31 results about "Chronic cough" patented technology

The embodiment of the invention provides a traditional Chinese medicine preparation for improving lung qi and yin deficiency constitution and a preparation method thereof. The traditional Chinese medicine preparation is prepared from the following raw materials: 1-3 parts of American ginseng, 2-15 parts of Chinese yam, 1.5-9 parts of codonopsis pilosula, 1-6 parts of dendrobium officinale, 1.5-9 parts of rhizoma polygonati, 0.5-2 parts of schisandra chinensis, 2-6 parts of lily, 1-3 parts of pericarpium citri reticulatae, 1-2 parts of liquorice, 1-5 parts of folium mori, 1-3 parts of donkey-hide gelatin, 1-3 parts of mint, 1-6 parts of angelica sinensis and 2-9 parts of coix seeds. Therefore, the traditional Chinese medicine composition has the functions of tonifying qi and yin, clearing heat and moistening lung, replenishing blood and promoting salivation, and relieving cough and reducing sputum, and can be widely applied to chronic cough, various pneumonia, pulmonary tuberculosis, chronic obstructive pulmonary disease, lung malignant tumor, asthma remission period of asthma, respiratory failure and other syndrome-differentiated lung qi and yin deficiency patients.

This invention relates to a crystalline form of camlipixant and its use in pharmaceutical compositions as well as in therapy, in particular use in the treatment of refractory chronic cough. (I)

The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a preparation method of a traditional Chinese medicine composition for intractable chronic cough and application thereof; and particularly discloses a traditional Chinese medicine composition for treating intractable chronic cough, which comprises, by weight fraction, 10-40 parts of Poria cocos, 3-25 parts of fried licorice, 3-20 parts of Schisandra chinensis, 1-20 parts of dried ginger, 1-12 parts of Asarum, 3-20 parts of prepared pinellia, 3-20 parts of bitter apricot kernel, 5-40 parts of white mulberry bark, 3-25 parts of bupleurum, 3-25 parts of wind-protecting plant, 5-40 parts of north-sand peony and 1-5 pieces of centipede. The application is a pure traditional Chinese medicine prescription, has high safety and good efficacy, and can quickly relieve symptoms of intractable chronic cough patients, and is suitable for clinical popularization and application due to wide drug source.

Systems, methods, and computer programs disclosed herein relate to training and using a machine learning model for classifying individuals suffering from chronic cough at least partially based on information about cough events of the patient.

The invention discloses an application of a Chinese prickly ash extract in cigarettes, the Chinese prickly ash extract used in the application comprises chain aliphatic hydrocarbon and Chinese prickly ash volatile oil, and the mass ratio of the chain aliphatic hydrocarbon to the Chinese prickly ash volatile oil is 1: 2-1: 5; the chain aliphatic hydrocarbon is long-chain n-alkane, and the number of carbon atoms in the long-chain n-alkane is 16-30; chain aliphatic hydrocarbon and pepper volatile oil in the pepper extract are directly mixed with tobacco shreds or added into cigarettes by means of blasting beads, so that the cigarettes have natural, pure and thicker fragrance, internal heat and pungency of the tobaccos can be greatly reduced, the taste of the cigarettes is obviously improved, and the components are extracted from pepper, safe, reliable and free of toxic and side effects. The pepper volatile oil can also expel phlegm dampness of a human body, so that the risk of inducing diseases such as asthma and chronic cough is reduced, and the harm to the human body is reduced compared with a traditional cigarette.

The invention relates to the use of camlipixant in the treatment of cough, in particular chronic cough, and drug-drug interactions when administered with a CYP3A4 inducer and / or CYP2C8 inducer.

Provided herein are compounds, including ifenprodil, and pharmaceutical compositions for use in treating refractory chronic cough. The compounds and pharmaceutical compositions may also be suitable for treating refractory chronic cough in subjects also diagnosed with idiopathic pulmonary fibrosis.

The invention relates to the technical field of data processing, in particular to a system and a method for auxiliary analysis of hormone-sensitive chronic cough, and the method comprises the following steps: collecting target indexes of a patient, including allergic disease history, sour regurgitation heartburn symptom, hematophilic granulocyte count, CRP, IgE, FEV1 / FVC and FeNO; preprocessing the target index to obtain a preprocessed index; and generating a risk score corresponding to the hormone-sensitive chronic cough according to the pretreatment index. In order to solve the problems that in the prior art, hormone-sensitive cough diagnosis indexes need to depend on a complex detection instrument to be collected, and implementation is difficult, on the basis of regression analysis, the indexes of auxiliary analysis are determined to be clinical data which can be obtained easily based on clinical symptoms, blood routine indexes, lung function examination and the like of a patient, and the hormone-sensitive cough diagnosis indexes are obtained. And a related auxiliary analysis system is established, so that complex instruments required in the traditional medical examination process are omitted, and the medical examination process can be quickly completed in any level of medical institutions.

The invention relates to a salt derivative of (R)-6-(5-fluoropyridin-2-yl)-8-methoxy-N-(1-(5-methyl-1, 2, 4-oxadiazol-3-yl) ethyl) quinazoline-4-amine, in particular to a salt derivative of (R)-6-(5-fluoropyridin-2-yl)-8-methoxy-N-(1-(5-methyl-1, 2, 4-oxadiazol-3-yl) ethyl) quinazoline-4-amine, and a salt derivative of (R)-6-(5-fluoropyridin-2-yl)-8-methoxy-N-(1-(5-methyl-1, 2, 4-oxadiazol-3-yl) ethyl) quinazoline-4-amine. The present invention relates to mesylate and ethanesulfonate salts of 2, 4-oxadiazol-3-yl) ethyl) quinazolin-4-amine, pharmaceutical compositions containing such salts, and therapeutic uses thereof. The salts of the invention are useful in the treatment of diseases or conditions associated with respiratory diseases, in particular chronic cough.

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating refractory chronic cough and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-12 parts of ephedra, 6-12 parts of semen armeniacae amarae, 6-12 parts of scutellaria baicalensis, 6-12 parts of gardenia jasminoides, 4-8 parts of platycodon grandiflorum, 6-12 parts of radix ophiopogonis, 6-12 parts of thunberg fritillary bulb, 6-12 parts of exocarpium citri rubrum, 6-12 parts of poria cocos, 4-8 parts of white mulberry root-bark, 4-8 parts of rhizoma anemarrhenae, 4-8 parts of semen trichosanthis and 6-12 parts of honey-fried licorice root. The compatibility of the traditional Chinese medicine composition accords with the theory of monarch, minister, assistant and guide in traditional Chinese medicine, the compatibility is ordered, and the whole formula has the effects of dispelling cold, clearing heat, nourishing yin, relieving cough and reducing phlegm. Clinical effects show that after the traditional Chinese medicine composition is used for treating the refractory chronic cough for two weeks, the total effective rate of treatment reaches up to 97.73%, and the treatment effect is remarkable.

The present invention relates to methods for treating patients with chronic cough with nalbuphine compositions as well as treating cough, breathlessness, or dyspnea associated with IPF with nalbuphine compositions, wherein the method provides a therapeutic effect in a patient.

The invention provides a cough-relieving medicine for treating chronic cough after respiratory virus infection and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The cough-relieving medicine disclosed by the invention is prepared from fructus mume, radix platycodonis, herba taraxaci, rhizoma dioscoreae, honeysuckle flower, fructus jujubae and fructus momordicae. According to the invention, dandelion and honeysuckle are used as monarch drugs, momordica grosvenori and platycodon grandiflorum are used as ministerial drugs, Chinese yam and jujube are used as adjuvant drugs, and dark plum is used as a conductant drug. By adjusting the composition of the raw materials, the raw materials play a synergistic role, and the prepared cough relieving medicine has the effects of tonifying lung deficiency, eliminating cold-dampness, eliminating dampness and heat, freeing lung qi and the like.

The present application relates to the technical field of tongue diagnosis image enhancement processing, and specifically to a method for detecting chronic cough syndrome differentiation in traditional Chinese medicine based on tongue diagnosis image enhancement, comprising: obtaining a patient's tongue diagnosis grayscale image; analyzing the tongue coating roughness reflected in the grayscale co-occurrence matrix of each edge pixel point in each direction, and combining the degree of difference in the tongue coating roughness corresponding to each direction to obtain the significance of multi-directional cracks in the tongue coating of the local area of ​​each edge pixel point; by analyzing the average level and change of the multi-directional crack significance of edge pixels near each edge pixel point, obtaining the fluid loss attention of each pixel point; and using an adaptive contrast enhancement algorithm based on the fluid loss attention to perform contrast enhancement on the tongue diagnosis grayscale image, and using a convolutional neural network in combination with the enhanced tongue diagnosis image to detect chronic cough. The present application can significantly enhance the tongue diagnosis image and improve the contrast enhancement accuracy of the tongue diagnosis image.

1. Name of the product in this design: Fog reservoir (for both mouth and nose). 2. Intended use of this design: an inhalation device for the simultaneous treatment of rhinitis, asthma, adenoid hypertrophy, allergic rhinitis-asthma syndrome, chronic cough, and COPD. 3. The key design feature of this product is its shape. 4. The picture or photo that best illustrates the key design points: Design 1 Combined State Diagram 1. 5. Design 1 is designated as the basic design. 6. Other situations requiring explanation: In the 3D diagram of component 1, part A is made of transparent material.

1. Name of the product under this design: Diaphragm Pacemaker (DSR‑1). 2. Purpose of the product of this design: For the auxiliary treatment of shortness of breath or difficulty breathing, chronic cough, sputum, and wheezing symptoms caused by chronic obstructive pulmonary disease. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the key points of the design: main view.

The application belongs to the technical field of Chinese patent medicines, and provides a use of Guiling tablets in the preparation of a medicine for treating stress urinary incontinence or bladder cough. On the basis of the known efficacy of Guiling tablets, a commercially available Chinese patent medicine, for treating kidney deficiency causing asthma and lung deficiency causing chronic cough, the application uses the kidney tonifying and qi consolidating effect of Guiling tablets to treat stress urinary incontinence or bladder cough, and very significant effects are observed on the incontinence of urine caused by excessive cough and asthma due to kidney deficiency in the middle-aged and the elderly, especially in middle-aged and elderly women.

The present invention provides a traditional Chinese medicine composition for treating cough caused by a cold, and its preparation method and application, belonging to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition of the present invention is composed of cooked aconite root, dried ginger, ginseng, stir-fried white atractylodes macrocephala, roasted licorice root, stir-fried coix seed, poria, bupleurum root, white peony root, immature bitter orange, ephedra, apricot kernel, forsythia suspensa, gypsum, cicada slough, and amethyst. The present invention uses aconite root and dried ginger to warm yang as the main medicine; ginseng and atractylodes macrocephala nourish the middle and replenish qi; bupleurum root and white peony root, one ascending and one astringing, and apricot kernel invigorating qi, which not only soothe the liver and regulate qi to avoid qi stagnation, but also guide warming herbs upward, as the ministerial medicine; coix seed and poria strengthen the spleen and eliminate dampness; ephedra, apricot kernel, gypsum, forsythia suspensa, cicada slough, and amethyst to promote lung function and relieve cough; roasted licorice root relieves urgency, harmonizes the middle, and can also harmonize the other medicines as the guiding medicine; the combination of these medicines achieves the effects of warming yang, regulating qi, promoting lung function and relieving cough. The composition of the present invention is used for treating post-infectious cough and chronic cough of lung and spleen yang deficiency type, with a total effective rate of up to 94.4%, a low recurrence rate and no adverse reactions.

A class of arylcarboxamide compounds, their preparation methods, and pharmaceutical uses. Specifically, the present invention relates to compounds represented by general formula (I), their preparation methods, and pharmaceutical compositions containing the compounds, as well as their use as P2X3 receptor antagonists, and for treating and / or preventing diseases associated with P2X3 receptor activity, such as chronic cough, pain, endometriosis, and overactive bladder. The definitions of the substituents in general formula (I) are the same as those in the specification.

A digital therapeutic method for delivering personalized Behavioral Cough Suppression Therapy through an electronic device, such as a smartphone, operates by collecting both objective data (such as cough sounds detected by the device's microphone and analyzed by a processor) and subjective data (self-reported by the patient through the app). By combining these two data streams, the device automatically generates personalized recommendations for cough suppression strategies. The method includes detecting patterns in cough events, such as trends over time, bouts of coughing, or periods of reduced coughing, and adjusting recommendations dynamically. The system also tracks adherence to therapy, guides patients through suppression training sessions, and generates progress reports. It can elicit potential cough triggers and deliver specific advice for managing them. Importantly, the recommendation engine can use machine learning to refine its suggestions based on ongoing data, enabling increasingly tailored and effective support.

The present invention relates to salt derivatives of (R)-6-(5-fluoropyridine-2-yl)-8-methoxy-N-(1-(5-methyl-1,2,4-oxadiazole-3-yl)ethyl)quinazoline-4-amine, and more particularly to mesylates and esylates of (R)-6-(5-fluoropyridine-2-yl)-8-methoxy-N-(1-(5-methyl-1,2,4-oxadiazole-3-yl)ethyl)quinazoline-4-amine, pharmaceutical compositions containing them, and their therapeutic uses. The salts of the present invention may be useful in the treatment of respiratory diseases, particularly diseases or conditions associated with chronic cough.

The invention relates to the technical field of tongue diagnosis image enhancement processing, in particular to a traditional Chinese medicine chronic cough syndrome differentiation detection method based on tongue diagnosis image enhancement, and the method comprises the steps: obtaining a tongue diagnosis gray image of a patient; and analyzing the roughness of the tongue coating embodied in the gray-level co-occurrence matrix of each edge pixel point in each direction, and combining the difference degree of the roughness of the tongue coating corresponding to each direction to obtain the multi-direction crack significance of the dry crack of the tongue coating in the local area of each edge pixel point. By analyzing the average level and the change condition of the multidirectional crack significance of the edge pixel points near each edge pixel point, acquiring the body fluid loss attention of each pixel point, and according to the body fluid loss attention, performing contrast enhancement on the tongue diagnosis grayscale image by adopting a self-adaptive contrast enhancement algorithm, so as to obtain the image of the tongue diagnosis grayscale image. And detecting the chronic cough by combining the convolutional neural network with the enhanced tongue diagnosis image. According to the invention, the tongue diagnosis image can be significantly enhanced, and the contrast enhancement precision of the tongue diagnosis image is improved.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating plateau chronic cough, which is prepared from the following raw materials in parts by weight: 2-30 parts of thunberg fritillary bulb, 2-30 parts of burdock root, 1-15 parts of radix asparagi, 1-15 parts of bamboo shavings, 1-15 parts of honey white mulberry root-bark, 1-15 parts of fructus chebulae, 1-10 parts of pericarpium citri reticulatae, 1-15 parts of herba houttuyniae, 1-15 parts of radix glehniae, 2-30 parts of radix astragali and 2-10 parts of fructus momordicae.

The invention relates to the use of camlipixant in the treatment of cough, in particular chronic cough, and drug-drug interactions when administered with a CYP2C8 inhibitor.

The invention relates to a polymer triple-energy patch medicine film and a preparation method thereof, and relates to the technical field of traditional Chinese medicine external application, the medicine film is prepared by mixing medicine freeze-dried powder and a polymer film-forming material according to the mass ratio of 1: 1, and the medicine freeze-dried powder is prepared by grinding, freeze-drying and superfine grinding of traditional Chinese medicinal materials such as semen brassicae, corydalis tuber, asarum and euphorbia kansui; the high-molecular film-forming material is prepared from a polydimethylsiloxane cross-linked polymer, polyglycerol-3 isostearate, a nitrogen-copper complex, artemisia argyl oil and superfine silica powder in parts by weight. The stability and permeability of the traditional Chinese medicine are improved through freeze drying and ultra-micro treatment technologies, rapid film forming and stable application are achieved by introducing an organic silicon film forming system, the drug effect release efficiency and skin safety are remarkably improved, and the three-volt patch is particularly suitable for treating respiratory system diseases such as children asthma, chronic cough and allergic rhinitis. Meanwhile, an intelligent mobile terminal program developed in a matched mode can achieve application period reminding, acupoint guiding and medication science popularization, and family nursing compliance is enhanced.

The invention discloses a traditional Chinese medicine composition for treating chronic cough caused by phlegm-dampness obstructing lung and wind-disturbing reversed-qi flow as well as a preparation method and application of the traditional Chinese medicine composition, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 18 parts of radix bupleuri, 7 to 14 parts of radix scutellariae, 10 to 18 parts of rhizoma pinelliae, 10 to 14 parts of cortex magnoliae officinalis, 8 to 12 parts of semen armeniacae amarae, 7 to 12 parts of lumbricus, 10 to 15 parts of poria cocos, 6 to 12 parts of fructus perillae, 6 to 12 parts of radix platycodonis and 8 to 12 parts of radix angelicae sinensis. The radix bupleuri and the pinellia ternate are used as monarch drugs for treating core pathogenesis, the ministerial drugs are used for assisting and synergism, the adjuvant drugs are used for comprehensively complementing the pathogenesis and performing targeted conditioning, so that the drugs are used for guiding channels and regulating the middle warmer, strengthening the body resistance and harmonizing and progressively increasing layer by layer, the symptoms such as cough, asthma and excessive phlegm are quickly relieved, and the effects of reducing phlegm, clearing damp, regulating qi activity, fixing and protecting lung and spleen and completely eradicating relapse are achieved. The traditional Chinese medicine composition accords with the principle that the symptoms are treated when urgent treatment is carried out and the root is treated when slow treatment is carried out, and a unique treatment scheme is formed.

The invention discloses an application ointment for chronic cough and asthma diseases, a preparation method and a use method, which can effectively treat chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease, bronchiectasis, chronic cough, pulmonary fibrosis and the like with cough and asthma as main symptoms, and is non-invasive, convenient and non-irritant to skin. The application ointment for treating the chronic cough and asthma diseases is prepared from the following raw materials in percentage by mass: 12 to 13 percent of herba ephedrae, 12 to 13 percent of semen armeniacae amarae, 24 to 26 percent of perillaseed, 12 to 13 percent of semen brassicae, 12 to 13 percent of semen raphani, 5 to 7 percent of datura seed, 12 to 13 percent of earthworm, 1 percent of sesame oil and 2 percent of ginger juice.

The invention discloses a preparation method of a traditional Chinese medicine ointment for treating cough. The preparation method comprises the following steps: step 1, preparing materials; step 2, crushing; step 3, mixing; step 4, extracting and concentrating; step 5, forming; the prescription is derived from a classic famous prescription, and the whole prescription has the effects of replenishing qi to invigorate the spleen, drying dampness, reducing phlegm, ventilating the lung and relieving cough. A chronic cough patient with a long course of disease is often deficient in both qi and yin. Ginseng with mild medicine property has strong energy tonifying capacity, but can help dampness to generate heat or warm dryness hurts lung yin, and is not the best choice for phlegm-dampness symptoms. The radix pseudostellariae has the effects of tonifying qi and yin, is mild in nature, can promote salivation and moisten the lung while tonifying qi of the spleen and the lung, and conforms to the chronic cough pathogenesis of spleen deficiency and excessive dampness and slight lung fluid damage.

The invention belongs to the technical field of traditional Chinese medicines and provides a traditional Chinese medicine composition for treating acute and chronic cough and a preparation method thereof. The composition comprises thunberg fritillary bulb, trichosanthes kirilowii maxim, white mulberry root-bark, honeysuckle, fructus forsythiae, scutellaria baicalensis, radix isatidis, rhizoma pinelliae preparata, semen armeniacae amarae, fructus arctii, poria cocos, pericarpium citri reticulatae, lumbricus, peach kernel, platycodon grandiflorum, magnolia flower, lily and liquorice, is mainly used for treating the phlegm-heat obstructing lung syndrome, and has the common symptoms of cough, yellow and thick phlegm cough, fever, asthma, red, swollen and painful throat or nasal obstruction, dry mouth and the like. The traditional Chinese medicine composition disclosed by the invention has a very good curative effect on acute bronchitis, acute attack of chronic bronchitis, cough allergic asthma and cough after cold, particularly can quickly relieve the symptoms such as catarrhal symptom, nasal obstruction, saliva, excessive sputum and cough, and has a wide market application prospect.

1. Name of the product under this design: Diaphragm Pacemaker (DSR‑2). 2. Purpose of the product of this design: For the auxiliary treatment of shortness of breath or difficulty breathing, chronic cough, sputum, and wheezing symptoms caused by chronic obstructive pulmonary disease. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the key points of the design: main view.