Preparation method of high-selectivity ceftriaxone sodium magnetic molecularly imprinted polymer

A magnetic molecular imprinting and ceftriaxone sodium technology, applied in the fields of alkali metal compounds, chemical instruments and methods, alkali metal oxides/hydroxides, etc., can solve the problem of unreliable detection of analytes, complex pretreatment process, and target To solve the problem of low concentration of substances, to achieve the effect of excellent magnetic response, good selectivity and high adsorption capacity
CN111269366AActive Publication Date: 2020-06-12HANGZHOU DIANZI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HANGZHOU DIANZI UNIV
Publication Date
2020-06-12

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Abstract

The invention discloses a preparation method of a high-selectivity ceftriaxone sodium magnetic molecularly imprinted polymer. The preparation method comprises the following steps: firstly, synthesizing superparamagnetic Fe3O4 nanoparticles with hydroxylated surfaces in one step by taking triethylene glycol and ferric acetylacetonate as raw materials through a polyol method; then taking the superparamagnetic Fe3O4 nano particles, tetraethoxysilane and ammonia water as raw materials, preparing Fe3O4@SiO2 nano particles by a sol-gel method, and modifying amino groups on the surfaces of the nano particles by utilizing 3-aminopropyltriethoxysilane; then with the ceftriaxone sodium as a template molecule, methacrylic acid as a functional monomer, acetonitrile and methanol as pore-foaming agents,ethylene glycol dimethacrylate as a cross-linking agent and azodiisobutyronitrile as an initiator, preparing the magnetic molecularly imprinted polymer with specific adsorption performance on ceftriaxone sodium. The superparamagnetism and specific adsorption capacity of the ceftriaxone sodium magnetic molecularly imprinted nanoparticles are effectively improved. The preparation method is simple,the cost is low, and the ceftriaxone sodium magnetic molecularly imprinted nanoparticles have wide application prospects.
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Description

Technical field

[0001] The invention belongs to the fields of material science and technology and food safety detection, and relates to a preparation method and application of a magnetic molecularly imprinted polymer, in particular to a preparation method and application of a ceftriaxone sodium magnetic molecularly imprinted polymer. Background technique

[0002] Antibiotics are a class of drugs that can be used as chemotherapeutic agents for the prevention and treatment of bacterial diseases in humans and animals, and as growth promoters in animal husbandry or agriculture. However, the use of antibiotics for a long time has produced a large number of residues, which will directly or indirectly enter the aquatic and terrestrial environment. In recent years, antibiotic residues have been detected in milk and dairy products, meat and aquatic products, and water environments. Antibiotic residues in the environment and food can produce antibiotic resistance genes (ARG), and cause se...

Claims

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