4results about How to "Has antitumor activity" patented technology

The application discloses a series of gold complexes with beta-carboline derivatives as ligands, a synthesis method and application thereof, and belongs to the technical field of medicines.The synthesis method of the gold complexes is that beta-carboline derivatives are used as ligands to perform a coordination reaction with potassium tetrachloroaurate in a mixed solvent composed of methanol and dichloromethane, wherein the proportion of the methanol in the mixed solvent is greater than or equal to 30 v / v %.Part of the complexes has a significant anti-proliferation effect on Mcl-1-dependent tumor cells (such as MV-4-11), and the activity is equivalent to that of cisplatin, so that the complexes are expected to be used as anti-tumor therapeutic drugs.

This invention discloses carbon nanodots, their preparation method, and their applications, relating to the field of carbon nanomaterials technology. The carbon nanodots are prepared by solvothermal treatment of nicotinamide, urea, and citric acid or its derivatives. The citric acid derivative is selected from citrate, citric acid hydrate, or citrate hydrate. This invention synthesizes carbon nanodots using nicotinamide as a precursor under solvothermal treatment, simultaneously integrating intrinsic bioactivity, efficient photothermal conversion capability, and red fluorescence imaging function. This multifunctional synergistic therapy overcomes the limitations of single-therapy approaches. Furthermore, the carbon nanodots provided by this invention exhibit extremely high biocompatibility.

The present application relates to the technical field of biological medicine, in particular to an anti-tumor grifola frondosa water-soluble protein complex preparation and a preparation method thereof.The preparation raw materials of the complex preparation include the following components in parts by weight: grifola frondosa water-soluble protein 2-3 parts, fermentation preparation 0.8-1.2 parts, rosemary acid 0.1-0.2 parts.

This invention belongs to the field of medicinal chemistry and relates to an antitumor compound. Specifically, this invention provides an antitumor compound of Formula I or a pharmaceutically acceptable salt, stereoisomer, tautomer, polymorph, solvate, racemate, prodrug, or metabolite thereof, which exhibits good antitumor activity.