100 results about "Sodium heparin" patented technology

The invention provides a sustained-release microneedle for treating ill-conditioned pregnancy and a preparation method and application thereof, and relates to the technical field of biological medicines.The sustained-release microneedle for treating ill-conditioned pregnancy comprises a base and a needle tip on the base, the needle tip part of the gel microneedle is made of heparin medicine, and the needle tip part of the gel microneedle is made of gelatin. The heparin medicine comprises heparin, heparin sodium, low-molecular heparin, low-molecular heparin sodium or low-molecular heparin calcium; the needle point part comprises a heparin photo-crosslinking monomer, and the base comprises a biocompatible polymer matrix. The sustained-release microneedle for treating pathological pregnancy provided by the embodiment of the invention has good mechanical strength, skin permeability and anticoagulant activity, can reduce skin bruises caused by subcutaneous injection of heparin, improves abortion caused by infection and inflammation and abortion caused by APS (anti-phospholipid antibody syndrome), can realize sustained release of drugs and increase of drug loading capacity, and has good application prospects. Sustainable drug delivery is achieved, and frequent injection is avoided.

The utility model discloses a purification mechanism for heparin sodium, which belongs to the technical field of heparin sodium and comprises a stirring tank, a filter tank is arranged on the outer side of the stirring tank, a water storage tank is fixedly connected to the upper surface of the filter tank, and a water suction pump is fixedly connected to the upper surface of the filter tank. The power input end of the water suction pump penetrates through the water storage tank and extends into the water storage tank, and the power output end of the water suction pump penetrates through the filter tank and extends into the filter tank and fixedly communicates with a water outlet pipe. According to the purification mechanism for the heparin sodium, by arranging a micro forward and reverse rotation motor, a threaded rod, a moving plate and a cleaning plate, power needed during cleaning can be provided under the action of the micro forward and reverse rotation motor, the micro forward and reverse rotation motor can drive the threaded rod to rotate, and therefore the heparin sodium is purified under the action of rotation of the threaded rod; and a moving plate and a cleaning plate are driven to move, so that impurities adsorbed on the filter plate can be cleaned.

The invention provides a heparin sodium detection method and system based on deep learning, which are suitable for the technical field of data processing, and the method comprises the following steps: carrying out feature extraction on heparin sodium detection spectrum signal information and heparin sodium detection electrochemical signal information; obtaining heparin sodium detection spectral signal feature information and heparin sodium detection electrochemical signal feature information; according to the heparin sodium detection spectral signal feature information, the heparin sodium detection electrochemical signal feature information, the heparin sodium detection signal feature optimization iteration times and the heparin sodium detection signal feature optimization amplitude information, generating heparin sodium detection signal optimization feature information; and performing classification processing on the heparin sodium detection signal optimization feature information to obtain heparin sodium detection information. The method is used for fully optimizing the heparin sodium detection signal through a deep learning method so as to improve the accuracy, robustness and reliability of heparin sodium detection.

The present invention discloses the application of a water-soluble and positively charged fluorescent probe TPA-3Py for the detection of sodium heparin. TPA-3Py is obtained by covalently connecting three methylated vinylpyridines to the three arms of a triphenylamine molecule respectively. Heparin can induce the aggregation-induced emission effect of this fluorescent molecule. With the increase of the heparin content, the fluorescence intensity increases significantly, showing a good fluorescence turn-on response, overcoming the deficiency that the fluorescence probe quenches due to aggregation during the detection of heparin in the prior art. When a 10 μM aqueous solution of TPA-3Py is used for the detection of heparin, a stable fluorescence intensity is achieved within 5 minutes, the linear range is 0 - 6.14 mg / L (R<supgt;2< / supgt> = 0.9938), the lowest detection limit is 49.53 ng / mL, and the quantum yield reaches 4.85%. For the detection of sodium heparin, the TPA-3Py probe adopted in the present invention overcomes the quenching phenomenon caused by aggregation and exhibits a significant AIE effect. The fluorescent probe TPA-3Py for the detection of sodium heparin in the present invention has high sensitivity, high fluorescence intensity, rapid response and stable signal. The fluorescent molecular structure of TPA-3Py is simple, and the detection method is simple and easy to implement, which is worthy of popularization and application in the determination of the sodium heparin content.

The invention discloses a drying device for enoxaparin sodium production, and relates to the technical field of biological production drying tools. Comprising a body, three sets of supporting legs are installed on the periphery of the body, and a first motor is installed in the center of the top end of the body; through cooperation of the first motor and the stirring mechanism, the enoxaparin sodium material in the main body can be uniformly stirred by the double-helical-ribbon stirring blade, and meanwhile, the telescopic plate is matched with the spring, so that the scraping plate can be freely adjusted according to the actual condition of the inner wall of the main body, and the scraping plate is prevented from being abraded when enoxaparin sodium enoxaparin sodium enoxaparin sodium enoxaparin sodium enoxaparin sodium enoxaparin sodium enoxaparin sodium is dried; through cooperation of the microbubble assembly and the aeration pipe, the water removal efficiency is improved, and then the deep drying function can be achieved; through cooperation of a drainage ring and a second motor, the operation convenience is improved, and then the function of timely drainage of water in the drying process can be achieved; and through cooperation of an electric push rod, a first limiting block and a second limiting block, the production continuity is improved, and then the function of efficiently collecting the dried materials can be achieved.

The invention relates to an NK cell culture medium and an NK cell culture method, and relates to the technical field of cell culture.The NK cell culture medium comprises a basic culture medium and an additive, and the additive is prepared from, by concentration, 200-400 IU / L of cytokines, 3-6 mmol / L of nutritional supplements, 1-2 mmol / L of metabolism regulators, 90-110 mg / L of vitamin C, 150-300 micrograms / mL of plant polysaccharides, 1-2 micrograms / mL of 1, 2-propylene glycol, 1-2 micrograms / L of 1, 3-propylene glycol and 1, 3-propylene glycol. The medicine is prepared from 50-100 [mu] mol / L of 1, 3-dicaffeoylquinic acid, 48-52 [mu] g / mL of nano-scale hydroxyapatite, 14-16 [mu] mol / L of a signal channel regulator, 5-10 IU / L of heparin sodium and 10-80 [mu] g / mL of astragaloside IV-liposome. The culture medium and the culture method can efficiently amplify the NK cells and maintain the activity and the functional stability of the NK cells.

This invention discloses a NK cell culture kit, its culture method, and its application. The kit includes an amplification medium, a high-efficiency induction medium, an NK-A coating solution, an NK-B mixture, and an NK-C mixture. The amplification medium contains basal medium, NAD+, human serum albumin, transferrin, β-glucan, glutathione, β-mercaptoethanol, and linoleic acid. The high-efficiency induction medium, in addition to the amplification medium components, contains soybean peptides, nicotinamide, inulin, and N-acetyl-L-cysteine. The NK-A coating solution contains heparin sodium, monoclonal antibodies, and antibodies. The NK-B mixture contains Inbakicept, IL-2, and IL-15. The NK-C mixture contains linolenic acid, IL-2, and IL-18. The Inbakicept factor in the kit can activate NK cells and enhance their cytotoxicity; linolenic acid can inhibit T cell proliferation, increase NK cell purity, and enhance cell efficacy.

The utility model discloses a filtering device for heparin sodium precipitation, and belongs to the technical field of filtering devices. The filtering device for heparin sodium precipitation comprises a fixing frame body, five filtering openings are formed in the side face of the fixing frame body at equal intervals, filtering nets are clamped to the inner walls of the filtering openings, fixing valves are connected to the side faces of the filtering openings through threads, and discharging pipelines are fixedly connected to the side faces of the fixing valves. One end of the discharge pipeline is in threaded connection with a protective cover, the inner wall of the fixed frame body is in sliding connection with a cleaning frame, and a fixed fan set is arranged on one side of the fixed frame body; according to the utility model, the five equidistant filter ports are designed, and the filter screen is clamped in each filter port, so that the filter area and the filter efficiency are effectively improved. Meanwhile, due to the design of the cleaning frame, the user can conveniently slide the cleaning frame to clean residues on the filter screen, and the situation that the filter efficiency is reduced due to blockage of the filter screen is avoided.

The present invention provides a highly sensitive carbon nanotube-based flexible humidity sensor and a method for preparing the same. A highly dispersed carbon nanotube conductive ink is impregnated onto a flexible non-woven fabric as a humidity-sensitive layer using a padding method, and nanofibers are sprayed onto the fabric using electrospinning technology as an encapsulation layer to prepare a highly sensitive carbon nanotube-based flexible humidity sensor. The carbon nanotube conductive ink used is uniformly dispersed by sodium heparin, and the presence of sodium heparin gives the sensor higher humidity sensitivity and biosafety. In addition, a viscose fiber non-woven fabric with a three-dimensional porous mesh structure is used as the flexible substrate, and a nanofiber layer is used as the encapsulation layer, both of which have good flexibility, hygroscopicity, breathability, and comfort. The sensor has the advantages of high sensitivity, fast response speed, and high biosafety, and has broad application prospects and market prospects in the fields of flexible sensing equipment, medical care, biosensing, agricultural environmental protection, and the like.

The invention relates to a method for detecting the concentration content of maropitant based on canine plasma, which comprises the following steps: S1, preparing canine blank plasma, selecting 2-4-year-old beagle, collecting blood in a non-anesthetic state, filling the blood into a heparin sodium anticoagulation blood collection tube, centrifuging for 10 minutes at 4 DEG C and 4000 rpm, separating the plasma, and cryopreserving at low temperature; s2, preparing an internal standard working solution, a double-blank sample, a matrix effect reference pure solution sample, a matrix effect sample and a recovery rate sample, and preparing an analyte standard substance (glasspirenn) and an internal standard substance (trazodone); the invention relates to the technical field of detection of the content of glasspiren. According to the method, a trazodone internal standard method is adopted for determination, and the established content determination method for analyzing and determining the analyte glasspirenn in the dog plasma by using the ultra-high performance liquid chromatography-tandem mass spectrometer is good in accuracy and high in precision, and can be applied to plasma sample content determination in pharmacokinetic research of the analyte glasspirenn in a dog body.

To provide a medicine liquid supply device that is hard to be limited to a packaging material of medicine liquid such as heparin and can be used for multiple treatments by a packaging unit of medicine liquid.SOLUTION: A medicine liquid supply device supplies medicine liquid to a blood circuit included in a blood purification device that purifies blood. The medicine liquid supply device includes: a composition holding part to which an anticoagulant stored in a container can be introduced from the container and that holds a composition containing at least the introduced anticoagulant; and a connection part that connects the composition holding part to the blood circuit and enables the composition to be guided out to the blood circuit from the composition holding part.SELECTED DRAWING: Figure 1

The present invention discloses a cell cold storage protection solution and a preparation method and application thereof, and belongs to the field of cell preservation technology. The present invention provides a cell cold storage protection solution, the formula composition includes a compound electrolyte solution, red blood cell preservation solution, heparin sodium, human serum albumin, human platelet lysate and glucose. When preparing the cell cold storage protection solution, mix and prepare it under sterile conditions at room temperature. When the cell cold storage protection solution of the present invention is used to refrigerate a stem cell preparation, the activity of the stem cells is still above 85% after refrigeration for 96 hours, and the growth, proliferation and differentiation potential of the stem cells can be maintained.

The present invention discloses a heparin sodium raw material leak detection device, which specifically relates to the field of testing the sealing performance of heparin sodium raw materials under a vacuum environment, including a raw material storage cylinder, wherein the heparin sodium raw material is stored inside the raw material storage cylinder, the top of the raw material storage cylinder is sealedly connected with a raw material cylinder cover, the bottom of the raw material cylinder cover is installed with a supporting piston ring, the supporting piston ring is piston-shaped and slidingly connected to the inner cavity of the raw material storage cylinder, a disc-shaped airbag part is fixedly installed on the top of the inner cavity of the raw material cylinder cover, and the inner cavity of the disc-shaped airbag part is filled with fluorescent gas for detecting sealing performance; a round hole is opened in a through-shaped manner on the top of the raw material cylinder cover. A puncture needle penetrates the prefabricated isolation membrane and the two-layer disc-shaped airbag part, at which time the fluorescent gas in the disc-shaped airbag part leaks out, and the fluorescent gas between the raw material cylinder cover and the supporting piston ring is used to detect the sealing effect of the gap of the connecting thread tooth groove between the raw material storage cylinder and the raw material cylinder cover.

A sample storage tube comprises an upper tube body, an outer extending tube is arranged at the upper end of the upper tube body, a movable rod is arranged in the outer extending tube in a penetrating mode, a suction cup is arranged at the lower end of the movable rod, when the suction cup moves in the upper tube body, heparin sodium can be pumped into the upper tube body, heparin sodium can be conveniently stored through the upper tube body, and heparin sodium sampling can be conveniently carried out. The lower end of the upper pipe body is provided with a connecting column, the lower end of the connecting column is provided with a downward extending ring, a movable ring is movably arranged in the downward extending ring, the movable ring is provided with a movable pipe, the movable pipe penetrates through the connecting column, the periphery of the upper end of the movable pipe is provided with a plurality of notches, the lower end of the movable pipe is sleeved with a first spring, and the first spring is located on the upper side of the movable ring; when the movable pipe moves outwards under the action of the first spring and the notch is not arranged in the connecting column, the upper pipe body can be in a closed state, so that the reserved sample of the heparin sodium can be conveniently stored, and the heparin sodium can be prevented from being scattered in the transferring process.

The temporary heparin sodium crude product storage tank comprises a tank body, a discharging pipe is arranged on the side wall of the tank body in a communicating mode, a discharging valve is installed on the discharging pipe, a cover body is detachably installed above the tank body, a bottom plate is arranged below the tank body, and a plurality of universal wheels are arranged below the bottom plate; two bent rods are symmetrically arranged at the front end of the bottom plate, two sliding grooves are symmetrically formed in the rear end of the bottom plate in the length direction in a penetrating mode, clamping blocks are movably arranged in the sliding grooves in the length direction, and each bent rod comprises two vertical sections and a horizontal section arranged between the vertical sections. And the clamping blocks are used for being matched with the inner walls of the rear ends of the sliding grooves to clamp and fix the bent rods of the next group of heparin sodium crude product temporary storage tanks. According to the scheme, the storage tanks can be connected and fixed, the storage area of the crude heparin sodium product is more ordered, more time and labor are saved when workers transfer the crude heparin sodium product, and therefore the production efficiency of heparin sodium is improved.

The utility model discloses filtering equipment for high-titer crude heparin sodium production, and relates to the technical field of heparin sodium preparation, the filtering equipment for high-titer crude heparin sodium production is provided with a driven gear ring, a first centrifugal barrel, a driving motor and a driving gear, after the driving motor is started, the first centrifugal barrel is driven by the driven gear ring, and the driving gear is driven by the first centrifugal barrel to rotate; when heparin sodium is filtered, a driving gear is driven to rotate, the driving gear rotates to drive a driven gear ring to rotate, and the driven gear ring drives a first centrifugal barrel to rotate in the rotating process, so that the first centrifugal barrel and a second centrifugal barrel in the first centrifugal barrel perform double filtering operation on the heparin sodium in the second centrifugal barrel, and the first centrifugal barrel can be detached from the driven gear ring; and the inner walls of the first filtering tank and the second filtering tank can be cleaned from the position of the driven gear ring, so that the condition that bacteria are bred in the time device can be avoided, and the influence on normal filtering is avoided.

The invention discloses a heparin sodium raw material leak detection device, and particularly relates to the field of testing the sealing performance of a heparin sodium raw material in a vacuum environment, the heparin sodium raw material leak detection device comprises a raw material storage cylinder, the heparin sodium raw material is stored in the raw material storage cylinder, and the top of the raw material storage cylinder is connected with a raw material cylinder cover in a sealed manner; a supporting type piston ring is installed at the bottom of the raw material barrel cover, the supporting type piston ring is slidably connected to an inner cavity of the raw material storage barrel in a piston shape, a disc-shaped air bag part is fixedly installed at the top of the inner cavity of the raw material barrel cover, and the inner cavity of the disc-shaped air bag part is filled with fluorescent gas used for detecting the sealing performance; a round hole is formed in the top of the raw material cylinder cover in a penetrating mode. A puncture needle penetrates through the prefabricated isolating membrane and the two layers of disc-shaped air bag parts, at the moment, fluorescent gas in the disc-shaped air bag parts leaks out, and the fluorescent gas between the raw material barrel cover and the supporting type piston ring is used for detecting the sealing effect of a gap of a connection type thread tooth groove between the raw material storage barrel and the raw material barrel cover at the moment.

The invention provides a heparin sodium product sampling device, and relates to the technical field of detection sampling devices, the heparin sodium product sampling device comprises a sampling barrel, a sampling nozzle, a piston and a drawing rod, the sampling nozzle is communicated with one end of the sampling barrel, the piston is slidably mounted in the sampling barrel, and one end of the drawing rod is fixedly connected with the piston; a plugging plate is fixedly installed in the sampling nozzle, a through hole is formed in the plugging plate in a penetrating mode, and the sampling nozzle is further provided with two plugging blocks. According to the heparin sodium product sampling device provided by the invention, the sampling barrel, the sampling nozzle, the piston, the drawing rod, the plugging plate, the two plugging blocks, the elastic reset structure and the adjusting structure are arranged, and an adjustable one-way valve structure is arranged in the sampling nozzle, so that when a sample is sampled or squeezed out, the position of the two plugging plates is adjusted; therefore, the sample is ensured to enter and flow out at the corresponding stage, the situation that the sample flows out of the sampling barrel in the storage or transfer process can be reduced, waste and pollution are reduced, and the accuracy of a detection result is ensured.

The utility model discloses an enzymatic hydrolysis device for producing sodium heparin with high water solubility. The utility model relates to the technical field of sodium heparin production devices. The enzymatic hydrolysis device for producing sodium heparin with high water solubility drives a transmission shaft and a stirring blade to perform stirring operation through a motor, cooperates with an intelligent temperature control box and a liquid pump to drive a heat energy medium into a heat exchange tube, so that the heat energy medium is heated in a spiral distribution around an inner stirring tube, which is convenient for realizing uniform heating, and uses a heat preservation layer made of polyurethane foam material to prevent heat loss, which is beneficial to improving the production quality of sodium heparin. The temperature inside the device is monitored at all times through a temperature sensor, and the temperature sensor is electrically connected to the intelligent temperature control box, so that the intelligent temperature control box can control the temperature change in the processing process in real time, thereby making timely adjustments, which is beneficial to improving the accuracy of temperature control of the enzymatic hydrolysis device for producing sodium heparin with high water solubility.

The utility model provides a resin adsorption tank for extracting heparin sodium, which comprises a box body, a circular fixing plate is arranged in the box body, a stirring device is arranged on the surface of the circular fixing plate, the stirring device comprises a first motor, and one end of an output shaft of the first motor is fixedly connected with a first gear through a coupler; the first gear is meshed with two second gears, the bottoms of the first gear and the two second gears are connected with a first stirring piece and a second stirring piece respectively, the box cover is arranged at the top of the box body, a connecting frame is arranged between the box cover and the circular fixing plate, and a second motor is installed at the top of the connecting frame. According to the resin adsorption tank for extracting the heparin sodium, provided by the utility model, the stirring device, the connecting frame and the second motor are respectively arranged between the circular fixing plate and the box cover, so that raw materials in the box body can be fully stirred; and after the whole device is used, the stirring device can be detached from the interior of the box body to clean the residues, so that the residues are prevented from being left.

The invention discloses a semisolid culture medium for screening hybridoma cells. The semisolid culture medium comprises a basic culture medium, a three-dimensional skeleton component and a functional active component, wherein the three-dimensional skeleton component comprises enzymolysis matrigel and methyl cellulose. According to the invention, a brand new combination of synergistic effect of a matrigel-methylcellulose three-dimensional skeleton and a hyaluronic acid-heparin sodium functional compound system is constructed. The culture medium can significantly improve clone integrity, promote rapid proliferation of cells and efficiently enrich high-expression clone, realizes breakthrough of mainstream commercial culture media in screening efficiency and quality of monoclonal hybridoma cells, and is suitable for preparation of monoclonal antibodies.

Methods for maintaining aggregate stability and pluripotency of human stem cells are provided using chemically -defined culture media that includes heparin sodium salt and polyethylene glycol. Methods of modulating aggregate size and / or stability using chemically-defined culture media are also provided. The methods can be used with, for example, induced pluripotent stem cells or embryonic stem cells. Culture media and kits are also provided.

Provided are an eye repair composition and use thereof. The eye repair composition comprises ecdysterone, a fermented product of Tibetan kefir grains, and heparin sodium. The composition consisting of the three components of ecdysterone, fermented product of Tibetan kefir grains, and heparin sodium has effects on skin, especially skin around the eyes, in improving skin brightness, reducing the periocular melanin content, and eliminating dark circles.

The invention provides an online heparin sodium viscosity detection device, and relates to the technical field of detection devices.The online heparin sodium viscosity detection device comprises a base, a lifting rod and a machine body, the lifting rod is vertically installed on the base, the machine body is fixedly installed on an output shaft of the lifting rod, the machine body is located over the base, and a rotor connector is rotatably installed at the bottom of the machine body; a rotor is detachably mounted at the bottom end of the rotor connector; a storage groove is formed in the bottom face of the machine body. According to the heparin sodium online viscosity detection device provided by the invention, through the arrangement of the base, the lifting rod, the machine body, the rotor connector, the rotor, the protective cover, the plugging structure and the transmission structure, the retraction and extension of the protective cover can be controlled according to the use condition of an instrument; meanwhile, the plugging structure can be controlled to open or plug the opening in the bottom of the protective cover, so that the rotor connector is convenient to use and protect, manual operation of a worker is not needed, and the situation that the protective sleeve is lost can be reduced.

The invention relates to the field of eye cosmetics, in particular to a composition with anti-aging and whitening effects, a preparation method of the composition and the eye cosmetics. The composition is prepared from the following components in percentage by mass: 0.1-5% of a first active component, i.e., a curcuma zedoaria root extract; 0.1 to 5% of nicotinamide; 0.1 to 5% of acetylchitosamine; a 1%-30% acetyl ring (glutaryl hexapeptide-121) tetrapeptide-142 amide solution is prepared; a 0.1 to 5% acetyl tetrapeptide-5 solution; 0.1-2% of a yeast / rice fermentation product solution; 0.01 to 1 percent of heparin sodium; 1%-5% of 1, 2-pentanediol and the balance of water; through cooperation of multiple channels of inhibiting neural signals, promoting collagen, blocking melanin transfer, improving microcirculation and repairing skin barriers, the eye mask has an instant and long-acting anti-aging effect, has the effects of whitening, fading dark circles and relieving under-eye puffiness, and can effectively solve the problems of wrinkles, looseness, dark circles, under-eye puffiness and hyperpigmentation of eyes.

The invention relates to the technical field of adiponectin detection kits, and discloses an immunoturbidimetric kit for detecting ADP, wherein the kit comprises an R1 reagent and an R2 reagent; the R1 reagent comprises: a buffer solution, 10-100 mmol / L; NaCl, 0.1-1 mol / L; an anticoagulant, 10-100 mmol / L; an aggregation promoter, 0.1-1%; a surfactant, 0.1-1 g / L; a preservative, 0.5-1 g / L; and a blocking agent, 0.05-0.2 mg / mL; wherein the anticoagulant in the R1 reagent is EDTA-Na 2 , sodium heparin, sodium citrate or a combination thereof; R2 reagent: buffer and antibody-coated latex microspheres, the preparation process of which requires cross-linking liquid, blocking liquid and preservation liquid; the kit prepared by the present invention achieves the beneficial technical effects of reducing the difference in serum and plasma measurement values, reducing batch differences and improving stability.

The invention discloses a method for preparing ultra-low molecular weight heparin from nadroparin calcium waste, comprising the following steps: S1, collecting waste liquid, S2, oxidation, S3, primary precipitation, S4, secondary dissolution, S5, chromatography, S6, freeze drying. The invention uses waste in the process of producing nadroparin calcium from ordinary heparin sodium as raw material, and prepares ultra-low molecular weight heparin through oxidation, primary precipitation, secondary dissolution, chromatography, freeze drying and other steps, thereby solving the problem of waste waste and turning waste into treasure, improving the utilization rate of waste, reducing production cost, saving a large amount of resources, and the quality of the prepared ultra-low molecular weight heparin is within the specified standard. Therefore, the invention has a wide application prospect in the prevention and treatment of anticoagulation and antithrombosis.

The invention relates to the technical field of substance detection, in particular to a method for simultaneous online detection of protein content and sodium chloride content in a heparin sodium mixture. According to the method for simultaneously detecting the protein content and the sodium chloride content in the heparin sodium mixture on line, a double-layer model of'spectrum-protein content prediction 'and'protein content prediction value + density-sodium chloride content prediction' is established by introducing a density index, so that the weakness of near infrared in the aspect of inorganic matter quantification is effectively solved, and the accuracy of detection is improved. The two indexes of the protein content and the sodium chloride content in the heparin sodium mixture are monitored on line at the same time, and a technical basis is provided for industrial automatic production.

The utility model discloses a crushing device for heparin sodium, and relates to the technical field of heparin sodium processing. The heparin sodium smashing device comprises a base, a sliding plate is arranged on the upper surface of the base, a cylinder is fixedly installed at the top of the sliding plate, one side of the cylinder communicates with a discharging pipe, a damping spring is fixedly installed on the inner bottom wall of the cylinder, a net plate is fixedly installed at the top of the damping spring, and a cover body is arranged at the top of the cylinder; a motor is fixedly installed at the top of the cover body, a rotating rod is fixedly installed on an output shaft of the motor, the bottom of the rotating rod penetrates through the cover body and extends into the cylinder, and a smashing cutter is fixedly installed on the surface of the rotating rod. And therefore, a cylinder on the sliding plate can be conveniently shaken, and a damping spring is matched to prevent a screen plate from being blocked in the material crushing process, so that the passing ability of components in the device is improved.

The invention relates to the field of dissolving and stirring, in particular to a dissolving device for a heparin sodium production raw material pretreatment process, which comprises a dissolving kettle, a driving mechanism connected to the dissolving kettle, a rotating pipe connected to the driving mechanism, an anchor-type stirring paddle fixedly connected to the rotating pipe, and two fixed covers fixedly connected to the stirring paddle, the two fixing covers are arc-shaped, a plurality of cavities are formed in the inner sides of the two fixing covers, the cavities are through front and back, openings are formed in one ends of the cavities, mincing teeth are arranged on the upper inner walls and the lower inner walls of the cavities, two rotating shafts are connected to the driving mechanism, a plurality of rotating blocks are fixedly connected to the two rotating shafts, and a plurality of matching teeth are arranged on the upper faces and the lower faces of the rotating blocks. The device can utilize the stirring structure to conduct mincing treatment on the mucous membrane of the small intestine of the pig, and the stirring efficiency is further improved.