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249results about How to "Controllable degradation rate" patented technology

Injectable double-crosslinked hyaluronic acid aquagel and preparation method thereof

The invention discloses an injectable double-crosslinked hyaluronic acid aquagel and a preparation method thereof. The preparation method comprises the following steps: synthesizing formylated hyaluronic acid and amino / methylacryloyl bifunctional hyaluronic acid containing disulfide bond in the side chain, uniformly mixing the formylated hyaluronic acid and amino / methylacryloyl bifunctional hyaluronic acid containing disulfide bond in the side chain with a water-soluble photoinitiator, and carrying out photochemical polymerization to obtain the injectable double-crosslinked hyaluronic acid aquagel. The method has the advantages of accessible raw materials, mild reaction conditions, short reaction time, simple technique and the like. The prepared aquagel is formed by a Schiff base crosslinking mechanism and a photocrosslinking mechanism, and the two crosslinking networks are connected together. The crosslinking network chain of the aquagel contains the disulfide bond and Schiff base, and thus, the aquagel has dual sensitivities for reduction and pH. The hyaluronic acid aquagel has flexible and adjustable mechanical properties, microstructure, degradation property, swelling capacity and the like, is injectable, and has application prospects in the aspects of cell transfer, tissue engineering, three-dimensional cell culture and the like.
Owner:WUXI JIANGNAN CABLE

Chitosan modified alginate hydrogel three-dimensional porous bracket and preparation method thereof

InactiveCN101773683ARich sourcesControllable physical and chemical propertiesProsthesisPhosphateFreeze-drying
The invention relates to a chitosan modified alginate hydrogel three-dimensional porous bracket with specific in-vitro degradability and a preparation method thereof. The method comprises the following steps: dissolving sodium alga acid serving as a raw material in phosphate buffer solution; performing amidation reaction of a carboxyl group in the sodium alga acid and an amino group in a cross-linking agent cystamine or dimethyl cystinate under the activation of water-soluble carbodiimide to form a chemically crosslinked hydrogel; performing freeze drying on the hydrogel to obtain a porous bracket material of the hydrogel; and performing surface modification on the porous bracket by using chitosan. In solution of a reducing agent such as cysteine with an appropriate concentration, a disulfide bond in a hydrogel cross-bridge is degraded through a disulfide bond-sulfydryl conversion reaction, so the porous bracket is decomposed and dissolved and disappears. Therefore, the porous bracket can be used as an in-vitro cell culture template material. The hydrogel porous bracket researched by the invention has the characteristics of simple preparation, rich raw material source, low cost and availability. Various physiochemical performances, mechanical strength, degradation rate and surface properties of the bracket material are controllable within a large range.
Owner:TIANJIN UNIV

Prepration process for biologic hemostatic sponge material

A method of producing biological hemostasis spongy material. It comprises: taking chitosan / chitin as the main raw material, preparing the solution, defoaming and putting into a container and freeze-drying, forming a spongy layer with the thickness of 1-10mm; soaking with ammonia, ammonia / alcohol, ammonia / acetone, ammonia / methanol, washing with distilled water, freeze-drying and disinfecting. Theprepared hemostasis spongy material has abilities of stanching bleeding and promoting tissue rehabilitation.
Owner:北京益而康生物工程有限公司 +1

Preparation method of porous fiber with controllable degradation rate for tissue engineering scaffold

The invention relates to a preparation method of porous fiber with a controllable degradation rate for a tissue engineering scaffold, which comprises the following steps: uniformly mixing a biodegradable polymer and a pore-forming agent, vacuum drying, melt spinning, drawing, immersing into hydrochloric acid or distilled water to remove the pore-forming agent, and vacuum drying, thereby obtainingthe porous fiber with micro pores with the diameters of 10-100mum uniformly distributed on the surface thereof. The preparation method of the invention is simple and is applicable to industrial production. The diameters of the micro pores of the prepared fiber are matched with cell sizes, so that cells can be easily adhered into the micro pores on the surface of the fiber for growth. Simultaneously, the degradation rate is controllable.
Owner:DONGHUA UNIV

Method for preparing multifunctional biological repair material

A multifunctional biologic material for repairing skin, nerve and cartilage is prepared from chitosan, collagen and sodium hyaluronate through preparing their solutions, proportionally mixing, defomaing, loading in mould, freeze drying to become film or tube, immersing in ammonia water, drying, coating a solution layer of chitosan, chitosan / sodium hyaluronate, chitosan / collagen, or chitosan / collagen / sodium hyaluronate, and drying. Its advantages are high biocompatibility, mechanical strength and antibacterial power.
Owner:刘永庆

Fully biodegradable aliphatic polycarbonate mulch film and preparation method thereof

The invention relates to a fully biodegradable aliphatic polycarbonate mulch film and a preparation method thereof. The mulch film comprises the following raw materials by weight ratio: 30-50 parts of aliphatic polycarbonate butanediol ester, 10-50 parts of starch, 10-50 parts of polylactic acid, 1-5 parts of herbicide, 1.0-3.5 parts of antiblocking agent, 0.5-6 parts of lubricant, 4.0-15 parts of plasticizer, 1.5-4 parts of heat-resistance stabilizing agent, 0.05-1.5 parts of anti-oxidant, 0.5-2.0 parts of coupling agent, 0.05-1.5 parts of biodegradation promoter and 0.5-5.0 parts of photodegradation agent. The Fully biodegradable aliphatic polycarbonate mulch film can be prepared by mixing and stirring the raw materials and extruding to granulate by a twin-screw machine. The fully biodegradable aliphatic polycarbonate mulch film of the invention has the advantages of low cost, good temperature toleration, temperature tolerance and water resistance, and is capable of regulating the degradation rate and has the function of weeding.
Owner:JIANGSU XINGYE PLASTIC

I-type medical collagen material keeping original specific triple helix structure of collagen, product and application thereof

ActiveCN101569765ALow immunogenicityNo foreign body reactionProsthesisTissue repairTriple helix
The invention relates to an I-type medical collagen material keeping an original specific triple-helical structure of collagen, and an extraction method thereof, meninges / spinal meninges biomembrane made from the I-type medical collagen material, and a preparation process of the biomembrane, and application of the biomembrane to preparing meninges / spinal meninges tissue repair materials. The I-type medical collagen material keeping the original specific triple helix structure of collagen has the advantages of low immunogenicity, no foreign body reaction, good biocompatibility and controllabledegradation rate, the prepared meninges / spinal meninges biomembrane has certain stretching resistance strength, repairable and regenerative dura mater / spinal meninges tissue and tissue adhesion prevention / reduction, and the biomembrane is applicable to repair and regeneration of injured cerebral dura mater and spinal dura mater.
Owner:许和平

Injectable hollow hydroxyapatite microsphere/chitosan composite drug carrier material and preparation method thereof

The invention discloses an injectable hollow hydroxyapatite microsphere / chitosan composite drug carrier material. The material comprises the following components in percentage by weight: 0.5-2wt% of hollow hydroxyapatite, 2wt% of chitosan, 5.6wt% of beta-sodium glycerophosphate and 90.4-91.9 wt% of water. The preparation method comprises the following steps: first, loading drug in the hollow sodium hydroxyapatite microsphere; then, preparing chitosan thermo-sensitive hydrogel; finally, mixing the drug-loaded hollow hydroxyapatite microsphere and the chitosan thermo-sensitive hydrogel in a solid-liquid ratio of (0.05-0.2)g / 10ml, and stirring to obtain the injectable hollow hydroxyapatite microsphere / chitosan composite drug carrier material. The material can realize slow and controlled release of drug, gives the material injectable molding property, and realizse minimally invasive therapy to bone defect or fracture.
Owner:TONGJI UNIV

Degradable material capable of guiding the regeneration and renovation process of hard tissue and its preparation

The invention discloses a degradable material for conducting hard tissue regeneration and renovation, and its preparation method which comprises, using degradable biomaterial collagen, chitosan or hydroxyl chitosan, tertiary calcium phosphate or hydroxyapatite as principal raw material, preparing acid solution and suspending liquid, mixing to prepare hard tissue filler, wherein the prepared biological material has good compatibility with the wound tissue.
Owner:TSINGHUA UNIV

Medical composite material and preparing method thereof

The invention discloses a medical composite material and a preparing method thereof. The medical composite material comprises a base material and a degradable fiber material, wherein the base material is a cross-linking-type degradable polymer material which is of a three-dimensional network structure. The medical composite material has the mechanical strength higher than that of a linear high polymer material, and is easy to store, fracture can be avoided, and the requirements of high-strength medical devices can be met. In addition, the cross-linking-type polymer base material has the relative-low molecular weight and the simple and easy synthesis and preparing method and processing technology, and the technical problem that high-molecular-weight linear polymer is difficult in preparing and processing is solved.
Owner:上海发微医用材料有限公司

Preparation method of biodegradation polylactic acid based multicomponent block polymer

The present invention belongs to the field of polymer material technology, and is especially preparation process of biodegradable polylactic acid based polynary block polymer. The preparation process includes the first polycondensation of lactic acid, lactic acid and small molecular dibasic alcohol, or lactic acid and small molecular dibasic carboxylic acid to obtain lactic acid prepolymer in certain molecular weight; and the subsequent adding ester oligomer and chain expander to react under N2 atmosphere at pressure below 60 Pa and temperature of 150-230 deg.c for 10-45 min to obtain the biodegradable resin with high molecular weight. The biodegradable resin has flexibility and heat resistance higher than that of lactic acid homopolymer, adjustable degradation speed, simple preparation process and wide application, and the preparation process is easy use in industrial production.
Owner:TONGJI UNIV

Degradable corrosion-resistant high-toughness Zn-Fe zinc alloy for human body and application thereof

The invention provides a degradable corrosion-resistant high-toughness Zn-Fe zinc alloy for a human body and application thereof and relates to the field of medical implant materials. The corrosion-resistant high-toughness Zn-Fe zinc alloy provided by the invention is aimed at overcoming the defects in the prior art and has the advantages that the cost of adding materials is low, the strength is high, the plasticity is good, the degradation rate is controllable, and meanwhile, the Zn-Fe zinc alloy can be degraded by human bodies. The zinc alloy contains a Zn element and a Fe element, wherein the mass percent of Zn element is 90-99.998%, and the mass percent of Fe element is 0.002-10%. According to the zinc alloy provided by the invention, the cost of the added materials is low, degradation products of all ingredients of a prepared alloy material can be degraded through human body metabolism, the corrosion resistance is far higher than that of a magnesium alloy, the degradation rate is greatly lowered, a longer-time mechanical support can be provided, and the strength and toughness of the alloy material are good.
Owner:XIAN ADVANCED MEDICAL TECH

Method for preparing human-like collagen haemostatic sponge in scale

The invention discloses a method for preparing human-like collagen haemostatic sponge in scale, which comprises the following steps: dissolving human-like collagen into 1.0 to 2.0 percent solution; dissolving chitosan into 0.5 to 1.0 percent solution by dilute acid; mixing the two solutions evenly, adding glycerin and / or sorbitol into the solution, mixing, stirring and filtering the solution, and then defoaming the solution in vacuum; injecting the mixed solution into a die, pre-freezing the mixed solution at a temperature of between 40 DEG C below zero and 80 DEG C below zero, cross-linking the mixed solution by using 0.1 to 1.0 percent glutaraldehyde solution after freezing and drying, washing the cross-linked product for several times by using distilled water after the cross-linking is finished and vacuum-freezing and drying the washed product again, and then sterilizing the product by Co-60 to obtain a finished product of the human-like collagen haemostatic sponge. Compared with the conventional haemostatic materials broadly applied in clinic, the prepared haemostatic sponge has good mechanical property and excellent biocompatibility, thoroughly stops inevitable virus hidden trouble of animal collagen haemostatic materials, and ensures the safety of the haemostatic material in clinical usage.
Owner:NORTHWEST UNIV(CN)

Degradable corrosion-resistant high-toughness Zn-Fe-X zinc alloy for human body and application thereof

The invention provides a degradable corrosion-resistant high-toughness Zn-Fe-X zinc alloy for a human body and application thereof and relates to the field of medical implant materials. The zinc alloy contains a Zn element, a Fe element and an X element, wherein the X element is at least one of Mg, Ca and Sr, the mass percent of Zn element is 89.92-99.997%, the mass percent of Fe element is 0.002-10%, and the mass percent of X element is 0.001-0.08%. According to the zinc alloy provided by the invention, the cost of added materials is low, degradation products of all ingredients of a prepared alloy material can be degraded through human body metabolism, the corrosion resistance is far higher than that of a magnesium alloy, the degradation rate is greatly lowered, a longer-time mechanical support can be provided, and the strength and toughness of the alloy material are good.
Owner:XIAN ADVANCED MEDICAL TECH

Controlled degradable surgical suture thread and fabricating method thereof

The invention discloses a controlled degradable surgical suture thread and a fabricating method thereof. The innermost part is chitosan fiber core, the middle part is collagen layer, and the outermost part is ethyloic-chitosan layer. From innermost to outermost, the thickness ratio of each layer is 2:X:(3-X), wherein X is larger than 1 and smaller than 3. The value of X is related to degradation velocity of the surgical suture thread: the larger the value, the faster the degradation velocity of the surgical suture thread, and the shorter the healing period of wound suitable to be sutured; andthe smaller the value, the slower the degradation velocity of the surgical suture thread, and the longer the healing period of wound suitable to be sutured. The fabricating method of the surgical suture thread comprises: (1) preparing chitosan fiber core and collagen; (2) covering a layer of collagen outside the chitosan fiber; (3) covering a layer of ethyloic-chitosan outside the collagen cover of the chitosan fiber; (4) processing and polishing the suture thread prepared in (3) by an automatic coreless grinder, connecting with suture needles of different models to prepare into a finish product of surgical suture thread. The technical scheme of the invention has plentiful advantages: controllable degradation velocity, high tension strength, improved biocompatibility and anti-infectious property, quick wound healing, no obvious scars, good biocompatibility, etc.
Owner:GENERAL HOSPITAL OF THE SECOND ARTILLERY OF CHINESE PLA

Magnesium alloy bone surgery internal fixation and implantation material

The invention relates to a magnesium alloy internal fixation and implant material used in orthopedic surgeries, which is characterized in that the pure magnesium is used as the substrate, and calcium and zinc elements are added into the pure magnesium; wherein, the zinc accounts for 2-5%, and the calcium accounts for 1-3%. The magnesium alloy internal fixation and implant material used in orthopedic surgeries has the advantages of enjoying favorable biocompatibility, excellent mechanical property and controllable degradation rate, and meeting the demands for internal fixation and implant materials in orthopedic surgeries, thus being particularly suitable for screw plate systems and intramedullary pin systems.
Owner:BEIJING ALLGENS MEDICAL SCI & TECH +1

Magnesium oxide whisker/biodegradable polyester composite material and its preparation method and application thereof

ActiveCN103319866AImprove the interface binding forceImprove mechanical strength and modulusProsthesisIn situ polymerizationMagnesium
The invention discloses a magnesium oxide whisker / biodegradable polyester composite material and its preparation method and an application thereof. The composite material contains 0.1-60 wt% of magnesium oxide whisker and 40-99.9 wt% of biodegradable polyester. The magnesium oxide whisker / biodegradable polyester composite material provided by the invention has excellent mechanical properties, good biocompatibility and bone healing-promoting capability. Alkalinity of the magnesium oxide whisker also can regulate and control degradation rate of the biodegradable polyester, neutralize its acidic degradation products and reduce inflammatory response. The magnesium oxide whisker / biodegradable polyester composite material is a novel bone tissue repair material with an excellent osteogenic activity. The preparation method is a solution blended process or a melt blending method by using the magnesium oxide whisker and the biodegradable polyester as raw materials, or an in situ polymerization method by using the magnesium oxide whisker and a cyclic ester monomer as raw materials. According to the invention, preparation cost of the composite material is low; the preparation method is simple; condition is mild; and the preparation method is easy for industrial production.
Owner:JINAN UNIVERSITY

Biological-compatibility artificial ear and in-vitro rapid construction method thereof

InactiveCN104490491AAct as a hearing aidPossess in vitro regenerative capacityProsthesisNervous systemMalformed auricles
The invention discloses a biological-compatibility artificial ear and an in-vitro rapid construction method thereof, and belongs to the field of biological organ engineering and advanced manufacture. A rapid forming technology is used for constructing an artificial ear in vitro, and the artificial ear has a feature and functions similar with a natural auricle, and can be compounded with an artificial auricle assembly to restore hearing. The artificial ear comprises a skin simulation layer, a hydrogel layer, a hydrogel micro-capsule layer and a skeleton simulation layer, wherein the skin simulation layer and the skeleton simulation layer are made of a synthetic macromolecule material; the hydrogel layer and the hydrogel micro-capsule layer are made of a natural macromolecule material which contains cells and growth factors, have strong bioactivity and are favorable for the regeneration of (cartilage) tissues, blood systems and nervous systems. The biological-compatibility artificial ear also can be compounded with the artificial auricle assembly which comprises an inner part of the auricle and an outer part of the auricle. The biological-compatibility artificial ear can be used for a plastic surgery to replace the malformed auricle of a patient. After the artificial auricle assembly is compounded, the artificial ear can be used for treating and restoring the auditorily handicapped.
Owner:TSINGHUA UNIV

Thermo-sensitive tri-block polymer as well as preparation method and use thereof

The invention relates to medical polymers field, especially a temperature sensitive and biodegradable triblock copolymer with gel-sol transformation characteristics and preparation method thereof and usage. The triblock copolymer is PEG-PCL-PEG copolymer, the aqueous solution thereof performs Gel-Sol phase transformation along with the temperature rise and the phase transformation temperature is 40-55 degree. The PEG-PCL-PEG copolymer has a variety of excellent features to provide a new choice in field which is in need of temperature sensitive material.
Owner:SICHUAN UNIV

Degradable polyurethane material with active oxygen responsiveness and preparation method of degradable polyurethane material

The invention discloses a degradable polyurethane material with active oxygen responsiveness and a preparation method of the degradable polyurethane material. The degradable polyurethane material comprises a biodegradable polyester glycol soft segment and a hard segment composed of saturated aliphatic diisocyanate and reactive oxygen responsive small molecular diamine. The material is prepared bytaking poly(epsilon-caprolaclone glycol) (PCL) or polypropylene glycol fumarate (PPF) as macromolecular diols, saturated aliphatic diisocyanate as a raw material and reactive oxygen responsive small molecular diamine as a chain extender and adopting a two-step chain extension method. A polyurethane elastomer prepared from the degradable polyurethane material has good biocompatibility and responsiveness to reactive oxygen, the material and a degradation product are harmless to human bodies, so that the degradable polyurethane material can be widely applied to the fields such as biological medicines and tissue engineering and can be used for bone repair and myocardium generation.
Owner:ZHEJIANG UNIV

Completely biodegradable polyester material and preparation and application of completely biodegradable polyester

The invention discloses a completely biodegradable polyester material and preparation and application of the completely biodegradable polyester. The material comprises the following components: 60-98 percent of poly(L-lactic acid) and 2-40 percent of poly(L-lactic acid-caprolactone) copolymer, wherein the molecular weight of the copolymer is 10000-100000, a number ratio of lactic acid units to caprolactone units is (95:5) to (20:80), and the copolymer contains arms of 1-6 specific structures. The preparation method of the material comprises the following steps: dissolving poly(L-lactic acid) into an organic solvent in which polylactic acid can be dissolved, adding the copolymer in a formula amount, and fully stirring, so that the copolymer is completely dissolved; and adding a polymer solution into water or a mixed solution of water / alcohol, separating out the blend by precipitating, filtering, and drying, thereby preparing the to-be-prepared completely biodegradable polyester material. The material can be used for preparing corresponding products in the fields of artificial bones, scaffolds for tissue engineering and interventional medical equipment in biomedicine, and the prepared product has excellent mechanical property and biodegradability.
Owner:SICHUAN UNIV

Degradable stephanoporate stent material for inducting osseous tissue regeneration and repair and preparation thereof

The invention discloses a degradable support material which induces the regeneration and repair of bone tissues and a preparation method thereof, pertaining to the technical field of the preparation of biomaterials. Degradable biomaterials, such as konjac glucan-mannan and hydroxyapatite / collagen protein or calcium phosphate / collagen protein composite powder, or hydroxyapatite or calcium phosphate are adopted as raw materials in the invention. Konjac glucan-mannan powder and hydroxyapatite / collagen protein or calcium phosphate / collagen protein composite powder, or hydroxyapatite or calcium phosphate are added into aqueous solution of an alkaline gelata and fully heated to form gel, and then after freeze-drying, the degradable porous support material is prepared. Not only does the materialhave simple preparation technology and low cost, but also the biomaterial prepared has good biocompatibility. Cell tests show that the material can be universally applied to bone operation and is theantibacterial porous material with adjustable degradation rate in vivo and can promote and induce the repair of the bone tissues, thereby having the wide application value in surgical operation.
Owner:KUNMING UNIV OF SCI & TECH

Poly alpha-alcohol acid ester/chitosan ultrafine fiber hybridization film material and its preparation

A poly alpha alcohol acid ester / chitosan superfine fiber hybridization material and the preparation process thereof are disclosed. It belongs to tissue repairing material technology. The film having thickness of 10ª–m-50ª–m is formed by poly alpha alcohol acid ester fiber, the diameter of which being 50nmí½500nm, chitosan, the mass percent of which is 10-90%, polyvinyl alcohol or polyoxyethylene, the diameter thereof being 50nmí½500nm. The preparation process is as follows: dissolving PLA or PLGA into N,N- dimethytoluamide to prepare poly alpha alcohol acid ester spinning solution with concentration being 20%-25%, dissolving chitosan to acetic acid aqueous solution, adding polyvinyl alcohol or polyoxyethylene to solution to prepare for chitosan spinning solution with concentration 4%-8%, injecting said spinning solutions separately to the multi-channel electrostatic spinning device, conduct simultaneously electrostatic spinning and film converging in separate channels to prepare for film, with the voltage being 5kVí½30kV, liquid inventory being 0.1mL / hí½0.5mL / h, receiving range being 5cmí½25cm. The film has advantages of large water absorption, regulatable degrading rate and favorable cellular affinity.
Owner:TIANJIN UNIV

Medical anti-adhesion material with controllable degradation and preparation method thereof

The invention discloses a medical anti-adhesion membrane material with controllable degradation and a preparation method thereof, belonging to the field of biomedical materials. According to the invention, the membrane material is prepared by blending sodium hyaluronate and konjac klucomannan, using lactic acid as a property-modifying additive and using a mixed solution of ammonia water and anhydrous ethanol as a cross-linking agent; sodium hyaluronate is a good anti-adhesion material, but individually used sodium hyaluronate has a fast degradation speed and can not fulfill a good anti-adhesion effect; konjac klucomannan can control the degree of cross-linking, thereby realizing the goal of controllable degradation, and blending of sodium hyaluronate and konjac klucomannan enables sodium hyaluronate to be released slowly, thereby allowing the membrane material to meet demands for anti-adhesion action at different parts. The membrane material has the advantages of nontoxic degradation products, good biocompatibility, hygroscopicity and tensile properties, and the like, and can be used for intervertebral adhesion, intestinal adhesion, skin adhesion, intrauterine adhesion, etc.
Owner:KUNMING UNIV OF SCI & TECH

Synthetic polymer and natural extracellular matrix composite material, artificial blood vessel and preparation method thereof

The invention relates to a degradable synthetic polymer and natural extracellular matrix composite material, an artificial blood vessel and a preparation method thereof. Degradable synthetic polymer components during preparation can be selected from one or more materials to perform proportioning; support materials with different fiber diameters, different fiber arrangement, different apertures anddifferent pore structures can be prepared through various technologies such as electrospinning, wet spinning, melt spinning, 3D printing, pouring, phase separation and particle leaching; and naturalextracellular matrix components are wide in sources, can be selected from vascular tissues (such as the arteries and veins of pigs and cows) of different species of animal sources or the vascular tissues (such as umbilical cords) of human donors, and can flexibly adjust the components and content thereof according to needs. The composite material and the artificial blood vessel prepared by the preparation technology can have good mechanical properties, controllable space structures, appropriate degradation velocity and excellent biocompatibility and biological induction activity; and the composite material, the artificial blood vessel and the preparation method are simple in preparation technology, high in controllability, mild in condition and suitable for large-scale industrial production.
Owner:NANKAI UNIV

Enhanced calcium phosphate bone repair material and preparation method thereof

The invention relates to an enhanced calcium phosphate bone repair material and a preparation method thereof. The bone repair material is formed by mixing solid phase and liquid phase, wherein the solid phase comprises phosphoric acid calcium salt, a carbon material and PLGA (polylactic-co-glycolic acid) microspheres; and the liquid phase is any one of the following liquid materials: distilled water, normal saline, chitosan solution, phosphoric acid solution, sodium dihydrogen phosphate solution, dibasic sodium phosphate solution and citric acid solution. The preparation method comprises the following steps: acidifying and modifying the carbon material to obtain a chloracetylated carbon material; obtaining PLGA microspheres; preparing the liquid phase; and compositing, adding the chloracetylated carbon material into a liquid-phase solution for ultrasonic treatment, then quickly mixing the PLGA microspheres, the phosphoric acid calcium salt and the liquid-phase solution and uniformly stirring to obtain the enhanced calcium phosphate bone repair material. The enhanced calcium phosphate bone repair material has remarkably improved mechanical property, improved fragility and degradation property, favorable biocompatibility and syringeability and can be used for damage repair of osseous tissues.
Owner:RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN

Preparation method of sunlight photocatalysis degradation agricultural thin film

The present invention relates to preparation process of sunlight catalyzed degradable farm film. Organic photosensitizer sensitized nanometer TiO2 as the catalyst is mixed polyethylene resin in a double screw extruder to prepare photocatalytic polyethylene agglomerate containing photocatalyst in 20-40 wt%. The polyethylene agglomerate is then mixed with polyethylene resin and blown to prepare the sunlight catalyzed degradable farm film of 8-40 micron thickness and with photocatalyst content of 0.1-10 wt%. The sunlight catalyzed degradable farm film has simple preparation process, low cost, high efficiency photocatalytic degradation in controllable degradation rate, and effectively lowered harm to environment.
Owner:SHANGHAI UNIV

Method for preparing curcumin polymer

The invention discloses a method for preparing curcumin polymer, which comprises the following steps: dissolving curcumin and a monomer into organic solvent to carry out condensation polymerization under the action of a catalyst at 0-100 DEG C for 1 hour to 48 hours and carrying out purification processing to obtain a curcumin polymer, wherein the monomer is one or more of diacid monomer, anhydride monomer, dichloride monomer, diene monomer and diol monomer. The method is simple and has convenient operation, and the prepared and obtained curcumin polymer has favorable thermal stability, storage stability and controllable molecular weight and degradation rate; compared with curcumin, the curcumin polymer not only obviously improves the stability and the biological utilization ratio of the curcumin, but also obviously improves the cytotoxicity and the cancer resistance of the curcumin on cancer cells.
Owner:ZHEJIANG UNIV

Natural polymer film material with adjustable degradation rate and preparation method

The invention discloses a natural polymer film material with an adjustable degradation rate and a preparation method, which belongs to the technical field of environmentally-friendly polymer film materials. The natural polymer film material comprises the following components in percentage by mass: 5 to 55 percent of water, 35 to 50 percent of natural starch, 5 to 30 percent of konjac fine flour, 5 to 10 percent of lactic acid, 0.1 to 5 percent of glycerin, and 0.001 to 1 percent of tackifier prepared from ammonia water and ethanol. Rich food-grade natural polymer materials, such as the natural starch, the konjac fine flour and the like, form a main raw material source, so the film material does not damage a human body, and can be completely degraded under natural conditions. Process parameters in a process comprising mixing, microwave treatment, curtain coating and sizing are adjusted to realize regulation and control over the degradation rate of the film material, greatly reduce the viscosity of glue solution, expand the viscosity range of the glue solution, reduce the processing cost of the film and avoid detriments to the environment. The film can be widely applied to packaging, food preservation, beauty masks, agricultural mulching films, medical consumables, hygienic products, biochemical isolation or dialysis, and the like.
Owner:KUNMING UNIV OF SCI & TECH

Composite film for guiding bone tissue regeneration and preparation method of composite film

The invention relates to a composite film for guiding bone tissue regeneration and a preparation method of the composite film. The composite film is a double-layer film, wherein a bottom-layer film is an L-lactide and caprolactone copolymer (L-PLCA) cast film with a compact structure, and the molar ratio of monomer components is (50:50) to (95:05); a surface layer is an L-PLCA and hydroxyapatite (HA) or tricalcium phosphate (beta-TCP) compound electrospinning film with a micropore structure, wherein the mass ratio of HA or beta-TCP in the electrospinning film is 10-50wt%, and the particle size of the electrospinning film can be nano-grade or micro-grade. The double-layer composite film is relatively good in mechanical performance and bone-like apatite deposition induction capacity, favorable in flexibility and capable of realizing performance regulation through regulating the molar ratio of L-PLCA, the content of the component HA or beta-TCP and the microstructure of the electrospinning film so as to be a novel degradable double-layer composite film capable of guiding bone tissue regeneration.
Owner:CHENGDU ORGANIC CHEM CO LTD CHINESE ACAD OF SCI
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