Traditional Chinese medicine compound composition with treatment effect on rapid atrial fibrillation and preparation method of traditional Chinese medicine compound composition

Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine compound composition with a treatment effect on rapid atrial fibrillation and a preparation method of the traditional Chinese medicine compound composition. The traditional Chinese medicine composition comprises radix pseudostellariae, rhizoma polygonati, radix rehmanniae preparata, radix paeoniae alba, spina date seed, mulberry, jujube kernel, schisandra chinensis, Huai wheat, radix ophiopogonis, ligusticum wallichii, salvia miltiorrhiza, radix rehmanniae, coptis chinensis, radix paeoniae rubra, liquorice, fingered citron, calcined dragon bone, calcined oyster shell and rose. The invention aims at the basic pathogenesis of rapid atrial fibrillation dialectically belonging to insufficiency of heart yin, deficiency of essence and blood, unsmooth emotion, blood vessel stasis, stasis depression and fever which are caused by tachycardia and irregular pulse and rhythm. The clinical research proves that the traditional Chinese medicine compound composition can obviously reduce the recurrence frequency and recurrence rate of patients suffering from paroxysmal rapid atrial fibrillation and improve the symptoms of palpitation, chest distress, palpitation and the like of rapid atrial fibrillation, and has the advantages of good clinical curative effect and wide application prospect. The defects of western medicines can be well overcome.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine compound composition having a therapeutic effect on rapid atrial fibrillation and a preparation method thereof. Background Art

[0002] Atrial fibrillation is the most common chronic and recurrent arrhythmia in clinical practice. Atrial fibrillation itself and its complications such as heart failure and thromboembolism are seriously threatening human health, causing the incidence and mortality of stroke in patients to increase exponentially. Therefore, the study of the mechanism of atrial fibrillation has become a hot topic in the cardiovascular field at the end of the last century and this century.

[0003] At present, the treatment of atrial fibrillation is divided into drug therapy and non-drug therapy. Drug therapy includes antiarrhythmic drugs to control rhythm and ventricular rate, and the use of anticoagulants to prevent atrial fibrillation-related stroke. Non-drug treatment includes surgery, ablation surgery, synchronized direct current cardioversion, left atrial appendage occlusion, etc. However, there are controversies about the recurrence rate and safety, and the efficacy has not been satisfactory. Therefore, it is of great significance and value to study the clinical treatment of atrial fibrillation. Summary of the invention

[0004] The purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art and to provide a Chinese medicinal compound composition having a therapeutic effect on rapid atrial fibrillation and a preparation method thereof.

[0005] The technical scheme adopted by the present invention is as follows: a Chinese medicine compound composition having a therapeutic effect on rapid atrial fibrillation, which comprises the following components in parts by mass: 20-30 parts of Pseudostellariae Radix, 20-30 parts of Polygonatum sibiricum, 10-15 parts of Rehmannia glutinosa, 10-15 parts of White Peony Root, 20-30 parts of Morus Fructus, 20-30 parts of Ziziphus Jujuba Seed, 10-12 parts of Schisandrae Chinensis, 30-50 parts of Huai Triticum Vulgare, 10-15 parts of Ophiopogon japonicus, 10-15 parts of Chuanxiong, 20-30 parts of Salvia miltiorrhiza, 15-20 parts of Rehmannia glutinosa, 9-12 parts of Coptis chinensis, 10-15 parts of Red Peony Root, 10-15 parts of Licorice, 10-12 parts of Citron, 20-30 parts of Calcinated Dragon Bone, 20-30 parts of Calcinated Oyster, and 6-10 parts of Rose.

[0006] The preparation method of the Chinese medicinal compound composition having a therapeutic effect on rapid atrial fibrillation as described above comprises the following steps: (1) Take Radix Pseudostellariae, Polygonatum, Radix Rehmanniae Preparata, Radix Paeoniae Alba, Mulberry, Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Triticum Vulgare, Radix Ophiopogonis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Rhizoma Coptis Chinensis, Radix Paeoniae Rubrae, Radix Glycyrrhizae, Citron, Fructus Cibotii, Fructus Longifoliae, Fructus Ostreae, and Rose Flower slices according to their weight fractions, add water and boil twice, each time for 1 to 2 hours, combine the decoctions, filter and concentrate the filtrate, add ethanol with a volume concentration of 85% for alcohol precipitation. Filter off the precipitate, recover the filtrate and concentrate it at 80℃ to a relative density of 1.30 to 1.36 to obtain the extract; (2) Take the extract obtained in step (1) and prepare the extract with a pharmaceutically acceptable carrier into a drug in the form of an ointment, oral liquid, granules, capsules, tablets or pills.

[0007] The extract obtained by the above-mentioned Chinese medicine compound composition according to the above-mentioned method and a pharmaceutically acceptable carrier are prepared into a medicine in the form of ointment, oral liquid, granule, capsule, tablet or pill.

[0008] The inventors believe that the etiology and pathogenesis of yang-heat type atrial fibrillation are mainly deficiency of heart yin essence and blood, emotional distress, blood stasis, and prolonged stasis turning into heat. Among them, "heat" is the key to the occurrence of yang-heat type atrial fibrillation (astringent and rapid pulse). "Emotional distress" and "heart stasis" are necessary links for its occurrence. Heart deficiency is the fundamental factor in the formation of heart stasis. Based on the above understanding, the inventors designed a new Chinese medicine compound preparation and applied it clinically. The clinical efficacy is significant, and it can significantly improve the symptoms and signs of patients with rapid atrial fibrillation, the electrocardiogram efficacy, coagulation indicators and quality of life without obvious adverse reactions, and it can achieve the treatment purpose without the use of Western medicine. Especially for those who have poor results in Western medicine treatment, the decoction patent of the present invention can improve the body's function, control heart rhythm, and achieve improvement in quality of life.

[0009] Specifically, the Chinese herbal compound composition of the present invention is aimed at rapid atrial fibrillation in paroxysmal atrial fibrillation. It is based on the understanding of the basic pathogenesis of insufficient heart yin, deficiency of essence and blood, poor emotions, blood stasis, and stagnation turning into heat, which lead to symptoms such as palpitations, tachycardia, and arrhythmia. It establishes the treatment principles of tonifying qi, yin, nourishing blood, promoting blood circulation and unblocking meridians, clearing away heat and cooling blood, and astringing and consolidating to formulate the prescription.

[0010] The main medicines are Radix Pseudostellariae and Polygonatum sibiricum. The inventor believes that the fundamental cause of atrial fibrillation is heart deficiency, so it is necessary to replenish qi and nourish yin. The combination of Radix Pseudostellariae and Polygonatum sibiricum can effectively replenish the qi and yin of the human body.

[0011] The assistant medicines include cooked rehmannia, white peony root, mulberry, ophiopogon japonicus, schisandra chinensis, and Huai wheat, which have the effect of replenishing yin fluid, essence and blood.

[0012] The adjuvants include Chuanxiong, Danshen, Citron, Rose, Coptis, Radix Rehmanniae, Red Peony Root, Ziziphus Jujuba Seed, Mulberry, Calcined Dragon Bone, and Calcined Oyster. Chuanxiong and Danshen have the effects of promoting qi, activating blood circulation, and unblocking the meridians, avoiding blood stasis and inducing atrial fibrillation. The astringent and rapid pulse caused by the imbalance of the three elements and the rapid atrial fibrillation are caused by "heat", which can cause urgency, so it is necessary to clear away heat and cool blood. Therefore, Coptis, Radix Rehmanniae, Radix Salviae Miltiorrhizae, and Red Peony Root are used as adjuvants. In addition, Ziziphus Jujuba Seed and Mulberry, the sour taste can astringe and slow down the heart rate, and Calcined Dragon Bone and Calcined Oyster can also astringe and slow down the heart rate, so as to achieve the purpose of treating both the symptoms and the root cause.

[0013] Licorice is used as the medicine to harmonize the other medicines, and it can also invigorate the spleen and clear away heat and detoxify. At the same time, according to modern pharmacological research, licorice contains glycyrrhetinic acid and flavonoids, which have the effect of resisting arrhythmia.

[0014] The present invention uses the above-mentioned medicines in combination, and considers the dosage of each component, combines the relationship between the monarch, minister, assistant and envoy, and fully considers the synergistic enhancement and mutual restraint between the medicines, and designs the above-mentioned specific dosage formula to achieve the effects of replenishing qi, yin, nourishing blood, promoting blood circulation and unblocking meridians, clearing away heat and cooling blood, and astringing and consolidating.

[0015] In addition, the inventors have found that emotional injury can induce atrial fibrillation, because emotional injury or direct internal consumption of the heart's essence and blood can also damage the spleen and stomach, resulting in insufficient source of transformation and deficiency of essence and blood. Among them, worry, sadness, and joy can consume the heart's blood, heart essence, or damage the spleen and stomach; fear can cause the heart to be shaken and the qi mechanism to be disordered. Fear can cause the essence to be lost, and the virtual fire can go up, which can shake the mind and cause illness; depression and anger can hurt the liver, and the liver can take advantage of the spleen deficiency, resulting in insufficient source of essence and blood, and the heart can lose its nourishment, and blood stasis can induce atrial fibrillation. Therefore, the present invention adds bergamot to the prescription to relieve liver depression. Modern pharmacological research shows that bergamot has the effect of dilating coronary blood vessels and increasing coronary flow, and can slow down the heart rate. Rose can not only regulate qi to help activate blood circulation, but also can relieve liver depression, regulate emotions, and work together to help dredge blood vessels. Huai wheat is sweet and cool in nature, nourishes the heart and liver, replenishes yin and relieves restlessness. Huai wheat and licorice (Ganmai Dazao decoction minus red dates) of the present invention can treat restlessness in the heart, regulate emotions, and assist in relieving rapid atrial fibrillation.

[0016] The Chinese herbal compound composition configured based on the above ideas can be used in clinical practice to significantly reduce the recurrence frequency and recurrence rate of paroxysmal atrial fibrillation, and can significantly improve the clinical symptoms of atrial fibrillation such as palpitations, chest tightness, and panic, and has a definite effect in treating rapid atrial fibrillation (insufficient heart qi and yin, deficiency of essence and blood, poor emotions, blood stasis, and fever due to stagnation). It can be taken for a long time with few side effects, and the medication is safe and reliable. DETAILED DESCRIPTION

[0017] In order to make the purpose, technical solutions and advantages of the present invention more clear, the present invention will be described in further detail below.

[0018] The application indication of the Chinese medicine compound composition of the present invention is rapid atrial fibrillation, which belongs to the syndrome of insufficient heart qi and yin, poor emotions, deficiency of essence and blood, blood stasis, and stagnation of blood stasis and heat. The clinical manifestations include palpitations, fatigue, shortness of breath, chest tightness or chest pain, insomnia and forgetfulness, dull complexion, red tongue with thick yellow or less fur, and thin and rapid pulse.

[0019] The Chinese medicine compound composition of the present invention is specifically composed of the following parts by weight: 20-30 parts of Pseudostellariae Radix, 20-30 parts of Polygonatum sibiricum, 10-15 parts of Rehmannia glutinosa, 10-15 parts of White Peony Root, 20-30 parts of Morus Fructus, 20-30 parts of Ziziphus Jujuba Seed, 10-12 parts of Schisandrae Chinensis, 30-50 parts of Huai wheat, 10-15 parts of Ophiopogon japonicus, 10-15 parts of Chuanxiong, 20-30 parts of Salvia miltiorrhiza, 15-20 parts of Rehmannia glutinosa, 9-12 parts of Coptis chinensis, 10-15 parts of Red Peony Root, 10-15 parts of Licorice, 10-12 parts of Citron, 20-30 parts of Calcinated Dragon Bone, 20-30 parts of Calcinated Oyster Concha, and 6-10 parts of Rose.

[0020] The above Chinese medicine compound composition can be directly decocted in water and taken clinically, and has a significant therapeutic effect.

[0021] In order to facilitate the application of the Chinese medicine composition, the present invention also provides a method for preparing the above-mentioned Chinese medicine compound composition, which specifically comprises the following steps: (1) Take Radix Pseudostellariae, Polygonatum, Radix Rehmanniae Preparata, Radix Paeoniae Alba, Morus Alpiniae, Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Triticum Vulgare, Radix Ophiopogonis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Rhizoma Coptis Chinensis, Radix Paeoniae Rubrae, Radix Glycyrrhizae, Citron, Fructus Cibotii, Fructus Longifoliae, Fructus Ostreae, and Rose Flower slices according to the mass fractions mentioned above, add water and boil twice, each time for 1 to 2 hours, combine the decoctions, filter and concentrate the filtrate, add ethanol with a volume concentration of 85% for alcohol precipitation. Filter off the precipitate, recover the filtrate and concentrate it at 80°C to a relative density of 1.30 to 1.36 to obtain an extract; (2) Take the extract obtained in step (1) and prepare the extract with a pharmaceutically acceptable carrier into a drug in the form of an ointment, oral liquid, granules, capsules, tablets or pills.

[0022] Step (1) extracts and concentrates the active ingredients in each Chinese medicine to form an extract, which is then made into a drug in the form of an ointment, oral liquid, granule, capsule, tablet or pill that can be easily carried and taken. Clinical trials have shown that the effect is not inferior to that of a Chinese medicine decoction that is directly decocted and taken.

[0023] The following clinical trials illustrate the therapeutic effect of the Chinese herbal compound composition for treating rapid atrial fibrillation of the present invention.

[0024] 1. Clinical data and methods A total of 120 patients with paroxysmal tachycardia atrial fibrillation who visited Wenzhou Geriatric Hospital and Wenzhou Fuyantang Traditional Chinese Medicine Clinic between October 2001 and May 2024 and met the inclusion criteria were selected. The patients were characterized by insufficient heart qi and yin, deficiency of essence and blood, poor emotions, blood stasis, and fever due to stagnation.

[0025] As research subjects, the random number table was used in combination with the patients' tolerance to and willingness to take Chinese medicine.

[0026] (1) Diagnostic criteria: Western medicine diagnostic criteria: refer to the 2014 AHA / ACC / HRS Atrial Fibrillation Treatment Guidelines. Traditional Chinese medicine diagnostic criteria: refer to the 9th edition of Traditional Chinese Medicine Diagnostics published by China Traditional Chinese Medicine Press.

[0027] (2) Inclusion criteria: ① Meet the Western medical diagnostic criteria for atrial fibrillation; ②Age 50-90 years old; ③ The patient has had an atrial fibrillation episode of >30 seconds recorded by electrocardiogram or dynamic electrocardiogram within 6 months; ④Paroxysmal atrial fibrillation (lasting less than 7 days).

[0028] (3) Exclusion criteria: ① Atrial fibrillation associated with severe valvular heart disease: Atrial fibrillation associated with hyperthyroidism: Atrial fibrillation associated with cerebrovascular accident; ② Left ventricular ejection fraction less than 35%, New York Heart Association functional grade IШI or IV; ③Contraindications to anticoagulation; ④ Combined with left atrial thrombus; ⑤ Sick sinus node contraction syndrome, atrioventricular or bundle branch block; ⑥ Pregnant or breastfeeding women; ⑦ Those with allergic constitution or allergic to this drug; ⑧ Patients with severe primary diseases such as cerebrovascular, liver, kidney and hematopoietic system, and patients with mental illness.

[0029] (4) Treatment methods: The 80 clinical patients were randomly divided into two groups, with 40 cases in each group: Decoction group: Pseudostellariae Radix 30g, Polygonatum 30g, Rehmannia glutinosa 12g, White Peony Root 10g, Morus Alpiniae 20g, Ziziphus Jujuba Seed 30g, Schisandrae Chinensis 10g, Huai Wheat 50g, Ophiopogon japonicus 10g, Ligusticum chuanxiong 10g, Salvia miltiorrhiza 30g, Rehmannia glutinosa 15g, Coptis chinensis 10g, Red Peony Root 15g, Licorice 12g, Citron 10g, Calcinated Dragon Bone 20g, Calcinated Oyster 20g, Rose 10g, decocted in water, taken twice a day, the course of treatment is one month.

[0030] Extract group: 30g of Pseudostellariae Radix, 30g of Polygonatum, 12g of Rehmannia glutinosa, 10g of White Peony Root, 20g of Morus alba, 30g of Ziziphus jujuba seed, 10g of Schisandrae Chinensis, 50g of Huai wheat, 10g of Radix Ophiopogonis, 10g of Rhizoma Chuanxiong, 30g of Salvia miltiorrhiza, 15g of Radix Rehmanniae, 10g of Coptis chinensis, 15g of Red Peony Root, 12g of Ligusticum chuanxiong, 10g of Citron, 20g of Calcined Dragon Bone, 20g of Calcined Oyster, 10g of Rose, add water and boil twice, each time for 1~2 hours, combine the decoction, filter and concentrate the filtrate, add 85% ethanol by volume for alcohol precipitation. Filter out the precipitate, recover the filtrate and concentrate it at 80℃ to a relative density of 1.30~1.36 to obtain the extract, make it into granules, take it with boiled water after breakfast and dinner, and the course of treatment is one month.

[0031] (5) Establishment of clinical efficacy standards ① Marked effect, no paroxysmal AF or occasional AF, or a resting ventricular rate of <80 beats / min.

[0032] ②Effective: Paroxysmal AF attacks were reduced by more than 60%, including the duration and frequency of attacks.

[0033] ③ Invalid: Those who fail to meet the above-mentioned significant or effective standards.

[0034] (6) Treatment effect statistics From the above, we can see that in the decoction group, 14 cases of rapid atrial fibrillation were clinically effective, 32 cases were effective, 14 cases were ineffective, and the total effective rate was 76.6%; in the extract group, 18 cases of rapid atrial fibrillation were clinically effective, 29 cases were effective, 13 cases were ineffective, and the total effective rate was 78.3%.

[0035] (7) Case (1) Chen Moumou, female, 67 years old, lives in the third group of Shangdoumen, Lucheng District, Wenzhou City. The date of consultation is June 7, 2022. The patient has had paroxysmal atrial fibrillation for 7 years, with 1-2 attacks a week and an attack time of about 3 to 5 hours. Examination showed normal blood pressure, heart rate of 129 beats / min, irregular heartbeat, irritability, fatigue, atrial fibrillation, no pathological murmur, normal lungs, thin yellow greasy tongue coating, dark red tongue, thin, astringent and rapid pulse.

[0036] Western medicine diagnosis: coronary heart disease, paroxysmal atrial fibrillation.

[0037] The syndrome is characterized by deficiency of heart qi and yin, deficiency of essence and blood, blood stasis, and stagnation of blood. The treatment is to replenish qi, yin, blood, promote qi and blood circulation, clear away heat, cool blood, and astringe and consolidate.

[0038] Prescription: After taking this patented Chinese medicine preparation for one month, the patient did not develop atrial fibrillation after three months of follow-up.

[0039] (2) Jin Moumou, male, 72 years old, lives in Henghebei Community, Lucheng District, Wenzhou City. The consultation date is October 5, 2022. The patient has had paroxysmal atrial fibrillation for 10 years. He was originally taking Betaloc, which was controllable. In the past month, the disease has occurred frequently, three times a week, and each attack lasts 2 to 5 and a half hours, accompanied by palpitations and depression, thin tongue coating with dark white matter, and a sluggish and rapid pulse. Electrocardiogram shows atrial fibrillation and coronary artery insufficiency.

[0040] Syndrome differentiation: deficiency of heart qi and yin, deficiency of essence and blood, emotional distress, blood stasis, stagnation turning into heat. Treatment is to tonify qi, yin, nourish blood, promote qi circulation, activate blood circulation, clear away heat, cool blood, and astringe.

[0041] Prescription: This patented Chinese medicine preparation was taken for one month, and the patient did not suffer from atrial fibrillation after three months of follow-up.

[0042] (3) Zhu Moumou, male, 69 years old, lives in Chengxi Street, Lucheng District, Wenzhou City. The consultation date was July 23, 2021. The patient had paroxysmal atrial fibrillation for 8 years, with frequent attacks in the past six months, once every two days, each attack lasting about 45 minutes to 2 hours, accompanied by palpitations, chest tightness, dark thin yellow urine, and a sluggish and thin pulse.

[0043] Syndrome differentiation: deficiency of heart qi and yin, deficiency of essence and blood, blood stasis, stagnation turning into heat. Treatment is to tonify qi, yin, nourish blood, promote qi circulation, activate blood circulation, dredge meridians, clear away heat, cool blood, and astringe and consolidate.

[0044] Prescription: This patented Chinese medicine preparation was taken for 30 days, and the patient did not develop atrial fibrillation after two months of follow-up.

[0045] (IV) Wang Moumou, female, 78 years old, lives in Wolong Street, Chashan Town, Ouhai District, Wenzhou City. The consultation date is May 29, 2021. The patient has had paroxysmal atrial fibrillation for 7 years. In the past 2 months, the attacks have occurred 1 to 2 times a week, lasting about 3 to 5 hours, accompanied by palpitations and chest tightness. Examination showed normal blood pressure, heart rate of 110 beats / min, irregular heartbeat, atrial fibrillation, no pathological murmur, both lungs were normal, liver and spleen were not affected, the tongue coating was thin, yellow and greasy, and the pulse was thin, astringent and rapid.

[0046] Syndrome differentiation: deficiency of heart qi and yin, deficiency of essence and blood, emotional distress, blood stasis, stagnation turning into heat. Treatment is to tonify qi, yin, nourish blood, promote qi circulation, activate blood circulation, clear away heat, cool blood, and astringe.

[0047] Prescription: This patented Chinese medicine preparation was taken for one month, and the patient did not develop atrial fibrillation after two months of follow-up.

[0048] (5) Liu Moumou, female, 80 years old, lives in Xinqiaotou Community, Lucheng District, Wenzhou City. The date of consultation is March 3, 2023. The patient has had paroxysmal atrial fibrillation for 5 years, with 1 to 2 attacks per week in the past month, lasting about half an hour to an hour, accompanied by chest tightness, fatigue, and normal blood pressure. Her heart rhythm was irregular, with a heart rate of 105 beats / min. Electrocardiogram showed atrial fibrillation and coronary artery insufficiency.

[0049] Syndrome differentiation: deficiency of heart qi and yin, deficiency of essence and blood, emotional distress, blood stasis, stagnation turning into heat. Treatment is to tonify qi, yin, nourish blood, promote qi circulation, activate blood circulation, clear away heat, cool blood, and astringe.

[0050] Prescription: Take this patented Chinese medicine preparation for one month, and follow up for three months without atrial fibrillation.

[0051] (VI) Zheng, male, 82 years old, lives in Shanqian Street, Lucheng District, Wenzhou City. He was diagnosed on April 24, 2021. He has had paroxysmal atrial fibrillation for 11 years. In the past month, the attacks have been frequent, 3 times a week. Each attack can last up to 7 hours, accompanied by palpitations, chest tightness, thin white fur, dark red cracked fur, and thin and rapid pulse. Heart computer: atrial fibrillation, coronary artery insufficiency, diagnosed with coronary heart disease and paroxysmal atrial fibrillation.

[0052] Syndrome differentiation: deficiency of heart qi and yin, deficiency of essence and blood. Blood vessels are blocked, stagnation turns into heat, and treatment is to replenish qi, yin, nourish blood, promote qi and blood circulation, clear away heat, cool blood, and astringe and consolidate.

[0053] Prescription: This patented Chinese medicine preparation was taken for one month, and the patient did not develop atrial fibrillation after two months of follow-up.

[0054] The above disclosure is only the preferred embodiment of the present invention, which certainly cannot be used to limit the scope of the present invention. Therefore, equivalent changes made according to the claims of the present invention are still within the scope of the present invention.

Claims

1. A Chinese medicinal compound composition having a therapeutic effect on rapid atrial fibrillation, characterized in that: The Chinese medicine composition comprises the following components by weight: 20-30 parts of Pseudostellariae Radix, 20-30 parts of Polygonatum sibiricum, 10-15 parts of Rehmannia glutinosa, 10-15 parts of White Peony Root, 20-30 parts of Morus Fructus, 20-30 parts of Ziziphus jujuba seeds, 10-12 parts of Schisandrae Chinensis, 30-50 parts of Triticum truncatum, 10-15 parts of Ophiopogon japonicus, 10-15 parts of Ligusticum chuanxiong, 20-30 parts of Salvia miltiorrhiza, 15-20 parts of Rehmannia glutinosa, 9-12 parts of Coptis chinensis, 10-15 parts of Red Peony Root, 10-15 parts of Liquorice, 10-12 parts of Citron, 20-30 parts of Calcinated Dragon Bone, 20-30 parts of Calcinated Ostrinum Concha and 6-10 parts of Rose.

2. The method for preparing a Chinese medicinal compound composition having a therapeutic effect on rapid atrial fibrillation according to claim 1, characterized in that: It comprises the following method steps: (1) Take Radix Pseudostellariae, Polygonatum sibiricum, Radix Rehmanniae Preparata, Radix Paeoniae Alba, Morus Alpiniae, Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Triticum Vulgare, Radix Ophiopogonis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Rhizoma Coptis Chinensis, Radix Paeoniae Rubrae, Radix Glycyrrhizae, Citron, Fructus Cibotii, Fructus Longifoliae, Fructus Ostreae, and Fructus Rosae Decoction pieces according to their weight fractions, add water and decoct twice, each time for 1 to 2 hours, combine the decoctions, filter and concentrate the filtrate, add ethanol with a volume concentration of 85% for alcohol precipitation, filter out the precipitate, recover the filtrate and concentrate it at 80°C to a relative density of 1.30 to 1.36 to obtain an extract; (2) Take the extract obtained in step (1) and prepare the extract with a pharmaceutically acceptable carrier into a drug in the form of an ointment, oral liquid, granules, capsules, tablets or pills.

3. A drug having a therapeutic effect on rapid atrial fibrillation, wherein the drug is a paste, oral liquid, granules, capsules, tablets or pills prepared from a Chinese herbal compound composition having a therapeutic effect on rapid atrial fibrillation obtained by the preparation method as claimed in claim 2 and a pharmaceutically acceptable carrier.

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