Sodium hyaluronate irrigation solution for nonbacterial cystitis treatment

Abstract

The invention belongs to the field of biological medicines, and relates to a bladder irrigation solution which is used for treating the effective concentration of nonbacterial cystitis, is in contact with the internal surface epithelium and relevant structures of the bladder of a patient suffering from the nonbacterial cystitis to prevent and treat the nonbacterial cystitis and contains sodium hyaluronate. The bladder irrigation solution comprises a water-soluble mucous membrane adhesive material, an active component and a medically acceptable carrier and / or an additive. The water-soluble mucous membrane adhesive material is prepared from hyaluronic acid-cysteine and salt thereof, and the molecular weight is not less than 50,000 Dalton, and the use amount is smaller than 1 percent; the active component comprises glycosaminoglycan and / or amino monosaccharide; glycosaminoglycan is one or a combination of several of salt, chondroitin sulfate and dermatan sulfate of any proportion; amino monosaccharide is a combination of one or two of glucosamine and acetylglucosamine of any proportion. The irrigation solution contains the medically acceptable carrier and / or an additive which comprises an osmotic pressure adjusting agent, a pH adjusting agent, a preservative and water.

Description

technical field

[0001] The invention belongs to the field of biomedicine, in particular to a lavage solution for preventing and treating non-bacterial cystitis and a preparation method thereof. Background technique

[0002] Nonbacterial cystitis is a kind of chronic bladder inflammation with complicated etiology, difficult diagnosis, and difficult to eradicate. The main clinical manifestations are frequent urination, urgency, nocturia, suprapubic bladder pain, and some patients may be accompanied by painful urination and hematuria. Urine cultures were negative. Common classifications include interstitial cystitis, radiation cystitis, chemical cystitis, and other chronic bladder inflammations of nonbacterial causes.

[0003] Interstitial cystitis (interstitialcystitis, IC) is a syndrome of unknown etiology. In the early stage of pathological changes, the appearance under cystoscopy is normal or only partially congested. , There may be a variety of inflammatory cell infiltra...