Abstract of the DisclosureSystems and methods for manufacture of an
analyte-measuring device, including adhering a membrane
system that allows the passage of the
analyte therethrough to a sensing mechanism. The implantable
analyte-measuring device includes a body formed from a material that is substantially similar to the membrane
system so as to enable sufficiently strong adhesion therebetween, which enables a sufficiently strong
adhesive joint capable of withstanding
in vivo cellular forces. In some embodiments, the device body includes an insert to which the membrane
system is adhered, wherein the insert is formed from a material substantially similar to the membrane system to enable strong adhesion therebetween. The analyte-measuring device is designed with optimized device
sizing and maximum
membrane adhesion and
longevity to enable controlled transport of analytes through the membrane system
in vivo with improved device performance.