Schiff base fluorescent probe QCS and method for preparing same

A fluorescent probe and Schiff base technology, applied in the field of analytical chemistry, can solve the problems of inapplicability for on-site detection or large-scale application, lack of spectral characteristics, and difficulty in detection, and achieves diverse detection methods, wide application prospects, and high sensitivity. Effect

Active Publication Date: 2017-08-18
CHINA THREE GORGES UNIV
View PDF6 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods require expensive large-scale instruments, or complex sample pretreatment processes, as well as professional operations by professional technicians
Therefore, it is not suitable for on-site detection or large-scale promotion and application, and because Al 3+ Lack of spectral properties, more difficult to detect than other metal ions
Therefore, the development of Al with low cost, easy operation, high sensitivity, fast response and low detection limit 3+ The detection method is still a challenging task

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Schiff base fluorescent probe QCS and method for preparing same
  • Schiff base fluorescent probe QCS and method for preparing same
  • Schiff base fluorescent probe QCS and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 Schiff base probe QCS

[0022] (1) Preparation of 3-formylhydrazide-1-(quinolin-2-yl)-9H-β-carboline

[0023] Into a 250mL flask, add 3-methylformate-1-(quinolin-2-yl)-9H-β-carboline (3.5303g, 10mmol), 50mL of ethanol and 100mL of glycerol, and vigorously stir at 60°C for 1h; Then add hydrazine hydrate (10.0000g, 200mmol), reflux for 4h, cool, filter with suction, wash with 30mL ethanol at reflux for 3h, filter with suction, and dry in vacuo to obtain 3.3577g of yellow solid, yield: 95.12%. m.p.260.3~261.9℃, 1 H NMR (400MHz, DMSO-d 6 ):δ12.32(s,1H),10.24(s,1H),9.39(d,J=8.7Hz,1H),9.00(s,1H),8.79(d,J=8.4Hz,1H),8.60 (d,J=8.8Hz,1H),8.50(d,J=7.8Hz,1H),8.12~8.06(m,2H),7.94~7.90(m,1H),7.73~7.67(m,2H), 7.38(t, J=7.4Hz, 1H), 4.68(s, 2H). ESI-MS, m / z:354.1834[M+H] + .

[0024] (2) Schiff base probe QCS

[0025] Into a 100 mL flask, add 3-formylhydrazide-1-(quinolin-2-yl)-9H-β-carboline (0.3530 g, 1 mmol), salicylaldehyde (0.1220 g, 1 mmol),...

Embodiment 2

[0026] The detection Al of embodiment 2 Schiff base probe QCS 3+

[0027] (1) Preparation of stock solution and test solution

[0028] Weigh the probe QCS of 0.0046g, be dissolved in the DMF of 10mL and prepare 10 -3 mol / L stock solution, set aside for later use. The tests were all carried out in the mixed solution of V (ethanol): (double distilled water)=9:1, and the concentration of Schiff base probe QCS was 10 -3 mol / L. The concentration of metal nitrate is 10 -2 mol / L. All tests were repeated 3 times.

[0029] (2) Selectivity of Schiff base probe QCS

[0030] Common metal ions on Al 3+ There may be interference in the detection of Al 3+ Whether there is good selectivity at the time. The 14 metal compounds selected are: Al(NO 3 ) 3 9H 2 O, Ca(NO 3 ) 2 4H 2 O, Cr(NO 3 ) 3 9H 2 O, Mn(NO 3 ) 2 , Fe(NO 3 ) 3 9H 2 O, Co(NO 3 )2·6H 2 O, Ni(NO 3 ) 2 ·6H 2 O, Cu(NO 3 ) 2 ·3H 2 O, Zn(NO 3 ) 2 ·6H 2 O, AgNO 3 , Ba(NO 3 ) 2 , Hg(NO 3 ) 2 , Pb(NO ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a Schiff base fluorescent probe QCS 3-[N-(2-phenol methylene)] formylhydrazine base-1-(quinoline-2-base)-9H-beta-carboline QCS and a method for preparing the same. The method includes preparation steps of carrying out reaction on 3-methyl formate-1-(quinoline-2-base)-9H-beta-carboline and hydrazine hydrate to obtain 3-formylhydrazine-1-(quinoline-2-base)-9H-beta-carboline; carrying out reaction on the 3-formylhydrazine-1-(quinoline-2-base)-9H-beta-carboline and salicylaldehyde to obtain the Schiff base fluorescent probe QCS. The Schiff base fluorescent probe QCS and the method have the advantages that probe QCS solution is bright blue green in ultraviolet lamps (365 nm) in the presence of Al3+, new emission peaks occur at 490 nm locations of fluorescence emission spectra, and the fluorescence intensity is gradually improved along with increase of the concentration of the Al3+; the Schiff base fluorescent probe QCS can be used for quickly and quantitatively detecting micro/trace amounts of Al3+ from different sources in real time.

Description

technical field [0001] The invention belongs to the technical field of analytical chemistry, relates to a Schiff base probe QCS and a preparation method thereof, and applies it to the fluorescence detection and analysis of Al 3+ superior. Background technique [0002] Aluminum is the metal element with the highest content in the earth's crust. Because of its good electrical and thermal conductivity, high reflectivity and oxygen resistance, it is widely used in daily production and life, so that Al is widely distributed in the human living environment. 3+ . In humans, Al 3+ When the content accumulates to a certain level, it can destroy the central nervous system and immune system of the human body, cause hypochromic anemia of red blood cells, inhibit the activity of various enzymes in the body, accelerate the aging of the human body, and cause diseases such as Alzheimer's disease and Parkinson's disease. Also due to Al 3+ It accumulates slowly in the human body, and the ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/04C09K11/06G01N21/64G01N21/78
CPCC07D471/04C09K11/06C09K2211/1029G01N21/643G01N21/78
Inventor 但飞君刘璐璐韩雅莲曾晓燕陈玲
Owner CHINA THREE GORGES UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap