19 results about "Ceftriaxone" patented technology

The invention discloses application of ceftriaxone sodium in preparation of a medicine for preventing and / or treating pulmonary nodules, and belongs to the technical field of tumor prevention and treatment, ceftriaxone sodium is converted into inhalable aerosol particles through an aerosol inhalation device, targeted delivery of the medicine to the lung can be achieved, systemic adverse reactions caused by systemic administration are remarkably reduced, and the curative effect of the medicine is improved. Therefore, the medicine has a treatment effect on pulmonary nodules. Experimental results in the early stage prove that ceftriaxone sodium with different concentrations is subjected to aerosol inhalation to intervene in a mouse pulmonary nodule model induced by uratan, and the ceftriaxone sodium has a good prevention and treatment effect. The research can provide new experimental basis and reference for development of lung nodule related prevention and treatment medicines, provides new technical ideas for prevention and treatment of other diseases, and has important academic value and potential of further development and research.

Neisseria gonorrhoeae is one of the most common bacterial sexually transmitted infections (STI). Diagnosis depends on standard nucleic acid amplification testing (NAAT), which is impracticable in most low-resource settings, where the prevalence of this STI is highest. Consequently, such areas utilize syndromic management, which misses a high proportion of cases and leads to antibiotic overuse, contributing to the troubling rise of resistance to the commonly prescribed ciprofloxacin, cefixime and ceftriaxone antibiotics for the treatment of N. gonorrhoeae infections. A specific, highly sensitive and cost-effective lateral flow assay is disclosed that utilizes CRISPR-Cas orthologs, multiplex SHERLOCK technology and isothermal amplification via recombinase polymerase amplification (RPA) for the rapid detection of antibiotic resistance to ciprofloxacin, cefixime and / or ceftriaxone at the point of care. This approach has the potential to increase treatment efficacy in the field and mitigate the spread of antibiotic resistance.

The present application relates to the new use of Baotouweng decoction in the synergistic antibacterial effect of ceftriaxone, tetracycline and amikacin antibiotics. In the preparation of the composition or compound preparation, the dosage ratio of Baotouweng decoction and ceftriaxone, tetracycline and amikacin is between 6400:1-12800:1. The FIC index of Baotouweng decoction combined with ceftriaxone, amikacin or tetracycline is 0.1875-0.375, which is less than 0.5, that is, Baotouweng decoction combined with ceftriaxone, amikacin or tetracycline has synergistic antibacterial effect. The present application can effectively reduce the dosage of ceftriaxone, amikacin or tetracycline, and the MIC value of Baotouweng decoction combined with ceftriaxone, amikacin or tetracycline is reduced by 2-16 times compared with that of single use. Baotouweng decoction can be used as an antibacterial drug resistance reversal agent to improve the antibacterial therapeutic effect under the condition of reducing the dosage of antibacterial drugs.

The application relates to the technical field of special equipment manufacturing for pharmacy, in particular to an integrated multifunctional tank for ceftriaxone sodium production, which integrates multiple functions such as stirring, filtering, vacuum treatment, online reaction detection and flushing in one body. The tank body is composed of a top head, an inner cylinder and a bottom head, is equipped with a stirring assembly driven by a speed reducer motor, a feeding pipe opening assembly, a filtering assembly between the inner cylinder and the bottom head, an auxiliary filtering system with a sintered filter element group, a flushing assembly connected with the stirring assembly and a reaction detection assembly for real-time acquisition of reaction parameters. The application solves the problems of traditional ceftriaxone sodium production equipment, such as function dispersion, complicated operation steps and low production efficiency, simplifies the production process through integrated design, improves the controllability and stability of the production process and effectively guarantees the product quality.

The present application relates to a kind of ceftriaxone sodium crystallization acetone mother liquor effective ingredient whole recovery method, the method comprises: (1) recovery solvent;(2) recovery triethylamine;(3) recovery sodium acetate;(4) recovery ceftriaxone sodium.The whole recovery method of the present application can realize solvent, residual ceftriaxone sodium, triethylamine, sodium acetate in mother liquor whole recycling, maximizes recycling organic matter and salt, reduces organic matter, salt pollution environment, to meet the requirement of state to environmental governance, realizes the minimization of pollutant.

The present application relates to a kind of sterile closed smart drying system of ceftriaxone sodium, including dryer, field device layer, field control layer and monitoring management layer, field device layer includes each sensor and various functional valves, ceftriaxone sodium is cooled in vacuum state first in drying process, each sensor gathers data and is converted into signal transmission to field control layer and monitoring management layer, monitoring management layer shows drying state and each node parameter in real time, when the temperature in dryer drops to the lowest point, and solvent concentration meets process control standard, field control layer starts the heating cycle system of dryer and carries out temperature rising drying, when the temperature in dryer, vacuum, pressure, nitrogen inlet, moisture reaches preset value, various functional valves are automatically started and stopped.Ceftriaxone sodium sterile closed smart drying system of the present application can reduce the risk of contamination, drying process is closed, visual online intelligent control ceftriaxone sodium solvent residue and moisture value.

The application discloses a preparation method of a hydrophilic ceftriaxone magnetic molecular imprinting polymer, which comprises the following steps: taking magnetic iron-aluminum mixed hydroxide as a carrier, ceftriaxone as a template molecule, 3-amino-1,2,4-triazole as a functional monomer, ethylene glycol dimethacrylate as a crosslinking agent, ammonium persulfate as an initiator, and water as a porogen to prepare the hydrophilic ceftriaxone magnetic molecular imprinting polymer. The water-based ceftriaxone magnetic molecular imprinting polymer has high magnetization intensity and a more stable morphological structure, has good adsorption performance on ceftriaxone, reaches adsorption equilibrium within 30s, has an equilibrium adsorption capacity of 6.30mg / g, conforms to a quasi-second-order kinetic adsorption model, and can be directly applied to the determination of cephalosporin antibiotics in a water environment.

The invention relates to quinoline-2-carboxylic acid derivatives as well as a preparation method and application thereof. The quinoline-2-carboxylic acid derivative is a compound as shown in a formula IV or pharmaceutically acceptable salt, crystal form, solvate and optical isomer thereof. In the formula, R5 is selected from aryl, substituted aryl, 5-11-membered heteroaryl and substituted 5-12-membered heteroaryl; and R6 is selected from aryl, substituted aryl, 5-12-membered heteroaryl, substituted 5-12-membered heteroaryl, C3-C8 cycloalkyl, 3-8-membered heterocycloalkyl, C1-C6 alkyl, and C1-C6 monosubstituted or polysubstituted alkyl. The compound provided by the invention is combined with cephalosporin and carbapenem antibacterial drugs, such as ceftriaxone, meropenem and the like, so that the activity of the compound for expressing drug-resistant bacteria on NDM-1 can be effectively recovered. The compound disclosed by the invention shows good NDM-1 enzyme inhibition activity and can be used as a novel NDM-1 inhibitor.

The application belongs to the technical field of medicine, and particularly relates to a ceftriaxone sodium powder injection and a preparation method thereof. The water-soluble vitamin E and L-cysteine are used to synergistically play the roles of antioxidation and anti-aggregation, and effectively inhibit the polymer generation and the aggregation phenomenon in the crystallization process. The mesoporous silica modified by chitosan is used as a drug carrier, the ordered drug is promoted to enter the mesoporous channel through the positive charge mediation, the efficient loading of the drug is realized, and the biocompatibility is improved. The supercritical anti-solvent crystallization technology is used, the drug is in-situ crystallized in the mesoporous channel to form a highly dispersed state, the specific surface area of the drug is significantly increased, and the ultrafast dissolution is realized. The ceftriaxone sodium powder injection prepared by the application has the excellent characteristics of fast dissolution speed, uniform particle size, no aggregation, good stability, high safety, and high drug loading efficiency.

The invention provides bacillus C367 as well as a method and application thereof. The bacillus C367 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.36841; the bacillus C367 is separated from the Inner Mongolia cheese; the bacillus C367 can be used for preparing medicines for treating or preventing periodontal diseases; the invention provides a novel oral cavity probiotic bacillus C367, the bacillus C367 has an inhibition effect on periodontal disease bacteria, and the bacillus C367 is sensitive to antibiotics such as minocycline, amikacin, tetracycline, erythromycin, cefoperazone, streptomycin, kanamycin, gentamicin, vancomycin and ceftriaxone, and has good survival ability in an oral cavity.

The utility model belongs to the technical field of medicine production equipment, and particularly relates to a convenient-to-fix enamel reaction tank for producing ceftriaxone sodium, which comprises a tank body, two fixing mechanisms and a base, the tank body is fixed above the base, and a stirring mechanism is arranged on the tank body; the fixing mechanism comprises a telescopic rod assembly and a fixing clamping plate, the telescopic rod assembly comprises an outer sleeve and an inner rod, one end of the outer sleeve is an open end, the other end of the outer sleeve is a blind end, the inner rod is arranged in the outer sleeve in a penetrating mode, a spring damper is arranged between one end of the inner rod and the blind end of the outer sleeve, and the fixing clamping plate is fixedly connected with the other end of the inner rod; a forward and reverse rotation motor is arranged outside the base, a transmission cavity is formed in the base, a transmission mechanism is arranged in the transmission cavity, and the forward and reverse rotation motor can drive the two fixing mechanisms to be close to or away from each other through the transmission mechanism. According to the device, the tank body can be fixed conveniently, shaking in the stirring process can be relieved, the side turning phenomenon is avoided, and noise can be lowered.

The invention discloses application of a composition containing sulodexide and ceftriaxone in preparation of a medicine for treating bacterial meningitis, and belongs to the technical field of biological medicines. According to the invention, it is found for the first time that sulodexide and ceftriaxone are combined to have the effect of preventing and / or treating bacterial meningitis; animal experiments prove that the composition containing sulodexide and ceftriaxone improves cognitive impairment of a patient with bacterial meningitis by improving encephaledema of the patient with bacterial meningitis, reduces brain tissue damage of the patient with bacterial meningitis, inhibits brain neuroinflammation of the patient with bacterial meningitis, improves cognitive impairment of the patient with bacterial meningitis, and has a remarkable curative effect. Therefore, bacterial meningitis is prevented and / or treated, a new thought is provided for preparing bacterial meningitis products, and the application prospect is wide.

The invention belongs to the technical field of medicines, and particularly relates to a ceftriaxone sodium powder injection and a preparation method thereof. According to the invention, the water-soluble vitamin E and the L-cysteine are used for synergistically exerting anti-oxidation and anti-agglomeration effects, so that the agglomeration phenomenon in the polymer generation and crystallization process is effectively inhibited; chitosan modified mesoporous silica is adopted as a drug carrier, and drugs are promoted to orderly enter mesoporous channels through positive charge mediation, so that efficient loading of the drugs is realized, and biocompatibility is improved; by utilizing a supercritical anti-solvent crystallization technology, the drug is crystallized in situ in a mesoporous channel to form a highly dispersed state, and the specific surface area of the drug is obviously increased, so that the ultra-fast dissolution is realized; the ceftriaxone sodium powder injection prepared by the invention has the excellent characteristics of high dissolution speed, uniform particle size, no agglomeration, good stability, high safety and high drug loading efficiency.

This invention provides nitrogen-doped sulfonated carbon dots for detecting ceftriaxone sodium, their preparation method, and their applications, belonging to the fields of nanomaterial synthesis and antibiotic detection technology. The method involves: dissolving sodium diphenylamine sulfonate and sodium hydroxide in deionized water under stirring and heating; applying a direct current to obtain a mixed solution; centrifuging, filtration, and dialysis of the mixed solution; and finally, freeze-drying to obtain carbon dots. The nitrogen-doped sulfonated carbon dots prepared by this method exhibit strong blue fluorescence emission, and show fluorescence quenching and a significant change in fluorescence color upon the addition of ceftriaxone sodium, making them suitable as fluorescent nanosensors for detecting ceftriaxone sodium. Furthermore, this invention, based on the ability of nitrogen-doped sulfonated carbon dots to rapidly and sensitively detect ceftriaxone sodium in real samples, provides a new method and material for applications in the fields of biology, food safety, and environmental monitoring.

The invention relates to the technical field of ceftriaxone sodium production devices, and provides a ceftriaxone sodium crude product filtering device which comprises a gradient filtering tower and a deep purification box, the deep purification box is communicated with the gradient filtering tower, and the gradient filtering tower is used for carrying out solid-liquid separation on a ceftriaxone sodium crude product; the deep purification box is used for purifying ceftriaxone sodium crystal particles; the gradient filter tower comprises a tower body, the tower body is composed of a plurality of tower layers, the adjacent tower layers are communicated through flow guide holes, each tower layer is provided with a conical filter screen and an automatic scraping and collecting assembly, and each automatic scraping and collecting assembly comprises a cleaning anti-blocking scraper blade and a wet filter cake collecting tank. And the cleaning anti-blocking scraping plate is used for scraping wet filter cakes attached to the conical filter screen to the wet filter cake collecting tank. Wet filter cakes attached to the conical filter screen can be automatically scraped in time, the blocking risk is reduced, the automatic scraping and collecting assembly can input scraped solid crystal particles into the deep purification box, the discharging efficiency is improved, and the product pollution risk is reduced.

The invention discloses a pharmaceutical composition containing a pseudo-ginseng extract as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The invention provides a pharmaceutical composition containing a pseudo-ginseng extract, and tests prove that the pharmaceutical composition containing the pseudo-ginseng extract has a treatment effect on bacterial pneumonia induced by klebsiella pneumonia. Specifically, the pharmaceutical composition containing the pseudo-ginseng extract can significantly reduce the levels of IL-6, IL-1beta and TNF-alpha in alveolar lavage fluid; the mouse lung index is obviously reduced; the bacterial load in the lung tissue of the mouse is obviously reduced; the mouse lung tissue injury degree is obviously reduced; the number of neutrophils and the number of leukocytes in mouse blood are obviously reduced; the composition also has the effect of remarkably relieving increase of inflammatory factors in serum caused by klebsiella pneumoniae, and the effect is equivalent to or superior to that of a positive control drug ceftriaxone sodium. The invention provides a new choice and idea for clinical treatment of bacterial pneumonia.

The application discloses a ceftriaxone monoclonal antibody and application thereof, and belongs to the technical field of biology. The monoclonal antibody contains a heavy chain variable region and a light chain variable region, the heavy chain variable region and the light chain variable region are both composed of a complementarity determining region and a framework region, and the complementarity determining region is composed of CDR1, CDR2 and CDR3. The monoclonal antibody can be used for preparing a ceftriaxone detection product. The ceftriaxone colloidal gold detection test strip provided by the application has the characteristics of high sensitivity, good specificity and strong stability.

Described herein are novel compounds for use in treating substance addiction and withdrawal induced anxiety and depression, and methods of treating addictions and substance use disorders including alcohol abuse, opioid abuse, and nicotine abuse using compositions comprising MC-100093, wherein the compositions may further comprise ceftriaxone and / or additional therapeutic agents.

The application relates to the technical field of ceftriaxone sodium production devices, and provides a ceftriaxone sodium crude product filtering device which comprises a gradient filter tower and a deep purification box, the deep purification box is communicated with the gradient filter tower, the gradient filter tower is used for solid-liquid separation of ceftriaxone sodium crude products, and the deep purification box is used for purification of ceftriaxone sodium crystal particles; the gradient filter tower comprises a tower body, the tower body is composed of a plurality of tower layers, adjacent tower layers are communicated through flow guide holes, each tower layer is provided with a conical filter screen and an automatic scraping and collecting assembly, the automatic scraping and collecting assembly comprises a cleaning anti-blocking scraper and a wet filter cake collecting groove, and the cleaning anti-blocking scraper is used for scraping the wet filter cake attached to the conical filter screen to the wet filter cake collecting groove. The ceftriaxone sodium crude product filtering device can realize timely and automatic scraping of the wet filter cake attached to the conical filter screen, reduces the plugging risk, the automatic scraping and collecting assembly can input the scraped solid crystal particles into the deep purification box, improves the unloading efficiency, and reduces the product pollution risk.