Preparation method of porous fiber with controllable degradation rate for tissue engineering scaffold

A tissue engineering scaffold, porous fiber technology, applied in fiber processing, melt spinning, hollow filament manufacturing, etc., to achieve the effects of controllable degradation rate, low cost, and simple preparation method

Inactive Publication Date: 2010-07-21
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no single polymer or copolymer or polymer mixture of PGA, PLA, and PDO in China to prepare porous fibers and fabrics for tissue engineering scaffolds.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] PGA with a molecular weight of 100,000, slices of PLA with a molecular weight of 100,000 (the mass ratio of GA / LA is 75 / 25) and the pore-forming agent calcium carbonate with a particle diameter of 50 μm are in a ratio of 95% by weight: 5%. Mix evenly, dry in vacuum for 24 hours, then carry out melt spinning and stretching, then immerse the prepared fiber in 6% hydrochloric acid to remove the pore-forming agent, during which the hydrochloric acid solution is replaced every 6 hours, take out the fiber after 24 hours, vacuum After drying, porous fibers with uniform surface distribution and micropores with a diameter of 50-60 μm are obtained.

Embodiment 2

[0031] PGA with a molecular weight of 120,000, slices of PLA with a molecular weight of 120,000 (the mass ratio of GA / LA is 90 / 10) and the pore-forming agent calcium carbonate with a particle diameter of 20 μm are in a ratio of 98%: 2% by weight Mix evenly, dry in vacuum for 24 hours, then carry out melt spinning and stretching, then immerse the prepared fiber in 6% hydrochloric acid to remove the pore-forming agent, during which the hydrochloric acid solution is replaced every 6 hours, take out the fiber after 24 hours, vacuum After drying, a porous fiber with micropores with a diameter of 20-35 μm uniformly distributed on the surface is obtained.

Embodiment 3

[0033] The PGA with a molecular weight of 100,000, the slices of PDO with a molecular weight of 100,000 (the weight ratio of PGA and PDO is 50 / 50) and the pore-forming agent PVP with a particle size of 80 μm are uniformly mixed in a ratio of 99%:1% by weight , after vacuum drying for 24 hours, carry out melt spinning and stretching, and then immerse the prepared fiber in distilled water to remove the pore-forming agent, during which the distilled water is replaced every 6 hours, take out the fiber after 24 hours, and obtain a surface uniformly distributed after vacuum drying. Porous fibers with micropores with a diameter of 80-100 μm.

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Abstract

The invention relates to a preparation method of porous fiber with a controllable degradation rate for a tissue engineering scaffold, which comprises the following steps: uniformly mixing a biodegradable polymer and a pore-forming agent, vacuum drying, melt spinning, drawing, immersing into hydrochloric acid or distilled water to remove the pore-forming agent, and vacuum drying, thereby obtainingthe porous fiber with micro pores with the diameters of 10-100mum uniformly distributed on the surface thereof. The preparation method of the invention is simple and is applicable to industrial production. The diameters of the micro pores of the prepared fiber are matched with cell sizes, so that cells can be easily adhered into the micro pores on the surface of the fiber for growth. Simultaneously, the degradation rate is controllable.

Description

technical field [0001] The invention belongs to the field of preparation of porous fibers, in particular to a method for preparing porous fibers with controllable degradation rate for tissue engineering scaffolds. Background technique [0002] So far, the clinical applications in the field of biomedical polymer materials are mainly polyester materials, such as polyglycolic acid (PGA), polycaprolactone (PCL), polylactic acid (PLA), polydioxane Hexanone (PDO), etc. Therefore, aliphatic polyesters have been more and more widely used in the fields of implant materials in vivo and tissue engineering. In order to control the biodegradability of aliphatic polyesters, new biomedical polymer materials with different biodegradation rates can be prepared by changing the polymer structure, composition and morphology, which can significantly improve the physical and chemical properties of aliphatic polymers such as degradation and thermodynamics. So far, there is no single biomaterial ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F8/14D01F6/84D01F1/08D01D5/098D01D5/247A61L27/18A61L27/56A61L27/50A61L31/06A61L31/14
Inventor 张佩华郯志清陈南梁沈新元杨庆王文祖陈思诗唐乃杰张蓉
Owner DONGHUA UNIV
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