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34 results about "Diphenoxylate" patented technology

Diphenoxylate is a centrally active opioid drug of the phenylpiperidine series that is used in a combination drug with atropine for the treatment of diarrhea. Diphenoxylate is an opioid and acts by slowing intestinal contractions; the atropine is present to prevent drug abuse and overdose. It should not be given to children due to the risk that they will stop breathing and should not be used in people with Clostridium difficile infection.

Opiod tannate compositions

InactiveUS20040157784A1BiocideSalicyclic acid active ingredientsLevorphanolPentazocine
A composition comprising the tannate of an opioid. Suitable opioids include alfentanil, buprenorphine, butorphanol, carfentanil, cocaine, codeine, dezocine, diacetylmorphine, dihydrocodeine, dihydromorphine, diphenoxylate, diprenorphine, etorphine, fentanyl, heroin, hydrocodone, hydromorphone, beta-hydroxy-3-methylfentanyl, levo-alpha-acetylmethadol, levorphanol, lofentanil, meperidine, methadone, morphine, nalbuphine, nalmefene, o-methylnaltrexone, naloxone, naltrexone, oxycodone, oxymorphone, pentazocine, pethidine, propoxyphene, remifentanil, sufentanil, tilidine and tramadol. The opioid tannate may be readily prepared by reacting an opioid free base with tannic acid, either neat or in the presence of up to about 30 wt. % water, at a temperature of about 60 to about 150° C. and thereafter recovering the resultant opioid tannate. The opioid tannate may also be prepared by an alternative process that involves reacting the opioid free base with water at a temperature such that not more than about 10 wt. % of the opioid tannate will be decomposed and thereafter removing the water by freeze-drying.
Owner:JAME FINE CHEM

Biochemical rodenticide

A biochemical deratization, its composition consists of cultivator of killing active dung streptococcus, barium sulfate, diphenoxylate, grain and attractant. Weight percentage of the composition is as follows: nutrient medium of killing active dung streptoccus 3-5 %, barium sulfate 20-80%, diphenoxylate 0.01-0.05%, grain and attractant 15-75 %.
Owner:辽宁微科生物工程有限公司

Composition and manufacturing method and application thereof

The invention belongs to the field of medicine healthcare, and particularly discloses a composition and a manufacturing method and application thereof. The composition is manufactured from xylooligosaccharide, psyllium seed husks, citrus dietary fiber, barley grass and water-soluble dietary fiber, and achieves the good effects of relaxing bowels and adjusting the intestinal health due to the synergistic effect. The manufacturing method of the composition comprises the steps of smashing and mixing the xylooligosaccharide, psyllium seed husks, citrus dietary fiber, barley grass and water-soluble dietary fiber to obtain the composition, the effective ingredients of the raw materials are reserved to the maximum extent, and the obtained composition has the remarkable effect of relaxing bowels, and is easy to operate and suitable for industrial production. The composition has the remarkable improving effect on the intestine inhibiting effect caused by diphenoxylate, can remarkably shorten the defecation time, promote alvine motion and increase the number of defecations and the weight of defecations and has the much better effect than a raw material single experiment set. It is shown that the composite can remarkably improve constipation.
Owner:BY HEALTH CO LTD

Compound medicine for preventing and treating enteritis of poultry and preparation method thereof

The invention discloses a compound medicine for preventing and treating enteritis of poultry, which contains the following constituents by mass percent: 10-40% of antibiotics, 0.1-1% of obstruent, 2-12% of intestinal mucosa protector, and the balance of auxiliary material. The antibiotics constituent in the compound medicine is one or more of aminoglycosides, polymyxins and berberine hydrochloride. The obstruent is one of scopolamine methobr, atropine, diphenoxylate, loperamide and bismuth subnitrate, or combinations of more. The intestinal mucosa protector is one of vitamin K3, cimetidine and glutamine, or combination of more. The auxiliary material is one of oral glucose, anhydrous glucose, soluble starch, dextrin and cyclodextrin, or combination of more. The invention further discloses a preparation method of the compound medicine for preventing and treating enteritis of poultry.
Owner:JIANGSU WEITAILONG BIOTECH

Compound medicine for treating infantile diarrhea and preparation method of compound medicine

The invention relates to a medicine for treating infantile diarrhea, and in particular relates to a compound medicine for treating infantile diarrhea and a preparation method of the compound medicine. The medicine disclosed by the invention is prepared by taking glucurone, tannalbin and compound diphenoxylate as raw materials. The preparation method disclosed by the invention comprises the steps of evenly mixing the raw materials to prepare 100-120 meshes of powder, sterilizing and disinfecting, bagging and then sealing to obtain the medicine. The medicine for treating infantile diarrhea has the advantages of good curative effect, quick effect and no toxic and side effects.
Owner:申长乐

A medicine for treating chronic colitis

The invention discloses a medicine for treating chronic colitis, which has the following medicine composition: Codonopsis pilosula, Atractylodes macrocephala, moxibustion licorice, angelica, white spoon, cinnamon, nutmeg, woody fragrance, myrobalan, millet shell, dried ginger , Compound Diphenoxylate Tablets, Sulfasalazine Tablets. It has the effects of invigorating the spleen and replenishing qi, invigorating qi and promoting blood circulation, nourishing qi and invigorating the middle, warming the middle and dispelling cold, reducing astringency and relieving diarrhea, reducing inflammation and relieving pain, levating the anus and stopping prolapse. The process is simple, the raw materials are easily obtained, the cost is low, the effect is quick, and the cure rate is high, so it is a medicine for treating chronic colitis worthy of popularization.
Owner:范暄民

Compound enteritis capsule

The invention provides a compound enteritis capsule. It is characterized by simple treatment, convenient usage and functions of treating bacillary dysentery, acute and chronic enteritis. It makes use of the anti-biotic effect for bacillus coli and Bacillus dysenteriae of furazolidone, acts on intestine smooth muscle by using chlorhydric acid diphenoxylate, gets rid of crawl reflection of partial mucosa to reduce crawl by inhibiting intestine mucosa receptor, and increases intestine wall stage contraction and promotes water back-absorption in the intestine. The atropine sulfate can relieve intestine smooth muscle spasm and inhibit glandular secretion. The capsule comprises five chemical medicine, it can shorten the treating period for bacillary dysentery and acute enteritis, increase cure rate for various chronic colitis, and reduce pain for patient during injection, intravenous drip, bowel lavage and taking traditional medicine.
Owner:王留柱

Powder pharmaceutical formulations for treating infantile diarrhea

The present invention provides a powder pharmaceutical formulations for treating infantile diarrhea which overcomes weak pocket of other medicament for treating the disease. The powder pharmaceutical formulation is prepared by raw materials as follows: biofermin 0.1-1 g, compound diphenoxylate 0.25-2.5 mg, acetylsalicylic acid 0.3-0.15 g, chlorphenamine 0.04-0.2 mg and hydrochlorothiazidum tablet 1-5 mg, the above medicine are grinded to dead small, then are measured and packed for obtaining the powder pharmaceutical formulation. The powder pharmaceutical formulation for treating infantile diarrhea is used about twenty years and is consulted by patients 10000 times, wherein, males 5500 times, females 4500 times, curative rate 98% and efficiency rate 100%.
Owner:杨国强

Application of fulvic acid sodium in preparing drugs for treating diarrhea

The invention relates to an application of fulvic acid sodium in preparing drugs for treating diarrhea. Research discovers that the fulvic acid sodium in the invention has low toxicity, can restrain the gastrointestinal motility of a normal mice, can cooperate with reinforced compound diphenoxylate to restrain the gastrointestinal motility of the mice, can obviously improve the physical sign of a mice suffering splenasthenic diarrhea caused by rheum officinale, and restrain the gastrointestinal motility of the mice suffering diarrhea, thus treating the diarrhea; and the research shows that the fulvic acid sodium has obvious effect of treating the diarrhea.
Owner:KUNMING UNIV OF SCI & TECH +1

Drug for treating mink digestive tract diseases

The invention relates to a drug for treating mink digestive tract diseases and belongs to the technical field of drugs for veterinary use. The drug is prepared from 10 parts by weight of gentamycin, 7-8 parts by weight of diphenoxylate, 8-10 parts by weight of radix astragali, 8-10 parts by weight of wrinkled giant hyssop, 5-6 parts by weight of radix bupleuri and the balance glucose. Individual use or combined use of radix astragali, wrinkled giant hyssop and radix bupleuri does not produce effects of treating mink digestive tract diseases but through combination with gentamycin, the mixed drug has a mink digestive tract disease cure rate of 73.5% and has curative effects obviously higher than effects of colistin sulfate. Through further use of a small amount of resveratrol and tetramethylpyrazine, a drug having a higher mink digestive tract disease cure rate is obtained.
Owner:山东省动物疫病预防与控制中心

Dendrobium officinale mixture

The invention discloses a dendrobium officinale mixture. The dendrobium officinale mixture is prepared from the following traditional Chinese medicinal materials serving as raw materials in parts by weight: 10 to 12 parts of dendrobium officinale, 15 to 25 parts of raw atractylodis macrocephalae rhizome, 10 to 20 parts of radix scrophulariae, 10 to 20 parts of radix ophiopogonis, and 10 to 20 parts of raw radix rehmanniae. The dendrobium officinale mixture has the effects of increasing fluid, moistening dryness, nourishing yin, clearing heat, strengthening spleen and tonifying qi, and is used for constipation and the diseases that the defecating frequency is reduced, the excrement amount is little and hard in texture, a pleasant feeling disappears after defecating, and the defecating time or the defecating interval time is prolonged. In order to prove a good effect of the dendrobium officinale mixture to the constipation better, the effect of the mixture to a mouse with the constipation induced by compound diphenoxylate is investigated through an animal experiment; the effect shows that the mixture can promote the pushing of small intestines of the mouse with the constipation, promote defecation, protect intestinal mucosa and improve serum SOD.
Owner:ZHEJIANG CHINESE MEDICAL UNIVERSITY

Medicine for treating postoperative gastroenteropathy

A medicine for treating postoperative gastrointestinal diseases, which is composed of 6-12% of rhubarb, 14-26% of astragalus, 10-15% of hemp seed, 5-10% of Citrus aurantium, 5-10% of Magnolia officinalis, and 6% of Atractylodes Rhizoma ~12%, Muxiang 6~12%, Angelica 6~12%, Peach Kernel 5~10%, Paeonia suffruticosa 5~10%, the oral medicine prepared according to the conventional preparation method. The medicine of the present invention has been tested on the efficacy of the medicine, and the experimental results show that the medicine of the present invention can promote the defecation process of normal mice; Promoting effect; the medicine of the present invention also has obvious improvement effect on delayed gastric emptying and delayed intestinal propulsion in rats caused by abdominal surgery; the medicine of the present invention can resist the weakening of small intestine activity caused by compound diphenoxylate. The above results provide a reliable experimental basis for the drug of the present invention to be used for complications such as abdominal distension and constipation after abdominal surgery.
Owner:THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV

Western medicine compound pharmaceutic preparation for treating diphtheritic enteritis

The invention discloses a western medicine compound pharmaceutic preparation for treating diphtheritic enteritis. A Chinese medicine preparation comprises, by weight, 2-8 parts of dragon bones, 5-15 parts of fructus chebulae, 2-8 parts of nutmeg, 1-9 parts of honey-fried licorice roots, 5-15 parts of red halloysite, 5-13 parts of dogwood, 2-9 parts of szechwan Chinaberry fruits, 5-15 parts of rhizoma alismatis, 5-15 parts of elecampane and 1-9 parts of coptis chinensis. The western medicine preparation comprises, by weight, 0.1-0.5 part of diphenoxylate, 0.1-0.5 part of atropine sulphate, 0.8-1.2 parts of pectinesterase and 0.01-0.08 part of medicinal magnesium chloride. In the Chinese medicine preparation, the added components have the effects of warming the middle and benefiting qi, invigorating spleen and removing dampness and the like. The added western medicine preparation is obvious in sterilization effect, contributes to growth of an intestinal tract normal flora, and has an obvious curative effect on the diphtheritic enteritis, and the effect is quick.
Owner:郝丽娟

Wear-resistant, anti-oxidation and anti-seepage photoelectric hybrid cable

The invention discloses a wear-resistant, anti-oxidation and anti-seepage photoelectric hybrid cable. The cable comprises an outer protection layer, a hybrid cable core and a ratproof layer. The outer protective layer is prepared from the following components in parts by weight: 18 to 21 parts of linear low-density polyethylene, 3.1 to 4.6 parts of chlorinated paraffin-52, 1.3 to 2.2 parts of polyether modified silicone oil, 6 to 9 parts of barium sulfate, 3 to 6 parts of high-abrasion-resistance carbon black, 1 to 3 parts of 2, 6-di-tert-butyl-4-methylphenol and 4 to 5 parts of calcium carbonate. The ratproof layer is prepared from the following components in parts by weight: 5 to 7 parts of barium sulfate, 6 to 9 parts of diphenoxylate, 5 to 10 parts of phthalate, 3 to 5 parts of polyvinyl alcohol, 1.8 to 2.3 parts of mint extract, 10 to 13 parts of capsaicin and 4 to 6 parts of ethanol. The photoelectric hybrid cable prepared from the raw materials is good in mechanical properties, long in service life and capable of effectively preventing rats.
Owner:SICHUAN TIANYI COMHEART TELECOM

Medicinal preparation used for treating diarrhoea of livestock and poultry

The invention discloses a medicinal preparation used for protecting the livestock and poultry from diarrhea, which comprises the following raw materials by weight ratio: 1-20 parts of Radix Astragali, 1-20 parts of bighead atractylodes rhizome, 1-20 parts of licorice, 2-40 parts of white peony root, 20-150 parts of Limonite, 20-150 parts of red halloysite, 2-20 parts of pomegranate rind, 20-100 parts of alum, 3-30 parts of radix bupleuri, 4-10 parts of cimicifuga foetida, 1-20 parts of coptis and 0-3 parts of diphenoxylate. The components of the medicinal preparation are direct and mutual synergism, and has efficacy of supplementing the center and boosting qi, lifting up Yang and depression, antidarrhea with astringent, inhibiting smooth muscle spasm of gastrointestinal tract and alleviating peristaltic of gastrointestinal tract, and is capable of rapidly recovering the functions of gastrointestinal tract, thereby, the medicinal preparation has an obvious function of weight increasing.
Owner:河北征宇制药有限公司

Method for detecting diphenoxylate in biological sample by liquid chromatography-tandem mass spectrometry for criminal investigation

The invention relates to a method for detecting diphenoxylate in a biological sample by liquid chromatography-tandem mass spectrometry for criminal investigation. The method comprises the following steps: (I) extracting diphenoxylate from the biological sample; and (II) detecting diphenoxylate extracted in the step (I) by a liquid chromatography-tandem mass spectrometry instrument. The method provided by the invention improves the sensitivity of the detection of diphenoxylate in the biological sample to be detected, and reduces the degree of detection difficulty of diphenoxylate in the biological sample to be detected.
Owner:INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY

Method for measuring electrophysiological activity of colon muscles of mice

The invention discloses a method for measuring electrophysiological activity of colon muscles of mice and application thereof. The method comprises the following steps of: performing gavage on the mice by using compound diphenoxylate suspension to establish a constipation model, selecting medical suture needles, manufacturing copper wires into copper wire electrodes, and measuring the change of electrophysiological activity of colon. Compared with the result of the control group, the result shows that the slow wave colon frequency, the frequency variation coefficient, the amplitude and the amplitude variation coefficient of the mice in a constipation group have an extremely obvious difference P which is less than 0.01. The method for measuring the electrophysiological activity of colon muscles of mice has the advantages that 1, the measuring method is easily available in raw materials, simple, practicable, high in repeatability and high in success rate; 2, the method is slight in damage to a subject and suitable for mice and other animals; 3, according to the measuring method, the change of the electrophysiological activity of colon muscles of the mice can be objectively reflected; and 4, a powerful tool is provided for researching the movement mechanism of the colon and controlling constipation in the system.
Owner:XINXIANG MEDICAL UNIV

Antidiarrheal pharmaceutical composition

The invention discloses a composition of an antidiarrheal agent, which consists of the following weight portions of ingredients: 1.5-3 portions of compound diphenoxylate, 2.5-6 portions of prednisone and 5-15 portions of hydrochlorothiazide. The composition of the antidiarrheal agent has clear curative effect, good efficacy, rapid disappearance of diarrhea; diuresis effect of the hydrochlorothiazide is utilized to absorb water and reduce intestinal water, and the anti-inflammatory and anti-infection functions of prednisone are applied to mitigate clinic sympton, the cooperation of these three medicines accelerates the antidiarrheal speed and relieves the pain of the sufferers. The composition of the antidiarrheal agent has low cost, which is lower than Xieliting by 5-6 times.
Owner:韩耀云

Pharmaceutical composition for treating colitis

The invention provides a pharmaceutical composition for treating colitis, and relates to the technical field of disease treatment. The pharmaceutical composition for treating colitis comprises the following pharmaceutical compositions: compound endothelium corneum gigeriae galli tablets, oryzanol tablets, medroxyprogesterone acetate tablets, compound diphenoxylate tablets and prednisone acetate tablets, wherein the pharmaceutical composition is taken three times a day, four compound endothelium corneum gigeriae galli tablets are taken each time, three oryzanol tablets are taken each time, three medroxyprogesterone acetate tablets are taken each time, two compound diphenoxylate tablets are taken each time, and one prednisone acetate tablet is taken each time. According to the invention, thepharmaceutical composition is used for treating colitis patients, so that the pain of the colitis patients is effectively relieved, the treatment effect of the colitis patients is obvious, the effectis quick, the treatment period is short, and meanwhile, the pharmaceutical composition for treatment is relatively cheap and relatively convenient to obtain.
Owner:王全栋

Powder pharmaceutical formulations for treating infantile diarrhea

The present invention provides a powder pharmaceutical formulations for treating infantile diarrhea which overcomes weak pocket of other medicament for treating the disease. The powder pharmaceutical formulation is prepared by raw materials as follows: biofermin 0.1-1 g, compound diphenoxylate 0.25-2.5 mg, acetylsalicylic acid 0.3-0.15 g, chlorphenamine 0.04-0.2 mg and hydrochlorothiazidum tablet1-5 mg, the above medicine are grinded to dead small, then are measured and packed for obtaining the powder pharmaceutical formulation. The powder pharmaceutical formulation for treating infantile diarrhea is used about twenty years and is consulted by patients 10000 times, wherein, males 5500 times, females 4500 times, curative rate 98% and efficiency rate 100%.
Owner:杨国强

Application of fulvic acid sodium in preparing drugs for treating diarrhea

The invention relates to an application of fulvic acid sodium in preparing drugs for treating diarrhea. Research discovers that the fulvic acid sodium in the invention has low toxicity, can restrain the gastrointestinal motility of a normal mice, can cooperate with reinforced compound diphenoxylate to restrain the gastrointestinal motility of the mice, can obviously improve the physical sign of amice suffering splenasthenic diarrhea caused by rheum officinale, and restrain the gastrointestinal motility of the mice suffering diarrhea, thus treating the diarrhea; and the research shows that the fulvic acid sodium has obvious effect of treating the diarrhea.
Owner:KUNMING UNIV OF SCI & TECH +1

Application of ethanolamine in preparation of composition for preventing, relieving or treating constipation

The invention discloses application of ethanolamine in preparation of a composition for preventing, relieving or treating constipation. The composition comprises food, a health care product and a medicine. Ethanolamine promotes intestinal tract movement and prevents, relieves or treats constipation by increasing the content of serotonin in colon. Animal experiments prove that ethanolamine can significantly improve the small intestine propulsion rate and the defecation grain number of compound diphenoxylate modeling mice, and has the function of relieving constipation; Meanwhile, the ethanolamine promotes intestinal tract movement and prevents, relieves or treats constipation by increasing the content of serotonin in colon.
Owner:CHINA AGRI UNIV

Functional-oligosaccharide-containing saccharose-free hawthorn coils, preparation method therefor and application of functional-oligosaccharide-containing saccharose-free hawthorn coils

The invention discloses functional-oligosaccharide-containing saccharose-free hawthorn coils, a preparation method therefor and application of the functional-oligosaccharide-containing saccharose-free hawthorn coils. In view of the current situation that the traditional hawthorn coils are too high in saccharose content, functional oligosaccharides are selected or are compounded with xylitol so as to replace saccharose, and the functional-oligosaccharide-containing saccharose-free hawthorn coils are prepared according to production process flows of the traditional hawthorn coils. The hawthorn coils disclosed by the invention have the functions that constipation and obesity preventing effects of the hawthorn coils are surveyed by taking diphenoxylate-hydrochloride-induced mouse constipation models and high-fat high-fructose feed induced mouse obesity models, and the action of improving defecation parameters of constipation mice and regulating lipid metabolism of obese mice is more remarkable (P is smaller than 0.05). In summary, the hawthorn coils provided by the invention are saccharose-free, are suitable for being properly eaten by people suffering from hyperglycemia, hyperlipemia and hypertension and have the functions of preventing constipation and obesity.
Owner:CHINA AGRI UNIV

A traditional Chinese medicine composition preventing diarrhea

The invention relates to a medicine, particularly a traditional Chinese medicine composition preventing diarrhea. The composition includes a traditional Chinese medicine composition prepared by adopting 6-15 g of medicine terminalia fruit, 6-15 g of Chinese angelica, 6-15 g of radix aucklandiae and 6-15 g of debark peony root as raw materials and decocting the raw materials with water, and drying and crushing a decoction product, and a western medicine composition including 0.1-0.2 g of trimethoprim, 0.4-1 g of metronidazole, 0.05-0.3 g of isoniazide, 0.25-0.5 mg of diphenoxylate and 10-20 mg of vitamin B6. The weight of the western medicine composition is 1-80% of the weight of the traditional Chinese medicine composition preventing diarrhea. The traditional Chinese medicine composition preventing diarrhea is mainly used for treating chronic diarrhoea caused by various reasons. The effective rate is 98%, the curative rate is 80% or above, toxic and side effects are few and the traditional Chinese medicine composition preventing diarrhea is convenient to take.
Owner:莫燕芝

Application of chrysophanic acid in preparation of medicines for treating constipation

InactiveCN103919760ABroad pharmacological effectsOrganic active ingredientsDigestive systemMotilityPharmacometrics
The invention discloses application of chrysophanic acid in preparation of medicines for treating constipation. The key point of the technical scheme adopted by the invention is as follows: application of the chrysophanic acid in preparation of medicines for treating constipation caused by gastrointestinal motility dysfunction resulting from compound diphenoxylate medicines. The application disclosed by the invention is beneficial to finding of a new and effective medicine for preventing and treating constipation caused by gastrointestinal motility dysfunction resulting from compound diphenoxylate drugs, meanwhile, the application is used for further verifying the extensive pharmacological action of the chrysophanic acid, having important significance of promoting clinical application of traditional Chinese medicine chrysophanic acid to become a new clinical drug, and providing experimental evidence for illustration of the action mechanism of the chrysophanic acid and market promotion of the chrysophanic acid.
Owner:XINXIANG MEDICAL UNIV

Method for the detection of diphenoxylate in biological samples using liquid chromatography-tandem mass spectrometry for forensic purposes

ActiveCN103344710BTo overcome the shortcomings of the detection methodOvercome deficienciesComponent separationDiphenoxylateTandem mass spectrometry
The invention relates to a method for detecting diphenoxylate in a biological sample by liquid chromatography-tandem mass spectrometry for criminal investigation. The method comprises the following steps: (I) extracting diphenoxylate from the biological sample; and (II) detecting diphenoxylate extracted in the step (I) by a liquid chromatography-tandem mass spectrometry instrument. The method provided by the invention improves the sensitivity of the detection of diphenoxylate in the biological sample to be detected, and reduces the degree of detection difficulty of diphenoxylate in the biological sample to be detected.
Owner:INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY

Compound medicinal prepn. for treating colitis

A composite medicine for treating colitis is prepared from 7 Chinese-medicinal materials including black plum, dahurian angelica root, yam, liquorice, etc and 3 Western medicines including thiaminogen, diphenoxylate and fossyol.
Owner:邵海富
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