The invention relates to a method for preparing biaryl compound in pure water, which belongs to the technical field of catalytic
chemistry. The method utilizes the Suzuki cross-
coupling reaction between haloaromatic solution and
aryl boronic acid to prepare the biaryl compound. According to the
molar ratio of 0.5:0.75:1.0:0.0025 to 0.005:0.0025 to 0.02, the haloaromatic solution, the
aryl boronic acid, alkali, catalyst and ligand are added in 1ml to 2ml of water, and react under the protection of
nitrogen and the temperature of 100 DEG C for 10 to 120 minutes, the reaction mixture is added with 2ml of
ether for extraction after the reaction is finished, and is kept still under the
room temperature to separate phases, the water phase containing the catalyst is recycled, saturated
salt water is added in the
ether phase,
ethyl acetate is used to extract
reaction product, organic phases are merged, filtrate is concentrated,
column chromatography is used for separation, and thereby the analytically pure biaryl compound is obtained. The method has the following characteristics that: reaction takes place in green
solvent, i.e. pure water, and any
organic solvent does not need to added; the method solves the problem that water-insoluble substrate in the pure water
solvent system can hardly react; and the thermoregulated ligand is adopted to realize the separation and
recovery of the catalyst.