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Composition having effect of improving skin moisturization, removing skin keratin, improving skin elasticity, inhibiting erythema, improving skin wrinkles or improving skin photoaging, containing ionone or salt thereof as active ingredient

A technology for improving skin and skin keratin, applied to a composition containing ionone or its salt as an active ingredient to improve skin moisturizing, exfoliate skin, enhance skin elasticity, inhibit erythema, improve skin wrinkles or improve skin photoaging It can solve the problems of non-reporting and achieve the effects of reducing evaporation, improving skin wrinkles and inhibiting erythema.

Inactive Publication Date: 2019-02-15
PLANT SENSATION CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on the physiological activity of ionone is limited to the only report on the strong antibacterial activity of ionone against microorganisms harmful to the human body, and there is no report on other physiological activities at all.

Method used

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  • Composition having effect of improving skin moisturization, removing skin keratin, improving skin elasticity, inhibiting erythema, improving skin wrinkles or improving skin photoaging, containing ionone or salt thereof as active ingredient
  • Composition having effect of improving skin moisturization, removing skin keratin, improving skin elasticity, inhibiting erythema, improving skin wrinkles or improving skin photoaging, containing ionone or salt thereof as active ingredient
  • Composition having effect of improving skin moisturization, removing skin keratin, improving skin elasticity, inhibiting erythema, improving skin wrinkles or improving skin photoaging, containing ionone or salt thereof as active ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0090] 1. Wrinkle improvement effect of α-ionone using human skin fibroblasts

[0091] 1-1. Experimental method

[0092] 1) Cell culture

[0093] Human dermal fibroblasts (primary dermalfibroblast, normal, human, neonatal, ATCC No. PCS-201-010). Using fibroblast growth medium (promoted by Promo Cell, Germany, Heidelberg), the purchased cells were incubated at 37°C, 5% CO 2 grown in an incubator and used for experiments.

[0094] 2) Determination of the concentration of type Ⅰ procollagen C-peptide (Procollagen Type IC-peptide, PIP)

[0095] In order to study the biosynthetic performance of collagen, human fibroblasts were cultured at 1.0×10 6 The cells / well were dispensed into a 12-well plate, and α-ionone and vitamin C were added at a concentration of 100 μM, respectively. 2 Incubate for 24 hours in the incubator. After removing the medium in each well, wash once with phosphate-buffered saline (PBS), and then add 1 ml of phosphate-buffered saline, and wash at 20 mJ / c...

Embodiment 2

[0100] Example 2. Evaluation of skin wrinkle improvement, moisturizing and elasticity enhancing efficacy of α-ionone using mice

[0101] 2-1. Experimental method

[0102] 1) Preparation of experimental diet, feeding of experimental animals and ultraviolet irradiation

[0103] The 5-week-old female albino nude mice (Skh-1) used in this example were purchased from Orientbio Inc., Gyeonggi-do, Korea (Korea) and adapted to solid diet for 1 week. Expect. The experimental animals were divided into 4 groups, and 5 animals were assigned to each group for the experiment. The experimental groups used were divided into a normal control group not irradiated with ultraviolet light (-ultraviolet B), a ultraviolet irradiated group (+ultraviolet B), and a group ingested with α-ionone (αIO) or vitamin C (VitC) together with ultraviolet irradiation. During the feeding period, feed and water were freely ingested, the temperature was maintained at 22±1°C, the humidity was maintained at 60±5%...

Embodiment 3

[0142] Embodiment 3. Improve the functional test of skin wrinkles, skin irritation and exfoliation

[0143] 3-1. Nutritious cream containing α-ionone (experiment example 1) and nutrient cream not containing α-ionone (comparison Example 1) Preparation

[0144] table 3

[0145]

[0146] Among the components distinguished by the component numbers in the above Table 3, first, after dissolving components 1 to 8 by heating at 70°C, components 9 to 13 are dissolved and dispersed in component 14 and heated to 70°C. emulsification. Then, the above-mentioned emulsion was cooled to a temperature of 56°C, and thereafter, component 15 dissolved in component 9 dispensed was added and stirred, and cooled at room temperature to complete the preparation.

[0147] In Comparative Example 1 with respect to Experimental Example 1 described above, the composition and production method of the components other than α-ionone, which is Component 15, were prepared in the same manner.

[0148] ...

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Abstract

The present invention relates to a cosmetic composition, a health functional food composition, a pharmaceutical and a quasi-drug composition having an effect of improving skin wrinkles, improving skinmoisturization, removing skin keratin, improving skin elasticity, improving skin wrinkles, inhibiting erythema or improving skin photoaging, the composition containing ionone or a salt thereof as anactive ingredient. Since the ionone or a salt thereof of the present invention exhibits the activities of increasing skin moisture content, decreasing the amount of evaporation from skin, increasing the amount of procollagen secretion, promoting collagen biosynthesis, inhibiting collagen fiber damage, inhibiting collagen fiber decomposition, inhibiting erythema and inhibiting the thickening of a skin epidermal layer, the ionone or a salt thereof of the present invention can be effectively utilized as materials for functional cosmetics, health functional foods, pharmaceuticals and quasi-drugs,etc. that provide an effect of improving skin moisturization, removing skin keratin, improving skin elasticity, improving skin wrinkles, inhibiting erythema, improving skin wrinkles and / or improving skin photoaging.

Description

technical field [0001] This application is based on the Korean patent application No. 10-2016-0077927 and the filing date is June 22, 2016, and claims the priority of the Korean patent application. The entire content of the Korean patent application is incorporated herein. application for reference. [0002] The present invention relates to a composition comprising ionone or a salt thereof as an active ingredient. More specifically, it can be used to enhance skin moisture content, reduce skin moisture evaporation, increase procollagen secretion, promote collagen biosynthesis, inhibit collagen Protein fiber damage, inhibition of collagen fiber decomposition, inhibition of erythema and inhibition of hypertrophic activity of the skin epidermis ionone or its salt to provide improved skin moisturizing, exfoliation, enhance skin elasticity, inhibit erythema, improve skin wrinkles and / or Cosmetic composition, health food composition, medicine and quasi-drug composition for improving...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/35A23L33/10A23L33/15A23L33/18A61K8/36A61K8/64A61K8/67A61K8/9722A61Q19/08
CPCA23L33/105A23V2002/00A61K8/35A61K2800/28A61Q19/007A61Q19/08A23V2250/156A23V2250/702A23V2250/704A23V2250/708A23V2250/032A23V2250/0644A23V2250/28A23L33/10A23L33/18A23L33/15A61K8/361A61K8/64A61K8/676A23V2200/318A61K8/9706
Inventor 朴太瑄
Owner PLANT SENSATION CO LTD
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