2 results about "Dibasic sodium phosphate" patented technology

The application belongs to the technical field of veterinary medicine preparation, and particularly discloses a high-stability veterinary florfenicol effervescent granule and a preparation method thereof, and aims to solve the problem that florfenicol is prone to amide bond hydrolysis and racemization degradation in an acid-base environment of the effervescent granule in the prior art. In the application, a core-shell buffer mesocrystal with sodium phosphate dibasic as the core and citric acid as the shell is used as a drug active chemical protection core, and when water is encountered, the outer shell citric acid is instantaneously dissolved to establish a protective pH microenvironment; and a hydrophilic PEG / hydrogenated vegetable oil coated effervescent acid source is used to realize programmed disintegration. The product has outstanding accelerated stability, and the degradation product is less than 0.5% in 30 days, and the process is simple and controllable.