Liquiritin preparation and application thereof

A technology of liquiritin and preparations, applied in the field of liquiritin preparations and applications, can solve problems such as diseases or symptoms that have not yet been seen, and achieve the effect of promoting the excretion of phenol red in the airways of mice, with significant curative effect and strong expectorant effect

Inactive Publication Date: 2009-09-02
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no reports of it being prepared into medicine and treating any disease or symptom

Method used

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  • Liquiritin preparation and application thereof
  • Liquiritin preparation and application thereof
  • Liquiritin preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1. Composition and preparation process of Liquiritin Capsules

[0016]

[0017]

[0018] 2. Preparation basis and screening process

[0019] 2.1 Preparation Basis

[0020] Formulate Liquiritin Capsules according to pharmacodynamic tests, specifications: Liquiritin content 40mg / capsule.

[0021] The role of excipients in the prescription: sodium hydroxide: solubilizer; povidone: binder; meglumine: solubilizer; microcrystalline cellulose: diluent, disintegrant; lactose: diluent.

[0022] Dissolve liquiritin with ethanol solution of sodium hydroxide. The preliminary test shows that it is not completely dissolved at the theoretical value of complete salification of liquiritin (liquiritin: sodium hydroxide = 40:3.1), and a slight excess of sodium hydroxide is liquiritin. :Sodium hydroxide=40:3.2 can just dissolve completely.

[0023] Then concentrate and dry the solution to a concentrated solution, add different diluents and stir to disperse evenly, make wet granule...

Embodiment 2

[0056] Embodiment 2 pharmacodynamic research

[0057] The experimental protocol was designed with reference to the State Food and Drug Administration's "Compilation of Guiding Principles for Preclinical Research of New Drugs (Western Medicine) (Pharmacology, Pharmacology and Toxicology)". Using 2 kinds of antitussive drug experimental animal models, 2 kinds of expectorant drug experimental animal models and 3 kinds of anti-asthma test methods, the studies on the anti-asthma, antitussive and expectorant aspects of Liquiritin Capsules or Tablets were carried out. The test materials, methods and results are as follows:

[0058] 1. Materials:

[0059] Drugs and Reagents

[0060] 1) Citric acid: Shanghai Chemical Reagent No. 1 Factory, batch number 20070201, prepared with distilled water to a concentration of 15% for later use;

[0061] 2) Codeine Phosphate Tablets: Qinghai Pharmaceutical Factory, batch number 20060615; prepared into 0.5mg / ml suspension with distilled water;

...

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PUM

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Abstract

The invention provides a liquiritin preparation with the molecular formula of C26H30O13 and the molecular weight of 550. The liquiritin is singly prepared or by matching with other active components or auxiliary materials, and the preparation composition is counted in such a way that 1000 particles contain 40g of liquiritin. The liquiritin preparation has stronger effect for relieving cough and eliminating phlegm, therefore, the preparation can be singly prepared by liquiritin or by the liquiritin matching with other active components or auxiliary materials, can be used for improving symptoms of cough and profuse sputum, and can be applied to the preparation of medicine for curing acute cough, chronic cough and profuse sputum. The liquiritin preparation originates from natural plants, can be made into a health-care product, and provides the natural cough-relieving medicine with less toxic side effect and obvious healing effect for clinical treatment.

Description

technical field [0001] The invention belongs to the application of medicines, and relates to medicinal preparations and uses of liquiritin, in particular to the application of liquiritin in the preparation of medicines for treating cough and excessive phlegm. Background technique [0002] With the development of the global economy, industrial and civil pollution sources are increasing, coupled with factors such as poor environmental governance, the incidence of respiratory diseases is on the rise, and the mortality rate is also increasing year by year. At present, respiratory diseases have become one of the major human diseases. One of the "killers". However, this also creates a broader market space for companies that produce drugs for respiratory diseases. As an important part of respiratory system drugs, the market for expectorant and antitussive drugs is also increasing year by year. Cough and phlegm are the main symptoms of respiratory diseases, and the application of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P11/14A61P11/10
Inventor 谢强敏吴希美谢诒诚董新威曹睿
Owner ZHEJIANG UNIV
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