83 results about "Sodium heparin" patented technology

The invention provides a sustained-release microneedle for treating ill-conditioned pregnancy and a preparation method and application thereof, and relates to the technical field of biological medicines.The sustained-release microneedle for treating ill-conditioned pregnancy comprises a base and a needle tip on the base, the needle tip part of the gel microneedle is made of heparin medicine, and the needle tip part of the gel microneedle is made of gelatin. The heparin medicine comprises heparin, heparin sodium, low-molecular heparin, low-molecular heparin sodium or low-molecular heparin calcium; the needle point part comprises a heparin photo-crosslinking monomer, and the base comprises a biocompatible polymer matrix. The sustained-release microneedle for treating pathological pregnancy provided by the embodiment of the invention has good mechanical strength, skin permeability and anticoagulant activity, can reduce skin bruises caused by subcutaneous injection of heparin, improves abortion caused by infection and inflammation and abortion caused by APS (anti-phospholipid antibody syndrome), can realize sustained release of drugs and increase of drug loading capacity, and has good application prospects. Sustainable drug delivery is achieved, and frequent injection is avoided.

The invention provides a heparin sodium detection method and system based on deep learning, which are suitable for the technical field of data processing, and the method comprises the following steps: carrying out feature extraction on heparin sodium detection spectrum signal information and heparin sodium detection electrochemical signal information; obtaining heparin sodium detection spectral signal feature information and heparin sodium detection electrochemical signal feature information; according to the heparin sodium detection spectral signal feature information, the heparin sodium detection electrochemical signal feature information, the heparin sodium detection signal feature optimization iteration times and the heparin sodium detection signal feature optimization amplitude information, generating heparin sodium detection signal optimization feature information; and performing classification processing on the heparin sodium detection signal optimization feature information to obtain heparin sodium detection information. The method is used for fully optimizing the heparin sodium detection signal through a deep learning method so as to improve the accuracy, robustness and reliability of heparin sodium detection.

The present invention discloses the application of a water-soluble and positively charged fluorescent probe TPA-3Py for the detection of sodium heparin. TPA-3Py is obtained by covalently connecting three methylated vinylpyridines to the three arms of a triphenylamine molecule respectively. Heparin can induce the aggregation-induced emission effect of this fluorescent molecule. With the increase of the heparin content, the fluorescence intensity increases significantly, showing a good fluorescence turn-on response, overcoming the deficiency that the fluorescence probe quenches due to aggregation during the detection of heparin in the prior art. When a 10 μM aqueous solution of TPA-3Py is used for the detection of heparin, a stable fluorescence intensity is achieved within 5 minutes, the linear range is 0 - 6.14 mg / L (R<supgt;2< / supgt> = 0.9938), the lowest detection limit is 49.53 ng / mL, and the quantum yield reaches 4.85%. For the detection of sodium heparin, the TPA-3Py probe adopted in the present invention overcomes the quenching phenomenon caused by aggregation and exhibits a significant AIE effect. The fluorescent probe TPA-3Py for the detection of sodium heparin in the present invention has high sensitivity, high fluorescence intensity, rapid response and stable signal. The fluorescent molecular structure of TPA-3Py is simple, and the detection method is simple and easy to implement, which is worthy of popularization and application in the determination of the sodium heparin content.

The invention discloses a drying device for enoxaparin sodium production, and relates to the technical field of biological production drying tools. Comprising a body, three sets of supporting legs are installed on the periphery of the body, and a first motor is installed in the center of the top end of the body; through cooperation of the first motor and the stirring mechanism, the enoxaparin sodium material in the main body can be uniformly stirred by the double-helical-ribbon stirring blade, and meanwhile, the telescopic plate is matched with the spring, so that the scraping plate can be freely adjusted according to the actual condition of the inner wall of the main body, and the scraping plate is prevented from being abraded when enoxaparin sodium enoxaparin sodium enoxaparin sodium enoxaparin sodium enoxaparin sodium enoxaparin sodium enoxaparin sodium is dried; through cooperation of the microbubble assembly and the aeration pipe, the water removal efficiency is improved, and then the deep drying function can be achieved; through cooperation of a drainage ring and a second motor, the operation convenience is improved, and then the function of timely drainage of water in the drying process can be achieved; and through cooperation of an electric push rod, a first limiting block and a second limiting block, the production continuity is improved, and then the function of efficiently collecting the dried materials can be achieved.

The invention relates to an NK cell culture medium and an NK cell culture method, and relates to the technical field of cell culture.The NK cell culture medium comprises a basic culture medium and an additive, and the additive is prepared from, by concentration, 200-400 IU / L of cytokines, 3-6 mmol / L of nutritional supplements, 1-2 mmol / L of metabolism regulators, 90-110 mg / L of vitamin C, 150-300 micrograms / mL of plant polysaccharides, 1-2 micrograms / mL of 1, 2-propylene glycol, 1-2 micrograms / L of 1, 3-propylene glycol and 1, 3-propylene glycol. The medicine is prepared from 50-100 [mu] mol / L of 1, 3-dicaffeoylquinic acid, 48-52 [mu] g / mL of nano-scale hydroxyapatite, 14-16 [mu] mol / L of a signal channel regulator, 5-10 IU / L of heparin sodium and 10-80 [mu] g / mL of astragaloside IV-liposome. The culture medium and the culture method can efficiently amplify the NK cells and maintain the activity and the functional stability of the NK cells.

This invention discloses a NK cell culture kit, its culture method, and its application. The kit includes an amplification medium, a high-efficiency induction medium, an NK-A coating solution, an NK-B mixture, and an NK-C mixture. The amplification medium contains basal medium, NAD+, human serum albumin, transferrin, β-glucan, glutathione, β-mercaptoethanol, and linoleic acid. The high-efficiency induction medium, in addition to the amplification medium components, contains soybean peptides, nicotinamide, inulin, and N-acetyl-L-cysteine. The NK-A coating solution contains heparin sodium, monoclonal antibodies, and antibodies. The NK-B mixture contains Inbakicept, IL-2, and IL-15. The NK-C mixture contains linolenic acid, IL-2, and IL-18. The Inbakicept factor in the kit can activate NK cells and enhance their cytotoxicity; linolenic acid can inhibit T cell proliferation, increase NK cell purity, and enhance cell efficacy.

The utility model discloses a filtering device for heparin sodium precipitation, and belongs to the technical field of filtering devices. The filtering device for heparin sodium precipitation comprises a fixing frame body, five filtering openings are formed in the side face of the fixing frame body at equal intervals, filtering nets are clamped to the inner walls of the filtering openings, fixing valves are connected to the side faces of the filtering openings through threads, and discharging pipelines are fixedly connected to the side faces of the fixing valves. One end of the discharge pipeline is in threaded connection with a protective cover, the inner wall of the fixed frame body is in sliding connection with a cleaning frame, and a fixed fan set is arranged on one side of the fixed frame body; according to the utility model, the five equidistant filter ports are designed, and the filter screen is clamped in each filter port, so that the filter area and the filter efficiency are effectively improved. Meanwhile, due to the design of the cleaning frame, the user can conveniently slide the cleaning frame to clean residues on the filter screen, and the situation that the filter efficiency is reduced due to blockage of the filter screen is avoided.

The present invention provides a highly sensitive carbon nanotube-based flexible humidity sensor and a method for preparing the same. A highly dispersed carbon nanotube conductive ink is impregnated onto a flexible non-woven fabric as a humidity-sensitive layer using a padding method, and nanofibers are sprayed onto the fabric using electrospinning technology as an encapsulation layer to prepare a highly sensitive carbon nanotube-based flexible humidity sensor. The carbon nanotube conductive ink used is uniformly dispersed by sodium heparin, and the presence of sodium heparin gives the sensor higher humidity sensitivity and biosafety. In addition, a viscose fiber non-woven fabric with a three-dimensional porous mesh structure is used as the flexible substrate, and a nanofiber layer is used as the encapsulation layer, both of which have good flexibility, hygroscopicity, breathability, and comfort. The sensor has the advantages of high sensitivity, fast response speed, and high biosafety, and has broad application prospects and market prospects in the fields of flexible sensing equipment, medical care, biosensing, agricultural environmental protection, and the like.

The invention relates to a method for detecting the concentration content of maropitant based on canine plasma, which comprises the following steps: S1, preparing canine blank plasma, selecting 2-4-year-old beagle, collecting blood in a non-anesthetic state, filling the blood into a heparin sodium anticoagulation blood collection tube, centrifuging for 10 minutes at 4 DEG C and 4000 rpm, separating the plasma, and cryopreserving at low temperature; s2, preparing an internal standard working solution, a double-blank sample, a matrix effect reference pure solution sample, a matrix effect sample and a recovery rate sample, and preparing an analyte standard substance (glasspirenn) and an internal standard substance (trazodone); the invention relates to the technical field of detection of the content of glasspiren. According to the method, a trazodone internal standard method is adopted for determination, and the established content determination method for analyzing and determining the analyte glasspirenn in the dog plasma by using the ultra-high performance liquid chromatography-tandem mass spectrometer is good in accuracy and high in precision, and can be applied to plasma sample content determination in pharmacokinetic research of the analyte glasspirenn in a dog body.

To provide a medicine liquid supply device that is hard to be limited to a packaging material of medicine liquid such as heparin and can be used for multiple treatments by a packaging unit of medicine liquid.SOLUTION: A medicine liquid supply device supplies medicine liquid to a blood circuit included in a blood purification device that purifies blood. The medicine liquid supply device includes: a composition holding part to which an anticoagulant stored in a container can be introduced from the container and that holds a composition containing at least the introduced anticoagulant; and a connection part that connects the composition holding part to the blood circuit and enables the composition to be guided out to the blood circuit from the composition holding part.SELECTED DRAWING: Figure 1

The present invention discloses a cell cold storage protection solution and a preparation method and application thereof, and belongs to the field of cell preservation technology. The present invention provides a cell cold storage protection solution, the formula composition includes a compound electrolyte solution, red blood cell preservation solution, heparin sodium, human serum albumin, human platelet lysate and glucose. When preparing the cell cold storage protection solution, mix and prepare it under sterile conditions at room temperature. When the cell cold storage protection solution of the present invention is used to refrigerate a stem cell preparation, the activity of the stem cells is still above 85% after refrigeration for 96 hours, and the growth, proliferation and differentiation potential of the stem cells can be maintained.

The present invention discloses a heparin sodium raw material leak detection device, which specifically relates to the field of testing the sealing performance of heparin sodium raw materials under a vacuum environment, including a raw material storage cylinder, wherein the heparin sodium raw material is stored inside the raw material storage cylinder, the top of the raw material storage cylinder is sealedly connected with a raw material cylinder cover, the bottom of the raw material cylinder cover is installed with a supporting piston ring, the supporting piston ring is piston-shaped and slidingly connected to the inner cavity of the raw material storage cylinder, a disc-shaped airbag part is fixedly installed on the top of the inner cavity of the raw material cylinder cover, and the inner cavity of the disc-shaped airbag part is filled with fluorescent gas for detecting sealing performance; a round hole is opened in a through-shaped manner on the top of the raw material cylinder cover. A puncture needle penetrates the prefabricated isolation membrane and the two-layer disc-shaped airbag part, at which time the fluorescent gas in the disc-shaped airbag part leaks out, and the fluorescent gas between the raw material cylinder cover and the supporting piston ring is used to detect the sealing effect of the gap of the connecting thread tooth groove between the raw material storage cylinder and the raw material cylinder cover.

A sample storage tube comprises an upper tube body, an outer extending tube is arranged at the upper end of the upper tube body, a movable rod is arranged in the outer extending tube in a penetrating mode, a suction cup is arranged at the lower end of the movable rod, when the suction cup moves in the upper tube body, heparin sodium can be pumped into the upper tube body, heparin sodium can be conveniently stored through the upper tube body, and heparin sodium sampling can be conveniently carried out. The lower end of the upper pipe body is provided with a connecting column, the lower end of the connecting column is provided with a downward extending ring, a movable ring is movably arranged in the downward extending ring, the movable ring is provided with a movable pipe, the movable pipe penetrates through the connecting column, the periphery of the upper end of the movable pipe is provided with a plurality of notches, the lower end of the movable pipe is sleeved with a first spring, and the first spring is located on the upper side of the movable ring; when the movable pipe moves outwards under the action of the first spring and the notch is not arranged in the connecting column, the upper pipe body can be in a closed state, so that the reserved sample of the heparin sodium can be conveniently stored, and the heparin sodium can be prevented from being scattered in the transferring process.

The temporary heparin sodium crude product storage tank comprises a tank body, a discharging pipe is arranged on the side wall of the tank body in a communicating mode, a discharging valve is installed on the discharging pipe, a cover body is detachably installed above the tank body, a bottom plate is arranged below the tank body, and a plurality of universal wheels are arranged below the bottom plate; two bent rods are symmetrically arranged at the front end of the bottom plate, two sliding grooves are symmetrically formed in the rear end of the bottom plate in the length direction in a penetrating mode, clamping blocks are movably arranged in the sliding grooves in the length direction, and each bent rod comprises two vertical sections and a horizontal section arranged between the vertical sections. And the clamping blocks are used for being matched with the inner walls of the rear ends of the sliding grooves to clamp and fix the bent rods of the next group of heparin sodium crude product temporary storage tanks. According to the scheme, the storage tanks can be connected and fixed, the storage area of the crude heparin sodium product is more ordered, more time and labor are saved when workers transfer the crude heparin sodium product, and therefore the production efficiency of heparin sodium is improved.

The invention provides a heparin sodium product sampling device, and relates to the technical field of detection sampling devices, the heparin sodium product sampling device comprises a sampling barrel, a sampling nozzle, a piston and a drawing rod, the sampling nozzle is communicated with one end of the sampling barrel, the piston is slidably mounted in the sampling barrel, and one end of the drawing rod is fixedly connected with the piston; a plugging plate is fixedly installed in the sampling nozzle, a through hole is formed in the plugging plate in a penetrating mode, and the sampling nozzle is further provided with two plugging blocks. According to the heparin sodium product sampling device provided by the invention, the sampling barrel, the sampling nozzle, the piston, the drawing rod, the plugging plate, the two plugging blocks, the elastic reset structure and the adjusting structure are arranged, and an adjustable one-way valve structure is arranged in the sampling nozzle, so that when a sample is sampled or squeezed out, the position of the two plugging plates is adjusted; therefore, the sample is ensured to enter and flow out at the corresponding stage, the situation that the sample flows out of the sampling barrel in the storage or transfer process can be reduced, waste and pollution are reduced, and the accuracy of a detection result is ensured.

The utility model discloses an enzymatic hydrolysis device for producing sodium heparin with high water solubility. The utility model relates to the technical field of sodium heparin production devices. The enzymatic hydrolysis device for producing sodium heparin with high water solubility drives a transmission shaft and a stirring blade to perform stirring operation through a motor, cooperates with an intelligent temperature control box and a liquid pump to drive a heat energy medium into a heat exchange tube, so that the heat energy medium is heated in a spiral distribution around an inner stirring tube, which is convenient for realizing uniform heating, and uses a heat preservation layer made of polyurethane foam material to prevent heat loss, which is beneficial to improving the production quality of sodium heparin. The temperature inside the device is monitored at all times through a temperature sensor, and the temperature sensor is electrically connected to the intelligent temperature control box, so that the intelligent temperature control box can control the temperature change in the processing process in real time, thereby making timely adjustments, which is beneficial to improving the accuracy of temperature control of the enzymatic hydrolysis device for producing sodium heparin with high water solubility.

The utility model provides a resin adsorption tank for extracting heparin sodium, which comprises a box body, a circular fixing plate is arranged in the box body, a stirring device is arranged on the surface of the circular fixing plate, the stirring device comprises a first motor, and one end of an output shaft of the first motor is fixedly connected with a first gear through a coupler; the first gear is meshed with two second gears, the bottoms of the first gear and the two second gears are connected with a first stirring piece and a second stirring piece respectively, the box cover is arranged at the top of the box body, a connecting frame is arranged between the box cover and the circular fixing plate, and a second motor is installed at the top of the connecting frame. According to the resin adsorption tank for extracting the heparin sodium, provided by the utility model, the stirring device, the connecting frame and the second motor are respectively arranged between the circular fixing plate and the box cover, so that raw materials in the box body can be fully stirred; and after the whole device is used, the stirring device can be detached from the interior of the box body to clean the residues, so that the residues are prevented from being left.

The invention discloses a semisolid culture medium for screening hybridoma cells. The semisolid culture medium comprises a basic culture medium, a three-dimensional skeleton component and a functional active component, wherein the three-dimensional skeleton component comprises enzymolysis matrigel and methyl cellulose. According to the invention, a brand new combination of synergistic effect of a matrigel-methylcellulose three-dimensional skeleton and a hyaluronic acid-heparin sodium functional compound system is constructed. The culture medium can significantly improve clone integrity, promote rapid proliferation of cells and efficiently enrich high-expression clone, realizes breakthrough of mainstream commercial culture media in screening efficiency and quality of monoclonal hybridoma cells, and is suitable for preparation of monoclonal antibodies.

Provided are an eye repair composition and use thereof. The eye repair composition comprises ecdysterone, a fermented product of Tibetan kefir grains, and heparin sodium. The composition consisting of the three components of ecdysterone, fermented product of Tibetan kefir grains, and heparin sodium has effects on skin, especially skin around the eyes, in improving skin brightness, reducing the periocular melanin content, and eliminating dark circles.

The invention provides an online heparin sodium viscosity detection device, and relates to the technical field of detection devices.The online heparin sodium viscosity detection device comprises a base, a lifting rod and a machine body, the lifting rod is vertically installed on the base, the machine body is fixedly installed on an output shaft of the lifting rod, the machine body is located over the base, and a rotor connector is rotatably installed at the bottom of the machine body; a rotor is detachably mounted at the bottom end of the rotor connector; a storage groove is formed in the bottom face of the machine body. According to the heparin sodium online viscosity detection device provided by the invention, through the arrangement of the base, the lifting rod, the machine body, the rotor connector, the rotor, the protective cover, the plugging structure and the transmission structure, the retraction and extension of the protective cover can be controlled according to the use condition of an instrument; meanwhile, the plugging structure can be controlled to open or plug the opening in the bottom of the protective cover, so that the rotor connector is convenient to use and protect, manual operation of a worker is not needed, and the situation that the protective sleeve is lost can be reduced.

The invention relates to the field of eye cosmetics, in particular to a composition with anti-aging and whitening effects, a preparation method of the composition and the eye cosmetics. The composition is prepared from the following components in percentage by mass: 0.1-5% of a first active component, i.e., a curcuma zedoaria root extract; 0.1 to 5% of nicotinamide; 0.1 to 5% of acetylchitosamine; a 1%-30% acetyl ring (glutaryl hexapeptide-121) tetrapeptide-142 amide solution is prepared; a 0.1 to 5% acetyl tetrapeptide-5 solution; 0.1-2% of a yeast / rice fermentation product solution; 0.01 to 1 percent of heparin sodium; 1%-5% of 1, 2-pentanediol and the balance of water; through cooperation of multiple channels of inhibiting neural signals, promoting collagen, blocking melanin transfer, improving microcirculation and repairing skin barriers, the eye mask has an instant and long-acting anti-aging effect, has the effects of whitening, fading dark circles and relieving under-eye puffiness, and can effectively solve the problems of wrinkles, looseness, dark circles, under-eye puffiness and hyperpigmentation of eyes.

The utility model discloses a crushing device for heparin sodium, and relates to the technical field of heparin sodium processing. The heparin sodium smashing device comprises a base, a sliding plate is arranged on the upper surface of the base, a cylinder is fixedly installed at the top of the sliding plate, one side of the cylinder communicates with a discharging pipe, a damping spring is fixedly installed on the inner bottom wall of the cylinder, a net plate is fixedly installed at the top of the damping spring, and a cover body is arranged at the top of the cylinder; a motor is fixedly installed at the top of the cover body, a rotating rod is fixedly installed on an output shaft of the motor, the bottom of the rotating rod penetrates through the cover body and extends into the cylinder, and a smashing cutter is fixedly installed on the surface of the rotating rod. And therefore, a cylinder on the sliding plate can be conveniently shaken, and a damping spring is matched to prevent a screen plate from being blocked in the material crushing process, so that the passing ability of components in the device is improved.

The invention relates to the field of dissolving and stirring, in particular to a dissolving device for a heparin sodium production raw material pretreatment process, which comprises a dissolving kettle, a driving mechanism connected to the dissolving kettle, a rotating pipe connected to the driving mechanism, an anchor-type stirring paddle fixedly connected to the rotating pipe, and two fixed covers fixedly connected to the stirring paddle, the two fixing covers are arc-shaped, a plurality of cavities are formed in the inner sides of the two fixing covers, the cavities are through front and back, openings are formed in one ends of the cavities, mincing teeth are arranged on the upper inner walls and the lower inner walls of the cavities, two rotating shafts are connected to the driving mechanism, a plurality of rotating blocks are fixedly connected to the two rotating shafts, and a plurality of matching teeth are arranged on the upper faces and the lower faces of the rotating blocks. The device can utilize the stirring structure to conduct mincing treatment on the mucous membrane of the small intestine of the pig, and the stirring efficiency is further improved.

The heparin sodium waste liquid transfer tool comprises a barrel body, the top of the barrel body is provided with a flange, and the bottom of the flange is provided with a plurality of fixing grooves; a cover plate is arranged above the barrel body, the cover plate is of a cylindrical structure, a plurality of sliding grooves are formed in the cover plate in the radial direction, the sliding grooves are formed along the circumference of the cover plate in an array mode, guide rods are arranged in the sliding grooves in the radial direction of the cover plate, and sliding blocks are arranged on the guide rods in a sliding mode; a plurality of rotating plates are rotationally arranged on the edge of the cover plate, and the rotating plates are arranged on the outer sides of the sliding grooves and correspond to the sliding grooves one to one; the rotating plate comprises a transverse section and a vertical section, the transverse section is vertically arranged below the vertical section, a telescopic rod is arranged at the upper end of the transverse section, a fixing block is arranged at the upper end of a telescopic rod moving part, and the outer side of the telescopic rod moving part is sleeved with a spring; and a lifting ring is arranged above the cover plate. According to the scheme, the transfer in the horizontal direction and the vertical direction can be adapted at the same time, the situation that waste liquid is poured can be avoided, and pollution to the environment and harm to the health of workers are avoided.

1. Name of the design product: Medicine packaging box (Heparin Sodium Cream). 2. Use of the design product: For medicine packaging. 3. Design key points of the design product: The combination of shape and pattern. 4. Picture or photo that best shows the design key points: Expanded state diagram.

Disclosed is an anticoagulant manganese-containing stem cell coating, a preparation method and use thereof, which belong to the technical field of stem cell therapy. The preparation method includes the following steps: adding tannic acid, MnCl2·4H2O, and heparin sodium into a mesenchymal stem cell (MSC) suspension, mixing evenly to allow incubation to obtain an incubated stem cell solution, centrifuging the incubated stem cell solution, and collecting a resulting precipitate to obtain the anticoagulant manganese-containing stem cell coating.

The invention discloses a preparation method of a dalteparin sodium injection, and belongs to the technical field of medicines. The preparation method of the dalteparin sodium injection comprises the following steps: (1) adding the dalteparin sodium into the water for injection, and stirring to dissolve and clarify the liquid medicine; (2) adding activated carbon into the dissolved and clarified liquid medicine, stirring for 25-50 minutes, primarily filtering, and adjusting the pH value of the liquid medicine; and (3) filtering, sterilizing and filling to obtain the dalteparin sodium injection. Compared with the prior art, the preparation method of the dalteparin sodium injection provided by the invention has the advantages of simple process, low preparation cost, good stability and good compatibility.

The screening device for the heparin sodium production comprises a shell, a cavity is formed in the shell, a screening plate is movably connected in the cavity, a residue collecting assembly is movably connected in the cavity of the shell, a discharging opening is formed in one side of the shell, the screening plate penetrates through the discharging opening, a material collecting box is fixedly connected to the outer wall of the shell, and the material collecting box is arranged below the discharging opening. The inner wall of the shell is movably connected with a feeding plate, the upper end of the shell is provided with a feeding port, the feeding plate is arranged in the feeding port, the upper end of the shell is fixedly connected with a driving assembly, the driving assembly comprises a motor, the motor is fixedly connected to the upper end of the shell, the movable end of the motor is fixedly connected with a rotating disc, and the rotating disc is rotationally connected with a connecting rod. The connecting rod is rotationally connected to one end of the first supporting rod, and a collecting hopper is fixedly connected to the upper end of the shell. The heparin sodium crude product screening device has the advantages that automatic feeding is achieved through the feeding plate and the collecting hopper, automatic discharging is achieved through the inclined screening plate, so that heparin sodium crude products are automatically screened, and the screening efficiency is improved.

The invention discloses a composite material for preparing a flexible, dredged and degradable lymphatic vein anastomosis stent as well as a process and application thereof. The material is a functionally gradient composite fiber felt constructed based on a coaxial electrospinning technology, and comprises a structural skeleton matrix, an intelligent drug release system and a surface functionalization system. The structural framework matrix comprises a PLGA (poly (lactic-co-glycolic acid)) and PLLA blend, magnesium-based nanoparticles and nano tantalum powder; the intelligent drug release system comprises an environmental response type hydrogel carrier, rapamycin and heparin sodium; the surface functionalization system is covalently grafted RGD polypeptide. The preparation method comprises the steps of raw material pretreatment, composite spinning solution preparation, core-shell fiber preparation, integrated enhanced stabilization treatment, surface functional modification and sterilization. Through a unique material formula and process design, integration of multiple functions of flexible supporting, degradation controllability, intelligent drug release, endothelialization promotion, development and the like is achieved, and the problem of adaptability of a traditional intravascular stent in lymphatic vein anastomosis is effectively solved.

The utility model discloses a heparin sodium concentration device, which relates to the technical field of heparin sodium production and comprises a filter box and a concentration box, a plurality of heating plates are fixed in the concentration box along the height direction of the concentration box, the concentration box is divided into a plurality of independent concentration cavities by the plurality of heating plates, and electric heating wires are arranged in the heating plates. A conveying pipe is arranged between the filtering box and the concentration box, one end of the conveying pipe is connected with the bottom of the filtering box, each concentration cavity is connected with a branch pipe, the branch pipe is connected with the other end of the conveying pipe, an impurity filtering plate is arranged in the filtering box, impurities in the heparin sodium eluent are filtered out through the filtering box, and the quality of the heparin sodium eluent is improved; the heparin sodium eluent is injected into the plurality of concentration cavities through the plurality of branch pipes, so that the concentration box is divided into the plurality of concentration cavities with smaller volumes, and the problem of uneven heating caused by overlarge heparin sodium eluent accumulation and submission is avoided.