83 results about "Furazan" patented technology

The invention belongs to the field of pharmaceutical chemistry, and relates to a furazan derivative which is prepared by combining a coumarin parent nucleus and an isomer of the coumarin parent nucleus with a furazan oxide through linking of groups with different lengths and structures. It is proved by the experiments that the furazan derivative has excellent effects on inhibiting sensitive human tumour cells and drug-resistant tumor strains, and on inhibiting activity of normal growth of HUVEC for measuring an inhibiting action of neovascularization, and on inhibiting activity of cell proliferation of cis-platinum-resistant A2780 cell strains and gemcitabine-resistant HM231 cell strains. It is shown by an initial pharmacological mechanism that by releasing nitric oxide with the high concentration, the furazan derivative can induce apoptosis of cancer cells, inhibits MEK activity, and obviously inhibits phosphorylation of MEK in an MAPK/ERK channel, thereby generating a significant effect on inhibiting growth of a tumor. According to the composition in the invention, excellent basis for obtaining candidate medicines having inhibition activity of sensitive and drug-resistant tumors and for illustrating the pharmacological action is provided.

The invention discloses a benzenesulfonyl furazan modified gemcitabine derivative and a preparation method and use thereof. The benzenesulfonyl furazan modified gemcitabine derivative comprises a compound as shown in a universal formula I and pharmaceutically acceptable salts thereof. According to the rational drug design principle and the combination principle, the clinical pharmacology activity of gemcitabine is retained; meanwhile, with gemcitabine as a lead compound, a benzenesulfonyl furazan NO donor is respectively coupled to N4 amino of gemcitabine through different linking groups to synthesize a benzenesulfonyl furazan modified NO donor type gemcitabine derivative, in order to obtain a compound with stronger anti-tumor activity and better bioavailability than gemcitabine.

The invention discloses a preparation method and application of a hydroxyl porphyrin-based high-selectivity near-infrared fluorescence sulfur ion probe. The fluorescence probe is prepared by taking 5-hydroxyphenyl-11,15,20-triphenylporphyrin (TPP-OH) and 4-chlorine-7-nitro-1,2,3-benzoxadiazole (NBD-Cl) as materials, taking 4-dimethylamino pyridine (DMAP) as a catalyst, taking dichloromethane as a solvent and performing one step reaction under room temperature. The preparation method of the probe is simple, and a product is easy to separate and purify. Compared with an existing small organic molecule fluorescence probe, the fluorescence probe obtained by the preparation method has higher fluorescence emission wavelength (lumbda em is greater than 650nm), high-sensitivity and high-selectivity quick recognition and detection on a trace of hydrogen sulphide can be realized in a near-infrared region, and the application prospect is great in the field of environmental and biological detection.

The invention relates to compounds of the formula (I) in which Het is an azolyl, nitroazolyl or tetrazolyl radical, with the exception of 3-nitro-4-(4-nitro-l,2,3-triazol-1-yl)furazane. The invention also relates to the preparation of said compounds, and to energetic compositions containing at least one compound selected from the compounds of the formula (I) and the 3-nitro-4-(4-nitro-l,2,3-triazol-1-yl)furazane.

The invention discloses a compound containing rhodamine groups and benzofurazan groups and a preparation method and application thereof. The structural formula of the compound is as shown in the specification. The preparation method comprises the following steps: (1) enabling rhodamine B and diethylenetriamine to fully react in a solvent, removing the solvent, and performing preliminary separation and purification; (2) enabling rhodamine B acyl diethylenetriamine and 4-chloro-7-nitrobenzofuroxan to fully react in a solvent, monitoring the reaction process by virtue of TLC, and performing column elution after the reaction is ended, thereby obtaining the product. The method for detecting the concentration of mercury ions or iron ions comprises the following steps: (1) making a standard curve; (2) detecting and recording; and (3) calculating. The invention further discloses an application of the compound serving as an iron ion fluorescence probe or a mercury ion fluorescence probe. The invention also discloses an application of the compound serving as an iron ion specific fluorescence probe or a mercury ion specific fluorescence probe. The compound disclosed by the invention can serve as a specific fluorescence probe for mercury ions or iron ions, is used for detecting mercury ions or iron ions in the solution and is high in accuracy.

The invention discloses a lysine-modified benzofuroxan compound, a synthetic method, an application and a recovery method of the lysine-modified benzofuroxan compound as well as a method of detecting the concentration of copper ions. The structural formula of the lysine-modified benzofuroxan compound is shown in the specification. The synthetic method of the lysine-modified benzofuroxan compound comprises the following steps: 1) carrying out reaction on methanol, thionyl chloride and lysine to obtain lysine methyl ester hydrochloride; 2) in the presence of an acid binding agent, carrying out reaction on the lysine methyl ester hydrochloride and 4-chlorine-7-nitro-benzofuroxan, and carrying out column chromatography; and 3) dissolving the product obtained in the last step in alkali liquor, extracting for multiple times, regulating a pH value of a water phase, extracting for multiple times, collecting an extractant layer, and carrying out purification. The method of detecting the concentration of the copper ions comprises the following steps: 1) drawing a standard curve; 2) detecting and recording; and 3) carrying out calculation. The recovery method of the lysine-modified benzofuroxan compound comprises the following steps: adding a complexing agent aqueous solution into the compound solution containing the copper ions, uniformly mixing, extracting, collecting an organic phase, and removing a solvent. The lysine-modified benzofuroxan compound is applied to preparing a copper ion fluorescent probe. The synthesized lysine-modified benzofuroxan compound is capable of specifically detecting the copper ions, can be prepared into the probe and can also be recovered.

The invention relates to a preparation method of a TNT and TNP detection probe, and belongs to the field of small molecular fluorescent materials. The preparation method comprises the following steps:reacting 3,4-diamino furazan with sodium bicarbonate, and recrystallizing with DMSO/H2O to prepare 3,3'-diamino-4,4'-azofurazan; reacting the 3,3'-diamino-4,4'-azofurazan with 2-hydroxy-1-naphthaldehyde to prepare a difunctional fluorescent molecular probe; and filtering, washing, drying and weighing the product to obtain a dark red solid product, thereby obtaining the final product. The probe realizes simultaneous rapid selective recognition of TNT and TNP on an ultraviolet channel and a fluorescence channel, especially in the fluorescence channel, after TNT and TNP are added, fluorescence intensity of probe molecules is quenched to different degrees, and red shift of different degrees also occurs in an emission peak, so that the probe is very effective for differentially detecting TNT and TNP.

The invention discloses a gemcitabine/FTA/furazan conjugate in a NO-donor type, a preparation method and an application. A product in the invention is the novel gemcitabine/FTA/furazan conjugate in the NO-donor type or a pharmaceutically-acceptable salt thereof represented as the general formula I and the general formula II. The product has excellent functions of treating common tumor and drug-resistant tumor proliferation, can achieve a synergistic treatment effect of a plurality of drug fragments and is easy to prepare.

The invention discloses a method for synthesizing plasticizer 3-nitro furazan-4-methyl ether. The method comprises the following steps: adding hydroxylamine under the alkaline condition by taking ethyl cyanoacetate as a starting material to form a ring, so as to obtain 3-amino furazan-4-carboxylic acid; then, reducing carboxyl group on the furazan ring to an alcoholic extract hydroxyl group by using a sodium borohydride/zinc chloride system, so as to obtain 3-amino furazan-4-methanol; then, oxidizing an amino group on the furazan ring to a nitro group by using a hydrogen peroxide/concentrated sulphuric acid system, so as to obtain 3-nitro furazan-4-methanol; in the presence of pyridine, carrying out chloride substituent on the alcoholic extract hydroxyl group by using thionyl chloride, so as to obtain 3-nitro-4-chloromethyl methyl ether furazan; and finally, reacting 3-nitro-4-chloromethyl methyl ether furazan with sodium methoxide in acetonitrile to remove NaCl so as to obtain the target compound. Compared with the traditional nitrate plasticizer, the plasticizer synthesized by using the method has higher positive enthalpies of formation and thermal stability, lower sensitivity and melting point, and has potential application prospect in the field of solid propellants.

The invention relates to the field of energy-containing materials, in particular to a refining method of a DAOAF (3,3'-diamino-4,4'-azoxy furazan) explosive crystal. The refining method comprises thefollowing steps of (1) dissolving the raw materials of DAOAF and DMSO (dimethyl sulfoxide) by ultrasonic waves to form a DAOAF solution, and pouring the DAOAF solution into an atomizing spray head; (2) opening nitrogen gas to pressurize, enabling the DAOAF solution to form small mist droplets by the atomizing spray head, enabling the small mist droplets to be in contact with a non-solvent, stirring by the ultrasonic waves, and quickly crystallizing and separating DAOAF particles; (3) stirring the DAOAF particles by ultrasonic waves, filtering, and drying under the vacuum condition; (4) enabling a laser granularity meter and a SEM (scanning electron microscope) to perform granularity and morphology characterization on the re-crystallized DAOAF particles. The refining method has the advantages that the solvent can be quickly removed by a spray anti-solvent method, the materials are further crushed by stirring and ultrasonic waves, and the DAOAF crystal particles can be easily refined athigh efficiency; the refined DAOAF has better development prospect in the fields of slapper detonator primers, high-energy mixed explosives, and high-energy solid propellants.

The invention discloses a metal accelerated explosive and a preparation method thereof, and aims to solve the problem of low acceleration capability of the existing metal acceleration type explosive.The metal accelerated explosive comprises the following components in percentage by mass: 75%-83% of 3, 4-dinitrofurazan-based furazan oxide (D5030 [mu]m to 40 [mu]m), 15%-20% of nano aluminum powder(D50100nm to 200nm), 1%-4% of ethylene-vinyl acetate copolymer (EVA, model 28/150) and 1%-4% of paraffin (68 #). The preparation method comprises the following steps: preparing composite particles ofnano aluminum powder and 3, 4-dinitrofurazan-based furazan oxide (DNTF), and carrying out coating granulation by using EVA and paraffin to complete the preparation of the metal accelerated explosive molding powder. According to the explosive, on the premise that safety is guaranteed, high metal driving capacity can be achieved. The charging device is suitable for charging of armor-breaking warheads and explosion-killing warheads.

The invention belongs to the technical field of biochemistry, and particularly relates to a quinoxaline-N1,N4-dioxide derivative capable of inhibiting the activity of DNA topoisomerase, a preparationmethod and application of the quinoxaline-N1,N4-dioxide derivative. 4,5,-difluoro-2-nitroaniline is used as a raw material for synthesis of the quinoxaline-N1,N4-dioxide derivative, the quinoxaline-N1,N4-dioxide derivative reacts with sodium hypochlorite under catalysis of a basic catalyst, namely sodium hydroxide, and 5,6-difluoro-N-benzofuroxan is obtained; and then the quinoxaline-N1,N4-dioxidederivative reacts with different substrates in Beirut reaction and substitution reaction, and a series of the quinoxaline-N1,N4-dioxide derivative is obtained. According to the quinoxaline-N1,N4-dioxide derivative, the preparation method and application of the quinoxaline-N1,N4-dioxide derivative, quinoxoline-N1,N4-dioxide has good bacteriostatic activity to previously reported gram-negative bacteria, and also had good bacteriostatic activity to actinobacilluspleuropneumoniae and gram-positive bacteria such as staphylococcus aureus and streptococcus pneumoniae.

The invention discloses a synthetic method of 3-amino-4-hydroxyfurazan. The structure of 3-amino-4-hydroxyfurazan is represented by a formula shown in the specification. The method which treats 3,4-diaminofurazan as a raw material comprises the following steps: adding 3,4-diaminofurazan and 20-30% (mass) sulfuric acid into a reaction bottle under stirring, adding an aqueous solution of sodium nitrite into the reaction bottle at -5-5DEG C in a dropwise manner under a condition that the addition time is controlled in a range of 1.5-2.5h, reacting at -5-5DEG C for 2-3h after the addition, naturally heating to 20-25DEG C under stirring, carrying out water-bath heating to 40-60DEG C, reacting for 10-20min, cooling to 0-5DEG C, stirring for 20-40min, filtering, washing the obtained filter cake, and drying to obtain 3-amino-4-hydroxyfurazan. The method is mainly used for preparing 3-amino-4-hydroxyfurazan.

The invention relates to diazo(N-dinitryl ethyl) furazan energy-containing ionic salts and a preparation method thereof, and belongs to the technical field of energy-containing materials. The synthetic method comprises the following steps of: performing acid-base neutralization reaction of diazo(N-dinitryl ethyl) furazan and 2 times of organic base in mole to obtain corresponding energy-containing ionic salts or performing reaction of diazo(N-dinitryl ethyl) furazan sylvite with 2 times of hydrochloride in mole of corresponding cations; and filtering the precipitate to obtain the target product. The synthetic method provided by the invention is simple and easy to industrialize. 6 energy-containing ionic salts are better in thermal stability, the calculated detonation performance of the energy-containing ionic salts is far superior to that of TNT (Trinitrotoluene), and the detonation performance of part of compounds is approximate to that of RDX (Cyclotrimethylene Trinitramine). The diazo(N-dinitryl ethyl) furazan energy-containing ionic salts can be used as substituents of a nitroform explosive and a furazan explosive for improving oxygen balance in a mixed explosive and used as an oxygen supply component in a propellant.

The invention discloses a furoxan NO donor-type statin derivative and a preparation method thereof, and belongs to the technical field of medicinal chemical synthesis. The derivative has the structural formula represented by the following formula: wherein R is an alkyl, R1 is a statin residual group, and R2 is an aryl or an aryl sulfonyl. A statin drug is selected to "hybridize" with a NO donor, both NO and the statin drug have good therapeutic effects on atherosclerosis, and the problem of the mismatch of action mechanisms of NO and the statin drug is effectively avoided. In addition, 4-coumaric acid is selected as a linking group, and thus the therapeutic effect of the drug can be effectively enhanced. The compound can effectively release NO in vitro, and the useful attempt for the development of NO donor anti-atherosclerosis drugs is made.

The invention belongs to the technical field of material preparation, and particularly relates to a method for preparing nitrogen-doped graphene from furazan derivatives as a nitrogen source. The method comprises the following steps: dispersing graphene in water to obtain a graphene aqueous solution; adding the furazan derivatives to the graphene aqueous solution, performing heating and stirring at 50-70 DEG C for 30-60 min, performing cooling to 20-40 DEG C, and performing drying at constant temperature to obtain graphene-coated furazan derivative eutectic crystals; grinding the graphene-coated furazan derivative eutectic crystals into powder, and the powder is heated to 500-800 DEG C and kept at the constant temperature for 3-5 h to obtain nitrogen-doped graphene. Graphene in nitrogen-doped graphene uniformly coats the surface of the furazan derivative crystals without using additives such as adhesives and the like, and accordingly, surface performance of the furazan derivative crystals is completely maintained.

The invention discloses a method for preparing high-purity isradipine. The method includes dehydrating and condensating 4-formaldehyde benzofuroxan in atent solvent to form 2-acetyl-3-benzofuroxan-4-base-isopropyl acrylate; subjecting methyl acetoacetate to ammonolysis to form 3-amino crotonic acid methyl ester; subjecting 2-acetyl-3-benzofuroxan-4-base-isopropyl acrylate and 3-amino crotonic acid methyl ester to reaction to form isradipine. The method for preparing high-purity isradipine is simple in operation process, convenient to operate, high in yield and capable of preparing high-purity isradipine.

The invention provides a synthetic method for 3-(4-aminofurazan-3-radical)-4-(4-nitrofurazan-3-radical) furazan. 3-(4-aminofurazan-3-radical)-4-(4-nitrofurazan-3-radical) furazan (ANTF) is a low-melting-point (100 DEG C) explosive, is expected to replace TNT to be used in casting explosives, and is also an intermediate for synthesizing other novel explosives. An existing synthetic method of ANTF has the defects of being large in acid use amount, low in synthesis yield, strict in reaction condition and the like. 3,4-bis(3'-aminofurazan-4'-radical) furoxan (BAFF) is adopted as a raw material, 3,4-bis(3'-aminofurazan-4'-radical) furoxan (BAFF) and SnCl2.2H2O are firstly subjected to a reduction reaction to obtain 3,4-bis(aminofurazan-4-raidcal) furazan, and then 3,4-bis(aminofurazan-4-raidcal) furazan and H2O2 are subjected to an oxidizing reaction to obtain the target product 3-(4-aminofurazan-3-radical)-4-(4-nitrofurazan-3-radical) furazan. 3,4-bis(aminofurazan-4-raidcal) furazan is adopted as the raw material, H2O2 (20%-30%) is adopted as an oxidizing agent, Na2WO4 is adopted as a catalyst, and 3-(4-aminofurazan-3-radical)-4-(4-nitrofurazan-3-radical) furazan is synthesized under the acidic condition through the oxidizing reaction. The synthetic method has the advantages of being easy and convenient to operate, high in safety, controllable in process and the like.

The invention relates to the field of a medical technology and discloses a Benzofuroxan derivative and a preparation method and an application thereof. According to the invention, 1,4,5,6,7 sites of a Benzofuroxan structure are subjected to derivatization to obtain the Benzofuroxan derivative. The general molecular formula of the Benzofuroxan derivative is as shown in the specification. The compound provided by the invention has an obvious inhibiting effect on tumor cells and can be used in the preparation of antitumor drugs.

The invention discloses a synthesis method of a furazan oxide compound. The synthesis method comprises the following step of: oxidizing a glyoxime compound by taking iodobenzene diethyl ester as an oxidizing agent to carry out a reaction to obtain the furazan oxide compound. No heavy metal, acid or alkali participates in the reaction process. The method has the advantages of mild reaction conditions, high efficiency, green and environment-friendly process, simple post-treatment and the like, and is a synthetic method with a certain industrial value; besides, the reaction raw materials do not contain acyl chloride compounds with higher activity, no strict requirements are imposed on substituent groups of the furoxan compound, so that a new synthesis path is opened up for the furoxan compound containing groups which are easy to react with the acyl chloride compounds.

The invention provides a Pd (0) fluorescence probe based on 7-nitro-1,2,3-benzoxadiazole and a preparation method and application thereof. The Pd (0) fluorescence probe has high-efficiency and specific selectivity on Pd (0), is capable of overcoming interference of common metal positive ions and negative ions in a system, is wide in pH application range (4-8) and is a high-efficiency Pd (0) fluorescence probe; (2) the Pd (0) fluorescence probe has the lowest detection limit of 15nM aiming at Pd (0); (3) the Pd (0) fluorescence probe disclosed by the invention has the advantages of simple synthetic process, low cost, simple and convenient operation, high selectivity, high sensitivity, low detection limit, wide application prospects and the like.