9 results about "Furazolidone" patented technology

The invention belongs to the technical field of fluorescence detection, and particularly relates to a ratio-dependent up-conversion fluorescence nanoprobe for veterinary drug detection and a preparation method and application of the ratio-dependent up-conversion fluorescence nanoprobe. The invention provides a ratio type up-conversion fluorescent nanoprobe for veterinary drug detection. The ratio type up-conversion fluorescent nanoprobe comprises a core nanoparticle NaGdF4: Yb / Tm, an inner layer shell NaYbF4, a middle layer shell NaGdF4: Yb / Er and an outer layer shell NaYF4 from inside to outside, after the fluorescent probe is incubated with furaltadone and malachite green, the fluorescence intensity is quenched, the selectivity is good, and the fluorescent probe can be used for detecting furaltadone and malachite green; furthermore, as a ratio-type up-conversion fluorescent nanoprobe, the fluorescent nanoprobe can be excited by low-energy near-infrared light, does not cause light damage, has higher biological tissue penetration depth, no background fluorescence interference and higher signal-to-noise ratio, and is a fluorescence detection method for veterinary drug residues with excellent reliability; therefore, the technical problem of low reliability of fluorescence detection of veterinary drug residues in the prior art is solved.

The application discloses application of a genipin in preparation of a medicine for treating cholangiocarcinoma, and belongs to the field of biological medicines. The cell experiment result shows that the genipin can inhibit cholangiocarcinoma cell proliferation, migration and invasion capacity. The application proves that the genipin can effectively relieve occurrence and development of cholangiocarcinoma by constructing an in-situ cholangiocarcinoma animal model, observing mouse liver weight and liver coefficient, and observing liver tissue pathological HE staining. The application also verifies that the genipin can directly combine with PCSK9 by using proteomics, Western blot, molecular docking technology, surface plasmon resonance experiment and detection of cholesterol and lipid raft level, promotes accumulation of free cholesterol in tumor cells, disturbs cholesterol homeostasis and changes lipid raft structure, thereby playing an anti-tumor role. The application first finds that the genipin has specific effects in inhibiting cholangiocarcinoma progression, and is non-toxic and has no side effects, and can be used alone or in combination as a means for preventing and treating cholangiocarcinoma for development.

The invention discloses a visible / ultraviolet dual-light synergistically enhanced substrate, a preparation method thereof and application of the visible / ultraviolet dual-light synergistically enhanced substrate in rapid detection of veterinary drugs. According to the method, a gas-liquid interface self-assembly technology is combined with a light welding process, and the heterojunction composite Raman substrate Bi: ZnO-SUSNs of a Bi-doped zinc oxide nano array and urchin-shaped silver nanoparticles is prepared. The Bi: ZnO-SUSNs composite Raman substrate disclosed by the invention has excellent visible light / ultraviolet light dual response characteristics, and the detection sensitivity to target molecules can be greatly improved under dual-light driving by utilizing a PIERS mechanism. According to the method, trace detection of veterinary drugs such as malachite green, crystal violet and furacilin can be realized without complex pretreatment. In addition, the composite substrate also has a photocatalytic degradation function, can realize self-cleaning and reutilization, and has the advantages of low preparation cost, high detection speed, good repeatability and the like.

The invention belongs to the technical field of pesticide disinfestation, and discloses an insecticidal composition and application thereof.The insecticidal composition comprises an active component A and an active component B. The active component A is a compound shown in the formula I. The structure of the compound shown in the formula I is shown in the specification, and the active component B is any one of thiotraniliprole or fufenozide; the mass ratio of the active component A to the active component B is (1: 50)-(45: 1). According to the insecticidal composition disclosed by the invention, the insecticidal effect is remarkably improved by compounding the active ingredients with different action mechanisms, and the generation of drug resistance of pests can be effectively delayed due to the difference of target sites of different ingredients in the composition.

The present application relates to the technical field of traditional Chinese medicine. The purpose is to provide a traditional Chinese medicine hot compress for treating children's rhinitis, which comprises the following weight parts of traditional Chinese medicine raw materials: perilla seed 4-6 parts, radish seed 4-6 parts, white mustard seed 2-4 parts, xanthium 2-4 parts, cyperus 2-4 parts, asarum 1-2 parts, evodia 1-2 parts. The present application uses external application of medicine, the use mode is simple, and the patient compliance is high. Through precise proportioning of the prescription, the special prescription is suitable for special diseases, the force is special and one, and the chronic rhinitis patients can take the medicine for a long time, which is convenient, safe and reliable in curative effect. As a pure traditional Chinese medicine formula, its preparation and use are safer and more reliable than furazolidone and other hormone nasal drops in the treatment of rhinitis, and are green and safe.

The invention belongs to the technical field of medicines, and discloses a hydroxime compound derived from an aqueous extract of heads of angelica sinensis, a dehydrated furazan compound of the hydroxime compound, and preparation and application of the hydroxime compound and the dehydrated furazan compound. In particular discloses a hydroxime compound, a dehydrated furazan compound thereof, pharmaceutically acceptable salts of the dehydrated furazan compound and a pharmaceutical composition of the dehydrated furazan compound. The invention also discloses application of the compound in preparation of medicines for treating arthritis, asthma, chronic obstructive pneumonia, pneumonia, cystic fibrosis, diabetes, obesity, hypercholesterolemia, contact dermatitis, psoriasis, atopic dermatitis, stasis dermatitis, seborrheic dermatitis, neurodermatitis and the like, inflammatory enteritis, multiple sclerosis, Parkinson's disease, cardiovascular disease, autoimmune disease, gout and the like. The invention also relates to applications in medicines or health-care products for treating hyperuricemia and cancers. Activity evaluation of a cell model for starting reporter gene expression by using an NF-kappa B reaction element proves that the compound can significantly inhibit NF-kappa B induced transcriptional regulation and is expected to become a therapeutic drug for treating the various diseases.

The invention provides a lanthanide series metal organic framework fluorescence sensing material for detecting furazolidone as well as a preparation method and application thereof, and relates to the technical field of fluorescence detection. The preparation method of the fluorescent sensing material comprises the following steps: adding europium nitrate hexahydrate and 2, 3, 5, 6-tetra (4-carboxyl phenyl) pyrazine into a solvent, carrying out ultrasonic dispersion, transferring the system into a reaction kettle, carrying out solvothermal reaction, cooling to room temperature, centrifuging, washing and drying to obtain a transparent needle-shaped Eu-MOF crystal. The Eu-MOF fluorescent sensor disclosed by the invention has the characteristics of good stability, selectivity and quick response, overcomes the defects of poor stability (such as narrow pH range), low selectivity (susceptible to interference of coexisting ions / antibiotics) and the like in furazolidone (FZD) detection in the prior art, breaks through the technical bottleneck of FZD on-site quick detection, and has a wide application prospect. The trace residue detection of the FZD in animal feed, tap water and the like is realized, and the requirements of food safety on-site rapid screening are met.

This invention relates to the field of crop cultivation and discloses a method for strengthening seedlings of Solanaceae crops and the application of furazolidone. The method involves preparing an aqueous solution of furazolidone at a concentration of 3 mg / L to 6 mg / L, and spraying it onto the surface of the seedling trays after sowing but before emergence, until the trays are moist. Alternatively, it can be sprayed onto the seedlings when the cotyledons have expanded, until the leaves are moist. This invention allows for earlier application of the seedling-strengthening spray, prior to emergence after sowing, without inhibiting normal seed germination, avoiding excessive growth during the cotyledon stage, and especially inhibiting excessive elongation of the hypocotyls and epicotyls. It achieves a seedling-strengthening effect that other techniques cannot achieve. The method is simple to operate, uses readily available raw materials, requires minimal dosage, has low cost, is safe for seedlings, shortens the seedling period, eliminates the need for hardening-off, and saves labor, water, and fertilizer.

This invention relates to a europium-based metal-organic framework material constructed based on 4-((3-(pyrazin-2-yl)-1H-pyrazol-1-yl)methyl)benzoic acid ligand, its preparation method, and its applications. The invention pertains to the fields of metal-organic framework materials, luminescent functional materials, and fluorescence sensing technologies. The chemical formula of the europium-based metal-organic framework material prepared by this invention is: [Eu(ppmb)2(NO3)(H2O)2] n ; where ppmb is the ligand after deprotonation of Hppmb; the structure of Hppmb is; the europium-based metal-organic framework material belongs to the triclinic crystal system, space group P-1, and unit cell parameters are a=9.727(4) Å, b=14.197(5) Å, c=25.615(9) Å, α=77.899(1)°, β=86.231(1)°, γ=70.044(1)°, and it is used in the detection of furazolidone.