63 results about "Conventional treatment" patented technology

Introduced here are apparatuses and systems for mitigating contact pressures applied to a human body by the surface of an object, such as a chair, bed, or table. A pressure-mitigation apparatus can include a series of chambers whose pressure can be individually varied. When placed between a patient and a contact surface, the pressure-mitigation apparatus can vary the contact pressure on a specific anatomical region of the patient by controllably inflating and / or deflating one or more cell. Moreover, a pressure-mitigation system can be readily integrated into a conventional treatment regimen for a variety of different conditions.

The invention discloses a minimally invasive flexible piezoelectric-triboelectric hybrid nanometer nerve stimulation device and application thereof.The middle layer of the nerve stimulation device is a PVDF / TMCM-MnCl3 composite nanofiber membrane, Au electrodes are evaporated on the two faces of the PVDF / TMCM-MnCl3 composite nanofiber membrane, two gold wire or copper wire electrodes are connected with the Au electrodes respectively, and the two gold wire or copper wire electrodes are connected with the Au electrodes respectively. The surface of the Au electrode is subjected to primary packaging by adopting a PU waterproof film, and the surface of the PU waterproof film is subjected to secondary packaging by adopting PDMS. The nerve stimulation device is used for conventional treatment of SIRS. The vagus nerve stimulator can generate an adjustable current up to 0.85 mA under programmable ultrasonic driving, and can be directly used for VNS. The PTNG is ultrasonically driven in vitro to assist the VNS in treating lipopolysaccharide-induced SIRS rats, release of inflammatory factors such as TNF-alpha, IFN-gamma and IL-1beta can be effectively reduced, cytokine storm is relieved, and multi-organ tissue damage and dysfunction are relieved, so that the survival hope is improved.

The invention discloses a plant lactobacillus Kimate-F, a plant lactobacillus Kimate-6, a composite probiotic composition composed of the plant lactobacillus Kimate-F and the plant lactobacillus Kimate-6, and an application of the composite probiotic composition in relieving dog transportation stress and improving dog enteritis. The probiotic composition can effectively relieve dog transportation stress and remarkably reduce indexes such as corticosterone and active oxygen. In addition, the probiotic composition can effectively prevent or relieve canine enteritis, promote reproduction of beneficial bacteria in intestinal flora, inhibit proliferation of potential harmful bacteria, repair intestinal mucosal barrier and reduce inflammatory response. The invention has a wide application prospect, is especially suitable for dogs with long-distance transportation, stress susceptibility and poor intestinal function, and can also be used in cooperation with other conventional treatment means.

The invention discloses a vaginal dilator with a light source, which relates to the technical field of medical instruments and is characterized by comprising a dilation structure, a light source system, an adjusting structure and a handle. The expansion structure is formed by hinging upper and lower tooth parts, and the surface of the expansion structure is coated with a silica gel layer to ensure comfort and biocompatibility; an observation window is arranged at the front end of the upper tooth part; a light guide column is integrated in the lower tooth part. The light source system comprises an LED module and a turning structure, uniform floodlight source distribution and accurate point light source illumination are achieved through microprism texture processing and light guide fibers, and the irradiation angle can be adjusted to meet different inspection requirements. And the adjusting structure comprises a fine adjustment knob and an angle adjusting knob, so that accurate control of the expansion angle and flexible adjustment of the light source angle can be realized. The problems that in the prior art, the light source angle cannot be adjusted, and the dilation angle is not finely adjusted are solved, the examination accuracy and the comfort of a patient are improved, and the device is suitable for gynecological examination and conventional treatment.

The invention belongs to the technical field of biological medicines, and discloses application of decitabine or an optical isomer thereof, or a hydrate thereof, or a solvate thereof, or a prodrug thereof, or a derivative thereof, or a pharmaceutically acceptable salt thereof in preparation of medicines for preventing and / or treating nasopharynx cancer. Or application in preparation of drugs for inhibiting postoperative recurrence and growth of nasopharyngeal carcinoma. In-vivo and in-vitro experiments prove that decitabine has the activity of remarkably inhibiting growth of nasopharyngeal carcinoma cells and is efficient and low in toxicity; the in-situ gel is prepared into the in-situ gel and is locally administrated through the nasopharyngeal cavity, so that toxic and side effects caused by a conventional treatment method can be avoided, tumor recurrence and growth can be remarkably inhibited after nasopharyngeal carcinoma operation, good safety is achieved, a new medicine and a new means are provided for prevention and treatment of nasopharyngeal carcinoma, and therefore the in-situ gel has wide application prospects.

The present invention is part of the field of pharmacology and medicine and relates to the use of coumarin derivative compounds for the treatment of asthma and / or chronic obstructive pulmonary disease (COPD). The present inventors identified that inhaled braylin has high therapeutic efficacy in the treatment of asthma and COPD, with efficacy comparable to systemic dexamethasone, and presenting itself as an unprecedented alternative to conventional treatments.

This invention relates to the technical field of medical devices, and more particularly to a radiofrequency thermocoagulation contact switching device. The radiofrequency thermocoagulation contact switching device includes a central processing unit (CPU), a touch-enabled liquid crystal display circuit, a signal acquisition circuit, a signal expansion circuit, and a signal switching circuit. The touch-enabled liquid crystal display circuit is connected to the CPU, the signal acquisition circuit is connected to the CPU, the signal expansion circuit is connected to the CPU, and the signal switching circuit is connected to the signal expansion circuit. This device not only enables conventional treatment methods such as monopolar thermocoagulation and bipolar thermocoagulation, but also allows for simultaneous selection of multiple electrode contacts for multi-point synchronous thermocoagulation, reducing operational difficulty while expanding treatment options.

The utility model relates to the field of medical examination vehicles, in particular to a 5G mobile intelligent orthopaedic medical vehicle which comprises a vehicle body, a diagnosis inquiry area, a DR examination room, a physical examination area, a treatment area and a multifunctional examination room are sequentially arranged behind a cab in the vehicle body from front to back, and a traction bed examination room and a conventional treatment room are arranged in the treatment area side by side; an intelligent system is further carried on the vehicle and comprises a vehicle-mounted 5G router, a desktop computer, an intelligent central control system, an identity authentication device, a video monitoring system, a remote communication device, a temperature regulation and control system, an intelligent temperature measuring device, a disinfection system and a lighting system, and the vehicle-mounted 5G router is connected with the cloud platform. The system carries orthopedic medical resources to realize quick response to emergency situations, and diagnosis and treatment can be carried out at the first time. The medical vehicle is reasonably provided with five functional areas and is provided with an intelligent system, data and a cloud platform communicate with each other, the structure is compact, layout is reasonable, and accurate and efficient diagnosis and treatment are achieved.

The present invention relates to: an AAV-based PDE6B viral vector for treating retinitis pigmentosa, the AAV-based PDE6B viral vector containing a tissue-specifically expressed PDE6A promoter; and a use of thereof, and provides a gene therapy for treating retinitis pigmentosa caused by PDE6B gene deficiency. The in vivo therapeutic efficacy of seven types of AAV5-PDE6B vectors was confirmed using an AAV by using a PDE6A promoter that is tissue-specifically expressed in photoreceptor rod cells that develop retinitis pigmentosa. An AAV5-PDE6A-450-PDE6B vector was selected as a candidate due to exhibiting strong tissue-specific expression in photoreceptor rod cells under even off-target conditions, unlike the gene expression characteristics of an AAV5-CMV-PDE6B vector, and was tested so as to be usable in the development of a gene therapeutic agent for treating PDE6B-deficient retinitis pigmentosa patients. Therefore, the present invention, related to AAV5-PDE6B for retinitis pigmentosa treatment and containing a tissue-specifically expressed PDE6A promoter, provides retinitis pigmentosa patients with an important treatment option having improved safety, and can be expected to have fundamental therapeutic effects compared to conventional treatments.

The application discloses a biofilm-targeted self-assembled composite nano system, a preparation method and application thereof, and belongs to the field of pharmaceutical preparations. The active ingredient of the biofilm-targeted self-assembled composite nano system is composed of an organic ligand, metal ions and a gel matrix. The self-assembled composite nano system has double targeting properties. Not only can the self-assembled composite nano system efficiently target an infection site and stay at the infection site for up to 15 days, but also can target adhesion and effectively penetrate a biofilm to produce active oxygen, so that the problem that conventional therapeutic drugs are difficult to penetrate the biofilm due to the obstruction of the biofilm barrier is overcome. Meanwhile, the self-assembled composite nano system promotes the immune response of a host, so that the treatment effect on biofilm infection is improved.

Disclosed is the use of a composition comprising a TET pathway inhibitor and a ferroptosis inducer in the manufacture of a medicament for the treatment of malignant tumors. It is found that TET1 up-regulates expression of a ferroptosis key regulation gene GCH1 through an NF [kappa] B signal, promotes synthesis of BH4, activates a GPX4 non-dependent pathway, and plays a key hub role in controlling ferroptosis sensitivity. Through combined use of TET pathway inhibitors (including a TET inhibitor and a BH4 synthesis inhibitor), the sensitivity of tumor cells to the ferroptosis inducer can be significantly improved, and the in-vivo use dosage of the ferroptosis inducer is reduced to 1% (1 mg / kg) of the conventional treatment dosage. The composition of the TET pathway inhibitor and the ferroptosis inducer, provided by the invention, can be used for remarkably improving the ferroptosis induction curative effect of various malignant tumors, particularly ferroptosis insensitive tumors, and enhancing the safety and universality of ferroptosis induction treatment.

The present disclosure relates to PD-1 variants with improved binding affinity to PD-L1. In addition, the present disclosure relates to methods for preparing PD-1 variants and methods for screening PD-1 variants. The PD-1 variants disclosed herein effectively inhibit the binding between wild-type PD-1 and PD-L1, and therefore it is expected that the PD-1 variants have significantly higher immune cell penetration ability and anti-cancer effects or therapeutic effects on infectious diseases compared to conventional therapeutic agents for immune checkpoint inhibition. At the same time, the PD-1 variants can minimize the possibility of immunogenicity. In addition, the implementation of the glycosylated PD-1 variants can facilitate the convenient development of biopharmaceuticals.

The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and application thereof. Aiming at the pathogenesis that the spleen and stomach are damaged by antituberculous drugs, so that the spleen is disabled in transportation, damp turbidity is stopped, stomach is disharmonized and reduced, and cold and heat are mixed, the invention provides a traditional Chinese medicine composition consisting of nine medicines such as fresh ginger, ginger processed pinellia, roasted rhizoma atractylodis macrocephalae, rhizoma atractylodis, dried tangerine or orange peel and poria cocos. The traditional Chinese medicine composition disclosed by the invention has the advantages of few medicines, quick response, high safety and good curative effect, can be used for remarkably improving gastrointestinal reaction of a tuberculosis patient after chemotherapy by being combined with conventional treatment, has a clear synergistic effect and has a remarkable application advantage.

The present invention provides therapeutic agents for treating human asthma through administration of an IL-6 inhibitor to humans. Representative IL-6 inhibitors in the present invention include IL-6 receptor antibodies and IL-6 antibodies. Therapeutic agents of the present invention can yield therapeutic effects in severe asthma patients who need administration of high-dose steroids and such for alleviation of symptoms, or even in patients whose symptoms are difficult to control by common treatment.

Methods and apparatus for reducing the risk of neurological injury to a human fetus during labor and before are disclosed, which include the steps of: (1) identifying during labor the risk of neurological injury to a fetus by, conducting an analysis of fetal blood to determine at least a first base excess (BE) value for the fetus; (2) determining a multiple of the median for the BE value at the first period in time, wherein a risk of neurological injury to the fetus is indicated when the BE value is a predefined multiple of a median BE value; and (3) treating the fetus for which the risk of neurological injury is, by intervening in labor to reduce or eliminate the risk of neurological injury to the fetus through any conventional therapeutic measures.

The invention discloses a Chinese medicine formula for treating mechanical damage of long-snout catfish, belonging to the field of biological technology of aquaculture. The present invention relates to a medicine for treating mechanical damage of fish, which is composed of three kinds of Chinese medicines: cloves, fennel and rosemary. The crude drug mass ratio is cloves: fennel: rosemary = 2:5:5. After 12g of mixed crude drugs are crushed, 1200ml of water is added and directly decocted or 2.4g of Chinese medicine extracts are mixed and 800ml of water is added and decocted. Finally, the volume is adjusted to 600ml to obtain a "three-fragrant agent". Before use, the injured fish is soaked in 0.5-1% salt water for 15-20 minutes, and then the injured fish is treated for 7-10 days according to the ratio of 0.5-1.0% of the "three-fragrant agent" concentration. The Chinese medicine formula has low toxicity, avoids a series of negative effects caused by conventional treatment using antibiotics, and has good therapeutic effects for treating long-snout catfish and other catfish including scaleless fish such as yellow catfish and yellow catfish.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a healthy energy supporting, yang warming and meridian dredging paste which is technically characterized by being prepared from honey-fried ephedra, wine-processed cornus, safflower, red paeony root, stevia rebaudiana, prepared common monkshood daughter root, Chinese yam, kudzuvine root, prepared rhizome of rehmannia, platycodon grandiflorum, pollen typhae, ligusticum wallichii, angelica sinensis, radix achyranthis bidentatae, astragalus membranaceus, asarum, radix bupleuri, liquorice, peach kernel, lignum dalbergiae odoriferae and fructus aurantii according to a specific weight part ratio. According to the ointment formula, the theory of Zheng method of Yandezhi teaching professor and the experience of Radix Astragali-Radix Puerariae formula of Guizhongguang national medicine master are fused, a treatment system which warms yang, benefits qi, promotes blood circulation, removes blood stasis, strengthens the body resistance and dredges collaterals is established, and the ointment formula accurately aims at the core pathogenesis of yang deficiency and blood stasis type coronary heart disease angina pectoris and chronic heart failure. Clinical tests prove that the ointment is remarkably superior to conventional treatment (Plt; 0.05) in the aspects of improving traditional Chinese medicine syndromes and improving heart functions, and is good in safety; moreover, the preparation is an oral ointment, is moist and sweet in quality, is convenient to take for a long time, and has remarkable clinical application value and popularization prospect.

This invention relates to compositions and methods relating to a combination of naturally-occurring active ingredients useful for the regulation of kidney and excretory system function. The combination of active ingredients, comprising vitamin B6, vitamin E, iron, roundhead lespedeza, birch leaf, and red bilberry, improves the function of kidney structures. The present invention may be used to achieve lower blood nitrogen content, including help to eliminate creatinine, urea, uric acid, by improving glomerular filtration and thus delaying hemodialysis. The present invention may be used to achieve a pronounced anti-inflammatory effect on the kidneys and the urinary tract. The present invention may also be used on its own or as a part of conventional treatment for a long time or indefinitely.

The invention relates to a natural pharmaceutical composition for prevention and treatment of gastric ulcer and a preparation method of the natural pharmaceutical composition. The natural pharmaceutical composition comprises active natural medicinal ingredients. It is composed of turpentine oil, black seed oil, vitamin D and hyaluronic acid. The natural pharmaceutical composition provides a significant synergistic effect, combining anti-inflammatory, antibacterial, and gastroprotective properties, while also ensuring cost-effectiveness and minimal side effects compared to conventional treatments. Beside gastric ulcer is effective in relief of symptoms associated with gastric ulcer. The natural composition has the advantages of accurate curative effects, preparation stability, simplicity and feasibility in process and suitableness for industrial production.

Methods and devices for reducing the risk of human fetal nerve injury during and prior to delivery are disclosed. The method comprises the steps of: (1) identifying the risk of nerve injury in a fetus during delivery by analyzing the blood of the fetus to determine at least a first excess alkali (BE) value of the fetus during a first period of time of a first delivery process; (2) determining a median multiple of the BE value for the first period of time by dividing the BE value by a median BE value of a dataset comprising a population of fetal BE values established during the first birth process for the same period of time as the first period of time, indicating that the fetus has a risk of nerve injury; (3) treating the fetus indicated by the identification step to be at risk of said nerve injury, where said treatment step comprises intervening in delivery by any conventional therapeutic measures to reduce or eliminate the risk of said nerve injury in said fetus.

The invention relates to a traditional Chinese medicine composition for treating septicopyemia and application, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following components: rheum officinale, radix aconiti lateralis preparata, cassia twig, bighead atractylodes rhizome, coptis chinensis and honey-fried licorice root. The traditional Chinese medicine composition is used for preparing the medicine for treating septicopyemia, achieves the effects of inhibiting inflammatory response, improving hemodynamics and protecting important visceral organs such as heart, lung, liver and kidney by ascending lucidity and descending turbidity, combining purgation and tonification, clearing away heat and toxic materials and the like, serves as an auxiliary treatment means for septicopyemia, is combined with conventional treatment of western medicine, and has a remarkable treatment effect on septicopyemia. The survival rate and the clinical prognosis of the patient are improved.

The invention discloses a traditional Chinese medicine composition for treating hepatitis A as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials by weight: 30-80g of fried radix bupleuri, 30-80g of medicated leaven, 100-200g of fresh wild lysimachia christinae hance and 50-80g of honey (used for processing radix bupleuri). The traditional Chinese medicine composition has the technical effect of taking effect quickly, the symptoms are obviously improved, and the traditional Chinese medicine composition takes effect on that day: clinical observation shows that the symptoms such as inappetence, nausea and hypodynamia can be obviously improved within 24 hours after a patient takes the traditional Chinese medicine composition, and the traditional Chinese medicine composition is superior to conventional treatment (generally 2-3 days). The jaundice fading time is averagely 3-5 days and is obviously shortened compared with that of a traditional prescription (7-10 days), and the traditional Chinese medicine is particularly suitable for acute-stage patients.

The present invention relates to a novel anti-C-MPL antibody and a use thereof, and specifically, to an anti-C-MPL antibody having an effect of increasing platelet production and its number through the maturation of megakaryocytes in the bone marrow, and a use thereof. The novel anti-C-MPL antibody (2R13) of the present invention is a polymer material and has a longer half-life than the conventional therapeutic agents, and it has the advantage of low self-antibody production and low immunogenicity as an antibody agent. In addition, it can be used as a therapeutic agent for thrombocytopenia by increasing the platelet level of patients suffering from chronic or complication-induced immune thrombocytopenia.

The present invention is in the field of pharmacology and medicine and relates to the use of coumarin derivative compounds for treating asthma and / or chronic obstructive pulmonary disease (COPD). The inventors have found that inhaled Braylin has high therapeutic efficacy in treating asthma and COPD, and its efficacy is comparable to that of systemic dexamethasone, making it an unprecedented alternative to conventional treatments.

The present disclosure relates to an alternative intervention to improve skeletal muscle health in chronic kidney disease (CKD). CKD causes skeletal muscle complications that lead to increased risk of falls, hospitalizations and mortality. While exercise is a common treatment for these impairments in the general population, in patients with CKD exercise has shown only marginal improvements in aerobic capacity and inconsistent effects on muscle strength, walking distance, and timed-up-and-go tests indicating this ‘usual’ treatment is not enough in patients in CKD. The present disclosure relates to methods of using an aminoindazole to treat inflammation and metabolic derangements and to improve skeletal muscle health in CKD.

The invention provides a detection kit for the expression quantity of HGFAC protein in body fluid, a construction method of an IBD detection model and application of the method in IBD auxiliary diagnosis, treatment effect monitoring and prognosis outcome prediction, belongs to the field of biological medicine, and solves the problem of how to carry out IBD auxiliary diagnosis, treatment effect monitoring and prognosis outcome prediction through body fluid biomarkers. The method comprises the following steps: inputting body fluid data obtained by the HGFAC protein expression quantity in a body fluid sample detected by the detection kit into a Logistic regression model to obtain an IBD auxiliary diagnosis model; inputting target body fluid data after conventional treatment into a Logistic regression model to obtain an IBD treatment effect monitoring and prognosis outcome prediction model; and selecting an optimal random seed number according to an AUC value of an ROC curve established by the model to obtain an optimal model, and performing k-folding cross validation on the optimal model to obtain an optimal model. According to the invention, IBD auxiliary diagnosis, treatment effect monitoring and prognosis outcome prediction are carried out through the optimal model based on the body fluid biomarkers, and clinical requirements are met.

The invention discloses an external traditional Chinese medicine composition for promoting hair growth, relieving itching and controlling oil and application of the external traditional Chinese medicine composition. Belongs to the technical field of alopecia prevention. The traditional Chinese medicine composition is prepared from radix salviae miltiorrhizae, radix angelicae sinensis, flos rosae rugosae, herba menthae, cortex mori, cortex dictamni, herba ecliptae, radix polygoni multiflori, sasangua cake, rhizoma zingiberis recens, fructus gleditsiae, fructus phyllanthi and folium mori. The traditional Chinese medicine composition lotion which is convenient to use is prepared by combining a traditional Chinese medicine composition extracting solution with a shampoo matrix. When the lotion is independently used, hair growth of a patient suffering from androgenetic alopecia can be promoted, and the hair density and the final hair density can be improved. When the lotion is used together with a conventional treatment scheme, the final hair density can be remarkably improved, the alopecia score of a patient is reduced, and scalp greasiness and itching are reduced. The traditional Chinese medicine composition lotion has no adverse reaction when being used independently or combined with a conventional treatment scheme, and is good in safety.

The invention relates to the technical field of polyenoic acid ethyl ester purification, in particular to a method for reducing the content of low-boiling-point substances and high-boiling-point substances in polyenoic acid ethyl ester and application of the method, and the method comprises the following steps: putting the polyenoic acid ethyl ester into molecular rectification equipment, and sequentially carrying out first molecular rectification and second molecular rectification to respectively remove the low-boiling-point substances and the high-boiling-point substances. According to the method for removing the low-boiling-point substances and the high-boiling-point substances in the ethyl polyenoate, the physical purification principle is adopted, and impurities such as the low-boiling-point substances SDA and ARA and the high-boiling-point substances HPA and DPA in the ethyl polyenoate can be effectively removed through two times of molecular rectification, so that the purity and the quality of the product are improved. In addition, the method is high in yield, low in energy consumption, simple to operate, capable of utilizing conventional treatment devices of chemical plants, low in economic cost and suitable for industrial continuous production, and has important significance on preparation of high-quality ethyl polyenoate drugs.

This invention provides the application of a traditional Chinese medicine composition in the preparation of cardiovascular protective drugs after percutaneous coronary intervention (PCI) for myocardial infarction, specifically acute ST-segment elevation myocardial infarction (STEMI), with a TCM syndrome of "heart yang deficiency." The composition comprises raw Cornus officinalis, dried ginger, ginseng, Astragalus membranaceus, Atractylodes macrocephala, Alisma plantago-aquatica, Poria cocos, and Aconitum carmichaelii. The cardiovascular protective effects of this composition include improving cardiac function, inhibiting postoperative oxidative stress, reducing NT-proBNP, and decreasing the risk of cardiovascular events within one year post-surgery. It can be prepared as a decoction, oral liquid, or other dosage forms, and can be used in combination with conventional Western medicine treatments for synergistic effects. The composition of this invention is scientifically formulated, targets multiple points of action, and effectively addresses the problem of limited cardiovascular protection methods after PCI in STEMI patients, significantly improving patient prognosis and demonstrating good clinical application value.

The utility model relates to the technical field of boar transfer, in particular to a boar quick transfer device for boar breeding, and solves the problem that in the conventional treatment mode in the prior art, a worker uses a water gun to clean the bottom of an inner cavity of a transfer device, and the worker tries to flush excrement outwards. However, due to the limitation of the internal space structure of the transfer device, the cleaning mode is often difficult to achieve the thorough cleaning effect, and the problem that cleaning is not perfect enough exists. A rapid transfer device for matched breeding pigs for pig breeding comprises a cage body, a bottom frame is fixedly connected to the bottom of the cage body, universal wheels are installed at the four corners of the bottom of the bottom frame, a through groove is formed in one side of the cage body, a lead screw is horizontally arranged in an inner cavity of the bottom frame, and the outer ring of the lead screw is sleeved with a threaded sleeve; the outer ring of the threaded sleeve is fixedly connected with a connecting rod penetrating through the through groove. According to the utility model, the cleaning time and labor investment are reduced, a safer and more comfortable transfer environment is provided for swinery, and the disease transmission risk is reduced.