249results about How to "Controllable degradation rate" patented technology

The invention discloses an injectable double-crosslinked hyaluronic acid aquagel and a preparation method thereof. The preparation method comprises the following steps: synthesizing formylated hyaluronic acid and amino/methylacryloyl bifunctional hyaluronic acid containing disulfide bond in the side chain, uniformly mixing the formylated hyaluronic acid and amino/methylacryloyl bifunctional hyaluronic acid containing disulfide bond in the side chain with a water-soluble photoinitiator, and carrying out photochemical polymerization to obtain the injectable double-crosslinked hyaluronic acid aquagel. The method has the advantages of accessible raw materials, mild reaction conditions, short reaction time, simple technique and the like. The prepared aquagel is formed by a Schiff base crosslinking mechanism and a photocrosslinking mechanism, and the two crosslinking networks are connected together. The crosslinking network chain of the aquagel contains the disulfide bond and Schiff base, and thus, the aquagel has dual sensitivities for reduction and pH. The hyaluronic acid aquagel has flexible and adjustable mechanical properties, microstructure, degradation property, swelling capacity and the like, is injectable, and has application prospects in the aspects of cell transfer, tissue engineering, three-dimensional cell culture and the like.

The invention relates to a chitosan modified alginate hydrogel three-dimensional porous bracket with specific in-vitro degradability and a preparation method thereof. The method comprises the following steps: dissolving sodium alga acid serving as a raw material in phosphate buffer solution; performing amidation reaction of a carboxyl group in the sodium alga acid and an amino group in a cross-linking agent cystamine or dimethyl cystinate under the activation of water-soluble carbodiimide to form a chemically crosslinked hydrogel; performing freeze drying on the hydrogel to obtain a porous bracket material of the hydrogel; and performing surface modification on the porous bracket by using chitosan. In solution of a reducing agent such as cysteine with an appropriate concentration, a disulfide bond in a hydrogel cross-bridge is degraded through a disulfide bond-sulfydryl conversion reaction, so the porous bracket is decomposed and dissolved and disappears. Therefore, the porous bracket can be used as an in-vitro cell culture template material. The hydrogel porous bracket researched by the invention has the characteristics of simple preparation, rich raw material source, low cost and availability. Various physiochemical performances, mechanical strength, degradation rate and surface properties of the bracket material are controllable within a large range.

A method of producing biological hemostasis spongy material. It comprises: taking chitosan/chitin as the main raw material, preparing the solution, defoaming and putting into a container and freeze-drying, forming a spongy layer with the thickness of 1-10mm; soaking with ammonia, ammonia/alcohol, ammonia/acetone, ammonia/ methanol, washing with distilled water, freeze-drying and disinfecting. Theprepared hemostasis spongy material has abilities of stanching bleeding and promoting tissue rehabilitation.

A multifunctional biologic material for repairing skin, nerve and cartilage is prepared from chitosan, collagen and sodium hyaluronate through preparing their solutions, proportionally mixing, defomaing, loading in mould, freeze drying to become film or tube, immersing in ammonia water, drying, coating a solution layer of chitosan, chitosan/sodium hyaluronate, chitosan/collagen, or chitosan/collagen/sodium hyaluronate, and drying. Its advantages are high biocompatibility, mechanical strength and antibacterial power.

The invention relates to an I-type medical collagen material keeping an original specific triple-helical structure of collagen, and an extraction method thereof, meninges/spinal meninges biomembrane made from the I-type medical collagen material, and a preparation process of the biomembrane, and application of the biomembrane to preparing meninges/spinal meninges tissue repair materials. The I-type medical collagen material keeping the original specific triple helix structure of collagen has the advantages of low immunogenicity, no foreign body reaction, good biocompatibility and controllabledegradation rate, the prepared meninges/spinal meninges biomembrane has certain stretching resistance strength, repairable and regenerative dura mater/spinal meninges tissue and tissue adhesion prevention/reduction, and the biomembrane is applicable to repair and regeneration of injured cerebral dura mater and spinal dura mater.

The invention discloses an injectable hollow hydroxyapatite microsphere/chitosan composite drug carrier material. The material comprises the following components in percentage by weight: 0.5-2wt% of hollow hydroxyapatite, 2wt% of chitosan, 5.6wt% of beta-sodium glycerophosphate and 90.4-91.9 wt% of water. The preparation method comprises the following steps: first, loading drug in the hollow sodium hydroxyapatite microsphere; then, preparing chitosan thermo-sensitive hydrogel; finally, mixing the drug-loaded hollow hydroxyapatite microsphere and the chitosan thermo-sensitive hydrogel in a solid-liquid ratio of (0.05-0.2)g/10ml, and stirring to obtain the injectable hollow hydroxyapatite microsphere/chitosan composite drug carrier material. The material can realize slow and controlled release of drug, gives the material injectable molding property, and realizse minimally invasive therapy to bone defect or fracture.

The invention discloses a degradable material for conducting hard tissue regeneration and renovation, and its preparation method which comprises, using degradable biomaterial collagen, chitosan or hydroxyl chitosan, tertiary calcium phosphate or hydroxyapatite as principal raw material, preparing acid solution and suspending liquid, mixing to prepare hard tissue filler, wherein the prepared biological material has good compatibility with the wound tissue.

The invention discloses a medical composite material and a preparing method thereof. The medical composite material comprises a base material and a degradable fiber material, wherein the base material is a cross-linking-type degradable polymer material which is of a three-dimensional network structure. The medical composite material has the mechanical strength higher than that of a linear high polymer material, and is easy to store, fracture can be avoided, and the requirements of high-strength medical devices can be met. In addition, the cross-linking-type polymer base material has the relative-low molecular weight and the simple and easy synthesis and preparing method and processing technology, and the technical problem that high-molecular-weight linear polymer is difficult in preparing and processing is solved.

The invention discloses a method for preparing human-like collagen haemostatic sponge in scale, which comprises the following steps: dissolving human-like collagen into 1.0 to 2.0 percent solution; dissolving chitosan into 0.5 to 1.0 percent solution by dilute acid; mixing the two solutions evenly, adding glycerin and/or sorbitol into the solution, mixing, stirring and filtering the solution, and then defoaming the solution in vacuum; injecting the mixed solution into a die, pre-freezing the mixed solution at a temperature of between 40 DEG C below zero and 80 DEG C below zero, cross-linking the mixed solution by using 0.1 to 1.0 percent glutaraldehyde solution after freezing and drying, washing the cross-linked product for several times by using distilled water after the cross-linking is finished and vacuum-freezing and drying the washed product again, and then sterilizing the product by Co-60 to obtain a finished product of the human-like collagen haemostatic sponge. Compared with the conventional haemostatic materials broadly applied in clinic, the prepared haemostatic sponge has good mechanical property and excellent biocompatibility, thoroughly stops inevitable virus hidden trouble of animal collagen haemostatic materials, and ensures the safety of the haemostatic material in clinical usage.

The invention provides a degradable corrosion-resistant high-toughness Zn-Fe-X zinc alloy for a human body and application thereof and relates to the field of medical implant materials. The zinc alloy contains a Zn element, a Fe element and an X element, wherein the X element is at least one of Mg, Ca and Sr, the mass percent of Zn element is 89.92-99.997%, the mass percent of Fe element is 0.002-10%, and the mass percent of X element is 0.001-0.08%. According to the zinc alloy provided by the invention, the cost of added materials is low, degradation products of all ingredients of a prepared alloy material can be degraded through human body metabolism, the corrosion resistance is far higher than that of a magnesium alloy, the degradation rate is greatly lowered, a longer-time mechanical support can be provided, and the strength and toughness of the alloy material are good.

The invention discloses a controlled degradable surgical suture thread and a fabricating method thereof. The innermost part is chitosan fiber core, the middle part is collagen layer, and the outermost part is ethyloic-chitosan layer. From innermost to outermost, the thickness ratio of each layer is 2:X:(3-X), wherein X is larger than 1 and smaller than 3. The value of X is related to degradation velocity of the surgical suture thread: the larger the value, the faster the degradation velocity of the surgical suture thread, and the shorter the healing period of wound suitable to be sutured; andthe smaller the value, the slower the degradation velocity of the surgical suture thread, and the longer the healing period of wound suitable to be sutured. The fabricating method of the surgical suture thread comprises: (1) preparing chitosan fiber core and collagen; (2) covering a layer of collagen outside the chitosan fiber; (3) covering a layer of ethyloic-chitosan outside the collagen cover of the chitosan fiber; (4) processing and polishing the suture thread prepared in (3) by an automatic coreless grinder, connecting with suture needles of different models to prepare into a finish product of surgical suture thread. The technical scheme of the invention has plentiful advantages: controllable degradation velocity, high tension strength, improved biocompatibility and anti-infectious property, quick wound healing, no obvious scars, good biocompatibility, etc.

The invention relates to a magnesium alloy internal fixation and implant material used in orthopedic surgeries, which is characterized in that the pure magnesium is used as the substrate, and calcium and zinc elements are added into the pure magnesium; wherein, the zinc accounts for 2-5%, and the calcium accounts for 1-3%. The magnesium alloy internal fixation and implant material used in orthopedic surgeries has the advantages of enjoying favorable biocompatibility, excellent mechanical property and controllable degradation rate, and meeting the demands for internal fixation and implant materials in orthopedic surgeries, thus being particularly suitable for screw plate systems and intramedullary pin systems.

The invention discloses a magnesium oxide whisker/biodegradable polyester composite material and its preparation method and an application thereof. The composite material contains 0.1-60 wt% of magnesium oxide whisker and 40-99.9 wt% of biodegradable polyester. The magnesium oxide whisker/biodegradable polyester composite material provided by the invention has excellent mechanical properties, good biocompatibility and bone healing-promoting capability. Alkalinity of the magnesium oxide whisker also can regulate and control degradation rate of the biodegradable polyester, neutralize its acidic degradation products and reduce inflammatory response. The magnesium oxide whisker/biodegradable polyester composite material is a novel bone tissue repair material with an excellent osteogenic activity. The preparation method is a solution blended process or a melt blending method by using the magnesium oxide whisker and the biodegradable polyester as raw materials, or an in situ polymerization method by using the magnesium oxide whisker and a cyclic ester monomer as raw materials. According to the invention, preparation cost of the composite material is low; the preparation method is simple; condition is mild; and the preparation method is easy for industrial production.

The invention relates to medical polymers field, especially a temperature sensitive and biodegradable triblock copolymer with gel-sol transformation characteristics and preparation method thereof and usage. The triblock copolymer is PEG-PCL-PEG copolymer, the aqueous solution thereof performs Gel-Sol phase transformation along with the temperature rise and the phase transformation temperature is 40-55 degree. The PEG-PCL-PEG copolymer has a variety of excellent features to provide a new choice in field which is in need of temperature sensitive material.

The invention discloses a degradable polyurethane material with active oxygen responsiveness and a preparation method of the degradable polyurethane material. The degradable polyurethane material comprises a biodegradable polyester glycol soft segment and a hard segment composed of saturated aliphatic diisocyanate and reactive oxygen responsive small molecular diamine. The material is prepared bytaking poly(epsilon-caprolaclone glycol) (PCL) or polypropylene glycol fumarate (PPF) as macromolecular diols, saturated aliphatic diisocyanate as a raw material and reactive oxygen responsive small molecular diamine as a chain extender and adopting a two-step chain extension method. A polyurethane elastomer prepared from the degradable polyurethane material has good biocompatibility and responsiveness to reactive oxygen, the material and a degradation product are harmless to human bodies, so that the degradable polyurethane material can be widely applied to the fields such as biological medicines and tissue engineering and can be used for bone repair and myocardium generation.

The invention discloses a completely biodegradable polyester material and preparation and application of the completely biodegradable polyester. The material comprises the following components: 60-98 percent of poly(L-lactic acid) and 2-40 percent of poly(L-lactic acid-caprolactone) copolymer, wherein the molecular weight of the copolymer is 10000-100000, a number ratio of lactic acid units to caprolactone units is (95:5) to (20:80), and the copolymer contains arms of 1-6 specific structures. The preparation method of the material comprises the following steps: dissolving poly(L-lactic acid) into an organic solvent in which polylactic acid can be dissolved, adding the copolymer in a formula amount, and fully stirring, so that the copolymer is completely dissolved; and adding a polymer solution into water or a mixed solution of water/alcohol, separating out the blend by precipitating, filtering, and drying, thereby preparing the to-be-prepared completely biodegradable polyester material. The material can be used for preparing corresponding products in the fields of artificial bones, scaffolds for tissue engineering and interventional medical equipment in biomedicine, and the prepared product has excellent mechanical property and biodegradability.

The invention discloses a medical anti-adhesion membrane material with controllable degradation and a preparation method thereof, belonging to the field of biomedical materials. According to the invention, the membrane material is prepared by blending sodium hyaluronate and konjac klucomannan, using lactic acid as a property-modifying additive and using a mixed solution of ammonia water and anhydrous ethanol as a cross-linking agent; sodium hyaluronate is a good anti-adhesion material, but individually used sodium hyaluronate has a fast degradation speed and can not fulfill a good anti-adhesion effect; konjac klucomannan can control the degree of cross-linking, thereby realizing the goal of controllable degradation, and blending of sodium hyaluronate and konjac klucomannan enables sodium hyaluronate to be released slowly, thereby allowing the membrane material to meet demands for anti-adhesion action at different parts. The membrane material has the advantages of nontoxic degradation products, good biocompatibility, hygroscopicity and tensile properties, and the like, and can be used for intervertebral adhesion, intestinal adhesion, skin adhesion, intrauterine adhesion, etc.

The present invention relates to preparation process of sunlight catalyzed degradable farm film. Organic photosensitizer sensitized nanometer TiO2 as the catalyst is mixed polyethylene resin in a double screw extruder to prepare photocatalytic polyethylene agglomerate containing photocatalyst in 20-40 wt%. The polyethylene agglomerate is then mixed with polyethylene resin and blown to prepare the sunlight catalyzed degradable farm film of 8-40 micron thickness and with photocatalyst content of 0.1-10 wt%. The sunlight catalyzed degradable farm film has simple preparation process, low cost, high efficiency photocatalytic degradation in controllable degradation rate, and effectively lowered harm to environment.

The invention discloses a method for preparing curcumin polymer, which comprises the following steps: dissolving curcumin and a monomer into organic solvent to carry out condensation polymerization under the action of a catalyst at 0-100 DEG C for 1 hour to 48 hours and carrying out purification processing to obtain a curcumin polymer, wherein the monomer is one or more of diacid monomer, anhydride monomer, dichloride monomer, diene monomer and diol monomer. The method is simple and has convenient operation, and the prepared and obtained curcumin polymer has favorable thermal stability, storage stability and controllable molecular weight and degradation rate; compared with curcumin, the curcumin polymer not only obviously improves the stability and the biological utilization ratio of the curcumin, but also obviously improves the cytotoxicity and the cancer resistance of the curcumin on cancer cells.

The invention relates to a composite film for guiding bone tissue regeneration and a preparation method of the composite film. The composite film is a double-layer film, wherein a bottom-layer film is an L-lactide and caprolactone copolymer (L-PLCA) cast film with a compact structure, and the molar ratio of monomer components is (50:50) to (95:05); a surface layer is an L-PLCA and hydroxyapatite (HA) or tricalcium phosphate (beta-TCP) compound electrospinning film with a micropore structure, wherein the mass ratio of HA or beta-TCP in the electrospinning film is 10-50wt%, and the particle size of the electrospinning film can be nano-grade or micro-grade. The double-layer composite film is relatively good in mechanical performance and bone-like apatite deposition induction capacity, favorable in flexibility and capable of realizing performance regulation through regulating the molar ratio of L-PLCA, the content of the component HA or beta-TCP and the microstructure of the electrospinning film so as to be a novel degradable double-layer composite film capable of guiding bone tissue regeneration.