42 results about "Formylhydrazine" patented technology

The invention discloses a preparation method of an FSP1 inhibitor FSEN3, which comprises the following steps: by taking 4-methoxybenzoyl hydrazine and allyl isothiocyanate as raw materials, forming a thiourea intermediate through nucleophilic addition reaction, carrying out cyclization reaction under the action of alkali, then reacting with liquid bromine to construct a thiazolotriazole skeleton, and finally preparing the FSP1 inhibitor FSEN3. And then carrying out substitution reaction with indoline to obtain a target product FSEN3 as shown in a formula (I). The total synthesis method provided by the invention is mild in condition, simple and convenient to operate and high in total yield. # imgabs0 #

The invention discloses a covalent organic framework material, a preparation method of the covalent organic framework material, a hybrid organelle prepared from the covalent organic framework material, a preparation method and application, and relates to the field of bio-enzyme engineering. The preparation method comprises the following steps: dissolving 2, 5-bis (2-methoxyethoxy) terephthaloyl hydrazine in an aqueous solution of an organic solvent to form a dispersion liquid; and adding a monomer solution containing an aldehyde functional group into the dispersion liquid, carrying out an immobilization reaction in the presence of a catalyst, and carrying out centrifugal purification to obtain the covalent organic framework material. Therefore, the covalent organic framework material COFcap-2 is prepared by introducing a PEG-driven emulsion template method, and the covalent organic framework material can fix various biological elements, so that the tolerance of the biological elements to a bad environment is improved, and a protection effect is realized.

The invention belongs to the technical field of medical nano-materials, and particularly relates to a preparation method of a nano-metal covalent organic framework material for enhancing cell ferroptosis by consuming glutathione as well as an obtained product and application of the nano-metal covalent organic framework material. The material is prepared by the following steps: firstly, preparing a metal organic ligand Cu3-PyCA3; the preparation method comprises the following steps: firstly, preparing a metal organic ligand Cu3-PyCA3, then mixing the metal organic ligand Cu3-PyCA3, 2, 5-diethoxybenzene-1, 4-bis (formylhydrazine), mesitylene, 1, 4-dioxane and a trifluoroacetic acid solution, and then reacting to obtain a nano metal covalent organic framework Cu3-MCOF; and finally, uniformly mixing the activated hyaluronic acid solution and the Cu3-MCOF, and intensely stirring to obtain the Cu3-MCOF-coated HA. The nano-metal covalent organic framework provided by the invention can consume glutathione to enhance cell ferroptosis, and the nano-metal covalent organic framework Cu3-MCOF can quickly react with glutathione, so that the framework structure of the Cu3-MCOF is seriously damaged, the crystalline state disappears, a large number of ribbons are further assembled and generated, glutathione is consumed, and the ferroptosis of cells is enhanced. The ferroptosis tumor treatment enhancer has an application prospect.

The invention belongs to the technical field of novel functional materials and biosensing detection, and provides a preparation method and application of a pyrenyl-based covalent organic framework immunosensor. Specifically, a pyrenyl covalent organic framework is adopted as an electrochemiluminescence material, and free rotation of 1, 3, 6, 8-tetra (4-formylphenyl) pyrene is effectively inhibited through connection of formylhydrazine, so that non-radiative transition is weakened, and the electrochemiluminescence signal intensity is enhanced. The nickel-iron-carbon nano tube loaded with the gold nano particles is used as a substrate material, on one hand, the three-dimensional interconnected carbon nano tube can improve the electron transfer efficiency, and the large-area gold nano particles can immobilize more antibodies, and on the other hand, the uniformly dispersed iron-nickel active center can promote the generation of more tripropylamine free radicals with strong oxidizing property, so that the anti-tumor effect is improved. The luminous efficiency of the pyrenyl covalent organic framework is further improved. The carbohydrate antigen 242 is detected according to different electrochemical luminescence signal intensities of to-be-detected substances with different concentrations.

The invention belongs to the field of chemical medicine synthesis, and particularly relates to an acylhydrazone compound, a preparation method thereof and application of the acylhydrazone compound in camellia oleifera anthracnose and soft rot. The structure of the acylhydrazone compound is shown as a formula I, and the acylhydrazone compound is directly prepared from citronellal and formylhydrazine through a one-step reaction. The invention provides the acylhydrazone compound, the IC50 of the acylhydrazone compound on liver cancer can reach 7.0 mu M, and a new solution is provided for research and development of drugs for treating liver cancer. The EC50 (mg / L) of the strain can reach 1.65 when the strain is used in an oil-tea camellia anthracnose strain inhibition experiment, the EC50 (mg / L) of the strain can reach 1.38 when the strain is used in an oil-tea camellia soft rot strain inhibition experiment, and a new solution is provided for controlling oil-tea camellia anthracnose and soft rot. Meanwhile, the invention provides a synthesis method of citronellal and formylhydrazine through one-step reaction, and the synthesis method has the advantages of high yield, high raw material conversion rate, high selectivity and the like. And the formula I of the # imgabs0 # is shown in the specification.

This invention discloses a hydrazone-linked fluorine-substituted covalent organic framework material, its preparation method, and its applications, belonging to the field of semiconductor photocatalysis technology. The material is synthesized by hydrazone condensation of 1,3,5-trifluoro-2,4,6-tris(4-formylphenyl)benzene and terephthalohydrazide, denoted as F-TPDH-COF. A one-step solvothermal synthesis is employed, resulting in a mild, environmentally friendly, low-cost, and easily scalable process. The material obtained by this invention utilizes hydrazone bonds to achieve proton enrichment in acidic media, and fluorine atoms regulate the electronic structure to improve charge separation efficiency. Under pH=2 conditions, the photocatalytic hydrogen peroxide production rate reaches as high as 5825.2 μmolg. ‑1 h ‑1 Its activity and stability are significantly better than most existing COF photocatalytic materials, and it can be used for efficient photocatalytic preparation of hydrogen peroxide in acidic systems, showing good prospects for industrialization.

The invention discloses a method for preparing 1,4-cyclohexane diisocyanate, and belongs to the technical field of synthesis of diisocyanate. The preparation method is a one-step method to complete the overall reaction, the reaction route is simple, the raw materials are easily available, the conditions are mild, the use of highly toxic gas phosgene and explosive sodium azide is avoided, the safety is good, the product purity is not less than 98.5%, and the yield is 75% based on 1,4-cyclohexane diformyl hydrazide, which is suitable for large-scale production and is suitable for the application of pharmaceutical excipients. The synthesis route aims to use conventional, easy-to-obtain and cheap chemical materials to produce cyclohexane diisocyanate under relatively mild conditions. The process production prospect is good and it is easy to promote large-scale industrialization.

The application belongs to the technical field of fluorescent analysis and detection, and particularly relates to a tridentate Schiff base compound and a preparation method and application thereof. 2 The formylhydrazine Schiff base compound is widely applied in coordination chemistry, and a parent structure thereof can be used to better study the transformation of a complex under light stimulation, and the imino group also has good photoisomerization performance, at this time, the light stimulation can catalyze the ligand to produce more rich coordination modes, so the isomerization phenomenon of the compound under the action of ultraviolet light is tested, and the application of the compound in a colorimetric chemical sensor is studied. Further research is conducted on whether the compound has different ion selectivity after the conversion configuration under the action of ultraviolet light and the change of the coordination mode, and finally, the complex of the ligand Ni 2+ , Cu 2+ metal is synthesized.

The application belongs to the technical field of biodegradable polyester nucleating agent synthesis, and discloses a small-molecule hydrazide nucleating agent for improving the crystallization ability of polylactic acid, and a preparation method and application thereof.A novel polylactic acid nucleating agent designed and synthesized by the application is prepared by adding terephthaloyl chloride, methoxybenzoyl hydrazine and a bundling agent into a solvent and synthesizing at 60 DEG C.The nucleating agent is mixed with polylactic acid by a melt blending method, and is extruded or injection molded into a polylactic acid product, so that good nucleation efficiency is provided for polylactic acid during preparation, the nucleation effect is stable, the polylactic acid product obtained has a high crystallization peak temperature, excellent mechanical properties and other characteristics.The preparation method of the nucleating agent is simple, mass production can be realized, and the nucleating agent can be widely applied to the preparation of industrial polylactic acid plastic products.

The invention discloses a synthesis method of a C-13 labeled mercapto triazole derivative. The synthesis method comprises the following steps: (1) carrying out a reaction on C-13 potassium cyanide and S8 to prepare C-13 potassium thiocyanate; (2) carrying out nucleophilic substitution reaction on C-13 potassium thiocyanate and a benzyl bromide compound to obtain a compound 1; (3) carrying out nucleophilic addition reaction on the compound 1 and formylhydrazine to obtain a compound 2; (4) further cyclizing the compound 2 under an alkaline condition to obtain a compound 3; and (5) carrying out derivative reaction on the compound 3 to obtain a C-13 labeled target compound. According to the synthesis method, multi-step continuous reaction is adopted, operation is easy and convenient, the yield is high, and the utilization rate of the C-13 marker is greatly increased.

The invention discloses a preparation method of 3, 4-dimethyl pyrazole and phosphate thereof, and belongs to the technical field of agricultural chemistry. The preparation method comprises the following steps: carrying out dehydration condensation on 2-butanone and formylhydrazine, carrying out cyclization under an alkaline condition to obtain 3, 4-dimethyl pyrazole, and salifying with phosphoric acid to generate 3, 4-dimethyl pyrazole phosphate. The method disclosed by the invention is simple to operate, the two-step reaction can be continuously carried out, the used materials are sufficient in market supply, the use of high-activity metals such as hydrazine hydrate of a pipe product or metallic sodium of a dangerous article is avoided, and the product obtained by adopting the method has relatively strong market competitiveness.

The invention discloses an in-situ co-encapsulation laccase and a mediator. According to the in-situ co-encapsulated laccase disclosed by the invention, a covalent organic framework synthesized by 2, 5-bis (2-methoxyethoxy) terephthaloyl hydrazine and benzenetricarboxaldehyde is taken as a carrier, and laccase and a mediator are loaded in the carrier. According to the invention, the enzyme and the mediator are co-encapsulated in the covalent organic framework in situ under mild conditions (aqueous solution and room temperature) to prepare the high-performance biocatalyst, the combination of high affinity, high stability and high loading of the laccase and the carrier is realized, the biocatalytic activity of the laccase is improved, and the method can be used for removing pollutants.

The application relates to a preparation method and application of a fluorescent probe for continuously detecting cadmium ions and glutathione, and relates to the field of detection of cadmium ions and glutathione, in particular to a preparation method and application of an isoflurone fluorescent probe. The application solves the problem that the existing fluorescent probe detection method cannot realize continuous recognition of cadmium ions and glutathione under the same test condition. The preparation method of the probe is as follows: (E)-2-(3-(3-formyl-4-hydroxy styryl)-5,5-dimethylcyclohex-2-en-1-ylidene) propanedinitrile is condensed with quinoline-2-formylhydrazine to obtain the fluorescent probe XL. The fluorescent probe prepared in the application can highly selectively and quickly recognize cadmium ions, and the complex of the probe and the cadmium ions has good recognition selectivity for glutathione and is not interfered by other amino acids and anions. The detection method constructed in the application is sensitive and efficient, does not need expensive large-scale instruments and professional experimenters, and can realize detection of glutathione in a water body environment.

The invention belongs to the technical field of organic compounds, and particularly relates to a binuclear macrocyclic metronidazole metal complex as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) carrying out reflux reaction on 2-pyridine formylhydrazine, potassium hydroxide and carbon disulfide to prepare 5-(pyridine-2-yl)-1, 3, 4-oxadiazole-2-thiol; (2) respectively carrying out primary reflux on metronidazole, triethylamine and p-toluenesulfonyl chloride, and then carrying out secondary reflux on metronidazole and potassium iodide, so as to prepare 1-(2-iodoethyl)-2-methyl-5-nitro-1H-imidazole; and (3) carrying out reflux reaction on products prepared in the steps (1) and (2), and dissolving in an organic solvent containing silver salt to prepare the binuclear macrocyclic metronidazole metal complex. According to the binuclear macrocyclic metronidazole metal complex disclosed by the invention, the antibacterial effect of the current metronidazole metal complex can be further improved; the preparation method is simple and easy to implement, purification is convenient, and the prepared product is good in stability in air.

The invention discloses a perillaldehyde formylhydrazine compound and a preparation method and application thereof.The preparation method comprises the steps that perillaldehyde is subjected to an oxidation reaction to synthesize perillaldehyde, the perillaldehyde reacts with phenylhydrazine hydrochloride with different substituent groups to synthesize the perillaldehyde formylhydrazine compound, the compound has a general formula I, and R is H, 4-F, 3-F, 2-F, 4-Cl, 3-Cl, 2-Cl, 4-Br, 3-Br, 2-Br, 4-I, 4-CH3, 4-OCH3 and 2-Cl-4-F; the compound has a good prevention effect on pythium aphanidermatum and botrytis cinerea under an in-vitro condition, and can be used for preventing and treating fungal diseases of agricultural or forestry plants. The preparation method of the compound is simple and convenient, the yield is high, and the product property is stable.

The present invention discloses a preparation method, product and application of norbornene carboxylic acid hydrazide compounds. The norbornene carboxylic acid hydrazide compounds are synthesized by one-step reaction of 5-norbornene-2-carboxylic acid with substituted phenylhydrazine. The compound has the general formula I: wherein R is independently selected from H, halogen, and alkyl. The application of the norbornene carboxylic acid hydrazide in preventing and controlling fungal diseases of agricultural or forestry plants shows good control effects against Sclerotinia sclerotiorum, Gibberella zeae, and Botryosphaeria dothidea. The preparation method of the compound is simple, with a high yield and stable product properties.

The present invention belongs to the technical field of heterocyclic compounds, and specifically relates to a 1,2-benzothiazine Schiff base derivative and a preparation method thereof. 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid methyl ester-1,1-dioxide and hydrazine hydrate are refluxed to obtain 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid hydrazide-1,1-dioxide; 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid hydrazide-1,1-dioxide is reacted with potassium ferrocyanide to obtain 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid hydrazide-1,1-dioxide; 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid hydrazide-1,1-dioxide is refluxed with o-anisidine to obtain 1,2-benzothiazine Schiff base derivative. The present invention has good anti-tumor activity.

The present invention relates to a preparation method of marbofloxacin. The preparation method of the present invention is that under alkaline conditions, ethyl 2,3,4,5-tetrafluorobenzoate reacts with acetonitrile to prepare intermediate (I), intermediate (I) reacts with triethyl orthoformate and acetic anhydride and then reacts with formylhydrazine to prepare intermediate (II), intermediate (II) cyclizes under alkaline conditions to prepare intermediate (III), intermediate (III) is hydrolyzed with base and then cyclizes with formaldehyde to prepare intermediate (IV), and intermediate (IV) reacts with N -methylpiperazine and then through N -methylation to prepare marbofloxacin. The raw materials of the present invention are cheap, the reaction conditions are mild, the operation is easy, the product yield and purity are high, and it is suitable for industrial production.

The invention discloses a preparation method of azelastine hydrochloride, using N-methyl hexahydroazepine-4-one hydrochloride, benzoyl hydrazide and 2-(p-chlorophenylacetyl) benzoic acid as raw materials, and obtaining through condensation reduction, concentrated hydrochloric acid hydrolysis, cyclization reaction and salt-forming reaction steps, wherein in the cyclization reaction process, a mixed solvent of methanol and water is selected as a reaction solvent, and a cyclization reaction is performed after heat preservation treatment, so that azelastine free base can be precipitated in a solid form, is easy to filter, and has high quality. The present invention prepares azelastine hydrochloride, has high yield, high product purity, small solvent residue and good stability.

The invention provides a production process of phthalic hydrazide, which specifically comprises the following steps: step 1, adding phthalic anhydride and hydrazine hydrate into a solvent, heating to 60-80 DEG C, and reacting for 1-2 hours; and 2, cooling, carrying out centrifugal filtration, washing a filter cake with an organic solvent, and drying the filter cake at 130-140 DEG C for 8-12 h to obtain the phthalylhydrazine. In the first step, the reaction of phthalic anhydride and hydrazine hydrate is carried out at a relatively mild low-temperature reaction, so that the adverse effect of high temperature on hydrazine hydrate is reduced, and a reaction feeding product completely participates in the reaction, thereby being beneficial to improving the yield of a final product. In the second step, the organic solvent has a lower boiling point and is extremely easy to dry, the solid only needs to be directly heated after drying, the heating temperature is increased to 130-140 DEG C, the dehydration and cyclization efficiency is very high, and the two-in-one process of removing the solvent and reacting is adopted, so that the operation is simpler, the time is greatly shortened, and the production cost is reduced. And the solvent and excessive hydrazine hydrate can be fully recycled.

The invention relates to a compound capable of inhibiting the growth activity of Candida albicans, in particular to a pyrazolo [1, 5-a] pyrimidine-3-formyl hydrazine compound as well as a synthesis method and application of the pyrazolo [1, 5-a] pyrimidine-3-formyl hydrazine compound. The pyrazolo [1, 5-a] pyrimidine-3-formylhydrazine compound disclosed by the invention can be used for preparing a candida albicans antibacterial agent, and the structural formula of the pyrazolo [1, 5-a] pyrimidine-3-formylhydrazine compound is # imgabs0 #, in which R is a hydrogen atom, a halogen atom, a cyano group, a methyl group, an ethyl group, a propyl group, an isopropyl group, a tertiary butyl group, a methoxy group, a trifluoromethoxy group and a trifluoromethyl group. The in-vitro inhibition activity of 31 synthesized target compounds on 6 test bacteria is determined by adopting a microdilution method, and all the compounds have different degrees of inhibition effects on the test bacteria.

The present invention relates to the technical field of environmentally friendly materials, and discloses a polylactic acid nucleating agent and its preparation method and application. First, 5-sulfo dimethyl isophthalate sodium is reacted with hydrazine hydrate to prepare isophthalic acid hydrazide-5-sulfonate sodium, and then isophthalic acid hydrazide-5-sulfonate sodium is reacted with lactic acid, and a capping agent is added after a period of time to continue the reaction to obtain a novel nucleating agent. The present invention prepares a high heat-resistant polylactic acid composition by melt blending a nucleating agent and polylactic acid, and adding a very small amount of nucleating agent can greatly increase the crystallization rate of polylactic acid, and enables polylactic acid products to obtain better heat resistance. This type of nucleating agent preparation method is simple and has good industrial prospects.

This invention discloses a dibenzylamine-bridged DASA molecular switch for salicylaldehyde hydrazone and its preparation method. The DASA molecule has the structure 4-((benzyl((1E,3Z)-5-(1,3-dimethyl-2,4,6-trioxotetrahydropyrimidine-5(2H)-ylidene)-4-hydroxypentan-1,3-dien-1-yl)amino)methyl)-N′-((E)-2-hydroxybenzylene)benzoylhydrazide, which is prepared by reacting the donor (E)-4-((benzylamino)methyl)-N′-(2-hydroxybenzylene)benzoylhydrazide with the acceptor 5-(furan-2-methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione in methanol. Its advantages include: exhibiting excellent negative photochromic behavior in moderately strong aprotic polar solvents such as dichloromethane and acetonitrile; undergoing reversible linear-ring isomerization under visible light irradiation; showing significant changes in absorption peaks; and exhibiting good cyclic fatigue resistance. Furthermore, the introduced salicylaldehyde hydrazone group enhances its responsiveness to acids, bases, and metal ions, enabling reversible switching in various protic and aprotic solvents and selective recognition of different metal ions, thus showing broad application prospects in colorimetric sensing and metal ion detection.

The invention provides a method for detecting a genotoxic impurity formylhydrazine in a compound 2-((5-bromine-4-(2-chloro-4-cyclopropylnaphthyl-1-yl)-4H-1, 2, 4-triazole-3-yl)-sulfur) acetic acid, which comprises the following steps: reacting the compound, a solvent, formic acid and a derivatization reagent to obtain a test solution, and detecting the genotoxic impurity formylhydrazine in the compound 2-((5-bromine-4-(2-chloro-4-cyclopropylnaphthyl-1-yl)-4H-1, 2, 4-triazole-3-yl)-sulfur) acetic acid. The compound is-((5-bromo-4-(2-chloro-4-cyclopropyl naphthyl-1-yl)-4H-1, 2, 4-triazole-3-yl)-sulfur) acetic acid, and the structural formula of the compound is shown in the description. Formylhydrazine, a solvent, formic acid and a derivatization reagent are subjected to a reaction, and a reference substance solution is obtained; and respectively performing high performance liquid chromatography detection on the test solution and the reference solution to obtain a test chromatogram and a reference chromatogram. The method provided by the invention is good in specificity and good in durability. The method provided by the invention can be used for accurately detecting each genotoxic impurity in the raw material medicine or the preparation, the separation degree of each peak, the number of theoretical plates and the symmetry factor are good, and the response is high.

The invention discloses a synthesis method of dihydrazinophthalazine and an intermediate thereof, and belongs to the technical field of chemical medicine bulk drugs. 1, 4-dichlorophthalazine can be directly obtained in a microwave treatment mode by taking phthalylhydrazine as a raw material and utilizing a thionyl chloride-phosphorus oxychloride composite chlorination reagent under the condition of not using an organic solvent; the reaction efficiency and the yield are greatly improved, the production time is shortened, the production efficiency is improved, and the industrial production of dihydrazinophthalazine is further facilitated.

The invention belongs to the technical field of preparation of medical compounds, and particularly relates to a 5-(1H-indol-6-yl)-1, 3, 4-oxadiazole-2-formylhydrazine derivative as well as a preparation method and application thereof. The 5-(1H-indol-6-yl)-1, 3, 4-oxadiazole-2-formylhydrazine with a new structure is designed and synthesized by taking a quinoline compound and a hydrazide compound as a research basis and utilizing a molecular heterozygosis method and a bioisostere design thought, the derivative is low in reaction cost and high in yield, the reaction process is simple and easy to control, and the method is suitable for industrial production. And the derivatives have certain anti-prostatic cancer activity, and can be used for preparing anti-prostatic cancer drugs and researching the structure-function relationship of the compounds.

The application provides a kind of functionalized porous polyoxamide with alkane chain, preparation method and application.Functionalized porous polyoxamide with alkane chain is formed by polyvinyl triazine diamine (PVDAT) and cheap and easily available formic acid, oxalic acid, formamide, formylhydrazine and N, N-dimethylformamide functional monomer through oxamide polymerization reaction, the functionalized polyoxamide prepared by the application has large specific surface area and rich amino and hydroxyl functional groups, and the porous polymer skeleton also contains fatty long chain, and has good application prospect in the field of organic hydrocarbon gas adsorption separation and recovery of radioactive iodine element.

The present invention aims to provide a method for producing 3-methyl-1, 2, 4-thiadiazole-5-carbohydrazide safely and in high yield. The present invention relates to a method for producing 3-methyl-1,2,4-thiadiazole-5-carboxamide or a salt thereof without using toxic carbon monoxide gas. According to the present invention, a safe and high-yielding production method of 3-methyl-1, 2, 4-thiadiazole-5-carbohydrazide, which is an important synthetic intermediate 21 for fezolinetant useful as a medicament for the treatment of sex hormone-dependent diseases, can be provided.

The invention discloses a sulfur-containing covalent organic framework material coating as well as a preparation method and application thereof, and belongs to the technical field of coating materials. One end of 2, 5-bis (3-(ethylthio) propoxy) terephthaloyl hydrazine is bonded with a silane coupling agent, and the other end of 2, 5-bis (3-(ethylthio) propoxy) terephthaloyl hydrazine and 1, 3, 5-tris (4-formylphenyl) benzene are subjected to a condensation reaction, so that room-temperature in-situ synthesis of COF TFPB-DHzDs on the inner wall of a capillary tube is realized, and the COF TFPB-DHzDs are fixed on the inner wall of the capillary tube. According to the method disclosed by the invention, the in-situ synthesis of the COF TFPB-DHzDs at the room temperature is evaluated under the open tubular capillary gas chromatography. Experimental results show that the COF TFPB-DHzDs coating capillary column prepared in situ at room temperature has a good separation effect on seven sulfides. The preparation method disclosed by the invention is simple and easy to implement, low in cost and low in reagent consumption, and has a wide application prospect.