41 results about "Membrane adhesion" patented technology

The invention provides a preparation method of a composite artificial flap with a bionic structure and function induction activity. The preparation method comprises the following steps: S1, preparing an epidermis induction layer; s2, preparing a dermis functional remodeling layer; s3, preparation of a vascularization integration substrate layer; and S4, three-layer compounding and sterilization. Through an epidermis-basilar membrane-dermis three-layer integrated structure, a micron-nano multistage gradient pore and basilar membrane belt adhesion structure of natural skin is accurately simulated, and the problems of epidermis-dermis layering and non-uniform cell infiltration of an existing skin flap are solved.

The invention discloses a chitosan grafted tannic acid-iron composite coating solution based on mussel adhesion simulation and application of the chitosan grafted tannic acid-iron composite coating solution in mango preservation, and belongs to the technical field of food preservation. According to the method, tannic acid is grafted to chitosan through a free radical mediation method to form a compound, then ferric ions are added for crosslinking, and a composite coating film with mussel adhesion imitating characteristics is constructed. According to the method, the technical problems that a traditional chitosan coating film is poor in adhesion, low in polyphenol utilization rate and prone to failure in a high-humidity environment are solved, the shelf life of mangoes can be effectively prolonged, the postharvest loss is reduced, and the method has important industrial application value.

The invention discloses a glycyrrhiza cellulose reinforced polyacrylate pressure-sensitive adhesive and a preparation method thereof, and belongs to the technical field of polyacrylate pressure-sensitive adhesives, the preparation method comprises the following steps: extracting glycyrrhiza cellulose, treating glycyrrhiza cellulose microfibers, preparing a water-based polyacrylate emulsion, preparing an auxiliary agent, and mixing; the step of mixing comprises the following steps: mixing the treated glycyrrhiza cellulose microfibers, a water-based polyacrylate emulsion, an auxiliary agent, an anti-freezing agent, a defoaming agent and a mildew preventive, and stirring at room temperature to obtain the glycyrrhiza cellulose reinforced polyacrylate pressure-sensitive adhesive. The glycyrrhiza cellulose reinforced polyacrylate pressure-sensitive adhesive prepared by the invention has excellent water resistance, cohesive strength, adhesive film adhesion, transparency, storage stability and weather resistance.

This utility model provides a device for measuring the adhesion performance of reflective film, comprising: a base plate, a counterweight, a top plate, and a support plate. Two mounting columns are symmetrically arranged on the top of the base plate, and the top plate is positioned on top of the two mounting columns. A horizontal adhesive plate is provided at the bottom of the top plate for adhering the reflective film. A binding frame is provided on the counterweight for binding the ends of the reflective film. Vertical rods are also symmetrically arranged on the top of the base plate. Sliding seats are provided at both ends of the support plate, and the two sliding seats are slidably connected to the two vertical rods in the vertical direction. The support plate is located below the adhesive plate. Each sliding seat is provided with a locking component for locking it to the corresponding vertical rod. This invention solves the problem in the prior art where the hammer lacks support during the measurement of reflective film adhesion performance, affecting the measurement results.

The problem is to provide a porous membrane with a reduced phenomenon in which membranes firmly adhere to one another during production of the porous membrane (membrane adhesion). The problem is solved by a porous membrane comprising a hydrophobic polymer and a hydrophilic polymer, wherein an average value T of ratios of the number of counts of ions derived from the hydrophilic polymer to the number of counts of ions derived from the hydrophobic polymer is 1.0 or more when a surface of the porous membrane is measured by time-of-flight secondary ion mass spectrometry (TOF-SIMS).

To provide a method for screening a stratum corneum peeling accelerator that allows a degrading enzyme to effectively permeate an adhesion region between stratum corneum cells through which the degrading enzyme hardly permeates.SOLUTION: The problem has been solved by finding a method for screening a stratum corneum adhesive structure decomposition accelerator through evaluation of permeability of a stratum corneum adhesive structure decomposition enzyme relative to an adhesive region between stratum corneum cells.EFFECT: The present invention enables provision of a stratum corneum adhesive structure decomposition accelerator, and in addition, enables acquisition of an effect accompanying stratum corneum adhesive structure decomposition, and thereby, enables provision of a stratum corneum peeling accelerator, a skin transparency improving agent, and a stratum corneum thickness improving agent.SELECTED DRAWING: Figure 1

To provide a separation membrane element which can easily inhibit reduction of an effective area caused by a bonding portion of a separation membrane.SOLUTION: In a separation membrane element 100, a bag-like body 11 formed by a separation membrane 111 is connected to a water collection pipe 2 and a sealing part 113 for preventing mixing of a supply side fluid and a penetration side fluid is formed on an end surface of the bag-like body 11. A manufacturing method of the separation membrane element 100 includes: a lamination step in which the separation membrane 111 and a thread 12 and a non-woven fabric 112, functioning as passage materials for securing a fluid passage, are laminated to form a cylindrical lamination body 1; and a sealing step in which the sealing part 113 for preventing mixing of the supply side fluid and the penetration side fluid is formed on the end surface of the bag-like body 11 after the lamination step.SELECTED DRAWING: Figure 6

The invention relates to a high polymer material for resisting microbial film adhesion of a filter bag and a preparation method of the high polymer material, and belongs to the technical field of preparation of high polymer materials, organic functional groups such as carboxyl are introduced to the surface of SiO2 through a silane coupling agent to prepare a pretreated SiO2 filler, and then the pretreated SiO2 filler is used for enhancing PET to obtain SiO2-enhanced modified PET fibers. Finally, the fiber is soaked in protein subjected to acylation treatment, an amyloid protein layer is constructed on the surface of the fiber by reducing disulfide bonds, and the effect of preventing microbial adhesion is achieved. The anti-bioadhesion material prepared by the invention has the advantages of good mechanical properties and resistance to adhesion of microorganisms and algae.

The present invention relates to a non-injectable drug delivery system using mucoadhesive nanoparticles, and to mucoadhesive nanoparticles and a method for producing the same, which prevent deformation of the nanoparticles due to mucosal moisture, etc., and strengthen mucoadhesiveness to prevent loss by binding a mucoadhesive polymer to the surface of the nanoparticles. The present invention also relates to a composition for maturing antigen-presenting cells, a composition for treating infectious diseases, and a composition for treating cancer, which comprise the mucoadhesive nanoparticles. The present invention also relates to mucoadhesive nanoparticles loaded with immune active substances (such as antigens and adjuvants) for cancer treatment and immunotherapy based on antigen-presenting cells including dendritic cells (DCs), and a composition for immune anti-cancer treatment comprising the same.

The utility model provides an infusion port pasting film which comprises a foam dressing layer in the shape of a circular truncated cone, a through hole allowing an infusion port to be exposed is formed in the center of the foam dressing layer, the periphery of the bottom end of the foam dressing layer is connected with an outer pasting film, and the lower surface of the outer pasting film is covered with a bonding layer. The inner periphery of the bottom end of the through hole is connected with an inner adhesive film, and the lower surface of the inner adhesive film is covered with an adhesive layer. The lower surfaces of the foam dressing layer, the outer adhesive film and the inner adhesive film are jointly provided with tearable release paper; the foam dressing layer is adhered to the skin on the periphery of the infusion port through the outer adhesive film and the inner adhesive film to achieve heightening, and hollowing generated when the transparent film is adhered due to the fact that too much skin protruding out of the periphery of the infusion port is arranged at the infusion port is avoided.

The present disclosure relates to methods for preparing an active layer, typically a layer comprising a mucoadhesive material and one or more pharmaceutically active compounds or nutrients, and devices comprising such active layers. The method is designed to maintain the mucoadhesive material in a non-activated form during the preparation of the active layer and to allow the mucoadhesive material to be activated once near the target site.

This invention provides a high-performance elastomer-modified bitumen waterproof membrane, belonging to the field of waterproof membrane manufacturing. The invention comprises: bitumen, a high-performance bitumen-based waterproof membrane modifier, a polymer resin, a solubilizer, a second rubber powder, and a filler. The high-performance bitumen-based waterproof membrane modifier includes a novel thermoplastic elastomer, a moderately pyrolyzed rubber polymer, and polyisobutylene rubber. The moderately pyrolyzed rubber polymer is obtained by stirring, mixing, and high-temperature pyrolysis of the first rubber powder and a first free radical scavenger. The novel thermoplastic elastomer is obtained by chemical grafting of the moderately pyrolyzed rubber polymer, a second thermoplastic elastomer, and a second free radical scavenger. Compared to traditional elastomer-modified bitumen waterproof membranes, this invention exhibits superior resistance to heat and oxygen, and aging in complex environments. It also demonstrates superior high-temperature anti-flow and low-temperature crack resistance, and superior membrane adhesion, significantly extending the service life of building waterproofing layers.

The present invention addresses the problem of providing a novel fusion protein that can efficiently deliver a drug such as an oligonucleotide therapeutic or a small molecule drug to a target site and can more effectively suppress side effects (systemic exposure to the drug). The present invention relates to a fusion protein that includes an antibody domain (A) that has at least one antigen binding site, a stabilization domain (B) that has an α-helix structure and is linked to the antibody domain (A) directly or by a linker, and a membrane adhesion domain (C) that is linked to the stabilization domain (B) directly or by a linker. The present invention also relates to: a conjugate that is formed by bonding the fusion protein and a particle that has an organic membrane that includes a lipid that includes an amphoteric ion; and a pharmaceutical composition that includes the conjugate.

The present invention provides hydrophobically modified biopolymers comprising a hydrophobically modified chitosan comprising benzenediol groups, optionally a portion of which is oxidized to the corresponding quinones. The biopolymers exhibit a surprising ability to modulate mucosal adhesion, material cohesiveness, and material hemostatic effects to provide next generation hemostatic agents and the like. Accordingly, in other aspects, the invention provides compositions comprising the modified biopolymers of the invention and methods for the treatment of bleeding and wounds.

The invention discloses a microsphere adsorbent for removing circulating tumor cells through blood perfusion and a preparation method and application of the microsphere adsorbent, and relates to the technical field of medical adsorbents for blood perfusion, the microsphere adsorbent comprises a carrier and ligands grafted to the surface of the carrier, the carrier is composed of agarose gel microspheres 2B and analogues thereof, the ligands comprise HA-N3 and CE, hA grafted on the microspheres by using an azide-alkyne click chemical reaction can be specifically combined with a transmembrane adhesion glycoprotein CD44 receptor, and CE is grafted on the HA through an amidation reaction and is specifically combined with a glucose transporter 1GLUT1 receptor on the surface of CTCs. When peripheral blood flows through the device filled with the adsorbent, the CTCs are selectively adsorbed. According to the adsorbent, the capturing efficiency of CTCs is remarkably improved, the adsorbent is used for blood perfusion treatment, the adsorbent can be used as a substitute or supplement for existing clinical surgical resection, chemotherapy or radiotherapy, the risk of tumor distal metastasis is effectively reduced, patient injury is reduced, and the cure rate is increased.

Pharmaceutical composition comprising a bilayer mucoadhesive film comprising at least two consecutive interconnected layers and incorporating at least one active agent selected from proteins, nucleic acids and combinations thereof, adapted for buccal administration. Said films for use as a medication, in particular for use in treating viral diseases. A method for preparing said film, comprising the steps: a) preparing a backing layer by spreading a liquid composition comprising a water-insoluble polymer, and allowing to dry at ambient conditions to obtain a dried layer; b) preparing a liquid mucoadhesive mixture containing at least one active agent selected from proteins, nucleic acids, and combinations thereof, pouring the mucoadhesive mixture onto the dried layer from step (a), and allowing to dry at ambient conditions to obtain a dried bilayer film; and c) cutting the dried bilayer film into the desired shape and size.

The present disclosure provides hydrophobically-modified biopolymers, including hydrophobically-modified chitosans, which comprise benzenediol groups, optionally where a portion are oxidized to the corresponding quinone. The biopolymers demonstrate a surprising ability to tune mucoadhesive properties, material cohesive properties, and hemostatic action of the material, to provide next generation hemostats, among other uses. Accordingly, in other aspects, the disclosure provides compositions comprising the modified biopolymers of the disclosure as well as methods for bleed and wound treatment.

A liquid ejecting head includes: an ejecting port for ejecting a liquid; a pressure chamber in which pressure acts on the liquid ejected from the ejection port; a flow path communicating with the pressure chamber; a substrate forming a flow path; and an organic film constituting a part of a wall surface of the flow path and suppressing vibration of the liquid in the flow path, in which the organic film is adhered to the substrate with an adhesive, and the organic film and the adhesive are bonded by a siloxane bond.

The invention features a mucosal coating composition including: (i) water: (ii) at least one mucoadhesive polymer / polysaccharide (e.g., a concentration between 0.1-20% w / v); and (iii) at least one surfactant (e.g., a concentration between 0.005-5% w / v). Exhibit long-lasting residence times on mucosal tissues and prophylactic protection against transmucosal pathogens.

This application discloses a bulk acoustic wave (BAW) filter with improved film-layer adhesion and its fabrication method. It relates to the field of filtering technology. The BAW filter includes a substrate and a resonant structure, wherein the resonant structure is disposed on the substrate and includes a working region and a non-working region surrounding the working region. In the non-working region, a buffer structure is provided between the piezoelectric layer of the resonant structure and adjacent film layers. By introducing a buffer structure in the non-working region, the stress distribution between the piezoelectric layer and adjacent film layers is made more uniform, reducing the stress difference between the piezoelectric layer and adjacent film layers. This effectively prevents separation of the piezoelectric layer and adjacent film layers or wafer warping, thereby enhancing the robustness and reliability of the device. This solves the technical problem in the prior art where the stress difference between the piezoelectric layer and adjacent film layers in BAW filters leads to device structural damage and reduced reliability.

An edged cataplasm and a manufacturing process are disclosed. The edged cataplasm includes a support layer; a drug layer, which adheres to the bottom of the support layer; a cross-type release film, which adheres to the bottom of the drug layer. The cross-type release film includes a first-release film piece and a second-release film piece, and the adjacent edges of the first-release film piece and the second-release film piece are partially overlapped. In addition, the edged cataplasm further includes a waterproof-breathable adhesive layer, which adheres to the top of the support layer and coated with silver ions or a nano antibiotic layer; a polyethylene terephthalate (PET) film, which adheres to the top of the waterproof-breathable adhesive layer. The PET film includes a first part and a second part, and the adjacent edges of the first part and the second part are arranged as an aligned S-shaped edge.

A building membrane having a generally planar core having a top surface and a bottom surface, a polymeric back coat positioned below the bottom surface of the core; a polymeric face coat positioned above the top surface of the core; an adhesive base on at least a portion of the back coat adapted for adhering the building membrane to a building substrate.

The invention discloses a bionic hydrogel interface regulated COF / ceramic composite membrane and a preparation method and application thereof.The composite membrane comprises a ceramic basement membrane, a hydrogel middle layer and a covalent organic framework selection layer, a ceramic membrane substrate is modified with functional groups, hydrogel and the ceramic basement membrane are connected through the functional groups, and the covalent organic framework selection layer is formed; then growing a COF selection layer on the surface of the hydrogel in situ through an interfacial polymerization method; the preparation method comprises the following steps: cleaning the ceramic substrate membrane, and then performing functional group modification; immersing the functional group modified ceramic substrate membrane into a hydrogel precursor solution for adsorption, then immersing into a cross-linking agent solution, and drying; and growing a covalent organic framework selection layer. According to the invention, the bionic hydrogel middle layer is adopted to regulate and control the interface of the COF and the ceramic membrane, the membrane layer adhesion and the membrane forming integrity are obviously improved, and the hydrogel layer promotes the uniform and compact growth of the COF membrane, reduces the interface defects and enhances the mechanical stability, so that the composite membrane has high water flux and high pollutant interception performance.

The present invention relates to a method for preparing a hydrophobic thin film by in-situ assembly of dopamine. First, under weakly alkaline conditions, dopamine undergoes an oxidation-crosslinking reaction and self-polymerizes into a polydopamine thin film that adheres to the surface of the substrate. The surface of the substrate is washed and dried. Then, it is placed in an anhydrous acylation reagent solution to undergo an esterification reaction and an amidation reaction to generate a hydrophobic polymer, and a hydrophobic thin film is obtained on the substrate. The present invention uses an acylation reagent to undergo a secondary esterification reaction and an amidation reaction with the polydopamine thin film deposited on the substrate to generate a hydrophobic thin film with high adhesion. The acyl group is grafted in-situ at -OH and NH2 on the hydrophobic thin film, modifying the hydrophilic property to a hydrophobic property. This method is simple, fast, and green, and has broad application prospects in various fields such as architectural coatings, biomedicine, purification and environmental protection, and functional textiles.

Dissolvable unit dose film constructs are made by providing a muco-adhesive composition including a muco-adhesive polymer matrix in which the muco-adhesive polymer matrix has a water-soluble polymer, water-dispersible polymer, water-swellable polymer, or combinations thereof and a liquid carrier. The method further includes drying the muco-adhesive composition to remove at least a portion of the liquid carrier, forming a muco-adhesive film substrate, forming a composition for an active layer, the composition including a polymer matrix in which the polymer matrix for the active layer composition includes a water-soluble polymer, water-dispersible polymer, water-swellable polymer, or combinations thereof, an active ingredient and a liquid carrier. The method further includes depositing the composition for the active layer onto the muco-adhesive substrate as a plurality of individual volumes and removing the liquid carrier from the plurality of deposited individual volumes to form a plurality of dissolvable film active layers on the muco-adhesive substrate.

This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents and one or more biologically active substances to mucosal surfaces within the GI tract and methods for the manufacture and the use of these compositions.

The present invention relates to a nano-in micro formulation, capable of enhancing the oral bioavailability of drugs. Said formulation is made of a drug loaded composite nanoparticles made of protein-polymer, which is embedded within a microsystem (nano-in micro) made of multiple layers, each layer serving specific function such as enteric protection, muco-adhesion, muco-penetration, release modification, efflux inhibition, all functions collectively resulting in the enhanced bioavailability of loaded drug by at least two-fold when compared with control free drug. The present invention also discloses the process for conceiving said nano-in micro formulation and describes the use of said nano-in micro formulation in the treatment of cancer and other diseases.

The invention belongs to the technical field of biological medicines, and particularly relates to a spermidine functionalized Janus hydrogel microneedle system as well as a preparation method and application thereof. The Janus hydrogel microneedle system is composed of a mucous membrane adhesion layer (HTSO hydrogel) and an anti-adhesion layer (GSC hydrogel), the mucous membrane adhesion layer is formed by dynamic Schiff base crosslinking of hyaluronic acid-spermidine conjugate and oxidized dextran loaded with lidocaine, and the anti-adhesion layer is composite hydrogel composed of carboxymethyl chitosan, gelatin and silk fibroin. The Janus hydrogel microneedle system provided by the invention can directly deliver a drug to mucous membrane tissues, so that the permeability of the drug is improved, the compliance of a patient is improved through painless local drug delivery, and the Janus hydrogel microneedle system shows lasting adhesion in an oral environment, effectively inhibits ferroptosis activity and active oxygen, remodels a local immune microenvironment and has a good application prospect. In-vivo angiogenesis and epithelium regeneration are promoted.

The present disclosure provides a mucoadhesive whitener composition, comprising: (a) from about 1 to about 40 wt.% of at least one primary adhesive polymer, (b) from about 1 to about 40 wt.% of at least one secondary adhesive polymer, (c) from about 0.5 to about 10 wt.% of at least one rheology modifier, (d) from about 1 to about 30 wt.% of at least one whitening agent, (e) from about 1 to about 20 wt.% of at least one neutralizer, (f) from about 0.1 to about 90 wt.% of at least one oral care acceptable anhydrous carrier (g) from about 0.1 to about 30 wt.% of at least one oral care ingredient and (h) optionally, from about 0.25 to about 10 wt.% of at least one divalent cationic donor. The present disclosure also provides a device for delivering a mucoadhesive whitener composition.

The present invention belongs to the technical field of intimate care, and specifically relates to a production device and process for an artemisia annua intimate antibacterial care solution. The fermentation device includes: a tank body: the tank body is provided with an air outlet, an air inlet pipe, a discharge port and a feed port; a bacteria filtering membrane: the bacteria filtering membrane is arranged in the air inlet pipe; an air pump: the air pump is communicated with the air inlet; a stirring mechanism: the stirring mechanism is used for stirring the composite bacteria in the tank body; a linkage mechanism: the linkage mechanism includes: a linkage mechanism: the linkage mechanism is used for driving the turntable to rotate, a turntable: the turntable is hermetically and rotationally connected to the air inlet pipe, the turntable is matched with the air inlet pipe, there are two bacteria filtering membranes, and the bacteria filtering membranes are arranged mirror-symmetrically on the turntable, and the turntable is matched with the linkage mechanism. This solution solves the problem that excessive bacteria and large particle impurities will adhere to the bacteria filtering membrane after long-term use.