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Preparation method of high-selectivity ceftriaxone sodium magnetic molecularly imprinted polymer

A magnetic molecular imprinting and ceftriaxone sodium technology, applied in the fields of alkali metal compounds, chemical instruments and methods, alkali metal oxides/hydroxides, etc., can solve the problem of unreliable detection of analytes, complex pretreatment process, and target To solve the problem of low concentration of substances, to achieve the effect of excellent magnetic response, good selectivity and high adsorption capacity

Active Publication Date: 2020-06-12
HANGZHOU DIANZI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complex composition of the sample and the low concentration of the target substance, the analysis of ceftriaxone sodium in food and biological samples requires a lot of sample pretreatment
Selective pretreatment techniques can eliminate matrix effects, however, due to lack of selective adsorption capacity, traditional sample pretreatment techniques, such as solid phase extraction (SPE), may lead to co-extraction of matrix interferences, making it impossible to reliably detect analytically thing
Moreover, conventional SPE sorbents bind target analytes through extraction columns, and the pretreatment process is complex and time-consuming

Method used

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  • Preparation method of high-selectivity ceftriaxone sodium magnetic molecularly imprinted polymer

Examples

Experimental program
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Effect test

Embodiment 1

[0041] (1) Preparation of superparamagnetic Fe 3 O 4 Nanoparticles

[0042] After dissolving the iron acetylacetonate in triethylene glycol, venting nitrogen to remove oxygen and stirring, react for 20-40 minutes at a temperature of 150-200℃ and a speed of 200-400rpm; then turn off the stirrer, insert the condenser, React for 20-40min at 250-300℃;

[0043] (2) The solution prepared in step (1) is continuously vented with nitrogen until it is cooled to room temperature, and the reaction product A is washed with ethyl acetate to completely remove the excess triethylene glycol and by-products; the washed precipitate is ultrasonically dispersed into ethanol In the preparation of Fe 3 O 4 Magnetic fluid

[0044] (3) Preparation of Fe 3 O 4 @SiO 2 Nanoparticles

[0045] Add the magnetic fluid and ammonia prepared in step (2) to the ethanol-water solution, stir for 20-40 min at a temperature of 20-40°C and a rotation speed of 200-400 rpm; then add tetraethoxysilane dropwise to the ethanol ...

Embodiment 2

[0058] The steps of Example 2 and Example 1 are the same, but the difference lies in the ratio of ingredients in the reaction, which are specifically as follows:

[0059] In the step (1), the mass ratio of triethylene glycol to iron acetylacetonate is 16:1.

[0060] In the step (2), Fe 3 O 4 The concentration of the magnetic fluid is 3.5 mg / mL.

[0061] In the step (3), Fe 3 O 4 The mass ratio of magnetic fluid, ammonia, tetraethoxysilane, and 3-aminopropyltriethoxysilane is 1100:12:6:1.

[0062] In the step (5), ceftriaxone sodium, Fe 3 O 4 @SiO 2 The mass ratio of nanoparticles, azobisisobutyronitrile, ethylene glycol dimethacrylate, and methacrylic acid is 2500:700:250:7:1.

[0063] In the step (5), the volume ratio of the acetonitrile-methanol solution is 1.1:1.

[0064] The magnetic molecularly imprinted polymer of ceftriaxone sodium prepared in this embodiment has a particle size of about 80 nm and a magnetic saturation intensity of 20 emu / g.

Embodiment 3

[0066] The steps of Example 3 and Example 1 are the same, but the difference lies in the ratio of ingredients in the reaction, which are specifically as follows:

[0067] In the step (1), the mass ratio of triethylene glycol to iron acetylacetonate is 17:1.

[0068] In the step (2), Fe 3 O 4 The concentration of the magnetic fluid is 4 mg / mL.

[0069] In the step (3), Fe 3 O 4 The mass ratio of magnetic fluid, ammonia, tetraethoxysilane, and 3-aminopropyltriethoxysilane is 1200:14:7:1.

[0070] In the step (5), ceftriaxone sodium, Fe 3 O 4 @SiO 2 The mass ratio of nanoparticles, azobisisobutyronitrile, ethylene glycol dimethacrylate, and methacrylic acid is 3000:800:300:9:1.

[0071] In the step (5), the volume ratio of the acetonitrile-methanol solution is 1.2:1.

[0072] The magnetic molecularly imprinted polymer of ceftriaxone sodium prepared in this embodiment has a particle size of about 100 nm and a magnetic saturation intensity of 16 emu / g.

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Abstract

The invention discloses a preparation method of a high-selectivity ceftriaxone sodium magnetic molecularly imprinted polymer. The preparation method comprises the following steps: firstly, synthesizing superparamagnetic Fe3O4 nanoparticles with hydroxylated surfaces in one step by taking triethylene glycol and ferric acetylacetonate as raw materials through a polyol method; then taking the superparamagnetic Fe3O4 nano particles, tetraethoxysilane and ammonia water as raw materials, preparing Fe3O4@SiO2 nano particles by a sol-gel method, and modifying amino groups on the surfaces of the nano particles by utilizing 3-aminopropyltriethoxysilane; then with the ceftriaxone sodium as a template molecule, methacrylic acid as a functional monomer, acetonitrile and methanol as pore-foaming agents,ethylene glycol dimethacrylate as a cross-linking agent and azodiisobutyronitrile as an initiator, preparing the magnetic molecularly imprinted polymer with specific adsorption performance on ceftriaxone sodium. The superparamagnetism and specific adsorption capacity of the ceftriaxone sodium magnetic molecularly imprinted nanoparticles are effectively improved. The preparation method is simple,the cost is low, and the ceftriaxone sodium magnetic molecularly imprinted nanoparticles have wide application prospects.

Description

Technical field [0001] The invention belongs to the fields of material science and technology and food safety detection, and relates to a preparation method and application of a magnetic molecularly imprinted polymer, in particular to a preparation method and application of a ceftriaxone sodium magnetic molecularly imprinted polymer. Background technique [0002] Antibiotics are a class of drugs that can be used as chemotherapeutic agents for the prevention and treatment of bacterial diseases in humans and animals, and as growth promoters in animal husbandry or agriculture. However, the use of antibiotics for a long time has produced a large number of residues, which will directly or indirectly enter the aquatic and terrestrial environment. In recent years, antibiotic residues have been detected in milk and dairy products, meat and aquatic products, and water environments. Antibiotic residues in the environment and food can produce antibiotic resistance genes (ARG), and cause se...

Claims

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Application Information

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IPC IPC(8): C08F292/00C08F222/14C08J9/26B01J20/26B01J20/30B01J20/28
CPCC08F292/00C08J9/26B01J20/268B01J20/103B01J20/06B01J20/28009C08J2351/10C08J2201/0424
Inventor 王晨宇杨王辉黄智淼毛卓淇
Owner HANGZHOU DIANZI UNIV
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