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Dermatan sulfate is a glycosaminoglycan (formerly called a mucopolysaccharide) found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs. It is also referred to as chondroitin sulfate B, although it is no longer classified as a form of chondroitin sulfate by most sources. The formula is C₁₄H₂₁NO₁₅S.
Specific hyaluronate lyase and its encoding gene and use
PendingCN122168581ABacteriaPeptide/protein ingredientsHyaluronan degradationUnsaturated disaccharide
The present application relates to a specific hyaluronate lyase and its coding gene and application, and belongs to the technical field of biology and enzyme engineering. The specific hyaluronate lyase sHAase is an amino acid sequence as shown in SEQ ID NO. 1, or an amino acid sequence with homology of > 90% to the amino acid sequence shown in SEQ ID NO. 1, or an amino acid sequence formed by modifying, substituting, deleting or adding at least one amino acid in the amino acid sequence shown in SEQ ID NO. 1, and still having hyaluronic acid degradation activity. The present application also provides the coding gene, preparation method and use of the specific hyaluronate lyase sHAase. The hyaluronate lyase has very high substrate selectivity for hyaluronic acid, does not act on other glycosaminoglycans such as chondroitin sulfate, dermatan sulfate, heparin or heparan sulfate, and can cleave hyaluronic acid into degradation products mainly composed of unsaturated disaccharides, which is conducive to detection and separation.
Owner:SHANDONG UNIV