8results about How to "Has antitumor activity" patented technology

The present invention discloses a compound with anti-tumor activity and its preparation method and application, belonging to the field of biomedicine technology. The new compound prepared by the present invention is a light yellow amorphous powder, soluble in methanol, with a maximum absorption peak of 280nm in the ultraviolet spectrum, and a molecular formula of C 30 H 37 N7O5, after one-dimensional H NMR spectroscopy ( 1 HNMR), one-dimensional carbon nuclear magnetic resonance spectroscopy ( 13 C-NMR), two-dimensional nuclear magnetic resonance spectrum (HMBC), high-resolution mass spectrometry (HRMS), and the molecular structure was determined as follows: #imgabs0# The purity of the new compound with anti-tumor activity obtained by the method of the present invention is more than 97%. The MTT method was used to test the in vitro anti-tumor activity of the new compound. The experimental results showed that this new compound not only has an inhibitory effect on human lung cancer cells A549, but also has an inhibitory effect on human breast cancer cells MDA-MB-231, human liver cancer cells HepaRG, human pancreatic cancer cells PANC-1, and human gastric cancer cells MKN-1.

The application discloses a series of gold complexes with beta-carboline derivatives as ligands, a synthesis method and application thereof, and belongs to the technical field of medicines.The synthesis method of the gold complexes is that beta-carboline derivatives are used as ligands to perform a coordination reaction with potassium tetrachloroaurate in a mixed solvent composed of methanol and dichloromethane, wherein the proportion of the methanol in the mixed solvent is greater than or equal to 30 v / v %.Part of the complexes has a significant anti-proliferation effect on Mcl-1-dependent tumor cells (such as MV-4-11), and the activity is equivalent to that of cisplatin, so that the complexes are expected to be used as anti-tumor therapeutic drugs.

The synthesis method comprises the following steps: adding a methylthio phenyl alkynone compound as shown in a formula (I), 2-bromo-2, 2-difluoro-N-aryl acetamide as shown in a formula (II) and DABSO as shown in a formula (III) into a reaction solvent, carrying out stirring reaction under the conditions of nitrogen protection and illumination, and carrying out filtering, washing and drying, thereby obtaining the methylsulfonyl thioflavone derivative as shown in the formula (I). The synthesis method comprises the following steps: adding a methylthio phenyl alkynone compound as shown in the formula (I), 2-bromo-2, 2-difluoro-N-aryl acetamide as shown in the formula (II) and DABSO as shown in the formula (III) into the reaction solvent; after the reaction is finished, the reaction liquid is subjected to post-treatment to obtain a target compound, namely the methylsulfonyl-containing thioflavone derivative with the anti-tumor activity, shown as a formula (IV), the reaction equation is # imgabs0, and DABSO is a bis (sulfur dioxide)-1, 4-diazabicyclo [2.2. 2] octane adduct; in the formula (I) and the formula (IV), R is selected from a bromine atom or a pyridine ring; r1 is selected from a cyano group, a halogen group or a thienyl group. The method has the advantages of simple operation process, cheap and easily available raw materials, mild reaction conditions, environmental protection, atom economy and high yield.

This invention discloses carbon nanodots, their preparation method, and their applications, relating to the field of carbon nanomaterials technology. The carbon nanodots are prepared by solvothermal treatment of nicotinamide, urea, and citric acid or its derivatives. The citric acid derivative is selected from citrate, citric acid hydrate, or citrate hydrate. This invention synthesizes carbon nanodots using nicotinamide as a precursor under solvothermal treatment, simultaneously integrating intrinsic bioactivity, efficient photothermal conversion capability, and red fluorescence imaging function. This multifunctional synergistic therapy overcomes the limitations of single-therapy approaches. Furthermore, the carbon nanodots provided by this invention exhibit extremely high biocompatibility.

The invention discloses a novel terpenoid compound and a preparation method and application thereof. The terpenoid compound is a natural compound obtained by fermenting and culturing Micromonospora sp. HM134 and then extracting and separating the terpenoid compound, and the terpenoid compound has good anti-tumor activity.

The invention relates to a quinoxalinone diaryl methane compound as well as a synthesis method and application thereof. The synthesis method comprises the following steps: under the action of an HAT catalyst and a photocatalyst, a compound a and a compound b react under the irradiation of blue light to obtain the quinoxalinone diaryl methane compound shown in the formula (I). The synthesis method of the quinoxalinone diaryl methane compound has the advantages of very high selectivity, high product yield, atom economy, simple method, high efficiency, mildness, greenness, environmental protection, low synthesis cost and the like, avoids the problems of metal residues and the like caused by the use of a transition metal catalyst, and is suitable for industrial production. The invention provides a simple and effective synthesis strategy and method for developing more heterocyclic diaryl methane derivative active drug molecules. The quinoxalinone diaryl methane compound prepared by the invention has certain anti-tumor activity and can be applied to preparation of medicines for treating tumors. # imgabs0 #

The present application relates to the technical field of biological medicine, in particular to an anti-tumor grifola frondosa water-soluble protein complex preparation and a preparation method thereof.The preparation raw materials of the complex preparation include the following components in parts by weight: grifola frondosa water-soluble protein 2-3 parts, fermentation preparation 0.8-1.2 parts, rosemary acid 0.1-0.2 parts.

This invention belongs to the field of medicinal chemistry and relates to an antitumor compound. Specifically, this invention provides an antitumor compound of Formula I or a pharmaceutically acceptable salt, stereoisomer, tautomer, polymorph, solvate, racemate, prodrug, or metabolite thereof, which exhibits good antitumor activity.