The invention discloses a preparation method of a
nucleotide tackifying polylipoic acid-based
underwater adhesive, and belongs to the field of
underwater adhesives. The preparation method comprises the following steps: dissolving three monomers of adenylic acid,
lipoic acid and methacryloyloxyethyl trimethyl
ammonium chloride in a
mixed solution of
dimethyl sulfoxide and water, and carrying out a
polymerization reaction under a heating condition of 50 DEG C to finally prepare the
nucleotide tackifying polylipoic acid-based
underwater adhesive. The adhesion property of the
lipoic acid polymer is remarkably improved by introducing the adenylic acid
monomer. The
adhesive prepared by the preparation method disclosed by the invention shows excellent adhesion capacity to various materials (
metal, plastic, glass and wood) in a high-
humidity environment and an underwater environment, and the underwater
adhesion strength can reach 130.47 kPa. According to the invention, high-strength bonding of an adhesive material in an underwater environment is realized, the application range of the adhesive is widened, and the adhesive is expected to be applied to the fields of
tissue adhesives, underwater robots, wearable equipment and the like.