Synthesis method and application of disalicylaldehyde condensation 2-pyridine formylhydrazine schiff base

A technology of picolinyl hydrazide Schiff base and picolinyl hydrazide, which is applied in the field of synthesis of 5,5'-methylethylene disalicylaldehyde 2-pyridine carboxyl hydrazide Schiff base, can solve the problem of fresh There are reports and other issues, to achieve the effect of enhanced fluorescence intensity, novel structure, and naked eye recognition

Active Publication Date: 2019-09-06
HARBIN UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The preparation method of 5,5'-methylethylene disalicylaldehyde is simple, but its application in synthesis is rarely reported

Method used

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  • Synthesis method and application of disalicylaldehyde condensation 2-pyridine formylhydrazine schiff base
  • Synthesis method and application of disalicylaldehyde condensation 2-pyridine formylhydrazine schiff base
  • Synthesis method and application of disalicylaldehyde condensation 2-pyridine formylhydrazine schiff base

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specific Embodiment approach 1

[0030] Specific embodiment one: the structural formula of the double salicylaldehyde acetal 2-pyridine carbohydrazide Schiff base in this embodiment is as follows:

[0031]

specific Embodiment approach 2

[0032] Specific embodiment two: the synthetic method of salicylaldehyde 2-pyridine carbohydrazide type Schiff base is as follows:

[0033] Dissolve salicylaldehyde and 2-pyridinecarbohydrazide in different types of organic solvents under heating conditions; slowly add the hot solution of salicylaldehyde to the hot solution of 2-pyridinecarbohydrazide and heat to reflux After 1 h, a solid was precipitated, cooled, filtered with suction, washed with an organic solvent, and dried to obtain a pure fluorescent probe. Wherein, the molar ratio of salicylaldehyde to 2-pyridinecarbohydrazide is 1:2-3.

specific Embodiment approach 3

[0034] Embodiment 3: The difference between this embodiment and Embodiment 2 is that the organic solvent for dissolving salicylaldehyde is ethyl acetate. Others are the same as in the second embodiment.

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Abstract

The invention relates to a synthesis method and application of disalicylaldehyde condensation 2-pyridine formylhydrazine schiff base, and relates to a synthesis method and application of 5,5'-methylethylidene disalicylaldehyde condensation 2-pyridylformylhydrazine schiff base. The method constructs a novel disalicylaldehyde condensation 2-pyridine formylhydrazine schiff base fluorescent probe which is applied to aluminum ion detection. The preparation method comprises dripping a disalicylaldehyde solution into a 2-pyridine formylhydrazine solution, heating and refluxing to separate out a solid, cooling, filtering by suction, and washing to obtain the fluorescent probe. The detection limit of the probe for aluminum ions in a DMF solution is 6.21* 10<-8> mol / L, the fluorescence intensity isenhanced by 302 times, and the complexing ratio of probe molecules to aluminum ions is 1: 2. The probe has good selectivity and anti-interference performance, and can be widely applied to the analysisand detection of aluminum ions in industries such as environment, food, medicine and the like.

Description

technical field [0001] The invention relates to a synthesis method and application of 5,5'-methylethylene bis-salicylaldehyde 2-pyridinecarbohydrazide Schiff base. Background technique [0002] The content of aluminum in the earth's crust is second only to oxygen and silicon, and is the most abundant metal element in the earth's crust. Due to its excellent product performance, it is widely used in food packaging, catering utensils, medicine and food additives, etc. According to the report of the World Health Organization, the daily intake of aluminum ions in the human body ranges from 3 to 10 mg. Excessive intake and accumulation of aluminum ions will have a great impact on the central nervous system of the human body, such as Alzheimer's disease, Parkinson's syndrome, Memory loss and other diseases, in addition, may also induce the occurrence of infertility. In addition, excessive aluminum ions can also inhibit the growth of plant roots and stems. Therefore, how to quick...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D213/86C09K11/06G01N21/64
CPCC07D213/86C09K11/06G01N21/6428C09K2211/1007C09K2211/1029Y02A50/30
Inventor 武文菊冯俊凯由君喻艳超荆军凯
Owner HARBIN UNIV OF SCI & TECH
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