66results about How to "Strong side effects" patented technology

The invention belongs to the technical field of Chinese medicaments, and in particular relates to external Chinese medicinal lotion. The external Chinese medicinal lotion comprises the following components in portion by weight: 20 to 30 portions of common cnidium fruit, 20 to 30 portions of light-yellow sophora root, 20 to 30 portions of broom cypress fruit, 20 to 30 portions of glabrous greenbrier rhizome, 20 to 30 portions of cortex dictamni, 10 to 20 portions of raw stemona root, 10 to 30 portions of raw rhubarb, 10 to 30 portions of golden larch bark, 10 to 20 portions of corktree bark, and 6 to 10 portions of zanthoxylum husk. The conventional treatment method for gynecological inflammation, eczema and miliaria is medicament treatment which is easy to produce complications after long-term administration and has stronger side effect; and the external Chinese medicinal lotion for treating the inflammation, the eczema and the miliaria has little side effect, is simple and feasible, can be used for long term, and has better treatment effect.

The invention relates to a polymer composition loaded with a sirolimus compound or its derivative. The composition can have diversified forms. A necessary link includes preparing the sirolimus compound or its derivative and a polymer carrier into a micelle. Then according to needs, the micelle can be further prepared into a freeze-dried composition by a freeze-drying technology, or the micelle and other polymer and carrier can be prepared into a solid or semi-solid preparation. The polymer composition can be used for treating tumors, reducing rejection reactions after organ and tissue transplantation, promoting cell regeneration and repair, preventing excessive scar tissue growth after injury and preventing vascular restenosis and blood coagulation embolism, treating or inhibiting autoimmune diseases, and treating or inhibiting inflammation, etc.

The invention belongs to the field of medical technology and relates to preparation and application of a series of curcumin analogues. The curcumin analogues have structures as shown in the formula I, formula II and formula III, wherein R, R1 and R2 are as mentioned in the specification. Pharmaceutically acceptable salt and solvate of the curcumin analogues and a medicine containing the curcumin analogues or the pharmaceutically acceptable salt used as active components can be used in treatment of cancer. The curcumin analogues and the pharmaceutically acceptable salt have a good anticancer activity. A preparation method of the curcumin analogues is simple and feasible and is easy to operate.

The invention discloses an eosin liposome and making method, which comprises the following parts: 18-22mg eosin, 505-509mg lecithin, 90-95mg cholesterol, 73-77mg sodium deoxycholate, 505-509mg mannitol, 505-509mg lactose and 18-22mL phosphate buffer with pH value at 5.5-6.5. the making method comprises the following steps: (1) adding eosin, sodium deoxycholate, lecithin and cholesterol into chloroform; (2) decompressing; evaporating chloroform; (3) adding lactose and mannitol into phosphate buffer; (4) emulsifying phosphate buffer without fat film; (5) freezing; drying to obtain the product.

The invention relates to a chiral CB1 (cannabinoid) receptor inhibitor which is showed as a general formula A1 and a general formula A2 and has optical asymetery performance, and slat or solvate which is physiologically acceptable, in particular relates to a diaryl-replaced pyrazole ramification CB1 receptor inhibitor which is showed as the general formula A and the general formula B, has optical asymetery performance and is hypotoxic, and the method also discloses a preparation method and an application used for preparing medicaments for detoxification, weight losing, diabetes mellitus treatment or cardiovascular disease preventing, and all application on medical science related with the CB1 receptor inhibitor.

The present invention belongs to the technical field of medicine and biology, and relates to an antitumor drug synergism drug, particularly to a tumor treatment synergism drug composition comprising an autophagy inhibitor and adriamycin. The combination drug comprises one or a plurality of autophagy inhibitors and adriamycin, and is provided for treating tumors by adopting a combination administration or sequential use mode, wherein tumor cell autophagy induced by adriamycin can be inhibited to counteract antagonism effects of tumors on treatments of adriamycin due to autophagy so as to significantly enhance tumor treatment effects of adriamycin. The synergism drug composition is suitable for treatment of lymphoma, lung cancers, brain tumors, breast cancers and myeloma.

The invention provides a Mg-doped nickel-cobalt-aluminum ternary cathode material and a preparation method and application thereof. The Mg-doped nickel-cobalt-aluminum ternary cathode material has thechemical formula of (LiaNi1-x-yCoxAly)1-bMgbO2, with y>0, 1-x-y>0, 1< / =a< / =1.1, and 0<b< / =0.01. The preparation method comprises: sintering a ternary cathode material precursor Ni1-x-yCoxAly(OH)2+y;adding a lithium source and a doping material into the sintering resultant, and carrying out sintering; performing tertiary sintering to obtain the target product. The Mg-doped nickel-cobalt-aluminumternary cathode material prepared herein has good cycle performance. The preparation method having the triple sintering steps has simple technicality and controllable process and facilitates industrial large-scale production.

The invention provides a Ti-doped nickel-cobalt-aluminum ternary lithium ion battery positive pole material and a preparation method and use thereof. The material has a chemical formula of (LiaNi1-x-yCoxAly)1-bTibO2, x)0, y)0, 1-x-y)0, wherein a is greater than or equal to 1 and less than or equal to 1.1 and b is greater than 0 and less than or equal to 0.01. The preparation method comprises sintering a ternary positive electrode material precursor Ni1-x-yCoxAly(OH)2+y, adding a lithium source and a doping material into the sintering product, carrying out sintering and carrying out ternary sintering to obtain a desired product. The Ti-doped nickel-cobalt-aluminum ternary lithium ion battery positive pole material has excellent cycle performances. The preparation method comprises three sintering steps, has simple processes, is easy to control and is suitable for industrial production.

A Chinese medicine 'Compound Kushen lotion' for treating vaginitis, cervical erosion, morbid leukorrhea, pruritus vulvae, etc is prepared from 15 Chinese-medicinal materials including flavascent sophora root, honeysuckle flower, scutellaria root, liquorice root, etc through extracting, filtering and concentrating.

An application of the tumor cell nucleus monoantibody as the synergist in physically treating solid tumor by directionally combining with the necrotic tissue of tumor specifically and killing the tumor cells by the nuclein carried by it is disclosed. It features that the normal tissue can not be damaged.

The invention discloses a no-clean aggregation-induced cell membrane targeted dyeing reagent based on a purine skeleton, a preparation method and application thereof. According to the invention, the purine skeleton is adopted as the basis of a cell membrane dye, and through reasonable regulation design of lipid-soluble end and hydrophilic end, the cell membrane targeted dyeing reagent based on thepurine skeleton can be obtained. The reagent can stagnate on the cell membrane for a long time at the same time of targeted dyeing, and is beneficial to long-term monitoring. In addition, as the dyeing reagent has the characteristics of aggregation-induced compounds, emits weak or no light in good solvents and emits strong fluorescence in poor solvents, the dye also has the specific performance of no clean. The preparation method provided by the invention has the characteristics of high yield and mild reaction conditions, and the prepared dyeing reagent has large Stokes shift and high targeting ability.

A nickel-cobalt-aluminum ternary lithium ion battery anode material, and a preparation method therefor and an application thereof. The chemical formula of the material is (Li aNi 1-x-yCo xAl y) 1-bM bO 2, x>0, y>0, 1-x-y>0, 1<=a<=1.1, 0<b<=0.02. The preparation method for the material comprises: firstly sintering a ternary anode material precursor Ni 1-x-yCo xAl y(OH) 2+y; then adding the sinteredproduct into a lithium source for sintering; and finally adding a coating material and sintering to obtain a target product. The nickel-cobalt-aluminum ternary lithium ion battery anode material synthesized according to the preparation method has excellent cycle performance. The described preparation method is simple in technology, controllable in process and easy for industrial mass production.

The invention provides a medicine for treating heart failure in pet dogs. The medicine for treating the heart failure in the pet dogs is prepared from main medicines and auxiliary materials, the mainmedicines are prepared from the following percentage components: 0.5 to 5% of cannabinoid, 0.5 to 5% of cannabis oil, 0 to 1.2% of chitin, the balance of cannabidiol, wherein the cannabinoid, the cannabis oil, and the cannabidiol are extracted from industrial hemp, and the chitin is extracted from fish scales or oyster shells, and the auxiliary materials are medically acceptable auxiliary materials used for each dosage. The medicine prepared by the invention has good compatibility between the prepared pharmaceutical raw materials, and by conducting tests of preventing and treating heart failure in mice, the medicine has good therapeutic effects, and has small toxic and side effects, can be prepared into different dosage forms of drugs by conventional techniques, and has strong practicality.

The invention provides a liquiritin preparation with the molecular formula of C26H30O13 and the molecular weight of 550. The liquiritin is singly prepared or by matching with other active components or auxiliary materials, and the preparation composition is counted in such a way that 1000 particles contain 40g of liquiritin. The liquiritin preparation has stronger effect for relieving cough and eliminating phlegm, therefore, the preparation can be singly prepared by liquiritin or by the liquiritin matching with other active components or auxiliary materials, can be used for improving symptoms of cough and profuse sputum, and can be applied to the preparation of medicine for curing acute cough, chronic cough and profuse sputum. The liquiritin preparation originates from natural plants, can be made into a health-care product, and provides the natural cough-relieving medicine with less toxic side effect and obvious healing effect for clinical treatment.

The invention provides a doped nickel-cobalt-aluminum ternary lithium-ion battery positive electrode material as well as a preparation method and application. A chemical formula of the material is asfollows: (LiaNi1-x-yCoxAly)1-bMbO2, wherein x is greater than 0 and y is greater than 0; the 1-x-y is greater than 0; the a is greater than or equal to 1 and less than or equal to 1.1; the b is greater than 0 and less than or equal to 0.01. A preparation method of the material comprises the following steps: firstly, sintering a ternary positive electrode material precursor Ni1-x-yCoxAly(OH)2+y; then adding a sintered product into a lithium source and a doping material and sintering; finally, carrying out third-time sintering to obtain a target product. The doped nickel-cobalt-aluminum ternarylithium-ion battery positive electrode material synthesized by the preparation method provided by the invention has good circulating performance. The preparation method provided by the invention comprises three times of sintering steps and has the advantages of simple technology, controllable process and easiness for industrialized mass production.

The present invention discloses a copper glycyl-histidyl-lysine repair essence and a preparation method thereof. The copper glycyl-histidyl-lysine repair essence is characterized by consisting of thefollowing components in parts by weight: 70-75 parts of water, 4-6 parts of 1,3-propylene glycol, 2-4 parts of butanediol, 2-4 parts of a lactic acid bacteria fermentation lysis mixture, 2-3 parts ofan oat kernel extraction mixture, 2-3 parts of a brown algae extraction mixture, 2-3 parts of glycerin, 1-2 parts of a hydrolyzed soy protein mixture, 0.5-1.2 parts of a syzygium luehmannii fruit extract mixture, 0.6-1 part of a mulberry root extract mixture, 0.4-0.7 part of hyaluronic acid, 0.4-0.7 part of 1,2-hexanediol, 0.4-0.7 part of allantoin, 0.3-0.5 part of a centella asiatica extract, 0.3-0.5 part of p-hydroxyacetophenone, 0.3-0.5 part of a lotus flower extract mixture, 0.3-0.5 part of lactic acid, 0.1-0.2 part of copper glycyl-histidyl-lysine, 0.05-0.12 part of sunflower seeds, 0.05-0.12 part of hydrolyzed sclerotium gum, 0.05-0.12 part of sodium gluconate, 0.05-0.12 part of an achillea millefolium extract mixture, 0.04-0.06 part of glycyrrhiza glabra, 0.04-0.06 part of acetyl hexapeptide-8, 0.04-0.06 part of ascorbic acid, 0.02-0.04 part of a kappaphycus alvarezii extract, 0.005-0.011 part of a reed extract mixture, 0.005-0.011 part of a poria cocos extract mixture, 0.005-0.011 part of pentapeptide-3 and 0.005-0.011 part of disodium EDTA.

The invention relates to swim bladder collagen anti-oxidation and anti-fatigue protein peptide. The amino acid sequence of the swim bladder collagen anti-oxidation and anti-fatigue protein peptide is Gly-Glu-Pro-Gly-Pro-Met-Gly-Leu-Ala-Gly-Pro-Leu-Gly-Pro-Ala-Gly-Gly-Ser-Tyr-Glu-Ser-Lys-Pro-Asn-His, and the molecular weight of the swim bladder collagen anti-oxidation and anti-fatigue protein peptide is 6719.5718Da. The protein peptide has the advantages of being safe, free of toxic and side effects, capable of resisting oxidation and fatigue, high in activity, and the like.

The invention relates to a pest control technology, in particular to an attractant for a stored product pest stegobium paniceum and a preparation method thereof. The attractant is prepared by utilizing a radix notoginseng extract, an orange blossom extract, a lemon peel extract, a mint leaf extract, betaine, sodium alginate, guar gum, modified silicone and water. The attractant disclosed by the invention has the characteristics of small toxic and side effects, small residual quantity, efficient trapping and killing, long-acting release and high broad-spectrum property. The attractant disclosedby the invention is selected from natural components, is small in toxic and side effects and has strong attracting action on stored product pests such as the stegobium paniceum, tribolium castaneum,oryzaephilus surinamensis linne and sitophilus oryzae.

The present invention relates to a cosmetic composition, a health functional food composition, a pharmaceutical and a quasi-drug composition having an effect of improving skin wrinkles, improving skinmoisturization, removing skin keratin, improving skin elasticity, improving skin wrinkles, inhibiting erythema or improving skin photoaging, the composition containing ionone or a salt thereof as anactive ingredient. Since the ionone or a salt thereof of the present invention exhibits the activities of increasing skin moisture content, decreasing the amount of evaporation from skin, increasing the amount of procollagen secretion, promoting collagen biosynthesis, inhibiting collagen fiber damage, inhibiting collagen fiber decomposition, inhibiting erythema and inhibiting the thickening of a skin epidermal layer, the ionone or a salt thereof of the present invention can be effectively utilized as materials for functional cosmetics, health functional foods, pharmaceuticals and quasi-drugs,etc. that provide an effect of improving skin moisturization, removing skin keratin, improving skin elasticity, improving skin wrinkles, inhibiting erythema, improving skin wrinkles and / or improving skin photoaging.

The invention discloses an external use type natural medicine composition for preventing and treating acne. The external use type natural medicine composition is prepared from the following componentsof herba sophorae alopecuroidis extract, herba nasturtii officinale extract and flos spiraeae ulmariae extract; or aloperine, sophoridine, herba nasturtii officinale extract, and flos spiraeae ulmariae extract. The invention also provides a preparation method of the external use type natural medicine composition. The external use type natural medicine composition has the advantages that the composition is a natural medicine extract or a single compound composition, the natural property is good, the side effect is small, the easiness in production of medicine resistance is avoided, and the like; proofed by test, the bacteria-inhibiting and anti-inflammatory functions are better, and the growth, proliferation and inflammation of propionibacterium acnes , staphylococcus epidermidis and staphylococcus aureus are inhibited; the effects of inhibiting bacteria, resisting inflammatory and inhibiting grease excretion are realized, and the irritation to skin is smaller after using for a long time; the aloperine and sophoridine components have good synergistic function, the better bacteria-inhibiting and anti-inflammatory treatment effects are realized, and the application prospect is betterin acne treatment.

The invention discloses a disinfecting fan. A disinfecting device is arranged on a supporting rod of the fan, and a disinfecting function is achieved when the fan supplies air. A sterilizing and disinfecting function on fan blades and the external environment can be achieved without configuring an external disinfecting device. The disinfecting device comprises an ozone electrolysis generator set,an ozone mixing device and a spraying device. By means of power supply of a power source, ozone gas with a sterilizing and disinfecting effect is directly prepared and generated, and the prepared ozone gas is firstly introduced into the ozone mixing device to form ozone water; a disinfecting switch is pressed, a spraying motor drives a booster pump to work, and the ozone water in the ozone mixingdevice is drawn out to be sprayed to the fan blades through a plurality of disinfecting spraying pipes to disinfect the fan blades; and the disinfectant can be spread to the external environment through the rotating fan blades, ozone with the disinfecting function is prepared through the power source, and the disinfecting treatment function is achieved.

A recombinant fused egg albumen, its production are use are disclosed. The procedure is carried out by fusing, expressing, purifying to obtain final product. It can inhibit memory specifically, activate T-type cell and prolong half-life period. It can be used to large-scale prepare immune inhibiting product with high biological safety and specificity, treat, diagnose and inspect immune diseases.

A process for preparing the extract from the fresh ginger includes squeezing fresh ginger to obtain its juice, adding solid extractant chosen from starch, dextrin, cellulose, etc, extracting at 10-80 deg.C for 2-20 hrs, deposition, separating deposit, and drying to obtain the said extract, which is the mixture of volatile oil and gingerol.

The invention belongs to the technical field of preparation methods of rigid polyurethane foam, and discloses a method for preparing rigid polyurethane foam from epoxidized lignin polyol. The method comprises the following steps: adding polyether polyol into a reactor, adding lignin polyol, uniformly stirring, sequentially adding a catalyst, a foam stabilizer and a foaming agent, mixing, uniformly stirring, finally adding quantitative isocyanate, quickly stirring, and freely foaming to obtain the lignin-based rigid polyurethane foam material. The hydroxyl value ratio of the lignin polyol to the polyether polyol is (2: 8)-(4: 6). According to the method for preparing the lignin-based rigid polyurethane foam material, side reactions are few, and the prepared lignin-based rigid polyurethane foam material is excellent in mechanical property, high in uniformity and regularity of the structure and high in thermal stability.

The invention provides an Al-doping nickel-cobalt-aluminum ternary lithium ion battery positive electrode material as well as a preparation method and a purpose thereof. The material has a chemical formula of (LiaNi1-x-yCoxAly)1-bAlbO2, wherein the x is greater than 0; the y is greater than 0; 1-x-y is greater than 0; the a is greater than or equal to 1 but smaller than or equal to 1.1; the b is greater than 0 but smaller than or equal to 0.01. According to the preparation method of the material, firstly, a three-ingredient positive electrode material precursor Ni1-x-yCoxAly(OH)2+y is sintered; then, a lithium source and doping materials are added into the obtained materials after the sintering; sintering is performed; finally, the third time sintering is performed; target products are obtained. The doping nickel-cobalt-aluminum ternary lithium ion battery positive electrode material synthesized by the preparation method has excellent circulation performance. The preparation method comprises three times sintering steps; the process is simple; the process is controllable; the industrial mass production is easy.

The invention discloses a ceramide moisturizing cream and a preparation method thereof. The ceramide moisturizing cream is composed of the following components in parts by weight: a component 13: 1.8-2.5 parts of a beta-glucan mixture; a component 14: 1.8 to 2.5 parts of ceramide (3) mixture; a component 15: 1.8 to 2.5 parts of an extraction mixture of CLADOSIPHON OKAMURANUS; a component 16: 1-2 parts of a sodium hyaluronate mixture; a component 17: 1-2 parts of a MORUS NIGRA root extraction mixture; a component 18: 0.8 to 1.5 parts of glyceryl glucoside; a component 19: 0.8 to 1.5 parts of ectoin; and a component 21: 0.8 to 1.5 parts of a hamamelis virginiana (HAMAMELIS VIRGINIANA) leaf extraction mixture. The pure plant extract is adopted as a conditioner, the skin can be deeply nourished, and all the medicinal agents are kept within a reasonable range, so that effective conditioning can be guaranteed, and strong side effects are avoided.

The invention discloses a preparation method for an abalone fermentation product having a thrombolytic antihypertensive function, wherein the preparation method comprises the following steps: taking abalone tissues, washing cleanly, draining, freeze-drying, and crushing, to obtain an abalone freeze-dried powder; mixing a carbon source and the abalone freeze-dried powder with water, and adjusting the pH to 6.2-9.2; sterilizing, adding a bacillus subtillis natto suspension, at the temperature of 35-44 DEG C, ventilating, culturing for 45-60 h in a shaker, and thus obtaining an abalone fermentation liquid; centrifuging the abalone fermentation liquid, collecting a supernatant, concentrating, and freeze-drying to obtain the abalone fermentation product having the thrombolytic antihypertensive function. The abalone tissues are fermented by bacillus subtilis natto, nattokinase having thrombolytic effect can be generated, and abalone proteins also are degraded into proteins and polypeptides with smaller molecular weight, so as to be conducive to digestion and absorption; at the same time, the function of the fermentation product is further enriched, and the fermentation product gives full play to the thrombolysis, antihypertensive and antioxidant composite functions and the like.

The invention discloses a portulaca oleracea anti-allergic repair mask and a preparation method thereof. The portulaca oleracea anti-allergic repair mask comprises the following components in parts byweight; component 4, extract mixture from flowers / leaves / stems of portulaca oleracea 3-5 parts; component 5, extract mixture from leaves of hamamelis virginiana 3-5 parts; component 6, extract mixture from flowers of zantedeschia aethiopica 1.5-2.2 parts; component 7, extract mixture from flowers of citrus aurantium amara 1.5-2.2 parts; component 8, extract mixture from flowers of cereus grandiflorus 1.5-2.2 parts; component 9, extract mixture from gentiana lutea roots 1.5-2.2 parts; component 10, extract mixture from rhizomes / roots of taraxacum officinale 1.5-2.2 parts; component 11, extractmixture from rhizomes of artactyloides chinensis 1.5-2.2 parts; component 14, extract mixture from stalks of arundo donax 0.4-0.6 parts; and component 15, extract mixture from poria cocos sclerotium0.4-0.6 parts. According to the invention, all of the medicinal materials are kept within a reasonable range, so that effective conditioning can be ensured without stronger side effects.

The invention discloses an antisense oligonucleotide sequence against candida albicans infection and its use, screening an antisense oligonucleotide SEQ ID No:1 and its derivative using the core pseudoknot of candida albicans type I introne ribozyme as the targets, thus repressing the growth of the candida albicans. Test result shows that the antisense oligonucleotide can strongly repress the shearing reactivity of the candida albicans, and can result in the death of the candida albicans cells.

The invention discloses a carnosine firming-lifting facial mask and a preparation method of the mask. The carnosine firming-lifting facial mask comprises the following components in parts by weight: component four: 3-5 parts of honey extraction mixture; component five: 2-4 parts of American Sambucus (SAMBUCUS CANADENSIS) extraction mixture; component six: 2-4 parts of plankton (TETRASELMIS SUECICA) extraction mixture; components eight: 2-3 parts of hydrolyzed soy protein mixture; component nine: 1.5-2.5 parts of Helichrysum flower (HELICHRYSUM BRACTEATUM) extraction mixture; component ten: 1.5-2.5 parts of black mulberry (MORUS NIGRA) root extraction mixture; component twelve: 1-2 parts of centella (CENTELLA ASIATICA) extraction mixture; component thirteen: 0.6-1.1 parts of lotus (NELUMBIUM SPECIOSUM) flower extraction; component fifteen: 0.4-0.6 part of carnosine; and component sixteen: 0.4-0.6 part of bitter orange (CITRUS AURANTIUM AMARA) flower extraction mixture. According to thepresent invention, pure plant extracts are adopted as conditioning agents, the skin can be deeply nourished, and each medicinal agent is kept in a reasonable range, so that effective conditioning canbe ensured without strong side effects.