38 results about "Sodium heparin" patented technology

The invention provides a sustained-release microneedle for treating ill-conditioned pregnancy and a preparation method and application thereof, and relates to the technical field of biological medicines.The sustained-release microneedle for treating ill-conditioned pregnancy comprises a base and a needle tip on the base, the needle tip part of the gel microneedle is made of heparin medicine, and the needle tip part of the gel microneedle is made of gelatin. The heparin medicine comprises heparin, heparin sodium, low-molecular heparin, low-molecular heparin sodium or low-molecular heparin calcium; the needle point part comprises a heparin photo-crosslinking monomer, and the base comprises a biocompatible polymer matrix. The sustained-release microneedle for treating pathological pregnancy provided by the embodiment of the invention has good mechanical strength, skin permeability and anticoagulant activity, can reduce skin bruises caused by subcutaneous injection of heparin, improves abortion caused by infection and inflammation and abortion caused by APS (anti-phospholipid antibody syndrome), can realize sustained release of drugs and increase of drug loading capacity, and has good application prospects. Sustainable drug delivery is achieved, and frequent injection is avoided.

The invention discloses a drying device for enoxaparin sodium production, and relates to the technical field of biological production drying tools. Comprising a body, three sets of supporting legs are installed on the periphery of the body, and a first motor is installed in the center of the top end of the body; through cooperation of the first motor and the stirring mechanism, the enoxaparin sodium material in the main body can be uniformly stirred by the double-helical-ribbon stirring blade, and meanwhile, the telescopic plate is matched with the spring, so that the scraping plate can be freely adjusted according to the actual condition of the inner wall of the main body, and the scraping plate is prevented from being abraded when enoxaparin sodium enoxaparin sodium enoxaparin sodium enoxaparin sodium enoxaparin sodium enoxaparin sodium enoxaparin sodium is dried; through cooperation of the microbubble assembly and the aeration pipe, the water removal efficiency is improved, and then the deep drying function can be achieved; through cooperation of a drainage ring and a second motor, the operation convenience is improved, and then the function of timely drainage of water in the drying process can be achieved; and through cooperation of an electric push rod, a first limiting block and a second limiting block, the production continuity is improved, and then the function of efficiently collecting the dried materials can be achieved.

This invention discloses a NK cell culture kit, its culture method, and its application. The kit includes an amplification medium, a high-efficiency induction medium, an NK-A coating solution, an NK-B mixture, and an NK-C mixture. The amplification medium contains basal medium, NAD+, human serum albumin, transferrin, β-glucan, glutathione, β-mercaptoethanol, and linoleic acid. The high-efficiency induction medium, in addition to the amplification medium components, contains soybean peptides, nicotinamide, inulin, and N-acetyl-L-cysteine. The NK-A coating solution contains heparin sodium, monoclonal antibodies, and antibodies. The NK-B mixture contains Inbakicept, IL-2, and IL-15. The NK-C mixture contains linolenic acid, IL-2, and IL-18. The Inbakicept factor in the kit can activate NK cells and enhance their cytotoxicity; linolenic acid can inhibit T cell proliferation, increase NK cell purity, and enhance cell efficacy.

The utility model discloses a filtering device for heparin sodium precipitation, and belongs to the technical field of filtering devices. The filtering device for heparin sodium precipitation comprises a fixing frame body, five filtering openings are formed in the side face of the fixing frame body at equal intervals, filtering nets are clamped to the inner walls of the filtering openings, fixing valves are connected to the side faces of the filtering openings through threads, and discharging pipelines are fixedly connected to the side faces of the fixing valves. One end of the discharge pipeline is in threaded connection with a protective cover, the inner wall of the fixed frame body is in sliding connection with a cleaning frame, and a fixed fan set is arranged on one side of the fixed frame body; according to the utility model, the five equidistant filter ports are designed, and the filter screen is clamped in each filter port, so that the filter area and the filter efficiency are effectively improved. Meanwhile, due to the design of the cleaning frame, the user can conveniently slide the cleaning frame to clean residues on the filter screen, and the situation that the filter efficiency is reduced due to blockage of the filter screen is avoided.

The invention discloses a semisolid culture medium for screening hybridoma cells. The semisolid culture medium comprises a basic culture medium, a three-dimensional skeleton component and a functional active component, wherein the three-dimensional skeleton component comprises enzymolysis matrigel and methyl cellulose. According to the invention, a brand new combination of synergistic effect of a matrigel-methylcellulose three-dimensional skeleton and a hyaluronic acid-heparin sodium functional compound system is constructed. The culture medium can significantly improve clone integrity, promote rapid proliferation of cells and efficiently enrich high-expression clone, realizes breakthrough of mainstream commercial culture media in screening efficiency and quality of monoclonal hybridoma cells, and is suitable for preparation of monoclonal antibodies.

Provided are an eye repair composition and use thereof. The eye repair composition comprises ecdysterone, a fermented product of Tibetan kefir grains, and heparin sodium. The composition consisting of the three components of ecdysterone, fermented product of Tibetan kefir grains, and heparin sodium has effects on skin, especially skin around the eyes, in improving skin brightness, reducing the periocular melanin content, and eliminating dark circles.

The invention relates to the field of eye cosmetics, in particular to a composition with anti-aging and whitening effects, a preparation method of the composition and the eye cosmetics. The composition is prepared from the following components in percentage by mass: 0.1-5% of a first active component, i.e., a curcuma zedoaria root extract; 0.1 to 5% of nicotinamide; 0.1 to 5% of acetylchitosamine; a 1%-30% acetyl ring (glutaryl hexapeptide-121) tetrapeptide-142 amide solution is prepared; a 0.1 to 5% acetyl tetrapeptide-5 solution; 0.1-2% of a yeast / rice fermentation product solution; 0.01 to 1 percent of heparin sodium; 1%-5% of 1, 2-pentanediol and the balance of water; through cooperation of multiple channels of inhibiting neural signals, promoting collagen, blocking melanin transfer, improving microcirculation and repairing skin barriers, the eye mask has an instant and long-acting anti-aging effect, has the effects of whitening, fading dark circles and relieving under-eye puffiness, and can effectively solve the problems of wrinkles, looseness, dark circles, under-eye puffiness and hyperpigmentation of eyes.

The utility model discloses a crushing device for heparin sodium, and relates to the technical field of heparin sodium processing. The heparin sodium smashing device comprises a base, a sliding plate is arranged on the upper surface of the base, a cylinder is fixedly installed at the top of the sliding plate, one side of the cylinder communicates with a discharging pipe, a damping spring is fixedly installed on the inner bottom wall of the cylinder, a net plate is fixedly installed at the top of the damping spring, and a cover body is arranged at the top of the cylinder; a motor is fixedly installed at the top of the cover body, a rotating rod is fixedly installed on an output shaft of the motor, the bottom of the rotating rod penetrates through the cover body and extends into the cylinder, and a smashing cutter is fixedly installed on the surface of the rotating rod. And therefore, a cylinder on the sliding plate can be conveniently shaken, and a damping spring is matched to prevent a screen plate from being blocked in the material crushing process, so that the passing ability of components in the device is improved.

The invention discloses a preparation method of a dalteparin sodium injection, and belongs to the technical field of medicines. The preparation method of the dalteparin sodium injection comprises the following steps: (1) adding the dalteparin sodium into the water for injection, and stirring to dissolve and clarify the liquid medicine; (2) adding activated carbon into the dissolved and clarified liquid medicine, stirring for 25-50 minutes, primarily filtering, and adjusting the pH value of the liquid medicine; and (3) filtering, sterilizing and filling to obtain the dalteparin sodium injection. Compared with the prior art, the preparation method of the dalteparin sodium injection provided by the invention has the advantages of simple process, low preparation cost, good stability and good compatibility.

The invention discloses a composite material for preparing a flexible, dredged and degradable lymphatic vein anastomosis stent as well as a process and application thereof. The material is a functionally gradient composite fiber felt constructed based on a coaxial electrospinning technology, and comprises a structural skeleton matrix, an intelligent drug release system and a surface functionalization system. The structural framework matrix comprises a PLGA (poly (lactic-co-glycolic acid)) and PLLA blend, magnesium-based nanoparticles and nano tantalum powder; the intelligent drug release system comprises an environmental response type hydrogel carrier, rapamycin and heparin sodium; the surface functionalization system is covalently grafted RGD polypeptide. The preparation method comprises the steps of raw material pretreatment, composite spinning solution preparation, core-shell fiber preparation, integrated enhanced stabilization treatment, surface functional modification and sterilization. Through a unique material formula and process design, integration of multiple functions of flexible supporting, degradation controllability, intelligent drug release, endothelialization promotion, development and the like is achieved, and the problem of adaptability of a traditional intravascular stent in lymphatic vein anastomosis is effectively solved.

The application provides a method for producing heparin sodium through microbial fermentation and belongs to the technical field of polysaccharide preparation and is subordinated to IPC classification number C08B37.The method comprises the following steps: crushing pig small intestinal mucosa, high-pressure treatment, ultrasonic treatment, inoculating composite microorganisms for anaerobic fermentation, adsorbing the fermentation liquor through resin, eluting, alcohol precipitation, collecting the precipitate and obtaining heparin sodium.The pig small intestinal mucosa is crushed, high-pressure treated and ultrasonically treated, the dissolution of heparin sodium and nutrient components is promoted, the binding force between heparin sodium and other impurities is weakened, the composite microorganisms can not only decompose polysaccharide-protein compound and intercellular substance components in the mucosa but also degrade protein, fat and other impurity components in the mucosa, and the interference of the impurities on the extraction process of heparin sodium is reduced, and the resin can enrich heparin sodium and realize the separation of heparin sodium and the fermentation liquor.The various steps have a synergistic effect, and the titer and yield of heparin sodium are improved.

The invention discloses a base material coated with an anticoagulant coating and a preparation method of the base material. The preparation method comprises the following steps: immersing a base material into a polyhydroxy polymer solution, and carrying out hydroxylation modification on the surface of the base material to prepare a base material 1; immersing the base material 1 into the multi-amino polymer solution, and fully reacting to prepare a base material 2; immersing the base material 2 into a polymer solution containing a coupling agent and carboxyl and / or sodium carboxylate groups, and fully reacting to prepare a base material 3; immersing a base material 3 into the multi-amino polymer solution, and fully reacting to prepare a base material 4; and immersing the base material 4 into a heparin sodium solution, and fully reacting to prepare the heparin-grafted anticoagulant coating. The prepared anticoagulant coating is good in uniformity, high in coverage degree, firm and lasting in anticoagulant effect, and the heparin grafting content on the surface of the material can be regulated and controlled according to actual clinical requirements.

The invention discloses a preparation process of enoxaparin sodium, and relates to the technical field of biological medicine, the process comprises the following steps: constructing a non-oxidizing and chromatography-free reaction-separation synergistic system, and sequentially completing quaternary ammonium salinization, benzyl esterification, alkaline beta-elimination degradation, activated carbon decoloration under neutral pH, gradient ultrafiltration classification, nanofiltration concentration and buffer replacement. And finally, carrying out terminal degerming filtration and freeze drying to accurately enrich a target active fragment of 2000-8000 Daltons. According to the present invention, the obtained product has characteristics of high anti-Xa / anti-IIa activity ratio, complete 1, 6-anhydrosugar chain end structure and narrow molecular weight distribution, the product yield achieves 82-86%, the batch-to-batch consistency and the green manufacturing level of the process are significantly improved, and the reliable and efficient technical path is provided for the large-scale production of the high-quality enoxaparin sodium.

The application discloses a preparation process of enoxaparin sodium, and relates to the technical field of biological medicines.The process comprises the following steps: constructing a non-oxidative and non-chromatographic reaction-separation cooperative system, sequentially completing quaternary ammonium saltization, benzyl esterification, alkaline beta-elimination degradation, active carbon decolorization under neutral pH, gradient ultrafiltration fractionation, nanofiltration concentration and buffer replacement, finally performing terminal sterilization filtration and freeze-drying, and precisely enriching target active fragments with 2000-8000 daltons.The product obtained by the application has a high anti-Xa / anti-IIa activity ratio, complete 1,6-dehydration sugar chain end structure and narrow molecular weight distribution, the product yield reaches 82%-86%, and the batch consistency and green manufacturing level of the process are significantly improved, so that a reliable and efficient technical path is provided for large-scale production of high-quality enoxaparin sodium.

The utility model discloses automatic packaging equipment for heparin sodium production, which comprises a conveyor, a fixed frame is fixedly connected in the conveyor, limiting rods are symmetrically and fixedly connected in the fixed frame, an adjusting frame is slidably connected to the outer sides of the limiting rods, and connecting rollers are symmetrically and rotatably connected to the outer side of the adjusting frame. A second lead screw is rotationally connected into the fixing frame. According to the automatic packaging equipment for heparin sodium production, the conveyor, the infrared sensor, the fixing base, the first rotary knob, the first lead screw, the sliding block and the code spraying machine are arranged, so that the function of spraying codes on heparin sodium in the heparin sodium packaging process is achieved, and the position of the code spraying machine can be adjusted when the code spraying machine is used; the applicability is better; and by arranging a second rotary knob, a transmission shaft, a second bevel gear, a first bevel gear, a second lead screw, an adjusting frame and a connecting roller, the function of adjusting the tensioning degree of a conveyor belt is achieved, the conveying process is more stable, and use is convenient.

The application relates to the technical field of heparin sodium production, in particular to a heparin sodium production drying device, which comprises a drying box, a sealing cover is arranged at the top of the drying box, a drain pipe is fixedly connected to the bottom of one side of the drying box, an air inlet pipe is fixedly connected to the bottom of the rear side of the drying box, a drying assembly is arranged in the drying box, the drying assembly comprises a cavity, a barrel is arranged in the cavity, a plurality of through holes are formed in the barrel, a motor is fixedly installed at the bottom of the drying box, a spline sleeve is rotationally connected to the bottom side in the drying box, a spline shaft is clamped on the spline sleeve, a plurality of mounting seats are fixedly connected to the bottom of the cavity, and a plurality of rollers are rotationally connected to the mounting seats. The drying device is provided with the drying assembly, the double drying mode can improve the drying efficiency when the heparin sodium is dried, the dried materials can be conveniently collected and cleaned, and the production efficiency of the heparin sodium is effectively improved.

The invention discloses a membrane filtration device for heparin sodium production and a filtration method in the technical field of filtration for heparin sodium production, and the membrane filtration device comprises a shell, the outer wall of the shell is provided with a feeding pipe, a concentrated solution outlet pipe and a permeate outlet pipe, the inner wall of the shell is provided with symmetrical supporting plates, the supporting plates are provided with first through holes, and a liquid collection cavity is formed between the supporting plates and the shell; the membrane filtration assembly comprises a hollow fiber membrane bundle and a driving mechanism; a cross flow disturbance sheet; wherein when the hollow fiber membrane bundle rotates, the cross-flow disturbance sheet and the surface of the hollow fiber membrane bundle generate relative motion and periodically change the local flow direction and the flow velocity of fluid nearby the cross-flow disturbance sheet. According to the membrane filtration device, relative movement is generated between the cross-flow disturbance sheet and the surface of the hollow fiber membrane bundle, so that high shear force is directly generated on the membrane surface, pollutants and a gel layer can be effectively stripped and prevented from being attached, the flow direction and the flow speed of local fluid are periodically changed, a concentration polarization boundary layer is strongly interfered and thinned, and the membrane filtration efficiency is improved. And the rising speed of the transmembrane pressure difference is obviously delayed.

This utility model discloses a heparin sodium purification and separation device, including a fixed frame, a drive shaft rotatably connected inside the fixed frame, a placement seat fixedly connected to one end of the drive shaft, a rotating shaft rotatably connected inside the placement seat, a turntable fixedly connected to one end of the rotating shaft, transmission grooves evenly spaced inside the turntable, and a sliding frame slidably connected inside the placement seat. This utility model relates to the field of separation equipment technology. This heparin sodium purification and separation device achieves the function of clamping and fixing containers of different sizes by setting a knob, worm gear, worm wheel, rotating shaft, turntable, transmission groove, push rod, sliding frame, and arc-shaped clamping plate, facilitating subsequent purification and separation of heparin sodium. By setting a motor, drive shaft, placement seat, placement cylinder, and filter cylinder, it achieves the function of driving the placement cylinder to rotate, thereby removing insoluble matter and impurities from the liquid through centrifugal force, making it convenient to use.

The application provides a heparin sodium detection method and system based on deep learning, which is suitable for the technical field of data processing. The method comprises the following steps: extracting features of heparin sodium detection spectrum signal information and heparin sodium detection electrochemical signal information to obtain heparin sodium detection spectrum signal feature information and heparin sodium detection electrochemical signal feature information; generating heparin sodium detection signal optimization feature information according to the heparin sodium detection spectrum signal feature information, the heparin sodium detection electrochemical signal feature information, a heparin sodium detection signal feature optimization iteration number and a heparin sodium detection signal feature optimization amplitude information; and performing classification processing on the heparin sodium detection signal optimization feature information to obtain heparin sodium detection information. The application is used for fully optimizing heparin sodium detection signals through the method of deep learning, so as to improve the accuracy, robustness and reliability of heparin sodium detection.

The utility model discloses a purification device for producing low molecular weight heparin sodium based on a heparin sodium crude product in the technical field of heparin sodium purification, which comprises a shell and a filter screen, the filter screen is arranged in the shell, the filter screen is rotatably connected with the shell, a first motor is arranged on one side of the shell, the output end of the first motor is fixedly connected with the filter screen, and the output end of the first motor is fixedly connected with the filter screen. A sliding groove is embedded in the bottom of the fixing frame, a sliding block is arranged in the sliding groove and slidably connected with the sliding groove, a threaded rod is arranged in the sliding groove and connected with the sliding block through threads, a motor box is arranged at one end of the fixing frame, a fixing rod is arranged at the bottom of the sliding block, and a brush plate is arranged at one end of the fixing rod; through the arrangement of the first motor, the fixing frame, the sliding groove, the sliding block, the threaded rod, the motor box and the brush plate, the automatic cleaning function of the filter screen is achieved, and the automatic cleaning function can be achieved only by starting the motor in the motor box to drive the threaded rod to rotate so as to drive the brush plate to slide on the surface of the filter screen.

The utility model relates to the field of heparin sodium, in particular to a heparin sodium raw material catalytic enzymolysis powder intervention device which comprises a mixing cylinder, a feeding port is formed in the outer wall of the top end of the mixing cylinder, a discharging port is formed in the outer wall of the bottom of the mixing cylinder, and supporting legs distributed at equal intervals are installed at the bottom of the outer wall of the mixing cylinder. An adding assembly is mounted on the outer wall of the mixing barrel; the adding assembly comprises a mounting seat mounted on the outer wall of the mixing barrel, a conveying pipe mounted in the mounting seat, an adding pipe connected to the top of one side of the conveying pipe, a hopper mounted at the bottom of the outer wall of one side of the conveying pipe and a spiral conveying shaft rotationally connected to the inner wall of the conveying pipe. The driving motor is started to drive the mixing shaft to rotate, the mixing shaft rotates to drive the material turning inclined plate and the auxiliary plate on the mounting frame to rotate, and the material turning inclined plate and the auxiliary plate continuously turn and mix materials at the bottom of the mixing barrel, so that the intervention efficiency is improved, and the mixing efficiency is improved.

The invention discloses an ultraviolet sterilization reaction box for dalteparin sodium production, and belongs to the technical field of medicine production equipment, the ultraviolet sterilization reaction box comprises a box body, a feeding pipe is inserted in the side wall of the box body, a partition plate is fixedly installed in the box body, a feeding groove is formed in the partition plate, and a sterilization assembly matched with the feeding groove is arranged in the box body. According to the scheme, the feeding groove is formed, under the action of buoyancy of dalteparin sodium, a buoyancy disc drives a vertical rod to move upwards, a blocking plate is driven to move upwards in the upward moving process of the vertical rod, and after the blocking plate is separated from the feeding groove, the dalteparin sodium uniformly flows downwards through the feeding groove; then, in the process that dalteparin sodium moves downwards through the feeding tank, dalteparin sodium stock solution can pass through the space between the first lamp belt and the second lamp belt, at the moment, the first lamp belt and the second lamp belt can uniformly irradiate the dalteparin sodium stock solution, and the effect of improving the sterilization effect is achieved.

An oral care composition is disclosed, comprising 0.01 to 10% by weight of a deposited polymer and a polyhydroxy fatty acid amide surfactant of formula (I); wherein R 1 It is a C1-C4 alkyl or hydroxyl-substituted C1-C4 alkyl; R 2 It is a straight-chain or branched, saturated or unsaturated hydrocarbon chain having 15 to 21 carbon atoms, and a beneficial agent selected from optical agents, antimicrobial agents and mixtures thereof; wherein the deposited polymers include xanthan gum, sodium alginate, pectin, modified starch, gelatin, carrageenan, gellan gum, fenugreek gum, konjac gum, tragacanth gum, arabic gum, γ-polyglutamic acid, sodium heparin, copolymers of methyl vinyl ether and maleic anhydride, polyacrylic acid, polystyrene sulfonate, deoxyribonucleic acid, poly(allylamine), locust bean gum, guar gum, polyglycolic acid, polylactic acid, poly(glycolic acid-co-lactic acid), chitosan, humic acid, phytic acid, derivatives thereof or mixtures thereof:

The utility model belongs to heparin sodium precipitation technical field, concretely is a kind of heparin sodium low-temperature precipitation collection device, including pivot, still including annular filter screen, setting in the lower of reaction kettle, annular filter screen bottom end is fixed with fixed plate, and fixed plate upper rotary plate, rotary plate both sides are fixed with the scraping blade that is attached with annular filter screen inner wall, heat conduction plate, be spiral and be fixed in the cavity that reaction kettle is opened, heat conduction plate and cavity form spiral flow channel, the upper and lower ends of reaction kettle are respectively equipped with with the liquid outlet pipe and liquid inlet pipe that communicate with cavity;The utility model can be collected to heparin sodium precipitation by the bucket-shaped container formed by annular filter screen and fixed plate, rotary plate drives scraping blade to rotate in annular filter screen inner wall scraping, avoid its blockage, secondly, realize the quick and even cooling of material in reaction kettle by heat conduction plate.

The invention relates to the technical field of virus utilization, and particularly provides a method for improving lentivirus titer, which is used for screening compounds, compound concentration and harvesting time used in a production process. On one hand, the mechanism provided by the invention is helpful for reducing reinfection of produced lentivirus BaEVless on production cells and improving virus titer; on the other hand, in the production process, the heparin sodium can remarkably reduce apoptosis after production cell fusion, prolong the cell survival time and increase the virus yield.

The utility model discloses a heparin sodium production technology field's a heparin sodium production transfer frame, including the shell, the shell four corners are fixedly connected with universal wheel, the shell is swinged to be connected with the storage rack, be provided with fixed assembly on the storage rack, the fixed assembly is used for fixing the storage rack, is seted up with the recess on the storage rack, the recess inner wall is fixedly connected with the rubber pad, is seted up with the slide on the shell, the fixed plate slidingly connected with in the slide, be provided with drive assembly on the shell, drive assembly is used for driving the fixed plate sliding, be fixedly connected with the push handle on the shell, the utility model possesses through the storage rack and the fixed plate to heparin sodium container fixed, thereby avoids the heparin sodium container to pour or fall in the transfer process's advantage.

The invention belongs to the technical field of smashing, and particularly relates to intelligent smashing equipment for heparin sodium production, which comprises a supporting structure, a smashing machine is arranged at the upper end of one side of the supporting structure, a protection mechanism is arranged at the upper end of the smashing machine, and a guide mechanism is arranged at an outlet of the lower end of the smashing machine. A conveying mechanism is arranged at one end of the supporting structure, and a grinding mechanism is arranged at the upper end of the conveying mechanism. According to the equipment, the grinding mechanism is arranged, the static grinding disc is connected with the sleeve on the fixing ring through the air cylinder, the piston rod of the air cylinder can drive the static grinding disc to slide up and down, the gap between the static grinding disc and the movable grinding disc is adjusted in real time, the grinding granularity can be accurately controlled through the design, and the requirements of different fine processing stages of heparin sodium raw materials are met; excessive grinding or insufficient grinding is avoided; and the air cylinder can adjust the pressure of the grinding static disc on the raw materials, and is matched with the rotation of the grinding movable disc to realize double grinding effects of extruding and shearing on the raw materials, so that the grinding efficiency and uniformity are improved.

The utility model discloses a heparin sodium concentration device belongs to heparin sodium production technical field, including two supports, the top of two supports all is fixedly arranged with the concentration platform, and the bottom plate is fixedly connected between two concentration platforms, and the top of bottom plate is provided with the conveyer belt for transporting heparin sodium solution, and the bottom plate and conveyer belt form the concentration cavity, and the bottom of bottom plate is communicated and is provided with the negative pressure device for the concentration of heparin sodium solution, and the negative pressure device below is provided with the collection barrel for collecting moisture, and the communication mechanism is arranged between negative pressure device and collection barrel, and negative pressure device and collection barrel are communicated through communication mechanism. Through the above setting, the collection barrel full of water is replaced, and the collection barrel full of water is replaced into the new collection barrel, and the subsequent concentration work of heparin sodium can continue, and the efficiency of heparin sodium concentration work is improved.

The utility model discloses a device for preparing crude heparin sodium from small intestinal mucosa, which comprises an integrated frame, a PLC (programmable logic controller) is mounted on one side of the integrated frame, and a primary enzymolysis tank and a secondary enzymolysis tank are respectively fixed at two ends inside the integrated frame. When the device runs, treated small intestine mucous membrane slurry is added into the primary enzymolysis tank through the corrosion-resistant pump on the feeding pipe fitting, and the external temperature control heating sleeves are fixed on the outer walls of the primary enzymolysis tank and the secondary enzymolysis tank; a water bath heating cavity which is provided with an electric heating wire and a temperature sensor and is arranged in the side wall of the external temperature control heating sleeve is matched, the temperature control heating effect on the primary enzymolysis tank and the secondary enzymolysis tank can be achieved, and then the timing control effect of the PLC is matched, so that after the temperature control timing reaction of the materials in the primary enzymolysis tank is achieved, the reaction time is shortened; and the material is automatically transferred into the secondary enzymolysis tank through a corrosion-resistant pump on the material transferring pipe fitting to complete secondary temperature control timing reaction, so that the device realizes continuous two-time enzymolysis treatment.

The utility model relates to the technical field of villus sample collection bottles, and provides an antenatal villus sample bottle which comprises a sample bottle body, a medicine storage device, a puncture outfit and a safety ring, the medicine storage device is detachably arranged on the sample bottle body, a medicine storage cavity is formed in the medicine storage device, and the medicine storage device is provided with a medicine outlet communicating with the medicine storage cavity and a bottle opening. The isolating membrane covers the medicine outlet, one end of the puncture outfit penetrates through the medicine storage device and is located in the medicine storage cavity to form a puncture part, the puncture part is slidably arranged on the medicine storage device in the puncture direction, and the safety ring is detachably connected with the puncture outfit and the medicine storage device. By arranging the medicine storage device for containing heparin sodium medicine and the sample bottle body for containing normal saline, when an antenatal villus sample needs to be collected, the isolating membrane is punctured through the puncture outfit, so that heparin sodium in a certain proportion in the medicine storage device is scattered into the sample bottle body to be mixed with the normal saline; the preparation method has the advantages of high speed and high efficiency, and can be used for completely eradicating the loss caused by wrong proportioning.