33 results about "Conventional treatment" patented technology

The invention belongs to the technical field of biological medicines, and discloses application of decitabine or an optical isomer thereof, or a hydrate thereof, or a solvate thereof, or a prodrug thereof, or a derivative thereof, or a pharmaceutically acceptable salt thereof in preparation of medicines for preventing and / or treating nasopharynx cancer. Or application in preparation of drugs for inhibiting postoperative recurrence and growth of nasopharyngeal carcinoma. In-vivo and in-vitro experiments prove that decitabine has the activity of remarkably inhibiting growth of nasopharyngeal carcinoma cells and is efficient and low in toxicity; the in-situ gel is prepared into the in-situ gel and is locally administrated through the nasopharyngeal cavity, so that toxic and side effects caused by a conventional treatment method can be avoided, tumor recurrence and growth can be remarkably inhibited after nasopharyngeal carcinoma operation, good safety is achieved, a new medicine and a new means are provided for prevention and treatment of nasopharyngeal carcinoma, and therefore the in-situ gel has wide application prospects.

This invention relates to the technical field of medical devices, and more particularly to a radiofrequency thermocoagulation contact switching device. The radiofrequency thermocoagulation contact switching device includes a central processing unit (CPU), a touch-enabled liquid crystal display circuit, a signal acquisition circuit, a signal expansion circuit, and a signal switching circuit. The touch-enabled liquid crystal display circuit is connected to the CPU, the signal acquisition circuit is connected to the CPU, the signal expansion circuit is connected to the CPU, and the signal switching circuit is connected to the signal expansion circuit. This device not only enables conventional treatment methods such as monopolar thermocoagulation and bipolar thermocoagulation, but also allows for simultaneous selection of multiple electrode contacts for multi-point synchronous thermocoagulation, reducing operational difficulty while expanding treatment options.

The present invention relates to: an AAV-based PDE6B viral vector for treating retinitis pigmentosa, the AAV-based PDE6B viral vector containing a tissue-specifically expressed PDE6A promoter; and a use of thereof, and provides a gene therapy for treating retinitis pigmentosa caused by PDE6B gene deficiency. The in vivo therapeutic efficacy of seven types of AAV5-PDE6B vectors was confirmed using an AAV by using a PDE6A promoter that is tissue-specifically expressed in photoreceptor rod cells that develop retinitis pigmentosa. An AAV5-PDE6A-450-PDE6B vector was selected as a candidate due to exhibiting strong tissue-specific expression in photoreceptor rod cells under even off-target conditions, unlike the gene expression characteristics of an AAV5-CMV-PDE6B vector, and was tested so as to be usable in the development of a gene therapeutic agent for treating PDE6B-deficient retinitis pigmentosa patients. Therefore, the present invention, related to AAV5-PDE6B for retinitis pigmentosa treatment and containing a tissue-specifically expressed PDE6A promoter, provides retinitis pigmentosa patients with an important treatment option having improved safety, and can be expected to have fundamental therapeutic effects compared to conventional treatments.

The application discloses a biofilm-targeted self-assembled composite nano system, a preparation method and application thereof, and belongs to the field of pharmaceutical preparations. The active ingredient of the biofilm-targeted self-assembled composite nano system is composed of an organic ligand, metal ions and a gel matrix. The self-assembled composite nano system has double targeting properties. Not only can the self-assembled composite nano system efficiently target an infection site and stay at the infection site for up to 15 days, but also can target adhesion and effectively penetrate a biofilm to produce active oxygen, so that the problem that conventional therapeutic drugs are difficult to penetrate the biofilm due to the obstruction of the biofilm barrier is overcome. Meanwhile, the self-assembled composite nano system promotes the immune response of a host, so that the treatment effect on biofilm infection is improved.

Disclosed is the use of a composition comprising a TET pathway inhibitor and a ferroptosis inducer in the manufacture of a medicament for the treatment of malignant tumors. It is found that TET1 up-regulates expression of a ferroptosis key regulation gene GCH1 through an NF [kappa] B signal, promotes synthesis of BH4, activates a GPX4 non-dependent pathway, and plays a key hub role in controlling ferroptosis sensitivity. Through combined use of TET pathway inhibitors (including a TET inhibitor and a BH4 synthesis inhibitor), the sensitivity of tumor cells to the ferroptosis inducer can be significantly improved, and the in-vivo use dosage of the ferroptosis inducer is reduced to 1% (1 mg / kg) of the conventional treatment dosage. The composition of the TET pathway inhibitor and the ferroptosis inducer, provided by the invention, can be used for remarkably improving the ferroptosis induction curative effect of various malignant tumors, particularly ferroptosis insensitive tumors, and enhancing the safety and universality of ferroptosis induction treatment.

The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and application thereof. Aiming at the pathogenesis that the spleen and stomach are damaged by antituberculous drugs, so that the spleen is disabled in transportation, damp turbidity is stopped, stomach is disharmonized and reduced, and cold and heat are mixed, the invention provides a traditional Chinese medicine composition consisting of nine medicines such as fresh ginger, ginger processed pinellia, roasted rhizoma atractylodis macrocephalae, rhizoma atractylodis, dried tangerine or orange peel and poria cocos. The traditional Chinese medicine composition disclosed by the invention has the advantages of few medicines, quick response, high safety and good curative effect, can be used for remarkably improving gastrointestinal reaction of a tuberculosis patient after chemotherapy by being combined with conventional treatment, has a clear synergistic effect and has a remarkable application advantage.

The present invention provides therapeutic agents for treating human asthma through administration of an IL-6 inhibitor to humans. Representative IL-6 inhibitors in the present invention include IL-6 receptor antibodies and IL-6 antibodies. Therapeutic agents of the present invention can yield therapeutic effects in severe asthma patients who need administration of high-dose steroids and such for alleviation of symptoms, or even in patients whose symptoms are difficult to control by common treatment.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a healthy energy supporting, yang warming and meridian dredging paste which is technically characterized by being prepared from honey-fried ephedra, wine-processed cornus, safflower, red paeony root, stevia rebaudiana, prepared common monkshood daughter root, Chinese yam, kudzuvine root, prepared rhizome of rehmannia, platycodon grandiflorum, pollen typhae, ligusticum wallichii, angelica sinensis, radix achyranthis bidentatae, astragalus membranaceus, asarum, radix bupleuri, liquorice, peach kernel, lignum dalbergiae odoriferae and fructus aurantii according to a specific weight part ratio. According to the ointment formula, the theory of Zheng method of Yandezhi teaching professor and the experience of Radix Astragali-Radix Puerariae formula of Guizhongguang national medicine master are fused, a treatment system which warms yang, benefits qi, promotes blood circulation, removes blood stasis, strengthens the body resistance and dredges collaterals is established, and the ointment formula accurately aims at the core pathogenesis of yang deficiency and blood stasis type coronary heart disease angina pectoris and chronic heart failure. Clinical tests prove that the ointment is remarkably superior to conventional treatment (Plt; 0.05) in the aspects of improving traditional Chinese medicine syndromes and improving heart functions, and is good in safety; moreover, the preparation is an oral ointment, is moist and sweet in quality, is convenient to take for a long time, and has remarkable clinical application value and popularization prospect.

This invention relates to compositions and methods relating to a combination of naturally-occurring active ingredients useful for the regulation of kidney and excretory system function. The combination of active ingredients, comprising vitamin B6, vitamin E, iron, roundhead lespedeza, birch leaf, and red bilberry, improves the function of kidney structures. The present invention may be used to achieve lower blood nitrogen content, including help to eliminate creatinine, urea, uric acid, by improving glomerular filtration and thus delaying hemodialysis. The present invention may be used to achieve a pronounced anti-inflammatory effect on the kidneys and the urinary tract. The present invention may also be used on its own or as a part of conventional treatment for a long time or indefinitely.

The invention relates to a natural pharmaceutical composition for prevention and treatment of gastric ulcer and a preparation method of the natural pharmaceutical composition. The natural pharmaceutical composition comprises active natural medicinal ingredients. It is composed of turpentine oil, black seed oil, vitamin D and hyaluronic acid. The natural pharmaceutical composition provides a significant synergistic effect, combining anti-inflammatory, antibacterial, and gastroprotective properties, while also ensuring cost-effectiveness and minimal side effects compared to conventional treatments. Beside gastric ulcer is effective in relief of symptoms associated with gastric ulcer. The natural composition has the advantages of accurate curative effects, preparation stability, simplicity and feasibility in process and suitableness for industrial production.

Methods and devices for reducing the risk of human fetal nerve injury during and prior to delivery are disclosed. The method comprises the steps of: (1) identifying the risk of nerve injury in a fetus during delivery by analyzing the blood of the fetus to determine at least a first excess alkali (BE) value of the fetus during a first period of time of a first delivery process; (2) determining a median multiple of the BE value for the first period of time by dividing the BE value by a median BE value of a dataset comprising a population of fetal BE values established during the first birth process for the same period of time as the first period of time, indicating that the fetus has a risk of nerve injury; (3) treating the fetus indicated by the identification step to be at risk of said nerve injury, where said treatment step comprises intervening in delivery by any conventional therapeutic measures to reduce or eliminate the risk of said nerve injury in said fetus.

The invention relates to a traditional Chinese medicine composition for treating septicopyemia and application, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following components: rheum officinale, radix aconiti lateralis preparata, cassia twig, bighead atractylodes rhizome, coptis chinensis and honey-fried licorice root. The traditional Chinese medicine composition is used for preparing the medicine for treating septicopyemia, achieves the effects of inhibiting inflammatory response, improving hemodynamics and protecting important visceral organs such as heart, lung, liver and kidney by ascending lucidity and descending turbidity, combining purgation and tonification, clearing away heat and toxic materials and the like, serves as an auxiliary treatment means for septicopyemia, is combined with conventional treatment of western medicine, and has a remarkable treatment effect on septicopyemia. The survival rate and the clinical prognosis of the patient are improved.

The present invention relates to a novel anti-C-MPL antibody and a use thereof, and specifically, to an anti-C-MPL antibody having an effect of increasing platelet production and its number through the maturation of megakaryocytes in the bone marrow, and a use thereof. The novel anti-C-MPL antibody (2R13) of the present invention is a polymer material and has a longer half-life than the conventional therapeutic agents, and it has the advantage of low self-antibody production and low immunogenicity as an antibody agent. In addition, it can be used as a therapeutic agent for thrombocytopenia by increasing the platelet level of patients suffering from chronic or complication-induced immune thrombocytopenia.

The present disclosure relates to an alternative intervention to improve skeletal muscle health in chronic kidney disease (CKD). CKD causes skeletal muscle complications that lead to increased risk of falls, hospitalizations and mortality. While exercise is a common treatment for these impairments in the general population, in patients with CKD exercise has shown only marginal improvements in aerobic capacity and inconsistent effects on muscle strength, walking distance, and timed-up-and-go tests indicating this ‘usual’ treatment is not enough in patients in CKD. The present disclosure relates to methods of using an aminoindazole to treat inflammation and metabolic derangements and to improve skeletal muscle health in CKD.

The invention discloses an external traditional Chinese medicine composition for promoting hair growth, relieving itching and controlling oil and application of the external traditional Chinese medicine composition. Belongs to the technical field of alopecia prevention. The traditional Chinese medicine composition is prepared from radix salviae miltiorrhizae, radix angelicae sinensis, flos rosae rugosae, herba menthae, cortex mori, cortex dictamni, herba ecliptae, radix polygoni multiflori, sasangua cake, rhizoma zingiberis recens, fructus gleditsiae, fructus phyllanthi and folium mori. The traditional Chinese medicine composition lotion which is convenient to use is prepared by combining a traditional Chinese medicine composition extracting solution with a shampoo matrix. When the lotion is independently used, hair growth of a patient suffering from androgenetic alopecia can be promoted, and the hair density and the final hair density can be improved. When the lotion is used together with a conventional treatment scheme, the final hair density can be remarkably improved, the alopecia score of a patient is reduced, and scalp greasiness and itching are reduced. The traditional Chinese medicine composition lotion has no adverse reaction when being used independently or combined with a conventional treatment scheme, and is good in safety.

This invention provides the application of a traditional Chinese medicine composition in the preparation of cardiovascular protective drugs after percutaneous coronary intervention (PCI) for myocardial infarction, specifically acute ST-segment elevation myocardial infarction (STEMI), with a TCM syndrome of "heart yang deficiency." The composition comprises raw Cornus officinalis, dried ginger, ginseng, Astragalus membranaceus, Atractylodes macrocephala, Alisma plantago-aquatica, Poria cocos, and Aconitum carmichaelii. The cardiovascular protective effects of this composition include improving cardiac function, inhibiting postoperative oxidative stress, reducing NT-proBNP, and decreasing the risk of cardiovascular events within one year post-surgery. It can be prepared as a decoction, oral liquid, or other dosage forms, and can be used in combination with conventional Western medicine treatments for synergistic effects. The composition of this invention is scientifically formulated, targets multiple points of action, and effectively addresses the problem of limited cardiovascular protection methods after PCI in STEMI patients, significantly improving patient prognosis and demonstrating good clinical application value.

The invention describes peptides with anticancer activity and exhibiting antagonistic activity against CD133 protein, which were obtained and designed by means of computer tools, evaluating physicochemical parameters of flexibility, hydrophilicity, hydrophobicity, antigenicity and total charge as described herein, in addition to the modeling of the protein, which allowed selecting 4 regions with the appropriate characteristics. After modeling the selected peptides, CD133 peptide-protein molecular docking was performed, where stable interactions were observed, even showing hydrogen bonds. Finally, the peptides of the invention showed anticancer effects against several cancer cell lines, including cancer cells resistant to conventional treatments such as triple negative breast cancer cells.

The invention relates to the field of pharmaceutical preparations, in particular to a foaming agent for vagina pH adjustment and a preparation method thereof. The foaming agent comprises the following components in parts by weight: 5-8 parts of lactobacillus microcapsules, 1-2 parts of fructo-oligosaccharide, 3-4 parts of glycogen, 0.2 part of phlorizin, 2 parts of lactic acid, 1 part of citric acid, 0.5 part of sodium citrate, 8-10 parts of a propellant, 3.0 parts of sodium alginate and the balance of water, wherein the total parts by weight of the components are 100. The lactobacillus microcapsule is prepared from the following components: lactobacillus, trehalose and chitosan. According to the present invention, the micro-ecology can be rapidly recovered on the basis of the direct killing of pathogenic microorganisms by using the conventional treatment drug in the spaced cooperation manner; the lactobacillus microcapsules can effectively protect stable existence of lactobacillus before colonization in vaginal mucosa; the fructo-oligosaccharide and the glycogen provide substrates for the lactobacillus, help the lactobacillus to proliferate quickly, continuously maintain an acid environment and eliminate pathogenic bacteria through competitive inhibition.

The invention relates to the technical field of tumor immunity, and discloses a sample treatment method for detecting a circulating mononuclear cell immune function and a tumor microenvironment macrophage immune function, which comprises the following steps: treating a peripheral blood sample and a tumor pathological tissue sample; according to the treatment method, the mononuclear cell purity is improved through CD14 magnetic bead sorting, the macrophage recovery rate is improved through mixed enzymatic hydrolysate, and the core improvement that mild reagents (a hypotonic hemolysis buffer solution and a BSA-containing stationary solution) protect the cell activity and the antigen integrity is achieved, so that the treatment method has the important significance in the aspects of the mononuclear cell purity, the macrophage recovery rate, the cell activity and the antigen fluorescence intensity. Compared with the prior art, the method provided by the invention has the advantages that the method provided by the invention has the advantages that the method provided by the invention is obviously superior to a conventional treatment method, the defects of low monocyte enrichment efficiency, poor macrophage recovery rate and insufficient cell activity and antigen integrity of the conventional method are overcome, and a higher-quality sample basis is provided for subsequent circulating monocyte subtype typing (Mo1-Mo4) and tumor microenvironment macrophage immune function detection.

The invention provides a treatment method for wasp stings. Honeybee pupa body fluid is applied to wasp stings wound treatment. The toxicity of the hornet venom is neutralized by the bioactive components of the bee pupa body fluid, so that rapid swelling and pain relieving are realized. Protease inhibitors, anti-inflammatory peptides and immunomodulatory substances in bee pupa body fluid can effectively inhibit the activity of pain-inducing factors such as phospholipase and hyaluronidase in venom. By means of the method, secondary damage caused by a traditional spine taking mode is avoided, body fluid permeation is promoted through local rubbing, and drug effect exertion is accelerated. Compared with a conventional treatment means, the method is easy and convenient to operate, natural in material taking and capable of remarkably shortening the effective time.

A new class of multi-functional lipid nanoparticles comprising a fluoropyrimidine-based therapeutic and a combination of helper lipids is disclosed. The disclosed lipid nanoparticles are formulated for efficient delivery of therapeutic agents to target cells and can be used in the treatment of cancers, including colorectal cancer. The disclosed lipid nanoparticles exhibit improved cellular uptake and increased toxicity to cancerous cells compared to free- fluoropyrimidine therapeutic and other conventional therapeutics. A method for treating cancer by administering the disclosed lipid nanoparticles is also disclosed herein.

The disclosure relates to an interdental papilla reconstruction method using hyaluronic acid. One aspect of the disclosure, the interdental papilla reconstruction method, can conveniently reconstruct the lost or receded interdental papilla compared to conventional treatment methods. In addition, according to an aspect of the disclosure, the interdental papilla reconstruction method, the interdental papilla can be effectively reconstructed without pain or side effects. Further, the interdental papilla reconstruction method of the disclosure is highly useful as a rescue treatment for quickly resolving unexpected gingival recession or interdental papilla loss occurring during dental treatments.

The present invention discloses a portable pulsed electromagnetic field therapy (PEMFT) system (100), comprising: a main body (101) configured for generating a pulsed electromagnetic field (PEMF), and a strap (102) configured to be wrapped around a hand, wherein the main body (101) comprises a PEMF emitter (7) configured to alternately emit a first pulse signal at a first frequency and a second pulse signal at a second frequency periodically; wherein the first frequency is 20Hz – 45Hz, and the second frequency is 50Hz – 90Hz, and the second frequency is at least 10Hz higher than the first frequency; and, wherein the strap (102) comprises a first attachment section (104) configured to cover a target treatment area (201), and the main body (101) is configured to be detachably mounted on the first attachment section (104). The present invention offers a non-invasive alternative to conventional treatment methods, providing a convenient and precise solution for enhancing cardiovascular health, delivering an effective and user- friendly treatment experience.

The present disclosure proposes a kit (100) and composition for treating edema, necrotizing fasciitis, restoring muscle perfusion, and limiting bacterial spread. The kit (100) comprises a topical antibiotic cream (102), plurality of antiseptic gauzes (104), an ordho cloth roller bandage (106), a crepe roller (108), a super absorbent gamjee roller (110), and a pair of surgical gloves (112). The proposed kit (100) treats edema of any type, including prevention of death through early intervention, avoiding surgery, minimizing morbidity, and reducing patient expenditure. The proposed kit (100) decreases muscle compartment pressure, increases blood flow to affected muscles, and prevents tissue necrosis. The proposed kit (100) significantly reduces patient expenditure compared to conventional treatments, making it affordable for a broader population.

A progressive cervical vertebra correction physical therapy pillow comprises a cervical vertebra correction pillow, the length of the cervical vertebra correction pillow is smaller than 160 mm, it is guaranteed that in the using state, the two ends of the cervical vertebra correction pillow are not in contact with the two shoulders, and the height of the cervical vertebra correction pillow is the same as the height preset in the corresponding correction period; the cervical vertebra correction pillow is different in height size in different correction time periods. A bottom plate, a head limiting part, a sleeping pillow and a side sleeping pillow are additionally arranged, the head limiting part, the sleeping pillow and the side sleeping pillow are all installed on the bottom plate, the cervical vertebra correcting pillow is adjustably installed on the bottom plate, and the distance between the cervical vertebra correcting pillow and the head limiting part is adjustable. The cervical spondylosis patients can be effectively improved and relieved after physical therapy is carried out on the cervical spondylosis patients, the cure rate of one treatment course of physical therapy can reach 80% or above, pure physical formula digital-analog physical therapy is adopted, medicine taking and operation are not needed, the pain feeling in the physical therapy process is small, the physical therapy cost is low, and the cure rate of cervical deformation diseases after physical therapy is higher than that of cervical deformation diseases after a conventional treatment scheme is adopted.

The present invention relates to a formulation optimized for a fusion protein dimer comprising an extracellular domain of an alpha subunit of an IgE Fc receptor. Specifically, the present invention relates to an aqueous pharmaceutical formulation comprising a fusion protein dimer comprising an extracellular domain of an alpha subunit of an IgE Fc receptor, histidine, proline, methionine, and poloxamer 188, wherein the pH of the formulation is from 6.0 to 7.0. The fusion protein present in the formulation according to the present invention is included at a high concentration, has improved stability, may be conveniently administered by subcutaneous injection, and has excellent IgE binding ability compared to a conventional therapeutic agent comprising an anti-IgE antibody. Thus, it can be usefully utilized as an injection for the treatment of allergic diseases mediated by IgE.

The present disclosure provides a blood coagulation factor FXI / FXIa inhibitor for treating pulmonary hypertension and / or hypertension. Specifically, provided is a method for treating and / or preventing pulmonary hypertension in a patient receiving a conventional treatment by means of administering the FXI / FXIa inhibitor; and a method for treating and / or preventing hypertension in a patient with essential hypertension by means of administering the FXI / FXIa inhibitor.

The invention provides a Notch1 regulation and control method based on a Notch1 super enhancer, relates to the technical field of biomedicine, and has the technical key points that two Notch1 super enhancer sequences are found through research, and the Notch1 super enhancer sequences are named as Notch1-AB and Notch1-CD. According to the application, Notch1-AB and Notch1-CD super enhancers are found and defined as specific key elements for regulating Notch1 high expression in vascular endothelial cells for the first time, and the two regulation paths are cut off through inhibitor inhibition or a gene editing technology, so that efficient and stable down-regulation of Notch1 and target genes thereof is realized, tissue cross reaction caused by direct targeting of Notch1 receptors is avoided, and the Notch1 and target genes thereof can be efficiently and stably regulated. The treatment specificity and safety are obviously improved; the regulation and control mode can adapt to multiple scenes such as conventional treatment and precision medical treatment, vascular diseases and tumors such as atherosclerosis and diabetic retinopathy can be covered, and the application limitation of existing Notch targeted therapy is broken through.

The invention discloses nursing and first-aid integrated multifunctional infusion equipment for patients in an emergency department, belongs to the technical field of first-aid infusion, and aims to solve the problems that the nursing and first-aid infusion equipment in the emergency department is mostly of a single-channel structural design, independent infusion of single liquid medicine is realized, and the infusion efficiency is low. Multiple requirements of conventional treatment medicine infusion, nutrition supplement and supply and first-aid medicine administration under sudden illness conditions of emergency patients are not easy to meet at the same time, in the actual emergency treatment process, medical staff need to frequently replace infusion pipelines or switch infusion equipment according to the illness conditions of the patients, the operation process is tedious, consumed time is long, and the operation cost is low. The device comprises a movable frame, three paths of liquid medicine can be conveyed in a mutually isolated mode, puncture is conducted through a single needle, incompatibility caused by mixing of in-vitro liquid medicine is avoided fundamentally, pain of a patient caused by multiple times of puncture is relieved, and the device has the advantages of being simple in structure, convenient to use and high in practicability. And multiple requirements of emergency treatment, nutrition supply and first-aid administration are synchronously met.

The utility model relates to the technical field of medical instruments, in particular to a dental chair capable of switching sterile treatment water, which is characterized in that a first liquid storage part is arranged on a box body; the second liquid storage part is mounted on the tool rack, and sterile liquid is contained in the first liquid storage part and the second liquid storage part; the liquid supply pipeline comprises a first liquid path communicated with the first liquid storage part, a second liquid path communicated with an external water source and a third liquid path communicated with the second liquid storage part; the downstream of the second liquid path is provided with a first branch and a second branch, the first branch is connected to the tool rack, the downstream of the second branch is provided with a mouthwash branch and a spittoon water branch, and the first liquid path is communicated with the mouthwash branch; and the control valve group is arranged on the liquid supply pipeline. According to the utility model, the switching of sterile liquid or conventional water sources supplied and conveyed by the liquid supply pipeline can be realized by controlling the opening and closing of the valve group, and the requirements of conventional treatment and sterile treatment on patients are met.