9 results about "Dibasic sodium phosphate" patented technology

The invention discloses a preparation method of a standard substance for analyzing phosphorus components in food, which comprises the following steps: (1) cutting off tendons, tendons, bones, skins and fat from fresh livestock meat or poultry meat, and crushing pure meat to obtain meat paste; (2) weighing a certain amount of meat paste, adding a calculated amount of disodium hydrogen phosphate aqueous solution into the meat paste, mixing, and continuously crushing and stirring until the mixture is uniform; (3) carrying out freeze drying on the standard-added and uniformly-mixed meat paste to obtain meat powder blocks; (4) crushing the meat meal blocks, and collecting freeze-dried powder; screening the freeze-dried powder by using a 60-mesh sieve; (5) detecting the moisture content of the sieved freeze-dried powder, wherein the moisture content is less than 5%; and (6) sub-packaging the freeze-dried powder, sealing the freeze-dried powder into independent packaging units, and performing uniformity test to obtain the phosphorus component analysis standard substance. The phosphorus component analysis standard substance has the advantages of uniform phosphorus content, good short-term and long-term stability and accurate content.

The present disclosure provides aqueous formulations comprising hydrocortisone sodium phosphate and monothioglycerol. In some embodiments, the formulations comprise monobasic sodium phosphate, dibasic sodium phosphate, or disodium EDTA. The present disclosure further provides a method of treating a disease or disorder in a subject by administering the aqueous formulation.

The invention discloses a preparation method of a slow-release star anise essential oil microcapsule, which comprises the following steps: standing star anise essential oil in a dark place, taking an upper-layer clarified phase, and carrying out ethanol-assisted emulsification, disodium hydrogen phosphate aqueous solution dispersion, high-speed shearing and ice-water bath cooling to form primary emulsion; sequentially introducing gelatin and Arabic gum to construct a composite membrane, adding modified starch to form a ternary structure, loading polylactic acid, and performing freezing-vacuum drying to form a shell; then adopting glutaraldehyde steam cross-linking to stabilize the network, dispersing with cold water, and curing with sodium carboxymethyl cellulose to obtain a stable dispersion liquid; carrying out particle size grading, ceramic membrane filtration and spray drying to obtain microcapsule powder, finally carrying out surface modification by octadecyltriethoxysilane, and adapting to a vaseline or water-based system. Through step-by-step assembly of multi-component wall materials, low-temperature induction of channel orientation and steam crosslinking, the structural stability is enhanced, surface hydrophobicity is used for regulating and controlling interface behaviors, the microcapsule is endowed with internal mass transfer regulation and control capability, and stable, uniform and long-time release of aroma is realized.

A composition of tirzepatide, comprising an agent selected from NaCl and propylene glycol; and dibasic sodium phosphate is provided.

The invention belongs to the field of collagen extraction, and particularly relates to a preparation method of a high-stability I-type collagen solution for injection and an obtained product. The method is realized by the following steps: firstly, pretreating a type I collagen freeze-dried product; and sequentially adding a sodium hyaluronate mixed solution and a chitosan mixed solution 3, fully and uniformly mixing, and adding a disodium hydrogen phosphate buffer solution to obtain the I-type collagen solution for injection. The preparation method disclosed by the invention is simple and easy to operate, the prepared animal-derived I-type collagen solution for injection is relatively good in uniformity and stability, and the selected components are safe and relatively excellent in effectiveness. The type I collagen and the chitosan have good effects of promoting cell proliferation, migration and repair, and related repair products are sold on the market; the type I collagen and the sodium hyaluronate have a good moisturizing effect; the trehalose component has good moisturizing and anti-oxidation effects, and particularly, the trehalose has excellent characteristics of keeping cell viability and biomacromolecule activity; the mannitol component has a good effect of improving the osmotic pressure molar concentration of the solution, the osmotic pressure of the solution can be basically kept consistent with the osmotic pressure of body fluid in the solution, and side effects such as edema are not prone to occurring.

The invention belongs to the field of stability evaluation of polypeptide bulk drugs, discloses a method for predicting the aggregation trend of tilpoitide based on a dynamic light scattering technology, and aims at solving the problems that an existing polypeptide aggregation detection technology is complex in pretreatment, cannot monitor in real time or is low in detection flux. The method comprises the following steps: dispersing polypeptide in a buffer solution with the pH value of 6.5-8.5, adding diethylene glycol-3-amino propyl ether and N '-(4-methoxy-2, 3, 6-trimethylbenzenesulfonyl)-L-arginine as cosolvents, and performing oscillation on an accelerated shaking table for 2-6 hours to prepare a polypeptide solution; determining aggregation when the particle size is greater than the theoretical size of the polypeptide monomer through dynamic light scattering detection; the buffer solution comprises one of a disodium hydrogen phosphate solution, a sodium chloride solution and a tris (2-chloroethyl) phosphate solution. The method disclosed by the invention can be used for rapidly and nondestructively monitoring the aggregation trend of the polypeptide in real time, further replaces a traditional detection method and intuitively represents the aggregation property of the polypeptide.

The present invention relates to a smokeless article for oral delivery comprising a pouch enclosing an oral nicotine delivery (OND) formulation, the OND formulation comprising at least two pH regulators selected from the list of sodium carbonate, sodium hydroxide, calcium lactate, sodium phosphate dibasic, sodium citrate, meglumine, ammonia, ammonium carbonate, and calcium carbonate. A method of manufacturing the article and kits comprising the article are also described.

A composition of tirzepatide, comprising an agent selected from NaCl and propylene glycol; and dibasic sodium phosphate is provided.

The application belongs to the technical field of veterinary medicine preparation, and particularly discloses a high-stability veterinary florfenicol effervescent granule and a preparation method thereof, and aims to solve the problem that florfenicol is prone to amide bond hydrolysis and racemization degradation in an acid-base environment of the effervescent granule in the prior art. In the application, a core-shell buffer mesocrystal with sodium phosphate dibasic as the core and citric acid as the shell is used as a drug active chemical protection core, and when water is encountered, the outer shell citric acid is instantaneously dissolved to establish a protective pH microenvironment; and a hydrophilic PEG / hydrogenated vegetable oil coated effervescent acid source is used to realize programmed disintegration. The product has outstanding accelerated stability, and the degradation product is less than 0.5% in 30 days, and the process is simple and controllable.