15 results about "Formylhydrazine" patented technology

This invention discloses a hydrazone-linked fluorine-substituted covalent organic framework material, its preparation method, and its applications, belonging to the field of semiconductor photocatalysis technology. The material is synthesized by hydrazone condensation of 1,3,5-trifluoro-2,4,6-tris(4-formylphenyl)benzene and terephthalohydrazide, denoted as F-TPDH-COF. A one-step solvothermal synthesis is employed, resulting in a mild, environmentally friendly, low-cost, and easily scalable process. The material obtained by this invention utilizes hydrazone bonds to achieve proton enrichment in acidic media, and fluorine atoms regulate the electronic structure to improve charge separation efficiency. Under pH=2 conditions, the photocatalytic hydrogen peroxide production rate reaches as high as 5825.2 μmolg. ‑1 h ‑1 Its activity and stability are significantly better than most existing COF photocatalytic materials, and it can be used for efficient photocatalytic preparation of hydrogen peroxide in acidic systems, showing good prospects for industrialization.

The application belongs to the technical field of fluorescent analysis and detection, and particularly relates to a tridentate Schiff base compound and a preparation method and application thereof. 2 The formylhydrazine Schiff base compound is widely applied in coordination chemistry, and a parent structure thereof can be used to better study the transformation of a complex under light stimulation, and the imino group also has good photoisomerization performance, at this time, the light stimulation can catalyze the ligand to produce more rich coordination modes, so the isomerization phenomenon of the compound under the action of ultraviolet light is tested, and the application of the compound in a colorimetric chemical sensor is studied. Further research is conducted on whether the compound has different ion selectivity after the conversion configuration under the action of ultraviolet light and the change of the coordination mode, and finally, the complex of the ligand Ni 2+ , Cu 2+ metal is synthesized.

The application belongs to the technical field of biodegradable polyester nucleating agent synthesis, and discloses a small-molecule hydrazide nucleating agent for improving the crystallization ability of polylactic acid, and a preparation method and application thereof.A novel polylactic acid nucleating agent designed and synthesized by the application is prepared by adding terephthaloyl chloride, methoxybenzoyl hydrazine and a bundling agent into a solvent and synthesizing at 60 DEG C.The nucleating agent is mixed with polylactic acid by a melt blending method, and is extruded or injection molded into a polylactic acid product, so that good nucleation efficiency is provided for polylactic acid during preparation, the nucleation effect is stable, the polylactic acid product obtained has a high crystallization peak temperature, excellent mechanical properties and other characteristics.The preparation method of the nucleating agent is simple, mass production can be realized, and the nucleating agent can be widely applied to the preparation of industrial polylactic acid plastic products.

The invention discloses a synthesis method of a C-13 labeled mercapto triazole derivative. The synthesis method comprises the following steps: (1) carrying out a reaction on C-13 potassium cyanide and S8 to prepare C-13 potassium thiocyanate; (2) carrying out nucleophilic substitution reaction on C-13 potassium thiocyanate and a benzyl bromide compound to obtain a compound 1; (3) carrying out nucleophilic addition reaction on the compound 1 and formylhydrazine to obtain a compound 2; (4) further cyclizing the compound 2 under an alkaline condition to obtain a compound 3; and (5) carrying out derivative reaction on the compound 3 to obtain a C-13 labeled target compound. According to the synthesis method, multi-step continuous reaction is adopted, operation is easy and convenient, the yield is high, and the utilization rate of the C-13 marker is greatly increased.

The invention provides a production process of phthalic hydrazide, which specifically comprises the following steps: step 1, adding phthalic anhydride and hydrazine hydrate into a solvent, heating to 60-80 DEG C, and reacting for 1-2 hours; and 2, cooling, carrying out centrifugal filtration, washing a filter cake with an organic solvent, and drying the filter cake at 130-140 DEG C for 8-12 h to obtain the phthalylhydrazine. In the first step, the reaction of phthalic anhydride and hydrazine hydrate is carried out at a relatively mild low-temperature reaction, so that the adverse effect of high temperature on hydrazine hydrate is reduced, and a reaction feeding product completely participates in the reaction, thereby being beneficial to improving the yield of a final product. In the second step, the organic solvent has a lower boiling point and is extremely easy to dry, the solid only needs to be directly heated after drying, the heating temperature is increased to 130-140 DEG C, the dehydration and cyclization efficiency is very high, and the two-in-one process of removing the solvent and reacting is adopted, so that the operation is simpler, the time is greatly shortened, and the production cost is reduced. And the solvent and excessive hydrazine hydrate can be fully recycled.

This invention discloses a dibenzylamine-bridged DASA molecular switch for salicylaldehyde hydrazone and its preparation method. The DASA molecule has the structure 4-((benzyl((1E,3Z)-5-(1,3-dimethyl-2,4,6-trioxotetrahydropyrimidine-5(2H)-ylidene)-4-hydroxypentan-1,3-dien-1-yl)amino)methyl)-N′-((E)-2-hydroxybenzylene)benzoylhydrazide, which is prepared by reacting the donor (E)-4-((benzylamino)methyl)-N′-(2-hydroxybenzylene)benzoylhydrazide with the acceptor 5-(furan-2-methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione in methanol. Its advantages include: exhibiting excellent negative photochromic behavior in moderately strong aprotic polar solvents such as dichloromethane and acetonitrile; undergoing reversible linear-ring isomerization under visible light irradiation; showing significant changes in absorption peaks; and exhibiting good cyclic fatigue resistance. Furthermore, the introduced salicylaldehyde hydrazone group enhances its responsiveness to acids, bases, and metal ions, enabling reversible switching in various protic and aprotic solvents and selective recognition of different metal ions, thus showing broad application prospects in colorimetric sensing and metal ion detection.

The invention discloses a synthesis method of dihydrazinophthalazine and an intermediate thereof, and belongs to the technical field of chemical medicine bulk drugs. 1, 4-dichlorophthalazine can be directly obtained in a microwave treatment mode by taking phthalylhydrazine as a raw material and utilizing a thionyl chloride-phosphorus oxychloride composite chlorination reagent under the condition of not using an organic solvent; the reaction efficiency and the yield are greatly improved, the production time is shortened, the production efficiency is improved, and the industrial production of dihydrazinophthalazine is further facilitated.

The invention belongs to the technical field of preparation of medical compounds, and particularly relates to a 5-(1H-indol-6-yl)-1, 3, 4-oxadiazole-2-formylhydrazine derivative as well as a preparation method and application thereof. The 5-(1H-indol-6-yl)-1, 3, 4-oxadiazole-2-formylhydrazine with a new structure is designed and synthesized by taking a quinoline compound and a hydrazide compound as a research basis and utilizing a molecular heterozygosis method and a bioisostere design thought, the derivative is low in reaction cost and high in yield, the reaction process is simple and easy to control, and the method is suitable for industrial production. And the derivatives have certain anti-prostatic cancer activity, and can be used for preparing anti-prostatic cancer drugs and researching the structure-function relationship of the compounds.

The present invention aims to provide a method for producing 3-methyl-1, 2, 4-thiadiazole-5-carbohydrazide safely and in high yield. The present invention relates to a method for producing 3-methyl-1,2,4-thiadiazole-5-carboxamide or a salt thereof without using toxic carbon monoxide gas. According to the present invention, a safe and high-yielding production method of 3-methyl-1, 2, 4-thiadiazole-5-carbohydrazide, which is an important synthetic intermediate 21 for fezolinetant useful as a medicament for the treatment of sex hormone-dependent diseases, can be provided.

The invention discloses a sulfur-containing covalent organic framework material coating as well as a preparation method and application thereof, and belongs to the technical field of coating materials. One end of 2, 5-bis (3-(ethylthio) propoxy) terephthaloyl hydrazine is bonded with a silane coupling agent, and the other end of 2, 5-bis (3-(ethylthio) propoxy) terephthaloyl hydrazine and 1, 3, 5-tris (4-formylphenyl) benzene are subjected to a condensation reaction, so that room-temperature in-situ synthesis of COF TFPB-DHzDs on the inner wall of a capillary tube is realized, and the COF TFPB-DHzDs are fixed on the inner wall of the capillary tube. According to the method disclosed by the invention, the in-situ synthesis of the COF TFPB-DHzDs at the room temperature is evaluated under the open tubular capillary gas chromatography. Experimental results show that the COF TFPB-DHzDs coating capillary column prepared in situ at room temperature has a good separation effect on seven sulfides. The preparation method disclosed by the invention is simple and easy to implement, low in cost and low in reagent consumption, and has a wide application prospect.

This invention relates to the field of pharmaceutical synthesis technology, and in particular to a method for removing viscous impurities during the synthesis of hexahydropyridazine, comprising the following steps: 1,2-dicarboxyhydrazide reacts with 1,4-dichlorobutane in stages under alkaline and potassium bromide catalytic conditions. After the reaction is complete, the mixture is filtered and distilled under reduced pressure to obtain a concentrated tetrahydropyridazine-1,2-dicarboxaldehyde solution. The concentrated tetrahydropyridazine-1,2-dicarboxaldehyde solution is then subjected to ethyl acetate extraction, dehydration and decolorization, cooling for impurity removal, and reduced pressure distillation to obtain purified tetrahydropyridazine-1,2-dicarboxaldehyde. The purified tetrahydropyridazine-1,2-dicarboxaldehyde is dissolved in anhydrous ethanol, and ethanol-hydrochloride is added dropwise while maintaining the temperature for reaction. After the reaction is complete, the mixture is crystallized, filtered, washed, and dried to obtain hexahydropyridazine dihydrochloride. This invention not only reduces and prevents side reactions and effectively removes viscous impurities, but also has low energy consumption and improves the product yield and purity of hexahydropyridazine dihydrochloride.

The invention provides a double-benzene-ring diazole compound, an emulsion type paraffin inhibitor and a preparation method of the double-benzene-ring diazole compound, the double-benzene-ring diazole compound and the emulsion type paraffin inhibitor, the double-benzene-ring diazole compound is obtained by reacting m-phenyl diisothiocyanate, benzoyl hydrazine and sodium azide, and the molar ratio of the m-phenyl diisothiocyanate to the benzoyl hydrazine to the sodium azide is (0.01-0.08): (0.01-0.05): (0.01-0.5). The emulsion type paraffin inhibitor is prepared from the following substances in percentage by mass: 10-20% of a double-benzene-ring double-azole compound, 30-50% of a solvent, 2-5% of an emulsifier, 1-5% of a mutual solvent and the balance of water. The double-benzene-ring double-azole compound provided by the invention has a double-azole ring and double-benzene-ring structure, and can be applied to crude oil produced liquids with different water contents and wide pH values. The emulsion type paraffin inhibitor has the advantages of fast effectiveness of an oil-based paraffin inhibitor and safety and environmental protection of a water-based paraffin inhibitor, and overcomes the defects that the oil-based paraffin inhibitor is inflammable and has great harm to the environment, and the water-based paraffin inhibitor has slow effectiveness and is easily influenced by temperature.

The application discloses a kind of covalent organic framework and its preparation method and application, it is related to functional adsorption material technical field.The covalent organic framework is by 1,3,5-tri (2-formylpyridine-5 group) benzene with 2,5-bis (3-hydroxypropoxy) terephthalic hydrazine as reaction precursor, with mesitylene and 1,4-dioxane is mixed, then add acetic acid as catalyst, crystallization is stationary in airtight anaerobic environment, after washing, vacuum drying, obtain covalent organic framework ACOF-PA.The covalent organic framework ACOF-PA has pyridine-hydrazine adsorption site and reverse π-π stacking mode, specific surface area is large, radiation resistance, hydrophilic and strong acid-base stability, the adsorption of palladium in high-level radioactive waste liquid has the characteristics of high adsorption rate, high adsorption capacity and high selectivity.

The invention discloses a novel process for preparing carboxybenzaldehyde, which comprises the following steps: reacting phthalic anhydride with hydrazine hydrate to obtain carboxybenzoyl hydrazine, heating and reacting in the presence of sodium sulfite to generate addition salt of aldehyde and sodium hydrogen sulfite, and resolving with strong acid to obtain carboxybenzaldehyde. According to the synthesis scheme, bromine with high toxicity is avoided, the initial raw materials including phthalic anhydride and hydrazine hydrate are low in price and easy to obtain, and the production cost is reduced.