The invention discloses a preparation method of sodium phosphate dibasic dodecahydrate, and the preparation method of the sodium phosphate dibasic dodecahydrate comprises the following steps: according to the weight ratio, weighing 1 part of sodium hydroxide to put into 3.125-10 parts of deionized water to dissolve into a clear solution; under stirring, adding 1.4375 parts of a phosphoric acid solution with a concentration of 85% by mass into the clear solution, adjusting the pH of the solution to 8.2-8.6; keeping the temperature to be 60-70 DEG C, continuing stirring the solution for 15-25min; measuring the solution pH, until the solution pH has no obvious changes, filtering; cooling a filtrate under stirring to 30-35 DEG C, precipitating for crystallization; continuing cooling to 20 DEG C, filtering by suction to separate a precipitated crystal and a mother liquid; and putting the crystal flat and scatteredly in a dish, and drying in air for 1-3h at room temperature. The preparation method of the sodium phosphate dibasic dodecahydrate has the advantages of short technological process, low requirement on equipment, stable and mild process conditions, easiness in control, no need for heating, condensation and proportion adjusting, crystallization at the room temperature, and suitability for industrialized production.