Chinese patent medicine for treating a chronic gastric disease caused by spleen deficiency. The Chinese patent medicine is prepared from the following raw materials in parts by weight: 10-17 parts of codonopsis pilosula, 8-10 parts of diverse wormwood herb, 5-10 parts of aspongopus, 5-10 parts of fructus piperis longi, 3-7 parts of semen raphani, 5-9 parts of poria cocos, 10-15 parts of maltose, 3-6 parts of fermented soybean, 2-6 parts of thickleaf croton root and 150-200 parts of yellow wine. A formula of the Chinese patent medicine is from common traditional Chinese medicine ingredients; most of the ingredients are medical and edible dual purpose ingredients; raw materials are cheap; the Chinese patent medicine is simple to prepare and convenient to use; through clinical application and pharmacological research for many years, the Chinese patent medicine has a significant curative effect on gastrointestinal functional disorders such as an irritable bowel syndrome, functional indigestion, functional abdominal distention and functional constipation; the active ingredients jointly exert an effect of promoting digestion, harmonizing a stomach, calming adverse-rising energy, stopping vomiting, promoting the circulation of qi, removing qi stagnation, soothing a liver and descending qi; the Chinese patent medicine has a good curative effect on gastroenteritis caused by various reasons; and due to the fact that many people have the disease and the Chinese patent medicine has the characteristics that the Chinese patent medicine is nontoxic and can be taken for a long time, the Chinese patent medicine has broad market prospects.
Owner:朱晓岩

Medicine for treating functional constipations

InactiveCN104587401ASolve the distress that requires long-term medicationTo achieve the purpose of treating constipationDigestive systemPlant ingredientsTherapeutic effectOfficinalis
The invention discloses a medicine for treating functional constipations, belongs to the technical field of traditional Chinese medicines, and aims at overcoming the problems that the medicine in the prior art is poor in treatment effect on functional constipations and the functional constipations cannot be cured once and for all. The medicine is prepared from the following raw materials in parts by weight: 10 parts of tatarian aster root, 10 parts of rhubarb stir-fried with wine, 30 parts of bunge cherry seed, 10 parts of immature bitter orange, 30 parts of dandelion, 10 parts of mangnolia officinalis, 10 parts of toasted almond, 30 parts of fried semen raphani, 10 parts of fried zedoary, 30 parts of polygonum multiflorum, 6 parts of cimicifugae foetidae, 10 parts of radix polygonati officinalis, 40 parts of cynomorium songaricum, 30 parts of semen cassia, 10 parts of areca-nut, 10 parts of rhizoma pinellinae praeparata, 10 parts of agilawood, 15 parts of polygonatum kingianum, 15 parts of dendrobium, 15 parts of radix ophiopogonis, 10 parts of fructus perillae, 15 parts of sinapis alba, 10 parts of herba epimedii and 10 parts of fingered citron. The medicine for treating various functional constipations is fast in acting, short in treatment course and accurate in curative effect; the recovery rate can be up to 95.5%; and the effective rate is 99.5%.
Owner:庄肃娟
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