1936results about How to "Low recurrence rate" patented technology

A stent, or device for repair and reconstruction of the spinal disc wall, or annulus fibrosus, after surgical incision or pathologic rupture, which is inserted through an aperture into the subannular space. The stent has radial extensions which are caused or allowed to expand into an expanded configuration to bridge the aperture. The stent thereby occludes the defective region from the inside of the vertebral disc and prevents the migration of nucleus pulposus therethrough, while also providing a scaffold for tissue growth.

Described herein are therapeutic targets expressed in cancer stem cells and methods for treating and diagnosing cancer by targeting such cells with antibodies, compounds, nucleic acid, or other therapeutic agent. In one embodiment described herein, therapeutic agents for the treatment of cancer are provided based on the identification of cancer stem cell targets. The present invention also includes therapeutic targets for cancer therapy and cancer stem cell-targeted therapy. The invention includes the treatment of cancer by the administration of compounds or agents that target cancer stem cells.

The present invention provides compounds of formula (I),wherein:R1 is unsubstituted C1-C6 alkyl;La is substituted or unsubstituted C1-C6 alkyl linker, substituted or unsubstituted C3-C10 carbocycle, substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, or substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S; andR2 and R3 are each, independently, H, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted C6-C10 aryl;or alternatively, R2 and R3, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S or a substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S.The invention also provides pharmaceutical compositions and methods for treating neurological diseases, such as multiple sclerosis.

The present invention provides methods for inhibiting interleukin-3 receptor-expressing cells, and, in particular, inhibiting the growth of such cells by using a diphtheria toxin-human interleukin-3 conjugate (DT-IL3) that is toxic to cells expressing the interleukin-3 receptor. In preferred embodiments, the DT-IL3 conjugate is a fusion protein comprising amino acids 1-388 of diphtheria toxin fused via a peptide linker to full-length, human interleukin-3. In certain embodiments, the methods of the present invention relate to the administration of a DT-IL3 conjugate to inhibit the growth of cancer cells and / or cancer stem cells in humans, which cells express one or more subunits of the interleukin-3 receptor. Exemplary cells include myeloid leukemia cancer stem cells. In other embodiments, the methods of the present invention relate to ex vivo purging of bone marrow or peripheral blood to remove cells that express one or more subunits of the interleukin-3 receptor such that the purged bone marrow or peripheral blood is suitable, e.g., for autologous stem cell transplantation to restore hematopoietic function.

The invention relates to a Chinese medicinal preparation for treating cancer, and the Chinese medicinal preparation is prepared from 110 raw material drugs, such as yew, barbed skullcap herb, hairyvein agrimony and laggera pterodonta. The preparation can be oral solution, granules, powder, capsules, electuary and tablets. 110 Chinese medicaments are adopted, and monarch, minister, assistant and guide drugs are reasonably compatible and are comprehensively taken to play the effect of treating both principal and secondary aspect of cancers. The raw material drugs adopted in the Chinese medicinal preparation are common Chinese medicaments, and are low in manufacture cost and small in side effect. The medicament has the advantages of capabilities of effectively strengthening the body immunity and attacking pathogen without hurting a body along with quick response, high curative rate, high heal rate, low relapse rate, treatment of both principal and secondary aspect of cancers, safety and reliability, and can be used for treating various types of cancers, especially lung cancer, gastric cancer, liver cancer, esophagus cancer, pancreatic cancer, cervical cancer and breast cancer.

The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3Rα) chain, and compositions comprising such antibodies. The present invention provides methods for inhibiting or reducing an IL3Rα-expressing cell population, the methods comprising contacting a population of IL3Rα-expressing cells (e.g., cancer cells and / or cancer stem cells) with an antibody that binds to IL3Rα. The present invention also provides antibody conjugates comprising an antibody that binds to an IL3Rα chain linked to a cytotoxic agent or anticellular agent and compositions comprising such conjugates. The present invention also provides methods for preventing, treating and / or managing a disorder associated with IL3Rα-expressing cells (e.g., a hematological cancer), the methods comprising administering to a subject in need thereof an antibody that binds to IL3Rα.

The invention discloses a traditional Chinese medicine preparation for treating cancer, which is prepared by 103 types of bulk drugs such as solidago decurrens, Chinese sage herb, hypericum japonicumand the like. A preparation method of the traditional Chinese medicine preparation comprises the following steps: preparing the bulk drugs into water extract by a conventional method; using the prepared water extract for preparing oral solution by a traditional method; drying the obtained water extraction, then conducting grinding and sieving; taking the throughs for extracting powder, and using the extracted powder for preparing tablets, granules, electuaries or capsules by a traditional method. The preparation method also can be as follows: sieving out the dust of the bulk drugs, conductinggrinding and sieving, taking the throughs, conducting disinfection and sterilization to obtain raw powder, and using the raw powder for preparing tablets, granules, electuaries or capsules by a traditional method. With drugs mixed rationally, the traditional Chinese medicine preparation addresses both the symptoms and root causes of cancer. The bulk drugs are frequently-used common Chinese drugs,have low preparation cost and small side effect, and can effectively enhance own immunity, attack pathogen while do not damage body. The traditional Chinese medicine preparation can cure various typesof cancer, particularly lung cancer, stomach cancer, liver cancer, esophageal cancer, pancreatic cancer, cervical cancer and breast cancer.

This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.

The subject invention provides for methods of reducing the relapse rate and / or reducing the accumulation of physical disability in a relapsing-remitting multiple sclerosis human patient, the method comprising orally administering to the patient a daily dose of 0.6 mg laquinimod.The subject invention also provides for pharmaceutical oral unit dosage forms of 0.6 mg laquinimod for use in reducing the relapse rate and / or for use in reducing the accumulation of physical disability in a relapsing-remitting multiple sclerosis human patient.

The present invention relates to a method of preventing or treating benign estrogen sensitive gynecological disorders in a female mammal, wherein the method comprises the administration to said female mammal of a combination of progestogen and androgen in an amount that is therapeutically effective to prevent or reduce the symptoms of these disorders. The present method is particularly suitable for preventing or treating disorders selected from the group consisting of endrometriosis, adenomyosis, uterine fibroids, dysmenorrhoea, menorrhagia and metrorrhagia. Another aspect of the invention relates to a pharmaceutical kit comprising a plurality of oral dosage units which comprise a progestogen in an amount equivalent to 3-500 μg levonorgestrel and either 5 to 250 mg dehydroepiandrosterone or 1 to 50 mg testosterone undecanoate.

The invention discloses a medicament for treating deficiency of kidney, frequent micturition, urgent urination and prostatitis, which is prepared from 38 Chinese medicinal herbs: common curculigo rhizome, tuber fleeceflower root, ginseng, hippocamp, common macrocarpium fruit, malaytea scurfpea, siberian solomonseal rhizome, hairy antler, songaria cynomorium herb, root of red-rooted salvia, sevenlobed yam rhizome, epimedium, astragalus, raw rehmannia root, prepared rehmannia root, cochinchnese asparagus root, ophiopogon root, shizandra berry, medlar, cinnamomvine, white poria, seal's genitals, hawthorn fruit, raspberry, chaff flower root, platycladi seed, eucommia bark, Chinese angelica, medicinal indianmulberry root, south dodder seed, desertliving cistanche, polygala root, phellodendron, anemarrhena root, cassia bark, placenta, prepared common monkshood daughter root and black sesame seed. The medicament has the advantages of addressing both symptoms and root causes along with appropriate compatibility, good curative effect, short treatment course, high cure rate, low recurrence rate, no toxic or side effect, convenience for application, low treatment cost and the like.

A CD40 signal blocking agent comprising, as an active ingredient, s-triazolo[1,5-a]pyrimidine derivative represented by the following formula (1) or a pharmaceutically acceptable salt thereof, is disclosed

The present invention provides compounds of formula (I),wherein:R1 is unsubstituted C1-C6 alkyl;La is substituted or unsubstituted C1-C6 alkyl linker, substituted or unsubstituted C3-C10 carbocycle, substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, or substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S; andR2 and R3 are each, independently, H, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted C6-C10 aryl;or alternatively, R2 and R3, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S or a substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S.The invention also provides pharmaceutical compositions and methods for treating neurological diseases, such as multiple sclerosis.

The invention relates to an oral traditional Chinese medicine for treating skin diseases. The oral traditional Chinese medicine is prepared from radix lithospermi, rhizoma smilacis glabrae, fructus gardeniae, cortex dictamni, common peony roots, radix scrophulariae, rehmanniae radix, isatis indigotica forts, radix sophorae flavescentis, lalang grass rhizome, flos sophorae, radix sileris, puncturevine caltrop fruits, red-rooted salvia roots, ligusticum wallichii, large-leaved gentian, processed polygonum multiflorum, Chinese angelica, white paeony roots and licorice roots. The oral traditional Chinese medicine is a pure traditional Chinese medicine prescription, reduces the recurrence rate of psoriasis and obviously improves the cure rate. In the invention, by mixing the Chinese angelica, the white paeony roots, the isatis indigotica forts and the licorice roots for use, the organism immunity can be enhanced greatly and the problem of recurrence of the psoriasis due to cold and pharyngitis can be solved. The oral traditional Chinese medicine has high effective rate to the psoriasis more than 98 percent and also has 100 percent cure rate to conventional skin diseases such as acne, cutaneous pruritus, pityriasis rosea, eczema, lichen planus, neurodermatitis, urticaria, seborrheic dermatitis, and the like.

The invention provides a novel biological-material complex patch which is of a laminated structure comprising a basic layer and an additional layer. The novel biological-material complex patch is characterized in that the basic layer is an patch made from an artificial synthetic material; the additional layer is a biological patch made from an extracellular matrix / acellular tissue matrix material, or a synthetic-material patch made from an artificial synthetic biological material or the artificial synthetic biological material and an artificial synthetic degradable material; and the basic layer and the additional layer are integrated through a surgical suture or a medical adhesive or other methods. The biological-material complex patch has the advantages of easiness for peripheral tissue growth and angiogenesis, adhesion prevention, degradability, good infection resistance and the like of the biological material and the advantages of easiness for tissue growth by of a big mesh, excellent infection resistance, difficulty for generating hydrops, non-degradability, high late mechanical strength and durability of the artificial-synthetic-material patch, adopts a simple production method, is more effective after being applied in clinic, and ensures recent and late relapse and infection rates to be lower.

The externally applied plaster for treating infantile fever is developed on the infantile physiological and pathological characteristics and fever cause and is prepared with 18 kinds of Chinese medicinal materials, including sweet wormwood, eucalyptus leaf, mint, schizonepta, etc. and through decoction, concentration, crushing, mix and other steps. It has the functions of dispelling wind and other pathogenic evil, clearing away heat and toxic material, resolving stagnation and alleviating mental depression, is used to treat infantile fever diseases, and has obvious curative effect and high safety.

The present invention is directed to compounds, compositions thereof, and the use of the compounds and compositions for the treatment and prevention of breast cancer. In one embodiment, the present invention relates to the use of a substituted triphenyl butene or prodrug thereof for the treatment of breast cancer in mono-therapy or in combination therapy, or for a reduction in the recurrence rate of previously-treated breast cancer.

The invention relates to methods of diagnosing or monitoring a psychotic disorder in a subject comprising providing a test biological sample from the subject, performing spectral analysis on said test biological sample to provide one or more spectra, and, comparing the one or more spectra with one or more control spectra. The invention also relates to methods for diagnosing or monitoring psychotic disorders such as schizophrenic or bipolar disorders, comprising measuring the level of one or more biomarkers present in a biological sample taken from a test subject, said biomarkers being selected from the group consisting of transthyretin, ApoA1: VLDL, LDL and aromatic species such as plasma proteins. The invention also relates to sensors, biosensors, multi-analyte panels, arrays, assays and kits for performing methods of the invention.

The present invention provides methods for stabilizing, reducing or eliminating cancer cells. In particular, the present invention provides prophylactically and / or therapeutically effective regimens for the prevention, treatment and / or management of cancer, the regimens comprising administering one or more cancer therapies to a subject to reduce a cancer cell population. The therapy(ies) in the prophylactically and / or therapeutically effective regimen can be administered at a lower dose than currently used or known to one of skill in the art and / or for a longer period of time and / or more frequently than currently administered or known to one of skill in the art.

The invention discloses a medicament for treating mammitis which is prepared from the following raw materials (by weight proportion): Chinese honeylocust spine, dandelion, honeysuckle, capsule of weeping forsythia, Bupleurum root, green tangerine orange peel, dried orange peel, Chinese angelica root, radix paeoniae rubrathe, dried rehmannia root, figwirt root, root of herbaceous peony, globe thistle, seed of cowherb, oyster shell, astragalus root, licorice root.

The invention discloses antibacterial body shaping gel for regulating microecological balance and a preparation method. The body shaping gel is prepared from the following raw materials in parts by weight: 1-3 parts of hydroxyethyl cellulose, 4-6 parts of radix sophorae flavescentis extract, 3-5 parts of radix stemonae extract, 1-3 parts of collagen peptide, 3-5 parts of fructus cnidii extract, 3-5 parts of cortex phellodendri extract, 2-4 parts of pericarpium zanthoxyli fruit extract, 2-4 parts of saffron crocus extract, 2-3 parts of snow lotus herb extract, 1-3 parts of hamamelis virginianaleaf extract and 2-5 parts of lactobacillus. The body shaping gel disclosed by the invention can kill harmful pathogenic bacteria in vagina, protect the beneficial floral in vagina, regulate the microecological balance of vagina and enhance the immunity of the female reproductive system; meanwhile, the body shaping gel also has the functions of clearing the uterus and eliminating toxin, repairingthe injured mucosa of vagina, improving the flabby and dry vagina and realizing compactness.

The invention discloses a traditional Chinese medicine composition for treating subacute thyroiditis. The composition is a preparation prepared from the following raw materials by weight: 15-30 parts of hedyotis diffusa, 9-15 parts of honeysuckle, 15-30 parts of dandelion, 15-30 parts of Chinese violet, 9-15 parts of root of common peony, 9-15 parts of radix scrophulariae, 9-15 parts of peach kernel, 9-15 parts of baked turtle shell and 15-30 parts of sweet wormwood. According to clinical study on the treatment of subacute thyroiditis, the traditional Chinese medicine composition provided by the invention has total effective rate of 93.34%, which is significantly better than 73.33% of a prednisone group, and can effectively reduce erythrocyte sedimentation rate and CRP of subacute thyroiditis patients, and effectively improve clinical symptoms of the patients; although the cooling time, improvement time of neck pain and regression time of neck tenderness are longer than those of the prednisone group, the goiter or nodule disappearance time shows no obvious difference from those of the prednisone group; relapse rate after drug withdrawal is 3.33%, which is significantly lower than 20% of the prednisone group; and the composition has little adverse reaction, which is significantly lower than that of the prednisone group. The invention also discloses a preparation method of the traditional Chinese medicine composition granules.

Method for treating a patient in need of therapy for a neurodegenerative disease by administering to that patient a therapeutically effective dose of a triglyceride oil containing both γ-linolenic acid and linolenic acid residues as triglyceride ester. The ratio of γ-linolenic acid to linolenic acid residues at the sn-2 position of the triglyceride is at least 0.8. The amount of γ-linolenic acid residues at the sn-2 position is at least 18%. The oil is administered at a dose sufficient to maintain or elevate TGF-β1 levels in the patient at a therapeutic level.

The invention discloses a Chinese medicinal preparation for treating helicobacter pylori concerned chronic gastritis, which is prepared from jiuxiang bug, rose, notoginseng root powder, astragalus, szechwon tangshen root, large-headed atractylodes rhizome, cassia twig, white paeony root, golden thread, medcinal evodia fruit, calcined ark shell, cuttlebone, fructus citri immaturus exsiccatus, common bletilla pseudobulb, cinnamomvine, mongolian dandelion herb, areca seed and liquorice root serving as raw materials in a certain weight ratio by a certain process according to different properties of each traditional Chinese medicine. The Chinese medicinal preparation has the advantages of scientific formula and reasonable compatibility, has the effects of warming middle-jiao and invigorating the spleen, regulating the flow of qi and harmonizing stomach, removing blood stasis and stopping pain, eliminating helicobacter pylori, promoting tissue regeneration and treating cutaneous pyogenic infection, protecting mucosa and healing stomach, promoting the healing of mucosa and reducing relapse, and particularly has the unique curative effect on symptoms such as epigastric pain, acid regurgitation, hiccough and eructation, anorexia and acratia, sallow complexion and the like which are caused by gastritis.

The invention relates to a treatment for rheumatism, rheumatoid, postpartum rheumatism, hyperosteogeny and lumbar disc herniation. The commodity name of the herbal medicine is 'Wind-cold-dampness Dispersed Powder' or 'Wind-cold-dampness Dispersed Capsule', and is a normally used TCM made of ephedra, achyranthis bidentatae, homalonemae rhizome, Chinese wolfberry fruit, parsnip, angelica, notopterygium, encommiae ulmoide carbon, cassia twig, mastic-frank incense, myrrha, pawpaw, Schizophragma integrifolium Oliv, anoelicae sinensis, liquorice, lovage and radix paeoniaalba. The madcine is quite efficient for rheumatism, rheumatoid, postpartum rheumatism, hyperosteogeny and lumbar disc herniation. Compared with other similar drugs, the invention can not only treat the symptoms but also the root cause. The clinical observation has proved the invention can treat rheumatism, rheumatoid, postpartum rheumatism, hyperosteogeny and lumbar disc herniation with exact effect and low cost. Compared with chemical drugs, the invention does not boast high efficacy, but also has less negative effects. As long as the patients use the medicine as required, the relapsed and invalidity cases will be significantly reduced.

The invention discloses a Chinese herbal preparation for treating nasosinusitis, rhinopolypus and nasopharyngitis. The Chinese herbal preparation consists of 17 Chinese herbs including Siberian cocklebur fruit, biond magnolia flower, small centipeda herb, szechwan lovage rhizome, heartleaf houttuynia herb, gypsum, milkvetch root, ahurian angelica root, platycodon root, field mint, calamus, luffa rattan carbon, pariphyllin, yellow croaker ear-stone, common burreed tuber, zedoray rhizome and radix glycyrrhizae, etc. Aiming at the cause and the pathogenesis of nasosinusitis, rhinopolypus and nasopharyngitis, the Chinese herbal preparation treats according to different symptoms and achieves good efficacy. The total effective rate is 96.1%, and the cure rate is 72.5%. The Chinese herbal preparation uses the materials exactly with reasonable compatibility and good efficacy. The problem that nasosinusitis, rhinopolypus and nasopharyngitis are difficult to cure is solved.

The invention belongs to the technical field of proprietary Chinese medicines, and particularly relates to a medicine for treating reflux esophagitis and a preparation method thereof. The invention mainly aims at solving the problems of the existing medicine for treating reflux esophagitis that long-term use of the medicine is easy to incur atrophic gastritis, symptoms and diseases are easy to relapse after medicine withdrawal, curative effect is poor, and the like. In the invention, radix bupleuri, radix paeoniae alba, fructus aurantii immaturus, tangerine peel, ligusticum chuanxiong hort, gardenia jasminoides ellis, rhizoma coptidis, pinellia ternate, evodia rutaecarpa, semen raphani, nacre and glycyrrhiza uralensis are mainly taken as active pharmaceutical ingredients of the medicine, and the specific preparation method comprises the following steps: firstly heating the fructus aurantii immaturus with bran, processing the pinellia ternate with ginger, dry-frying the semen raphani, processing the glycyrrhiza uralensis with honey, then putting the medicines together with the remaining other medicines in a container, adding a certain amount of water for decoction, concentrating decoction to clear cream, drying, preparing fine powder, adding lactose and aspartame in the fine powder, evenly mixing to prepare granules, and packaging after sterilization, so as to obtain the medicine. The medicine has the advantages of stable curative effect, lower recurrence rate after medicine withdrawal and the like.

The invention relates to methods of diagnosing or monitoring a psychotic disorder in a subject comprising providing a test biological sample from the subject, performing spectral analysis on said test biological sample to provide one or more spectra, and, comparing the one or more spectra with one or more control spectra. The invention also relates to methods for diagnosing or monitoring psychotic disorders such as schizophrenic or bipolar disorders, comprising measuring the level of one or more biomarkers present in a biological sample taken from a test subject, said biomarkers being selected from the group consisting of transthyretin, ApoA1, VLDL, LDL and aromatic species such as plasma proteins. The invention also relates to sensors, biosensors, multi-analyte panels, arrays, assays and kits for performing methods of the invention.

A Chinese medicine in the form of plaster for treating osteonosus and mastoplasia is prepared from 7 Chinese-medicinal materials including borneol, rhubarb, phellodendron bark, myrrh, etc. Its advantages are high curative effect, short coruse of treatment, and low recurrence rate.