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Enhanced calcium phosphate bone repair material and preparation method thereof

A repair material, calcium phosphate technology, applied in the field of medical biomaterials, can solve the problems of slow degradation, poor mechanical properties, low strength, etc., and achieve the effect of improved mechanical properties, significant mechanical properties, and good biocompatibility

Active Publication Date: 2013-04-03
RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, as a new type of orthopedic repair material, although the research progresses rapidly, there are still some problems to be solved in the existing materials, such as poor mechanical properties, high brittleness, low strength, and slow degradation speed.

Method used

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  • Enhanced calcium phosphate bone repair material and preparation method thereof

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preparation example Construction

[0033] On the other hand, the present invention also provides a method for preparing the above-mentioned enhanced calcium phosphate bone repair material, comprising the following steps:

[0034] 1. Acidification modification steps of carbon materials

[0035] Put the selected carbon material (carbon nanotube or graphene) into the container, and pour the mixed acid mixed by nitric acid and sulfuric acid, the mixed acid is preferably made of nitric acid and sulfuric acid according to the ratio of nitric acid: sulfuric acid = 1:3 The volume ratio is mixed, and then ultrasonic treatment is performed for 0.5-1.5h, and then the reflux reaction is carried out at a temperature of 50-100°C and magnetic stirring, and the heating rate is controlled at 10-25°C / min, and the reaction is about 8 hours later. After the reaction is complete, rinse the product with deionized water until the pH is 7, and after standing for 24 hours, centrifuge at 5000-10000 rpm to separate the acid-treated carbo...

Embodiment 1

[0050] 1. Acidification modification of carbon nanotubes

[0051] According to the volume ratio of nitric acid: sulfuric acid = 1:3, mix nitric acid and sulfuric acid to prepare mixed acid, put 100mg of carbon nanotubes into a 250ml three-neck bottle and then pour the mixed acid, and then place the mixture of carbon nanotubes and mixed acid solution in an ultrasonic Sonicate in the machine for 0.8h, then start the reflux reaction at a temperature of 100°C and magnetic stirring, control the heating rate at 10°C / min, and the reaction time is 8 hours. After the reaction is completed, wash the product with deionized water until the pH is 7, let it stand for 24 hours, and then centrifuge at 5000rpm to separate the acid-treated carbon nanotubes, and place them in a vacuum oven for drying at 60°C. The resulting product is carboxylated carbon nanotubes. Tube.

[0052] 2. Preparation of PLGA microspheres

[0053] Take 0.2g of PLGA solid and add it to 2ml of DCM solution, emulsify wit...

Embodiment 2

[0060] 1. Acidification modification of carbon nanotubes

[0061] The specific implementation process is the same as the carbon nanotube acidification modification process in Example 1.

[0062] 2. Preparation of PLGA microspheres

[0063] The specific implementation process is the same as the preparation process of the PLGA microspheres in Example 1.

[0064] 3. Preparation of liquid phase solution

[0065] Physiological saline with a concentration of 0.15mol / ml was prepared as a liquid phase solution.

[0066] 4. Composite

[0067] (1) Add 6 mg of acidified modified carbon nanotubes to 5 mL of normal saline, ultrasonicate for 15 minutes, and then mix polybasic calcium phosphate and PLGA microspheres in a mass ratio of 4:0.5 to obtain a solid-phase mixture; the polybasic phosphoric acid The calcium salt is composed of DCPA, TTCP, HA, β-TCP, OCP and ACP, and the mass percentage ranges of each component are: 5-15%, 35-50%, 5-20%, 32%-40%, 5-10% and 1-8%;

[0068] (2) Mix ...

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Abstract

The invention relates to an enhanced calcium phosphate bone repair material and a preparation method thereof. The bone repair material is formed by mixing solid phase and liquid phase, wherein the solid phase comprises phosphoric acid calcium salt, a carbon material and PLGA (polylactic-co-glycolic acid) microspheres; and the liquid phase is any one of the following liquid materials: distilled water, normal saline, chitosan solution, phosphoric acid solution, sodium dihydrogen phosphate solution, dibasic sodium phosphate solution and citric acid solution. The preparation method comprises the following steps: acidifying and modifying the carbon material to obtain a chloracetylated carbon material; obtaining PLGA microspheres; preparing the liquid phase; and compositing, adding the chloracetylated carbon material into a liquid-phase solution for ultrasonic treatment, then quickly mixing the PLGA microspheres, the phosphoric acid calcium salt and the liquid-phase solution and uniformly stirring to obtain the enhanced calcium phosphate bone repair material. The enhanced calcium phosphate bone repair material has remarkably improved mechanical property, improved fragility and degradation property, favorable biocompatibility and syringeability and can be used for damage repair of osseous tissues.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to an enhanced calcium phosphate bone repair material and a preparation method thereof. Background technique [0002] Natural bone is a special type of connective tissue composed primarily of organic and inorganic components. The organic matter is mainly collagen fibers, and the inorganic matter is mainly hydroxyapatite, but there are also other residual calcium phosphate phases. At present, the commonly used bone repair materials include autologous bone, allogeneic bone and artificial synthetic materials, but these materials are deficient to varying degrees and cannot meet clinical needs. For example, although autologous bone transplantation has no immune rejection and has a good repair effect, the material obtained is very limited and causes bone defects in the donor site; allogeneic bone transplantation is likely to cause immune rejection, poor repair effect, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/18A61L27/12A61L27/08A61L27/20B01J13/02C01B31/02C01B31/04
Inventor 佘振定李小丽谭荣伟王明波刘伟强
Owner RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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