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Biomaterial for preventing accretion after surgery and preparation method

A biomaterial and backup technology, applied in the field of biomedicine, can solve the problems of insufficient antibacterial performance and high price of hyaluronic acid products, and achieve the effect of adjustable degradation rate, good biocompatibility, and promotion of tissue repair

Inactive Publication Date: 2004-10-27
刘永庆
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high price of hyaluronic acid products, there are still obvious deficiencies in antibacterial performance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Dissolve chitosan with a deacetylation degree of 80% and a molecular weight of 200,000 Daltons (at 50° C.) in 2% acetic acid solution to make a 1% chitosan solution; add sodium hyaluronate In deionized water, prepare a sodium hyaluronate solution with a concentration of 1%. Add 1M HCl dropwise to the sodium hyaluronate solution and stir at the same time until the pH value reaches 4; add the above sodium hyaluronate solution to the chitosan solution in a ratio of 1:20 (v / v), stir and mix well Packed in containers, air-dried or freeze-dried to make a film with a thickness of 1 mm; soaked in 20% ammonia water for 5 minutes, then freeze-dried, Co 60 Disinfect and spare.

Embodiment 2

[0029] Dissolve carboxymethyl chitosan with a deacetylation degree of 90% and a molecular weight of 100,000 Daltons in 2% acetic acid solution to make a 1% carboxymethyl chitosan solution; add sodium hyaluronate Prepare 1% sodium hyaluronate solution in deionized water. Add 2M HCl dropwise to the sodium hyaluronate solution while stirring to mix the two thoroughly until the pH value reaches 3; add the above sodium hyaluronate solution to the carboxymethyl shell at a ratio of 1:50 (v / v) The polysaccharide solution is fully stirred and evenly distributed in containers, freeze-dried, and made into a tubular material with a wall thickness of 2 mm and an internal diameter of 20 mm (preparation of the tubular material: carboxymethyl chitosan / hyaluronic acid The sodium solution is injected into a ring-shaped mold made of concentric tubular polytetrafluoroethylene, and then dried); soaked in 20% ammonia water for 5 minutes, rinsed with distilled water. Then then add 0.1% Tranister so...

Embodiment 3

[0032] Dissolve chitosan and type I collagen with a deacetylation degree of 70% and a molecular weight of 300,000 Daltons in 1% acetic acid to prepare a solution of 1.5% chitosan and 1% collagen. Glycan and collagen solutions were mixed 20:1 (v / v). Add sodium hyaluronate and sodium carboxymethylcellulose into deionized water to prepare a 1% solution of sodium hyaluronate and sodium carboxymethylcellulose. The sodium hyaluronate and sodium carboxymethylcellulose solutions were mixed 1:1 (v / v). Add 1M HCl dropwise to the sodium hyaluronate / sodium carboxymethyl cellulose solution while stirring until the pH value reaches about 2; ) proportion into the chitosan / collagen solution, fully stirred and mixed. After soaking in 80% ammonia solution for 15 minutes, rinse with distilled water. Then add 1% (dry weight) of dextran 70 (dextran 70 can be dissolved in water first) and freeze-dry, Co 60 Disinfect and spare. In use, a small amount of 1% chitosan / calcium chloride (weight rati...

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PUM

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Abstract

A biologic material for preventing adhesion after operation is prepared from chitosan and sodium hyaluronate through preparing their solutions, proportionally mixing, defoaming, loading in mould, freeze drying to become film or tube, immersing the mixed liquid, flushing by distilled water drying and sterilizing. It is possible to attach the antiadhering medicine to it. Its advantages are high attachment, mechanical strength and antibacterial power, and better biocompatibility and bioactivity.

Description

technical field [0001] The invention relates to a biological material and a preparation method thereof, in particular to the preparation of a biological material for preventing postoperative adhesion prepared by using chitosan / sodium hyaluronate, and belongs to the technical field of biomedicine. Background technique [0002] Postoperative adhesions are a very common postsurgical complication, which refers to abnormal structures in which fibrous bands of connective tissue bond with adjacent tissues or organs after surgery. Adhesions can range from a thin film to dense tissue with vascular scarring. Severe cases often lead to intestinal obstruction, infertility, chronic pelvic pain, etc., increasing the difficulty of reoperation and the potential for further complications. The causes of adhesion can be attributed to ①surgical trauma; ②local ischemia; ③retention of foreign bodies; ④bleeding and exposed wound surface; ⑤bacterial infection. At present, there are two commonly u...

Claims

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Application Information

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IPC IPC(8): A61L31/08A61P41/00
Inventor 刘永庆
Owner 刘永庆
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